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Nmr Characterizations Of Candidate Battery Electrolytes, Stephen A. Munoz Sep 2018

Nmr Characterizations Of Candidate Battery Electrolytes, Stephen A. Munoz

Dissertations, Theses, and Capstone Projects

Enormous strides have been made in next-generation power sources to build a more sustainable society. Energy storage has become a limiting factor in our progress, and there are huge environmental and financial incentives to find the next step forward in battery technology. This work discusses NMR methods for characterizing materials for use in battery application, with a special focus on relaxometry and diffusometry. Examples are provided of various recent investigations involving novel candidate electrolyte materials with different collaborators. Works discussed in this thesis include: the characterization of a new disruptive solid polymer electrolyte technology, investigations of the dynamics of super …

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Crystal Structure Of A Homoleptic Zinc(Ii) Complex Based On Bis­(3,5-Diiso­Propyl­Pyrazol-1-Yl)Acetate, Josiah G. Elsberg, Nicholas G. Spiropulos, Adam C. Colson, Eric C. Brown Sep 2018

Crystal Structure Of A Homoleptic Zinc(Ii) Complex Based On Bis­(3,5-Diiso­Propyl­Pyrazol-1-Yl)Acetate, Josiah G. Elsberg, Nicholas G. Spiropulos, Adam C. Colson, Eric C. Brown

Chemistry and Biochemistry Faculty Publications and Presentations

Deprotonation of the methyl­ene group in bis­(3,5-diiso­propyl­pyrazol-1-yl)methane with nBuLi and reaction with carbon dioxide yields lithium bis­(3,5-diiso­propyl­pyrazol-1-yl)acetate (1). Treatment of 1 with ZnCl2 results in the com­pound bis­[bis­(3,5-diiso­propyl­pyrazol-1-yl)acetato]­zinc(II), [Zn(C20H31N4O2)2] (2), whose structure has monoclinic (P21/c) symmetry. The ZnII ion resides on an inversion center and is coordinated by two bis­(3,5-diiso­propyl­pyrazol-1-yl)acetate (bdippza) ligands. Each ligand facially coordinates the zinc center via κ3N,N′,O coordination modes to form a distorted octa­hedral complex with four …

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Eps 202-005: Society, Technology And Environment, Michael Bonchonsky Sep 2018

Eps 202-005: Society, Technology And Environment, Michael Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 244a-101: Organic Chemistry Ii Lab, Ngozi Onyia Sep 2018

Chem 244a-101: Organic Chemistry Ii Lab, Ngozi Onyia

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 475-101: Biochemistry Lab I, Yong Kim Sep 2018

Chem 475-101: Biochemistry Lab I, Yong Kim

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Evsc 627-101: Environmental Microbiology, Mengyan Li Sep 2018

Evsc 627-101: Environmental Microbiology, Mengyan Li

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 748-101: Nanomaterials, Zafar Iqbal Sep 2018

Chem 748-101: Nanomaterials, Zafar Iqbal

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 244-003: Organic Chemistry Ii, Ngozi Onyia Sep 2018

Chem 244-003: Organic Chemistry Ii, Ngozi Onyia

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 245-001: Organic Chemistry For Chemical Engineers, Ngozi Onyia Sep 2018

Chem 245-001: Organic Chemistry For Chemical Engineers, Ngozi Onyia

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Evsc 614-101: Quantitative Environmental Risk Assessment, Chaudhery Mustansar Hussain Sep 2018

Evsc 614-101: Quantitative Environmental Risk Assessment, Chaudhery Mustansar Hussain

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Chem 473-001: Biochemistry, Edgardo Farinas Sep 2018

Chem 473-001: Biochemistry, Edgardo Farinas

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Eps 202-007: Society, Technology And Environment, Michael Bonchonsky Sep 2018

Eps 202-007: Society, Technology And Environment, Michael Bonchonsky

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Evsc 385-101: Environmental Microbiology, Mengyan Li Sep 2018

Evsc 385-101: Environmental Microbiology, Mengyan Li

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

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Synthesis And Evaluation Of Densely-Functionalized Troponoids, Danielle R. Hirsch Sep 2018

Synthesis And Evaluation Of Densely-Functionalized Troponoids, Danielle R. Hirsch

Dissertations, Theses, and Capstone Projects

Herein, we document our efforts to expand the scope of troponoid synthetic methodology towards densely-substituted scaffolds. This body of work has focused primarily on an oxidopyrylium cycloaddition/ring-opening strategy for the synthesis and biochemical evaluation of troponoids for assistance in a variety of medicinal chemistry studies. In Chapter 1, we outline the use of this synthetic strategy in the profiling of a library of synthetic αHTs against an aminoglycoside antibiotic resistance enzyme known as aminoglycoside-2’’-O-nucleotidyltransferase [ANT(2’’)-Ia]. Enzymatic mechanistic insights have been gleaned from an assessment of troponoid/antibiotic synergistic potential. In particular, two synthetic constructs were identified as promising antibiotic adjuvant candidates, …

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Characterization And Quantification Of Covalent Modification Of Proteins Using Mass Spectrometry, Pratikkumar N. Rathod Sep 2018

Characterization And Quantification Of Covalent Modification Of Proteins Using Mass Spectrometry, Pratikkumar N. Rathod

Dissertations, Theses, and Capstone Projects

Identification and characterization of various post-translational modifications of protein is a key to understanding many unknown cellular processes. In the last few decades, mass spectrometry has evolved as an essential and effective analytical tool for qualitative and quantitative analysis of proteins. In this research, we have developed a novel MALDI-MS2 based quantification method for Desmosine and Isodesmosine, which served as cross-linking amino acids of elastin, in order to measure the elastin degradation in the body. This is the first quantification method that not only illustrates the potential of MALDI-Ion Trap MS2, but also improvement over the current …

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The Development Of Novel Platforms For The Imaging Of Cancer By Positron Emission Tomography, Brendon E. Cook Sep 2018

The Development Of Novel Platforms For The Imaging Of Cancer By Positron Emission Tomography, Brendon E. Cook

Dissertations, Theses, and Capstone Projects

The role of antibody-based imaging of cancer by positron emission tomography (PET) has expanded significantly in recent years and is poised to radically alter the way that cancer is diagnosed and treated. However, one hurdle that remains is the potentially harmful radiation dose that comes from these imaging agents, as the long circulation time of antibodies (days to weeks) necessitates the use of radionuclides with comparable physical half-lives (i.e. 89Zr, 124I, etc.). One particularly promising solution is the use of the inverse electron demand Diels-Alder (IEDDA) reaction between a 1,2,4,5-tetrazine (Tz) and a trans-cyclooctene (TCO) for pretargeting. …

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Vertical Vs. Adiabatic Ionization Energies In Solution And Gas-Phase: Probing Ionization-Induced Reorganization In Conformationally-Mobile Bichromophoric Actuators Using Photoelectron Spectroscopy, Electrochemistry And Theory, Maxim Vadimovich Ivanov, Denan Wang, Depeng Zhang, Rajendra Rathore, Scott A. Reid Sep 2018

Vertical Vs. Adiabatic Ionization Energies In Solution And Gas-Phase: Probing Ionization-Induced Reorganization In Conformationally-Mobile Bichromophoric Actuators Using Photoelectron Spectroscopy, Electrochemistry And Theory, Maxim Vadimovich Ivanov, Denan Wang, Depeng Zhang, Rajendra Rathore, Scott A. Reid

Chemistry Faculty Research and Publications

Ionization-induced structural and conformational reorganization in various π-stacked dimers and covalently linked bichromophores is relevant to many processes in biological systems and functional materials. In this work, we examine the role of structural, conformational, and solvent reorganization in a set of conformationally mobile bichromophoric donors, using a combination of gas-phase photoelectron spectroscopy, solution-phase electrochemistry, and density functional theory (DFT) calculations. Photoelectron spectral analysis yields both adiabatic and vertical ionization energies (AIE/VIE), which are compared with measured (adiabatic) solution-phase oxidation potentials (Eox). Importantly, we find a strong correlation of Eox with AIE, but not VIE, reflecting variations …

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The Importance Of Solvent Effects On The Mechanism Of The Pfeiffer Effect, Jamie Lunkley, Ngoc Nguyen, Kristina Tuminaro, Dana Margittai, Gilles Muller Aug 2018

The Importance Of Solvent Effects On The Mechanism Of The Pfeiffer Effect, Jamie Lunkley, Ngoc Nguyen, Kristina Tuminaro, Dana Margittai, Gilles Muller

Faculty Publications, Chemistry

The Pfeiffer effect is observed when an optically active compound such as an amino acid is introduced to a solution containing a labile racemic metal complex, and an equilibrium shift is obtained. The “perturbation” results in an excess of one enantiomer over the other. The shift is a result of a preferential outer sphere interaction between the introduced chiral species and one enantiomeric form (Λ or ∆) of a labile metal complex. Speculations regarding the mechanism of the Pfeiffer effect have attributed observations to a singular factor such as pH, solvent polarity, or numerous other intermolecular interactions. Through the use …

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Acetylcholinesterase Biosensor Platform Based On Bp2000 For The Detection Of Carbaryl, Ming-Han Zhang, Jun-Qiao Jiang, Jun-Jie Ge, Wei Xing Aug 2018

Acetylcholinesterase Biosensor Platform Based On Bp2000 For The Detection Of Carbaryl, Ming-Han Zhang, Jun-Qiao Jiang, Jun-Jie Ge, Wei Xing

Journal of Electrochemistry

With the purpose of providing a new method for carbaryl (a pesticide) detection, on the basis of the principle that acetylcholinesterase (AChE) activity can be restrained by carbaryl, an AChE biosensor platform based on BP2000 (as a fixation) was constructed by dropping method. As a result, it revealed that AChE immobilized on BP2000 maintained its catalytic activity for acetylcholine (ATCl), and due to the introduction of the BP2000 material, the effective electrochemical surface area of the modified electrode was enlarged. In addition, the electrochemical oxidation at the modified electrode occurred at low potential (0.630 V) accompanied by proton transmission. The …

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Influences Of Na-Mn Ratio On Electrochemical Performances And Intercalation-Deintercalation Processes Of Sodium Ion In NaXMno2, Yong-Chun Xie, Cheng Wang, Fang Jiang, Yang Yang, Jing Su, Yun-Fei Long, Yan-Xuan Wen Aug 2018

Influences Of Na-Mn Ratio On Electrochemical Performances And Intercalation-Deintercalation Processes Of Sodium Ion In NaXMno2, Yong-Chun Xie, Cheng Wang, Fang Jiang, Yang Yang, Jing Su, Yun-Fei Long, Yan-Xuan Wen

Journal of Electrochemistry

In this work, NaxMnO2 was synthesized by a solid-state reaction. The influences of Na:Mn ratio on the structure, morphology and electrochemical performance, and sodium ion intercalation/deintercalation processes were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, field emission scanning electron microscopy, cyclic voltammetry, electrochemical impedance spectroscopy and galvanostatic charge-discharge test. The prepared NaxMnO2 was mainly composed of Na0.7MnO2 and Na0.91MnO2, and the content of Na0.91MnO2 increased with the increase of Na:Mn ratio. However, the activation energy values of surface membrane diffusion, interfacial electrochemical reaction and …

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Modulating Restriction Endonuclease Activities And Specificities Using Neutral Detergents, Lori H. Conlan, Thomas J. José, Kevin C. Thornton, Cynthia M. Dupureur Aug 2018

Modulating Restriction Endonuclease Activities And Specificities Using Neutral Detergents, Lori H. Conlan, Thomas J. José, Kevin C. Thornton, Cynthia M. Dupureur

Educator Preparation & Leadership Faculty Works

It is well known that type II restriction enzyme activities and specificities can be modulated by altering solution conditions. The addition of co-solvents such as dimethyl sulfoxide (DMSO), alcohols and polyols can promote star activity, which is the cleavage of non-cognate sequences. While neutral detergents are often used to control protein aggregation, little is known about the effect of neutral detergents on restriction enzyme activities and specificities. We report here that BamHI, BglI, BglII, EcoRI, EcoRV, HindIII, MluI, PvuII, SalI and XhoI restriction endonucleases are remarkably tolerant of high concentrations …

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Sintering-Induced Nucleation And Growth Of Noble Metal Nanoparticles For Plasmonic Resonance Ceramic Color, Nathan Dinh, Michael C. Leopold, Ryan Coppage Aug 2018

Sintering-Induced Nucleation And Growth Of Noble Metal Nanoparticles For Plasmonic Resonance Ceramic Color, Nathan Dinh, Michael C. Leopold, Ryan Coppage

Chemistry Faculty Publications

This study demonstrates the formation of nanoparticles (NPs) from metal salts within ceramic glazes, such that the use of this colorant technology is more accessible to artisans, employs less metal content, is less environmentally harmful, and allows for the use of traditional kilns. Gold NPs have been demonstrated to possess a specific, low material loading use as a ceramic glaze colorant via plasmon resonance. Pre-synthesized gold NPs that are added to ceramic glazes have been found to significantly change in size after firing in both reductive and oxidative atmospheres, but still maintain some size relationships and color properties. Unfortunately, it …

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P62-Dependent Phase Separation Of Patient-Derived Keap1 Mutations And Nrf2, E. W. Cloer, P. F. Siesser, E. M. Cousins, D Goldfarb, D. D. Mowrey, Joseph S. Harrison, S. J. Weir, N. V. Dokholyan, M. B. Major Aug 2018

P62-Dependent Phase Separation Of Patient-Derived Keap1 Mutations And Nrf2, E. W. Cloer, P. F. Siesser, E. M. Cousins, D Goldfarb, D. D. Mowrey, Joseph S. Harrison, S. J. Weir, N. V. Dokholyan, M. B. Major

College of the Pacific Faculty Articles

Cancer-derived loss-of-function mutations in the KEAP1 tumor suppressor gene stabilize the NRF2 transcription factor, resulting in a pro-survival gene expression program that alters cellular metabolism and neutralizes oxidative stress. In a recent genotype-phenotype study, we classified 40% of KEAP1 mutations as ANCHOR mutants. By immunoprecipitation, these mutants bind more NRF2 than wild-type KEAP1 and ubiquitylate NRF2, but are incapable of promoting NRF2 degradation. BioID-based protein interaction studies confirmed increased abundance of NRF2 within the KEAP1 ANCHOR mutant complexes with no other statistically significant changes to the complexes. Discrete molecular dynamic simulation modeling and limited proteolysis suggest that the ANCHOR mutations …

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Synthesis Of The Complex Salt With Triphenylphosphine Bromide, Х Haitbayev,, X. Babaev, I Yuldashev, Aug 2018

Synthesis Of The Complex Salt With Triphenylphosphine Bromide, Х Haitbayev,, X. Babaev, I Yuldashev,

Scientific journal of the Fergana State University

This article affirms that one of the main factors for increasing the yield of fruit trees is their protection from pests and diseases. In recent years, plant protection has paid great attention to the use of harmless biological control methods for the environment, humans and animals. An example is the use of the use of pheromones, which can be separated from different insects. Practical significance is the production and use in practice of pheromones of insect pests by chemical methods, which adversely affect the plant world.

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Synthesis Of The Complex Salt With Triphenylphosphine Bromide, Х Haitbayev,, X. Babaev, I Yuldashev, Aug 2018

Synthesis Of The Complex Salt With Triphenylphosphine Bromide, Х Haitbayev,, X. Babaev, I Yuldashev,

Scientific journal of the Fergana State University

This article affirms that one of the main factors for increasing the yield of fruit trees is their protection from pests and diseases. In recent years, plant protection has paid great attention to the use of harmless biological control methods for the environment, humans and animals. An example is the use of the use of pheromones, which can be separated from different insects. Practical significance is the production and use in practice of pheromones of insect pests by chemical methods, which adversely affect the plant world.

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Instrumentation For Cryogenic Dynamic Nuclear Polarization And Electron Decoupling In Rotating Solids, Faith Joellen Scott Aug 2018

Instrumentation For Cryogenic Dynamic Nuclear Polarization And Electron Decoupling In Rotating Solids, Faith Joellen Scott

Arts & Sciences Graduate Student Theses and Dissertations

Dynamic nuclear polarization (DNP) increases the sensitivity of nuclear magnetic resonance (NMR) using the higher polarization of electron radical spins compared to nuclear spins. The addition of electron radicals for DNP to the sample can cause hyperfine broadening, which decreases the resolution of the NMR resonances due to hyperfine interactions between electron and nuclear spins. Electron decoupling has been shown to attenuate the effects of hyperfine coupling in rotating solids. Magic angle spinning (MAS) DNP with electron decoupling requires a high electron Rabi frequency provided by a high-power microwave source such as a frequency-agile gyrotron. This dissertation describes the development …

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Building On Nature: Spectroscopic Studies Of Photosynthesis-Inspired Pigments, Fused Light Harvesting Proteins, And Bacterial Reaction Center Mutants, Kaitlyn Faries Aug 2018

Building On Nature: Spectroscopic Studies Of Photosynthesis-Inspired Pigments, Fused Light Harvesting Proteins, And Bacterial Reaction Center Mutants, Kaitlyn Faries

Arts & Sciences Graduate Student Theses and Dissertations

Photosynthesis is the dominant form of solar energy conversion on the planet, making it critical to understand the fundamentals of the process in order to effectively mimic and improve upon it for human energy needs. The initial stages of photosynthesis include light harvesting and chemical conversion of that harvested energy via electron transport, with both of these stages relying on pigments (or chromophores) such as chlorophyll and specific protein architectures for the processes. In this work, the fundamental underpinnings of photosynthetic light harvesting and electron transport are explored via spectroscopy of various photosynthetic systems with altered natural pigments and proteins. …

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Regium Bonds Between Mn Clusters (M=Cu,Ag,Au And N=2-6) And Nucleophiles Nh3 And Hcn, Wiktor Zierkiewicz, Mariusz Michalczyk, Steve Scheiner Aug 2018

Regium Bonds Between Mn Clusters (M=Cu,Ag,Au And N=2-6) And Nucleophiles Nh3 And Hcn, Wiktor Zierkiewicz, Mariusz Michalczyk, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

The most stable geometries of the coinagemetal (or regium) atom (Cu, Ag, Au) clusters Mn for n up to 6 are all planar, and adopt the lowest possible spin multiplicity. Clusters with even numbers of M atoms are thus singlets, while those with odd n are open-shell doublets. Examination of the molecular electrostatic potential (MEP) of each cluster provides strong indications of the most likely site of attack by an approaching nucleophile, generally one of two positions. A nucleophile (NH3 or HCN) most favorably approaches one particular M atom of each cluster, rather than a bond midpoint or face. In …

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Molecular Determinants Of Substrate Specificity In Human Insulin-Degrading Enzyme, Lazaros Stefanidis, Nicholas D. Fusco, Samantha E. Cooper, Jilian E. Smith-Carpenter, Benjamin J. Alper Aug 2018

Molecular Determinants Of Substrate Specificity In Human Insulin-Degrading Enzyme, Lazaros Stefanidis, Nicholas D. Fusco, Samantha E. Cooper, Jilian E. Smith-Carpenter, Benjamin J. Alper

Chemistry & Physics Faculty Publications

Insulin-degrading enzyme (IDE) is a 110 kDa chambered zinc metalloendopeptidase that degrades insulin, amyloid beta, and other intermediate-sized aggregation prone peptides that adopt β-structures. Structural studies of IDE in complex with multiple physiological substrates have suggested a role for hydrophobic and aromatic residues of the IDE active site in substrate binding and catalysis. Here, we examine functional requirements for conserved hydrophobic and aromatic IDE active site residues that are positioned within 4.5 Angstroms of IDE bound insulin B chain and amyloid beta peptides in the reported crystal structures for the respective enzyme-substrate complexes. Charge, size, hydrophobicity, aromaticity, and other functional …

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Hgf-Induced Formation Of The Met–Axl–Elmo2–Dock180 Complex Promotes Rac1 Activation, Receptor Clustering, And Cancer Cell Migration And Invasion, Wenjing Li, Xiahui Xiong, Amro Abdalla, Salvador Alejo, Linyu Zhu, Fei Lu, Hong Sun Aug 2018

Hgf-Induced Formation Of The Met–Axl–Elmo2–Dock180 Complex Promotes Rac1 Activation, Receptor Clustering, And Cancer Cell Migration And Invasion, Wenjing Li, Xiahui Xiong, Amro Abdalla, Salvador Alejo, Linyu Zhu, Fei Lu, Hong Sun

Chemistry and Biochemistry Faculty Research

The MET proto-oncogene–encoded receptor tyrosine kinase (MET) and AXL receptor tyrosine kinase (AXL) are independently operating receptor tyrosine kinases (RTKs) that are functionally associated with aggressive and invasive cancer cell growth. However, how MET and AXL regulate the migratory properties of cancer cells remains largely unclear. We report here that the addition of hepatocyte growth factor (HGF), the natural ligand of MET, to serum-starved human glioblastoma cells induces the rapid activation of both MET and AXL and formation of highly polarized MET–AXL clusters on the plasma membrane. HGF also promoted the formation of the MET and AXL protein complexes and …

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