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Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz Jan 2020

Fluorescent Sensing Platform For Low-Cost Detection Of Cu$^{\Mathbf{2+}}$ By Coumarin Derivative: Dft Calculation And Practical Application In Herbal And Black Tea Samples, Tahi̇r Savran, Abdurrahman Karagöz, Şükri̇ye Ni̇han Karuk Elmas, Duygu Aydin, Furkan Özen, Kenan Koran, Fatma Nur Arslan, Ahmet Orhan Görgülü, İbrahi̇m Yilmaz

Turkish Journal of Chemistry

A fluorogenic probe based on a coumarin-derivative for Cu$^{2+}$ sensing in CH$_{3}$CN/H$_{2}$O media (v/v, 95/5, 5.0 \textmu M) was developed and applied in real samples. 3-(4-chlorophenyl)-6,7-dihydroxy-coumarin (MCPC) probe was obtained by synthetic methodologies and identified by spectral techniques. The probe MCPC showed remarkable changes with a ``turn-off'' fluorogenic sensing approach for the monitoring of Cu$^{2+}$ at 456 nm under an excitation wavelength of 366 nm. The response time of the probe MCPC was founded as only 1 min. The detection limit of the probe MCPC was recorded to be 1.47 nM. The binding constant and possible stoichiometric ratio (1:1) values …

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New Sandwich-Type Polymeric Potassium-Dicyanoargentate(I) Complex: Synthesis, Characterization And Enzymatic Activity, Nesri̇n Korkmaz Jan 2020

New Sandwich-Type Polymeric Potassium-Dicyanoargentate(I) Complex: Synthesis, Characterization And Enzymatic Activity, Nesri̇n Korkmaz

Turkish Journal of Chemistry

Coordination compounds containing dicyanoargentate(I) have remarkable biological potential due to their therapeutic antibacterial, antifungal, antibiofilm, and anticancer properties. In this study, a new dicyanoargentate(I)-based complex was synthesized and characterized by various procedures (elemental, thermal, FT-IR for complex) involving crystal analysis of the complex. In addition, the biological activity of this new compound on the acetylcholinesterase (AChE) enzyme, an important enzyme for the nervous system, was investigated. When the infrared (IR) spectrum of the complex is examined, the OH vibration peak resulting from H$_{2}$O molecules in the structure at 3948-3337 cm$^{-1}$ and at 2138 cm$^{-1}$, along with a CN peak coordinated …

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Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği Jan 2020

Bis Benzothiophene Schiff Bases: Synthesis And In Silico-Guided Biological Activity Studies, Yasemi̇n Ünver, Di̇lek Ünlüer, Şahi̇n Di̇rekel, Serdar Durdaği

Turkish Journal of Chemistry

Since benzo [$b$] thiophene scaffold is one of the privileged structures in drug discovery as this core exhibitsactivities for different biological problems, in this study bis (benzo[$b$]thiophene-2-yl) alkyl methanimine derivatives (1-9) were synthesized by reacting benzo[$b$]thiophene-2-carbaldehyde with diamines. All newly compounds were characterized by IR, $^{1}$H NMR and $^{13}$C NMR spectroscopic methods. Synthesized compounds were investigated using binary QSAR-based models on therapeutic activity prediction of synthesized compounds and they showed high predicted activities in following diseases: bacterial, angina, allergy, depression and obesity. Thus, they were then tested for their antimicrobial and antileishmanial activities as a result of this theoretical study. …

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Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda Jan 2020

Effect Of Mg Doping On Morphology, Photocatalytic Activity And Related Biological Properties Of Zn$_{\Mathbf{1-X}}$ Mg$_{X}$ O Nanoparticles, Bestenur Yalçin, Doğan Akcan, İbrahi̇m Ertuğrul Yalçin, Mehmet Can Alphan, Kenan Şentürk, İbrahi̇m İlker Özyi̇ği̇t, Lütfi̇ Arda

Turkish Journal of Chemistry

The objective of this study is to synthesize ZnO and Mg doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles via the sol-gel method, and characterize their structures and to investigate their biological properties such as antibacterial activity and hemolytic potential.Nanoparticles (NPs) were synthesized by the sol-gel method using zinc acetate dihydrate (Zn(CH$_{3}$COO)$_{2}$.2H$_{2}$O) and magnesium acetate tetrahydrate (Mg(CH$_{3}$COO)$_{2}$.4H$_{2}$O) as precursors. Methanol and monoethanolamine were used as solvent and sol stabilizer, respectively. Structural and morphological characterizations of Zn$_{1-x}$Mg$_{x}$O nanoparticles were studied by using XRD and SEM-EDX, respectively. Photocatalytic activities of ZnO and selected Mg-doped ZnO (Zn$_{1-x}$Mg$_{x}$O) nanoparticles were investigated by degradation of methylene blue (MeB). Results …

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Synthesis And Spectroscopic Properties Of (N/O) Mono- Anddispirocyclotriphosphazene Derivatives With Benzyl Pendant Arms: Study Ofbiological Activity?, Özlem İşcan, Reşi̇t Cemaloğlu, Nuran Asmafi̇li̇z, Zeynel Kiliç, Leyla Açik, Peli̇n Özbeden, Tuncer Hökelek Jan 2020

Synthesis And Spectroscopic Properties Of (N/O) Mono- Anddispirocyclotriphosphazene Derivatives With Benzyl Pendant Arms: Study Ofbiological Activity?, Özlem İşcan, Reşi̇t Cemaloğlu, Nuran Asmafi̇li̇z, Zeynel Kiliç, Leyla Açik, Peli̇n Özbeden, Tuncer Hökelek

Turkish Journal of Chemistry

The Cl replacement reactions of hexachlorocyclotriphosphazene (trimer; N3 P3 Cl6) with sodium (N-benzyl)- aminopropanoxides (1 and 2) produced monospiro- (3 and 4), cis-, and trans-dispirocyclotriphosphazenes (13-16). The monospiro tetrakis-aminocyclotriphosphazenes (5-12) were obtained by the Cl substitutions of 3 and 4 with different secondary amines. The cis- (13 and 14) and trans-dispirophosphazenes (15 and 16) possessed 2 chiral P centers, and they were able to present meso and racemic forms, respectively. Moreover, the structures of compounds 5 and 14 were designated using X-ray data. The absolute configuration of compound 14 was found as SR in the solid state. Analytical and spectroscopic …

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Highly Sensitive Fluorometric Method Based On Nitrogen-Doped Carbon Dotclusters For Tartrazine Determination In Cookies Samples, Abi̇di̇n Gümrükçüoğlu, Aysel Başoğlu, Sevgi̇ Kolayli, Sali̇ha Di̇nç, Meryem Kara, Mi̇raç Ocak, Ümmühan Ocak Jan 2020

Highly Sensitive Fluorometric Method Based On Nitrogen-Doped Carbon Dotclusters For Tartrazine Determination In Cookies Samples, Abi̇di̇n Gümrükçüoğlu, Aysel Başoğlu, Sevgi̇ Kolayli, Sali̇ha Di̇nç, Meryem Kara, Mi̇raç Ocak, Ümmühan Ocak

Turkish Journal of Chemistry

Nitrogen-doped carbon nanodots (CDs) were prepared via the solvothermal method, using urea and triethylene glycol as the starting materials. The as-prepared CDs had individual diameters of approximately 100 nm and were in clusters of different sizes. The surface composition and optical properties of the as-prepared CDs were characterized. They exhibited multicolor emission properties in the visible range when excited with a wide wavelength range. The aqueous solution of the CDs was used in highly sensitive tartrazine determination. The fluorescence quenching of the CDs was in a linear relationship with the concentrations of tartrazine in the range of 0.5-30.0 μM. The …

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Chemosensor Properties Of 7-Hydroxycoumarin Substituted Cyclotriphosphazenes?, Gönül Yeni̇lmez Çi̇ftçi̇, Sergen Yilmaz, Nagi̇han Bayik, Eli̇f Şenkuytu, Esra Nur Kaya, Mahmut Durmuş, Mustafa Bulut Jan 2020

Chemosensor Properties Of 7-Hydroxycoumarin Substituted Cyclotriphosphazenes?, Gönül Yeni̇lmez Çi̇ftçi̇, Sergen Yilmaz, Nagi̇han Bayik, Eli̇f Şenkuytu, Esra Nur Kaya, Mahmut Durmuş, Mustafa Bulut

Turkish Journal of Chemistry

The newly synthesized cyclotriphosphazene cored coumarin chemosensors 5, 6, and 7 were successfully characterized by $^{1}$H NMR, $^{31}$P NMR, and MALDI-TOF mass spectrometry. Additionally, the photophysical and metal sensing properties of the targeted compounds were determined by fluorescence spectroscopy in the presence of various metals (Li$^{+}$, Na$^{+}$ , K$^{+}$ , Cs$^{+}$ , Mg2$^{+}$ , Ca2$^{+}$ , Ba2$^{+}$ , Cr3$^{+}$ , Mn2$^{+}$ , Fe3$^{+}$ , Co2$^{+}$ , Al3$^{+}$ , Hg$^{+}$ , Cu2$^{+}$ , Zn2$^{+}$ , Ag$^{+}$ , and Cd2$^{+}$) . The fluorescence titration results showed that compounds 5, 6, and 7 could be employed as fluorescent chemosensors for Fe3$^{+}$ ions with …

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Ranolazine-Functionalized Cuo Nps: Efficient Homogeneous And Heterogeneouscatalysts For Reduction Of 4-Nitrophenol, Gul Naz Laghari Baloch, Sarfaraz Ahmed Mahesar, Sirajuddin Khan, Jan Nisar, Syed Tufail Hussain Sherazi Jan 2020

Ranolazine-Functionalized Cuo Nps: Efficient Homogeneous And Heterogeneouscatalysts For Reduction Of 4-Nitrophenol, Gul Naz Laghari Baloch, Sarfaraz Ahmed Mahesar, Sirajuddin Khan, Jan Nisar, Syed Tufail Hussain Sherazi

Turkish Journal of Chemistry

In the present study copper oxide nanoparticles (CuO NPs) were synthesized using a hydrothermal method with ranolazine as a shape-directing agent. Ranolazine-functionalized CuO NPs were characterized by various analytical techniques such as scanning electron microscopy (SEM), Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD). The SEM pattern confirmed the morphology of ranolazine-functionalized CuO NPs with well-defined rice-like structures. FTIR spectroscopy confirmed the interaction between CuO NPs and ranolazine. The XRD analysis indicated that the structure of ranolazine-functionalized CuO NPs was monoclinic crystalline and the size ranged between 9 and 18 nm with an average particle size of 12 nm. …

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Entrapment Of Organic Fluorophores In Calcium Phosphate Nanoparticles Withslow Release, Laila Sadallah, Aicha Boukhriss, Hassan Hannache, Said Gmouh Jan 2020

Entrapment Of Organic Fluorophores In Calcium Phosphate Nanoparticles Withslow Release, Laila Sadallah, Aicha Boukhriss, Hassan Hannache, Said Gmouh

Turkish Journal of Chemistry

Two organic fluorophores, fluorescein (F) and rhodamine B (Rd), were entrapped in calcium phosphate nanoparticles. The as-obtained nanoparticles can be used for biological release applications. For this aim, calcium phosphate nanoparticles were synthesized using the precipitation method. Structural analysis of these nanoparticles was performed using XRD, FTIR, and Raman spectroscopy, confirming that the synthesized nanoparticles were hydroxyapatite. TEM and SEM analyses demonstrated that these nanoparticles had a size of 20 nm and a well-defined morphology. F and Rd (about 0.5 wt.%) were entrapped in these nanoparticles and their release, as a function of time, was studied via UV-Vis spectroscopy. The …

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Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez Jan 2020

Blue Dye Degradation In An Aqueous Medium By A Combined Photocatalytic Andbacterial Biodegradation Process, Gabriela Perez Osorio, Flor Del Rocio Hernandez Gomez, Janette Arriola Morales, Maribel Castillo Morales, Jose Carlos Mendoza Hernandez

Turkish Journal of Chemistry

This paper aimed at implementing a treatment system for polluted water with textile dyes, starting with a photocatalytic decomposition process using sunlight as a source of energy and continuing with a bacterial biodegradation process, in order to reach degradation percentages higher than those obtained using only one of the processes mentioned above. When water treatment with the dye in the combined system was over, an acute ecotoxicity test was performed to make sure that toxic metabolites were not produced due to biodegradation. Solophenyl Blue azoic dye, and Erionyl Blue and Terasil Blue anthraquinone dye-colored solutions were treated with the Pd/Al$_{80}$ …

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Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani Jan 2020

Synthesis, Cytotoxic Assessment, And Molecular Docking Studies Of2,6-Diaryl-Substituted Pyridine And 3,4- Dihydropyrimidine-2(1h)-One Scaffolds, Zahra Hosseinzadeh, Nima Razzaghi-Asl, Ali Ramazani, Hamideh Aghahosseini, Ali Ramazani

Turkish Journal of Chemistry

Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytotoxic effects against several cancer cell lines. An easy and convenient method is reported for the synthesis of these derivatives, employing cobalt ferrite (CoFe$_{2}$ O$_{4}$ @SiO$_{2}$ -SO$_{3}$ H) magnetic nanoparticles under microwave irradiation and solvent-free conditions. The structural characteristics of the prepared nanocatalyst were investigated by FTIR, XRD, SEM, and TGA techniques. In vitro cytotoxic effects of the synthesized products were assessed against the human breast adenocarcinoma cell line …

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Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir Jan 2020

Synthesis, Spectroscopic Studies, And Antioxidant Activities Of Novelthio/Carbohydrazones And Bis-Isatin Derivatives From Terephthalaldehyde, Hali̇t Muğlu, Hasan Yakan, Temel Kan Bakir

Turkish Journal of Chemistry

New bis(isatins-thio/carbohydrazones) based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bis(thio/carbohydrazone) was synthesized by the reaction of (thio)/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, $^{1}$H NMR, and $^{13}$C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl (DPPH.) free radical scavenging method. Compound 2 showed the best antioxidant activity.

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Size-Dependent Interactions Of Lipid-Coated Gold Nanoparticles: Developing A Better Mechanistic Understanding Through Model Cell Membranes And In Vivo Toxicity, Arek M. Engstrom, Ryan A. Faase, Joe E. Baio, Marilyn R. Mackiewicz, Stacey L. Harper Jan 2020

Size-Dependent Interactions Of Lipid-Coated Gold Nanoparticles: Developing A Better Mechanistic Understanding Through Model Cell Membranes And In Vivo Toxicity, Arek M. Engstrom, Ryan A. Faase, Joe E. Baio, Marilyn R. Mackiewicz, Stacey L. Harper

Chemistry Faculty Publications and Presentations

Introduction: Humans are intentionally exposed to gold nanoparticles (AuNPs) where they are used in variety of biomedical applications as imaging and drug delivery agents as well as diagnostic and therapeutic agents currently in clinic and in a variety of upcoming clinical trials. Consequently, it is critical that we gain a better understanding of how physiochemical properties such as size, shape, and surface chemistry drive cellular uptake and AuNP toxicity in vivo. Understanding and being able to manipulate these physiochemical properties will allow for the production of safer and more efficacious use of AuNPs in biomedical applications.
Methods and Materials: Here, …

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A Statistical Analysis Of Trans-Resveratrol In Grape Cane From Ten Varieties Of Cultivated Wine Grapes (Vitus Spp.), Harold Rathburn, Peter Bell, Scott Cook, Darrell D. Mayberry, Emryse Geye, Ryann Goodrich Jan 2020

A Statistical Analysis Of Trans-Resveratrol In Grape Cane From Ten Varieties Of Cultivated Wine Grapes (Vitus Spp.), Harold Rathburn, Peter Bell, Scott Cook, Darrell D. Mayberry, Emryse Geye, Ryann Goodrich

Chemistry Faculty Publications and Presentations

trans-Resveratrol (resveratrol) has been shown to have various health benefits. As a consequence, there is an effort to determine plentiful sources of this molecule. Certain plants, such as grapes, synthesize resveratrol and therefore appear to be an excellent source of this chemical. Annual pruning of grapevine yields significant amounts of cane material that is normally mulched or simply burned. Previous studies have shown this grape cane to contain economically useful resveratrol. Texas is the seventh largest producer of grapes in the USA with over 162 ha currently under cultivation. As a result it is estimated that more than $3.2 …

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Intra- And Intermolecular Self-Assembly Of A 20-Nm-Wide Supramolecular Hexagonal Grid, Zhe Zhang, Yiming Li, Bo Song, Yuan Zhang, Xin Jiang, Ming Wang, Ryan Tumbleson, Changlin Liu, Pingshan Wang, Xin-Qi Hao, Tomas Rojas, Anh T. Ngo, Jonathan L. Sessler, George R. Newkome, Saw Wai Hla, Xiaopeng Li Jan 2020

Intra- And Intermolecular Self-Assembly Of A 20-Nm-Wide Supramolecular Hexagonal Grid, Zhe Zhang, Yiming Li, Bo Song, Yuan Zhang, Xin Jiang, Ming Wang, Ryan Tumbleson, Changlin Liu, Pingshan Wang, Xin-Qi Hao, Tomas Rojas, Anh T. Ngo, Jonathan L. Sessler, George R. Newkome, Saw Wai Hla, Xiaopeng Li

Physics Faculty Publications

For the past three decades, the coordination-driven self-assembly of three-dimensional structures has undergone rapid progress; however, parallel efforts to create large discrete two-dimensional architectures—as opposed to polymers—have met with limited success. The synthesis of metallo-supramolecular systems with well-defined shapes and sizes in the range of 10–100 nm remains challenging. Here we report the construction of a series of giant supramolecular hexagonal grids, with diameters on the order of 20 nm and molecular weights greater than 65 kDa, through a combination of intra- and intermolecular metal-mediated self-assembly steps. The hexagonal intermediates and the resulting self-assembled grid architectures were imaged at submolecular …

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Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n Jan 2020

Synthesis And Bioactivities Of 1-(4-Hydroxyphenyl)-2-((Heteroaryl)Thio)Ethanones As Carbonic Anhydrase I, Ii And Acetylcholinesterase Inhibitors, Cem Yamali, Hali̇se İnci̇ Gül, Yeli̇z Demi̇r, Cavi̇t Kazaz, İlhami̇ Gülçi̇n

Turkish Journal of Chemistry

The discovery of enzyme targeting inhibitors is a popular area of drug research. Biological activities of the compounds bearing phenol and heteroaryl groups make them popular groups in drug design targeting important enzymes such as acetylcholinesterase (AChE, E.C.3.1.1.7) and carbonic anhydrases (CAs, EC 4.2.1.1). 1-(4-hydroxyphenyl)-2-((aryl)thio)ethanones as possible AChE and CAs inhibitors were synthesized, and their chemical structures were confirmed by IR, $^{1}$H NMR, $^{13}$C NMR, and HRMS. The compounds 2 and 4 were found potent AChE inhibitors with the Ki values of 22.13 ± 1.96 nM and 23.71 ± 2.95 nM, respectively, while the compounds 2 (Ki $=$ 8.61 ± …

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Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş Jan 2020

Synthesis, Biological Evaluation Of Antioxidant-Antibacterial Activities And Computational Studies Of Novel Anthracene- And Pyrene-Based Schiff Base Derivatives, Ayşegül Gümüş, Veysi̇ Okumuş, Selçuk Gümüş

Turkish Journal of Chemistry

Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%-99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all. However, compound P3 at concentration of 200 \textmu g/mL possessed the highest metal chelating (45.8%) activity and power of reduction. In addition, P3 and A6 showed antibacterial activity …

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Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak Jan 2020

Magnetite Nanoparticles-Based Hydroxyl Radical Scavenging Activity Assay Ofantioxidants Using N, N-Dimethyl-P-Phenylenediamine Probe, Zi̇ya Can, Büşra Keski̇n, Ayşem Arda, Erol Erçağ, Mustafa Reşat Apak

Turkish Journal of Chemistry

Excessive amounts of reactive oxygen species (ROS), unless counterbalanced by antioxidants, can cause cellular damage under oxidative stress conditions; therefore, antioxidative defenses against ROS must be measured. With the development of nanotechnology, nanoparticles have found numerous applications in science, health, and industries. Magnetite nanoparticles (Fe$_{3}$O$_{4}$:MNPs) have attracted attention because of their peroxidase-like activity. In this study, hydroxyl radicals (?OH) generated by MNPs-catalyzed degradation of H$_{2}$O$_{2}$ converted the N,N-dimethyl-p-phenylenediamine (DMPD) probe into its colored DMPD$^{•+}$ radical cation, which gave an absorbance maximum at λ = 553 nm. In the presence of antioxidants, $^{•}$OH was partly scavenged by antioxidants and produced less …

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Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee Jan 2020

Synthesis, Characterization And Evaluation Of Antidengue Activity Of Enantiomeric Schiffbases Derived From S-Substituted Dithiocarbazate, Maqsood Maryam, Sang Loon Tan, Karen Ann Crouse, Mohamed Ibrahim Mohamed Tahir, Hui Yee Chee

Turkish Journal of Chemistry

A series of Schiff bases have been successfully synthesized through the acid-catalyzed condensation of S-substituted dithiocarbazates and three enantiomerically pure monoterpenes, (1R)-(+)-camphor, (1S)-(-)-camphor, (1R)-(-)-camphorquinone, (1S)- (+)-camphorquinone, (R)-(-)-carvone and (S)-(+)-carvone. Spectroscopic results revealed that the Schiff bases containing camphor or carvone likely adopted an E-configuration along the characteristic imine bond while those containing camphorquinone assumed a Z-configuration. The antidengue potential of these compounds was evaluated based on DENV 2 caused cytopathic effect (CPE) reduction-based in vitro evaluation. The compounds were validated through secondary foci forming unit reduction assay (FFURA). Compounds were also tested for their cytotoxicity against Vero cells. The compounds …

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The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu Jan 2020

The Production Of Enantiomerically Pure 1-Phenylethanol By Enzymatic Kineticresolution Method Using Response Surface Methodology, Ayşe Bozan, Rahi̇me Songür, Ülkü Mehmetoğlu

Turkish Journal of Chemistry

As the enantiomers of 1-phenylethanol are valuable intermediates in several industries, the lipase catalyzed kinetic resolution of (R,S) -1-phenylethanol is a relevant research topic. In this study, the goal was to determine the optimum reaction parameters to produce enantiomerically pure 1-phenylethanol by lipase (Novozyme 435) catalyzed kinetic resolution using response surface methodology (RSM). Reactions were performed with 40-400 mM (R,S)-1-phenylethanol, 120-1200 mM vinyl acetate and 2-22 mg/ mL biocatalyst concentrations (BC$_{L}$), at 20-60 °C and with a stirring rate of 50-400 rpm for 5-120 min. The samples were analyzed using high performance liquid chromatography (HPLC) with a Chiralcel OB column. …

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Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade Jan 2020

Innovational Combination Of Hetero-Bifunctional N-Peg Quinoline Scaffolds Derivatives With Improved Anticancer Activity Against Breast And Colon Cancer Cell Lines And P-Glycoprotein, Cytochrome P450 Enzyme Activity Prediction, Mahesh Gaidhane, Ajay Ghatole, Kushal Lanjewar, Kishor Hatzade

Turkish Journal of Chemistry

Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, …

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Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş Jan 2020

Newly Synthesized Peripherally Octa-Substituted Zinc Phthalocyanines Carrying Halogenterminated Phenoxy-Phenoxy Moiety: Comparative Photochemical And Photophysicalfeatures, Erkan Kirbaç, Ali̇ Erdoğmuş

Turkish Journal of Chemistry

This study reports the 3 new phthalonitrile derivatives, namely 4, 5 Bis-[4-(4-bromophenoxy) phenoxy] phthalonitrile (1), 4,5 Bis-[4-(4-chlorophenoxy) phenoxy]phthalonitrile (2), and 4, 5 Bis[4-(4-fluorophenoxy) phenoxy] phthalonitrile (3). Their octasubstituted zinc phthalocyanines (4, 5, 6) are reported for the first time in this study. The resulting compounds were characterized by utilizing some spectroscopic methods, such as UV-Vis, 1HNMR, FT-IR spectroscopy, as well as mass spectraand elemental analysis. To show photosynthesizer's potential, emission (FF), singlet oxygen (1O2), and photodegradation quantum yields (ΦΔ, Φd) of octaperipherally phthalocyanines (Pcs) were performed in the solutions, such as biocompatible solvent DMSO (dimethyl sulfoxide) as well as DMF …

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Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta Jan 2020

Chemical Composition, And Antibacterial And Antioxidant Activities Of Essential Oils From Laggera Tomentosa Sch. Bip. Ex Oliv. Et Hiern (Asteraceae), Tokuma Getahun, Vinit Sharma, Deepak Kumar, Neeraj Gupta

Turkish Journal of Chemistry

Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae), an endemic Ethiopian medicinal plant, is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil (EO) of its leaves and inflorescence were documented. However, no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover, there are no previous biological activity reports on any parts of the EOs of this plant. Thus, in this study, the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry …

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Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar Jan 2020

Synthesis And Molecular Docking Studies Of Quinoline Derivatives As Hiv Non-Nucleoside Reverse Transcriptase Inhibitors, Nivedita Bhardwaj, Diksha Choudhary, Akashdeep Pathania, Somesh Baranwal, Pradeep Kumar

Turkish Journal of Chemistry

Quinoline moiety is an important scaffold in the field of drug discovery and drug development, with a wide range of pharmacological activities. Quinoline derivatives are potent inhibitors for reverse transcriptase, which is responsible for the conversion of single-stranded viral RNA into double-stranded viral DNA.In the present study, we have designed and synthesized 2 series, namely pyrazoline and pyrimidine containing quinoline derivatives as non nucleoside reverse transcriptase inhibitors (NNRTIs). Eleven compounds were synthesized and characterized by 1H and 13C NMR and mass spectrophotometry. The synthesized compounds were also docked on an HIV reverse transcriptase binding site (PDB: 4I2P); most of these …

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Novel Bodipy-Bridged Cyclotriphosphazenes, Hande Eserci̇, Ezel Öztürk, Eli̇f Okutan Jan 2020

Novel Bodipy-Bridged Cyclotriphosphazenes, Hande Eserci̇, Ezel Öztürk, Eli̇f Okutan

Turkish Journal of Chemistry

Three new 2-component unsubstituted (4P), diiodo- (5P), and dibromo- (6P) distyryl-BODIPY-bridged cyclotriphosphazene dimers were designed and synthesized. The newly synthesized BODIPY-cyclotriphosphazene systems were characterized by $^{1}$H, $^{13}$C, and $^{31}$P NMR spectroscopy. The photophysical properties of the distryl-BODIPYs (4-6) and BODIPY-cyclotriphosphazene dyads (4P-6P) were studied by UV-Vis absorption and fluorescence emission spectroscopy. In these derivatives, the bino-type cyclotriphosphazene derivative bearing unsubstituted BODIPY unit 4 P exhibited high fluorescence and no singlet oxygen generation due to the lack of spin converter. The attachment of heavy atoms (iodine and bromine) enabled the production of singlet oxygen. The bino-type BODIPY-cyclotriphosphazenes (5P and 6P) were …

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Choline Derivatives Immobilized On Silica To Catalyze Transesterification Reaction For Production Of Glycerophosphocholine, Longhui Wei, Binglin Li, Xiaoli Zhang, Kai Tang, Wenwen Zheng, Dan Chen, Binxia Zhao Jan 2020

Choline Derivatives Immobilized On Silica To Catalyze Transesterification Reaction For Production Of Glycerophosphocholine, Longhui Wei, Binglin Li, Xiaoli Zhang, Kai Tang, Wenwen Zheng, Dan Chen, Binxia Zhao

Turkish Journal of Chemistry

Choline derivatives were covalently immobilized on the surface of γ -aminated silica. The obtained immobilized choline derivative was then successfully used for a transesterification reaction to produce glycerophosphocholine (GPC). Fourier transform infrared analysis and thermogravimetric analysis/differential thermal gravimetry indicated that the surface of the γ -aminated silica was covered by choline derivatives and the highest immobilization amount reached 1.1 mmol/g under optimal conditions. More importantly, the highest yield of GPC reached 97.9% during transesterification. With regard to GPC in food or medicine for human use, the immobilization technology can avoid catalyst contamination of the product and increase the safety of …

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Synthesis Of Metallo-Supramolecular Materials Based On Terpyridine Functionalized Double-Decker Silsesquioxane With Improved Complexation Efficienc, Asuman Çeli̇k Küçük, Jun Matsui, Tokuji Miyashita Jan 2020

Synthesis Of Metallo-Supramolecular Materials Based On Terpyridine Functionalized Double-Decker Silsesquioxane With Improved Complexation Efficienc, Asuman Çeli̇k Küçük, Jun Matsui, Tokuji Miyashita

Turkish Journal of Chemistry

Silsesquioxane-based transition-metal complexes have come to the forefront due to the ability of silsesquioxane to control nanostructures and properties. However, some difficulties in complete complexation and purification limit the widespread use of transition-metal-based supramolecular coordination complexes comprising silsesquioxane. Herein, 2 different approaches have been proposed for the synthesis of metallo-supramolecular materials on the basis of ruthenium(II)-terpyridine functional double-layer silsesquioxane (DDSQ) (Tpy/Ru-DDSQ) (Routes 1 and 2). In Route 1, complexation was followed by functionalization of DDSQ with the ligand, whereas in Route 2, complexation was performed before the ligand was inserted into the DDSQ. Tpy/Ru-DDSQ obtained from both approaches was characterized …

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Investigation Of The Effect Of Pan And Pan/Zno Photocatalysts On 100% Degradation Of Congo Red Under Uv Visible Light Irradiation And Lightless Environment, Si̇bel Zor, Bi̇lge Budak Jan 2020

Investigation Of The Effect Of Pan And Pan/Zno Photocatalysts On 100% Degradation Of Congo Red Under Uv Visible Light Irradiation And Lightless Environment, Si̇bel Zor, Bi̇lge Budak

Turkish Journal of Chemistry

PAn (polyaniline) and PAn/ZnO photocatalysts were synthesized using chemical polymerization of aniline. The structure characterization of the synthesized samples was analysed by using X-ray diffraction (XRD), Fourier transforminfraredspectroscopy(FT-IR),scanningelectronmicroscopy(SEM),transmissionelectronmicroscopy(TEM), and UV-Vis spectroscopy measurements, and thermal gravimetric analysis (TGA). The photocatalytic activities of PAn and PAn/ZnO (0.1g/100ml) on the degradation of the Congo red (CR) dye were studied under the UV visible light irradiation and the lightless environment and the efficiency of catalysts have been explained in details. Contribution of UV visible light irradiation on the 100% degradation of CR dye for the PAn and PAn/ZnO photocatalyst is determined. The reaction kinetics …

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Allylphenoxypiperidinium Halides As Corrosion Inhibitors Of Carbon Steel And Biocides, Gunay Mehdiyeva Muzakir, Musa Bairamov Rza, Shahnaz Hosseinzadeh Bahador, Gulnara Hasanova Musa Jan 2020

Allylphenoxypiperidinium Halides As Corrosion Inhibitors Of Carbon Steel And Biocides, Gunay Mehdiyeva Muzakir, Musa Bairamov Rza, Shahnaz Hosseinzadeh Bahador, Gulnara Hasanova Musa

Turkish Journal of Chemistry

A series of 1-(4-(2-allylphenoxy)butyl)piperidin-1-ium halides (4a-d) was synthesized and characterized via spectroscopic methods (FTIR, $^{1}$H NMR). The corrosion inhibition of the synthesized halides on carbon steel in water-salt-hydrocarbon environment, saturated with H$_{2}$S, was investigated. For this purpose, a series of techniques such as gravimetric measurement, potentiodynamic polarisation, and scanning electron microscope (SEM) were used and some thermodynamic parameters of corrosion process ($\Delta G_{ads.}$, $\Delta H^{0}_{ads.}$, $\Delta S^{0}_{ads.})$ were evaluated. The steel surface was checked by SEM, and the steel surface showed good surface coverage. The results showed that the synthesized compounds at the concentrations 125, 150 mg x L$^{-1}$ have …

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Synthesis, Characterization And Crystal Structures Of Platinum(Ii) Saccharinate Complexes With 1,5-Cyclooctadiene, Ceyda İçsel Jan 2020

Synthesis, Characterization And Crystal Structures Of Platinum(Ii) Saccharinate Complexes With 1,5-Cyclooctadiene, Ceyda İçsel

Turkish Journal of Chemistry

Two new platinum(II) complexes, namely [PtCl(sac)(COD)] (1) and [Pt(sac)$_{2}$(COD)] (2) (sac $=$ saccharinate and COD $=$ 1,5-cyclooctadiene), were synthesized and characterized by elemental analysis, IR, NMR, ESI-MS spectroscopic and thermal analysis (TG/DTA) methods. The platinum(II) complexes were prepared from the reaction of [PtCl$_{2}$(COD)] with Na(sac) • 2H$_{2}$O. The addition of the sac ligand resulted in the replacement of 1 and 2 chlorido ligands in [PtCl$_{2}$(COD)] to yield 1 and 2, respectively. The structures of the complexes were determined by single crystal X-ray diffraction and showed a distorted square planar coordination geometry around platinum(II). COD acted as a $\pi $-donor ligand, …

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