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Ultrasound-Assisted Dibutyl Phthalate Nanocapsules Preparation And Its Application As Corrosion Inhibition Coatings, Uday Bagale, Ammar Kadi, Irina Potoroko, Vinay Rangari, Minakshi Mahale May 2022

Ultrasound-Assisted Dibutyl Phthalate Nanocapsules Preparation And Its Application As Corrosion Inhibition Coatings, Uday Bagale, Ammar Kadi, Irina Potoroko, Vinay Rangari, Minakshi Mahale

Karbala International Journal of Modern Science

The current research employs an encapsulation of dibutyl phthalate (DBP) as a corrosion inhibitor in situ polymerization using a sonochemical method to form nanocapsules. The prepared nanocapsules were characterization by using Malvern particle size, Fouri-er transforms infrared spectroscopy (FTIR), Scanning electron microscope (SEM) and Transmission electron microscope (TEM), and thermal and mechanical test to check particle size, morphology, and stability of nanocapsules. Later prepared DBP nanocapsules were incorporated in standard epoxy coating to check its corrosion inhibition resistance. The results show that nanocapsules are spherical, with an average particle size of 337 nm. Scratch nanocapsules epoxy coating shows improves coating …

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Heterogeneous Catalytic Degradation Of Dye By Fenton-Like Oxidation Over A Continuous System Based On Box–Behnken Design And Traditional Batch Experiments, Imad M. Luaibi, Mohammed A. Atiya, Ahmed K. Hassan, Zainab A. Mahmoud May 2022

Heterogeneous Catalytic Degradation Of Dye By Fenton-Like Oxidation Over A Continuous System Based On Box–Behnken Design And Traditional Batch Experiments, Imad M. Luaibi, Mohammed A. Atiya, Ahmed K. Hassan, Zainab A. Mahmoud

Karbala International Journal of Modern Science

In this study, iron was coupled with copper to form a bimetallic compound through a biosynthetic method, which was then used as a catalyst in the Fenton-like processes for removing direct Blue 15 dye (DB15) from aqueous solution. Characterization techniques were applied on the resultant nanoparticles such as SEM, BET, EDAX, FT-IR, XRD, and zeta potential. Specifically, the rounded and shaped as spherical nanoparticles were found for green synthesized iron/copper nanoparticles (G-Fe/Cu NPs) with the size ranging from 32-59 nm, and the surface area was 4.452 m2/g. The effect of different experimental factors was studied in both batch and continuous …

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Optical Measurement And Performance Prediction Of Solar Pv System In Al-Khidhir Zone/Iraq, Faten Sh. Zainulabdeen, Jaber O. Dahloos, Ahmed F. Atwan, Naseer K. Kasim May 2022

Optical Measurement And Performance Prediction Of Solar Pv System In Al-Khidhir Zone/Iraq, Faten Sh. Zainulabdeen, Jaber O. Dahloos, Ahmed F. Atwan, Naseer K. Kasim

Karbala International Journal of Modern Science

People have tended for investing the sources of renewable energy, especially solar energy, as they are clean and environmentally friendly sources. The present work aims to invest the measured data of solar irradiance, maximum ambient temperatures and wind speed provided by Al Khidhir Meteorological Station to predict the minimum performance of photovoltaic solar systems (NT-R0E3E-SHARP) for electric power generation. The single diode model is used to calculate the minimum output power produced by solar module and its minimum conversion efficiency based on soalr irradiance, maximum ambient temperatures and wind speed throughout 2020. The results indicate that the annual solar irradiance …

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Determining The Structure And Activity Of A Pseudomonas Aeruginosa Protein, Ivyp2, Katherine Letsinger May 2022

Determining The Structure And Activity Of A Pseudomonas Aeruginosa Protein, Ivyp2, Katherine Letsinger

Master of Science in Chemical Sciences Theses

Various biophysical methods were employed to structurally characterize and assess the activity of an important resistance factor (Ivyp2) from the multi-drug resistant Gram-negative bacterium Pseudomonas aeruginosa. This opportunistic pathogen accounts for approximately 10% of all hospital-acquired infections in the United States and contains a number of virulence factors that aid in its ability to infect and colonize immunocompromised individuals and those with cystic fibrosis. One of these factors – inhibitor of vertebrate lysozyme, or Ivy – neutralizes the lytic activity of lysozyme, an antimicrobial enzyme part of the innate immune system that hydrolyzes the linkages between bacterial cell wall subunits. …

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Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas May 2022

Unusual High-Frequency Mechanical Properties Of Polymer-Grafted Nanoparticle Melts, Mayank Jhalaria, Yu Chang, Yucheng Huang, Brian C. Benicewicz, Sanat K. Kumar, George Fytas

Faculty Publications

Brillouin light spectroscopy is used to measure the elastic moduli of spherical polymer-grafted nanoparticle (GNP) melts as a function of chain length at fixed grafting density (0.47  chains/nm2) and nanoparticle radius (8 nm). While the moduli follow a rule of mixtures (Wood’s law) for long chains, they display enhanced elasticity and anomalous dissipation for graft chains <1⁢0⁢0  kDa. GNP melts with long polymers at high 𝜎 have a dry zone near the GNP core, surrounded by a region where the grafts can interpenetrate with chain fragments from adjacent GNPs. We propose that the departures from Wood’s law for short chains are due to the effectively larger silica volume fraction in the region where sound propagates—this is caused by the short, interpenetrated chain fragments being pushed out of the way. We thus conclude that transport mechanisms (of gas, ions, sound, thermal phonons) in GNP melts are radically different if interpenetrated chain segments can be “pushed out of the way” or not. This provides a facile new means for manipulating the properties of these materials.

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Computational And Spectroscopic Studies Of New Sulfur-Containing Dipole-Bound Anions, Nicholas Allen Kruse May 2022

Computational And Spectroscopic Studies Of New Sulfur-Containing Dipole-Bound Anions, Nicholas Allen Kruse

Honors Theses

Sulfur and Nitrogen are essential ingredients in both life-supporting and light-harvesting molecules. Their presence also usually leads to the delocalization of electrons and large dipole and quadrupole moments. Such molecules are sometimes able to form negative ions through the electrostatic binding of an excess electron. These so-called multipole-bound (dipole-bound, quadrupole-bound, etc.) anions have been shown to be important in radiation damage in biology and electron transport processes. Here, we present our recent computational and experimental results studying the creation of new multipole-bound anions.

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Covalent Modification Of Recombinant Protein With Reactive Thiols, Sawyer Dulaney, Bailey Taylor May 2022

Covalent Modification Of Recombinant Protein With Reactive Thiols, Sawyer Dulaney, Bailey Taylor

Honors Theses

Many diseases cause chronic and painful inflammation in different body systems. One of the front-line drug classes to treat such inflammation is Nonsteroidal Anti-Inflammatory Drugs (NSAIDs). Despite the benefits of oral administration of NSAIDs, there are drawbacks to their long-term usage because they can cause detrimental effects on off-target systems in the body such as the liver, kidney, or the lining of the intestinal tract. An alternative to NSAIDs is the usage of hydrogels for targeted drug delivery. Hydrogels can provide drug delivery in a specific portion of the site of inflammation, thus allowing higher doses of medication to be …

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The Design Of A Pcr-Based Assay To Detect And Isolate The Serine Palmitolytransferase Gene From Environmental Bacteria, Lana Taylor May 2022

The Design Of A Pcr-Based Assay To Detect And Isolate The Serine Palmitolytransferase Gene From Environmental Bacteria, Lana Taylor

Honors Theses

Sphingolipids are a natural class of lipids that function as structural elements of cell membranes and signaling molecules for important cellular activities such as cell growth, differentiation, apoptosis, recognition, and adhesion. These lipids can be found universally in eukaryotic cells as well as some species of bacteria, such as those found in the human gut microbiome and in the environment in soils. Though sphingolipid production is rare in bacteria, both eukaryotic and prokaryotic sphingolipid biosynthesis begin with the condensation of serine and palmitoyl CoA into 3-ketodihydrosphingosine catalyzed by the enzyme serine palmitoyltransferase (SPT). In recent years, several studies have shown …

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Development Of An Analytical Method For Determination Of Lead And Cadmium In Biological Materials By Gfaas Using Escherichia Coli As Model Substance, Michelle Catherine Gende, Martina Schmeling May 2022

Development Of An Analytical Method For Determination Of Lead And Cadmium In Biological Materials By Gfaas Using Escherichia Coli As Model Substance, Michelle Catherine Gende, Martina Schmeling

Chemistry: Faculty Publications and Other Works

In this work, an analytical method was developed for the determination of lead and cadmium in biological samples using graphite furnace atomic absorption spectrometry. Escherichia coli (E. coli) was chosen as model substance for this purpose as it is readily available in most laboratories and can be quickly and easily prepared with a high turnaround rate. Four different sample preparation methods were initially evaluated with respect to percent recovery, limit of detection, and limit of quantification, and the most promising one was developed further. The final process involving microwave assisted digestion of the sample with nitric acid …

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Aloso: Spectroscopy And Structure Of A New Group Of Astrochemical Molecules, Vincent J. Esposito, Tarek Trabelsi, Joseph S. Francisco May 2022

Aloso: Spectroscopy And Structure Of A New Group Of Astrochemical Molecules, Vincent J. Esposito, Tarek Trabelsi, Joseph S. Francisco

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

No abstract provided.

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Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry, Pallavi Ragi May 2022

Towards The Determination Of Estrone And 17Β-Estradiol In Dairy Cattle Waste Using Solid Phase And Stir Bar Sorptive Extractions With Liquid Chromatography-Mass Spectrometry And Gas Chromatography-Mass Spectrometry, Pallavi Ragi

Masters Theses & Specialist Projects

Steroidal hormones are naturally produced as a part of many physiological processes and are excreted in the urine and feces of animals and humans. Farm animals in concentrated animal feeding operations (CAFOs) are routinely implanted with synthetic and natural hormones to enhance growth and production, contributing significantly to environmental steroid hormone contamination. Every year around 49 tons of estrogens are generated by livestock waste in the United States alone. Due to rainfall and runoff, these steroid hormones reach the environment when animal waste is applied as manure. Studies show that estrogens and other steroidal hormones present in the surface waters …

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Nitrogen Doping Of Electrochemically Activate Carbon Screen-Printed Electrodes, Ethan Galloway May 2022

Nitrogen Doping Of Electrochemically Activate Carbon Screen-Printed Electrodes, Ethan Galloway

Undergraduate Honors Theses

Screen printed electrodes (SPEs), which are prepared by patterning conductive inks or pastes onto an insulating support (e.g., plastic film), are widely employed as sensing and biosensing platforms due to their ease of fabrication and relatively low cost. This is especially applicable to electrodes of this nature prepared with carbon-based inks (SPCEs). To date, the most successful and significant commercial application of SPEs has been as test strips for glucose meters. Despite the maturity of this technology, SPE research remains very active as improvements in sensitivity and selectivity, which often involve modifying the electrode surface, hold the key to advancing …

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Synthesis And Function Of Ion-Selective Single-Molecule Fluorescent Imaging Molecules And Materials, Alena A. Denisenko May 2022

Synthesis And Function Of Ion-Selective Single-Molecule Fluorescent Imaging Molecules And Materials, Alena A. Denisenko

Chemistry & Biochemistry Dissertations - Archive

Neutrinos are fermion subatomic particles that interact only by weak subatomic forces—making them almost impossible to detect. However, they can be produced in specific radioactive decay reactions, such as beta decay. We hypothesize the detection of double beta decay through the tagging of the Ba2+ daughter ion from 136Xe (136Xe —136Ba2+ + 2ν + 2β). The proposal is to develop single-molecule fluorescence imaging (SFMI) technology to investigate gaseous chemical constituents in high-pressure gases (ca. 30-150 psi) at gas-solid interfaces. To achieve proper SMFI, heterogenous self-assembled monolayers (SAMs) containing fluorophores that operate under dry conditions and are turned on when a …

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An Investigation Towards The Synthesis Of A Novel Conformationally Restricted Ethylenediamine Scaffold, Fanny Mai May 2022

An Investigation Towards The Synthesis Of A Novel Conformationally Restricted Ethylenediamine Scaffold, Fanny Mai

Theses, Dissertations and Culminating Projects

This study reports the synthesis of a novel conformationally restricted ethylenediamine scaffold that can be explored for drug discovery. There was significant progress in synthesizing the target scaffolds, but future studies are needed to finish this synthesis. This potential ethylenediamine compound may offer new scaffolds for exploration in drug design and orexin receptor antagonists with improved selectivity for OX1R and OX2R.

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Liquid Chromatography With Tandem Mass Spectrometry Method Development For The Determination Of Β–Defensins In Bovine Milk, Symone T. Whalin May 2022

Liquid Chromatography With Tandem Mass Spectrometry Method Development For The Determination Of Β–Defensins In Bovine Milk, Symone T. Whalin

Masters Theses & Specialist Projects

Bovine mastitis, caused by a wide array of pathogens, results in a substantial economic loss for the dairy cattle livestock industry. β-defensins are a part of the bovine’s innate immune system and act as the first line of defense against mastitis. Only foundational research has been done on β-defensins’ ability to treat and prevent mastitis. There have been no analytical methods reported in the literature for analyzing β-defensins in bovine milk. This research aims to create an analytical approach to determine β-defensins in bovine milk. It is challenging to determine an analyte in a complex sample matrix, and milk is …

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Investigation Of The Cellular Uptake And Cytotoxicity Of Ruthenium(Ii) Polypyridyl Complexes As A Function Of Lipophilicity, Matthew Guerrero May 2022

Investigation Of The Cellular Uptake And Cytotoxicity Of Ruthenium(Ii) Polypyridyl Complexes As A Function Of Lipophilicity, Matthew Guerrero

Chemistry & Biochemistry Theses - Archive

Ru(II) polypyridyl complexes have been one of the focal points of investigation for inorganic anti-cancer drugs, as they are robust enough to remain chemically intact in vivo and many show potent cytotoxicty. In particular, the RPC [Ru(dip)3]2+, where dip is 4,7-diphenyl-1,10-phenanthroline, is noted for its high cytotoxicity (IC50 ~2-5 uM) across a broad spectrum of cancer cell lines and more recently has been implicated as targeting microtubules, which is an unusual target for metal-based drugs. While the cellular uptake for [Ru(dip)3]Cl2 is among the highest seen for RPCs, its solubility in water or buffer is limited and problematic. In order …

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Investigation Of F420-Dependent Glucose-6-Phosphate Dehydrogenase Variants Using Ph Profiles And Stopped-Flow Spectrometric Ligand-Binding Methods, Ana Laura Alvarez May 2022

Investigation Of F420-Dependent Glucose-6-Phosphate Dehydrogenase Variants Using Ph Profiles And Stopped-Flow Spectrometric Ligand-Binding Methods, Ana Laura Alvarez

Chemistry & Biochemistry Theses - Archive

F420-dependent glucose-6-phosphate dehydrogenase (FGD) from Mycobacteria tuberculosis, catalyzes a reaction the conversion of glucose-6-phosphate (G6P) to 6-phosphogluconolactone using the oxidized F420 cofactor, which is reduced to F420H2. The reaction is important within M. tuberculosis, the cause of tuberculosis disease (TB) due to its health relevance for treatment of multiple drug resistant and extreme drug resistant strains of M. tuberculosis. TB affects millions of people worldwide, and although treatable, multiple drug resistant and extreme drug resistant forms of TB adds strain on the current generation of drugs. Since this enzyme is not found in humans, is an ideal drug target. A …

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Investigation Of The Analytical Utility Of The Inductively Coupled Plasma Mass Spectrometer (Icp-Ms) For The Quantification Of Proteins Via Lanthanide Labeling, Caitlin Elizabeth Dunlap May 2022

Investigation Of The Analytical Utility Of The Inductively Coupled Plasma Mass Spectrometer (Icp-Ms) For The Quantification Of Proteins Via Lanthanide Labeling, Caitlin Elizabeth Dunlap

Undergraduate Honors Thesis Collection

The discovery and ability to provide an absolute concentration of biomarkers in the body can facilitate early diagnoses of diseases. This information can also be used for more accurate and unique treatments for those patients. While major advances in molecular mass spectrometry allows for a sensitive identification of these biomarkers, they are limited to only four orders of magnitude in their dynamic ranges. Due to this, detection and quantitation of low abundant proteins, which tend to make up these vital biomarkers, is very difficult. On the other hand, ICP-MS offers a wider dynamic range (up to 12 orders of magnitude) …

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Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii, Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi May 2022

Establishing Pteridine Metabolism In A Progressive Isogenic Breast Cancer Cell Model – Part Ii, Lindsey Rasmussen, Zachary Foulks, Jiandong Wu, Casey Burton, Honglan Shi

Chemistry Faculty Research & Creative Works

Introduction: Determining the biological significance of pteridines in cancer development and progression remains an important step in understanding the altered levels of urinary pteridines seen in certain cancers. Our companion study revealed that several folate-derived pteridines and lumazines correlated with tumorigenicity in an isogenic, progressive breast cancer cell model, providing direct evidence for the tumorigenic origin of pteridines. Objectives: This study sought to elucidate the pteridine biosynthetic pathway in a progressive breast cancer model via direct pteridine dosing to determine how pteridine metabolism changes with tumorigenicity. Methods: First, MCF10AT breast cancer cells were dosed individually with 15 pteridines to determine …

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A Limited Look At The Educational Experiences Of Black Stem Professionals From The Butler Community And Beyond, Victoria Ann Templin May 2022

A Limited Look At The Educational Experiences Of Black Stem Professionals From The Butler Community And Beyond, Victoria Ann Templin

Undergraduate Honors Thesis Collection

This project looks at the STEM educational experiences of Black professionals from both the Butler community and outside of it. It focuses on the perspectives of five individuals (three Butler graduates and two non-Butler graduates) interviewed via Zoom and analyzes how their experiences compare to those of other Black STEM professionals across the nation. After completing the interviews and conducting thorough background research, all data was examined. It was found that what was discussed during the interviews paralleled what was discovered in the research, such as the importance of mentors and broadening the image of what a scientist looks like. …

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Long-Term Trends And Variability Of Pm₂.₅ Mass, Chemical Components, And Sources Over Nys, Hesham Abdelmonem Hassan May 2022

Long-Term Trends And Variability Of Pm₂.₅ Mass, Chemical Components, And Sources Over Nys, Hesham Abdelmonem Hassan

Legacy Theses & Dissertations (2009 - 2024)

Eighteen years of ambient PM2.5 mass and major components are used in this study to harmonize the carbonaceous fraction of PM2.5 data, and to examine long-term trends and seasonal variability changes. The major decreasing trend of PM2.5 mass and major inorganic ions reflects the ambient concentration response to clean air regulations and policies.Although elemental carbon shows a decreasing trend in agreement with most other PM2.5 components, organic carbon shows a different behavior of no-trend to slightly increasing trend in some sites. Organic carbon behavior indicates the growing role of non-combustion sources at the expense of decreasing combustion sources. Seasonal trends …

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An Entropic Approach To Dynamics, Pedro Henrique Moreira Pessoa May 2022

An Entropic Approach To Dynamics, Pedro Henrique Moreira Pessoa

Legacy Theses & Dissertations (2009 - 2024)

The present thesis deals with different aspects of probability, the method of maximum entropy, information geometry, and dynamical systems and their applications to statistical physics and complex systems. Those topics come together in the framework for dynamics termed entropic dynamics. Work on the topic was initiated by my PhD advisor Professor Ariel Caticha and many colleagues at University at Albany as a method for explaining the dynamical processes in quantum mechanics from first principles of probability theory.

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Theoretical Studies Of Benzoquinone Reactivity In Acidic And Basic Environments, Natali Majoras May 2022

Theoretical Studies Of Benzoquinone Reactivity In Acidic And Basic Environments, Natali Majoras

Honors Theses

Quinones are a class of organic compounds containing a six-membered unsaturated ring with two carbonyl groups. They are biologically relevant mostly due to their ability to participate in redox reactions. Prior experiments in our lab showed that quinones can induce protein modifications that are pH dependent. In an acidic environment the modifications were less significant than in a basic environment. Previous computational studies have also been carried out to model, in neutral solutions, the reaction between various quinones and various amines. Various amine groups are used as a model for the amino group of lysine to represent protein modification. The …

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A Performance Evaluation Of Architectural Coatings To Preserve Aerosol Paint On Concrete, Riley Morris May 2022

A Performance Evaluation Of Architectural Coatings To Preserve Aerosol Paint On Concrete, Riley Morris

All Theses

The growing movement of assigning cultural and heritage value to graffiti and street art is one without a preservation solution to ensure the longevity of these works in-situ in an outdoor environment. The goal of this thesis was to provide a comprehensive evaluation of six architectural topcoats’ performance when applied as a conservation treatment to outdoor aerosol graffiti and street art on concrete substrate. An artist’s quality, durable, color-fast spray-paint was applied to twenty-eight concrete test panels to mimic the application of graffiti or street art. Six topcoats, Prosoco SC-1, Prosoco Gloss n’ Guard WB, Keim Faceal Oleo HD®, Keim …

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Synthesis Of Allylic Synthons And Application Of Pyrrole Thiocarboxylic Acids In The Synthesis Of Pyrrole-Imidazole Alkaloids, Olatunji Seyi Ojo May 2022

Synthesis Of Allylic Synthons And Application Of Pyrrole Thiocarboxylic Acids In The Synthesis Of Pyrrole-Imidazole Alkaloids, Olatunji Seyi Ojo

Chemistry & Biochemistry Dissertations - Archive

The first part of this dissertation describes the synthesis of allylic compounds from terminal alkenes without the use of any catalysts or oxidants. One of the most versatile molecules in organic chemistry is allylic compounds. Their importance arises from their miscellaneous reactivity which makes them attractive to organic chemists. They are found in several molecules that have medicinal and synthetic utilities. The preparations of allylic compounds have been majorly through transition metal catalyzed process. The second part describes the formation of pyrrole-carboxamide in pyrrole-imidazole alkaloids. Pyrroleimidazole alkaloids have gained attention of synthetic chemists due to their potential therapeutical applications and …

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Spectroscopic Measurements Of Meibum Compositional, Structural, And Functional Relationships To Elucidate The Role Of Meibum In Dry Eye., Anthony Chigozie Ewurum May 2022

Spectroscopic Measurements Of Meibum Compositional, Structural, And Functional Relationships To Elucidate The Role Of Meibum In Dry Eye., Anthony Chigozie Ewurum

Electronic Theses and Dissertations

The major aim of my dissertation was to investigate the etiology of dry eye disease which affects about 7 million people in the United States, causing symptoms that can lead to visual disturbance. Correlation between dry eye and an abnormal lipid layer of the tear film has been found. Tear film lipids originate mostly from the meibomian glands. Cholesteryl ester (CE) and Wax ester (WE) lipids make up most of the human meibum lipidome and the CE/WE ratio has been shown to decrease in patients with meibomian gland dysfunction. Model studies using synthetic CE and WE, although providing some insight, …

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Surface-Functionalized Chemiresistive Films That Exploit H-Bonding, Cation-Pi, And Metal-Halide Interactions., Prasadanie Karunarathna Adhihetty May 2022

Surface-Functionalized Chemiresistive Films That Exploit H-Bonding, Cation-Pi, And Metal-Halide Interactions., Prasadanie Karunarathna Adhihetty

Electronic Theses and Dissertations

The development of gas sensors for detection of volatile organic compounds (VOCs) has been of interest in the sensing field for decades. To date, the use of metal nanoparticle-based chemiresistors for trace VOC detection, particularly gold nanoparticle-based sensors, is of great interest due to their high chemical stability, ease of synthesis, unique optical properties, large surface to volume ratio, and high level of conductivity. Much effort has been devoted towards gold monolayer protected clusters (Au MPCs) as chemiresistors to detect harmful VOCs. The present thesis documents the results of our efforts to exploit the advantages of functionalized Au MPCs chemiresistors …

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Development And Novel Applications Of Halogenating Agents., Sagar Ravso Mudshinge May 2022

Development And Novel Applications Of Halogenating Agents., Sagar Ravso Mudshinge

Electronic Theses and Dissertations

Organic halides are extensively utilized as synthetic intermediates in areas such as pharmaceuticals, agrochemicals, and material polymers. While many halogenating agents have been developed, they continue to have low efficiency or selectivity, are difficult to handle, and often have limited substrate scope. To address this issue, our laboratory has developed novel halogenating agents with improved stability and efficiency. In these studies, we demonstrated a novel application of halogenating reagent, HCl·DMPU, in the nitrile synthesis. We developed a novel method for C−SCF3/SeCF3 cross-coupling reactions using gold redox catalysis. We developed a novel trifluoromethylating agent in a cost-effective and …

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The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen May 2022

The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen

Honors College Theses

The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in …

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Design And Synthesis Of Thiazole-Based Small Molecules To Inhibit The Inflammatory Cytokine Oncostatin M, Samuel Randall May 2022

Design And Synthesis Of Thiazole-Based Small Molecules To Inhibit The Inflammatory Cytokine Oncostatin M, Samuel Randall

Boise State University Theses and Dissertations

The body’s innate ability to produce an inflammatory response due to tissue irritation or damage is essential for growth and survival. The inflammatory response can be triggered by numerous stimuli, including physical trauma, inhalation of dangerous debris (such as silica and asbestos), tobacco/alcohol consumption, microbiota, diet, and other lifestyle stressors. In a well-orchestrated inflammatory response, the circulatory system increases blood flow and capillary permeability in the inflamed area to deliver nutrients, white blood cells, and inflammatory mediating molecules. However, a dysregulated inflammatory response can lead to chronic inflammation. Emerging evidence continues to frame oncostatin M (OSM) as a pro-inflammatory cytokine …

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