Digital Commons Network^™

Nuclear Magnetic Resonance Study Of Co2 Capture By Fluoroalkylamines: Ammonium Ion Pka Depression Via Fluorine Modification And Thermochemistry Of Carbamylation, Brian Jameson, Kari Knobbe, Rainer Glaser

Chemistry Faculty Research & Creative Works

We are developing energy-efficient and reversible carbon capture and release (CCR) systems that mimic the Lys201 carbamylation reaction in the active site of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO). The multiequilibria scenario ammonium ion Xa ⇌ amine Xb ⇌ carbamic acid Xc ⇌ carbamate Xd requires the presence of both free amine and CO2 for carbamylation and is affected by the pKa(Xa). Two fluorination strategies aimed at ammonium ion pKa depression and low pH carbamylation were analyzed with (2,2,2-trifluoroethyl) butylamine 2b and 2,2-difluoropropylamine 3b and compared to butylamine 1b. The determination of K1 and ΔG1 of the carbamylation reactions requires the solution of …

Natural Product Co-Metabolism And The Microbiota–Gut–Brain Axis In Age-Related Diseases, Mark Obrenovich, Sandeep Kumar Singh, Yi Li, George Perry, Bushra Siddiqui, Waqas Haq, V. Prakash Reddy

Chemistry Faculty Research & Creative Works

Complementary alternative medicine approaches are growing treatments of diseases to standard medicine practice. Many of these concepts are being adopted into standard practice and orthomolecular medicine. Age-related diseases, in particular neurodegenerative disorders, are particularly difficult to treat and a cure is likely a distant expectation for many of them. Shifting attention from pharmaceuticals to phytoceuticals and "bugs as drugs" represents a paradigm shift and novel approaches to intervention and management of age-related diseases and downstream effects of aging. Although they have their own unique pathologies, a growing body of evidence suggests Alzheimer's disease (AD) and vascular dementia (VaD) share common …

Extracellular Poly(Hydroxybutyrate) Bioplastic Production Using Surface Display Techniques, Kevin Beaver, Ashwini Dantanarayana, Willisa Liou, Markus Babst, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Poly(hydroxybutyrate) is a biocompatible, biodegradable polyester synthesized naturally in a variety of microbial species. A greener alternative to petroleum-based plastics and sought after for biomedical applications, poly(hydroxybutyrate) has failed to break through as a leading material in the plastic industry due to its high cost of production. Specifically, the extraction of this material from within bacterial cells requires lysis of cells, which takes time, uses harsh chemicals, and starts the process again with growing new living cells. Recently, surface display of enzymes on bacterial membranes has become an emerging technique for extracellular biocatalysis. In this work, a fusion protein lpp-ompA-phaC …

Modulatory Effects Of Deacetylated Sialic Acids (A Sugar Residue) In Nk-Mediated Cytotoxicity And Targeted Therapy By Receptor Tyrosine Kinase Inhibitors, Mathias Tawiah Anim

Electronic Theses and Dissertations

The complex nature of the biology of cancer is still an unraveling science, yielding several biomarkers that have served as molecular targets for detection and treatment of the disease. How sugars, glycans, play a role has remained relatively uninvestigated. Sialic acid (Sia), a sugar residue on the surface of cells, has been identified as a hallmark of cancer and its progression. Sialic acid can be highly functionalized, but we became interested in acetylated Sias. This functional group is modulated by Sialate O- acetylesterase (encoded by the gene SIAE) and Sialate O-acetyltransferase (encoded by CASD1), enzymes that play a crucial role …

Design, Synthesis, And Evaluation Of Acetyl Coa Synthetase Inhibitors, Michael Emmett Heene

Graduate Research Theses & Dissertations

Invasive fungal species provide a challenge to the current drug landscape, only partiallymet by approved drugs. The Acetyl Coenzyme Synthetase (ACS) enzymes are an attractive target for antifungal compounds because normal mammalian cells do not rely on ACS for energy metabolism while fungal cells do rely on ACS. This work focuses on the design and synthesis of inhibitors of various fungal ACS enzymes. The first class of inhibitors is based on the 2-aminothiazole scaffold originating from a saturation transfer difference (STD) nuclear magnetic resonance (NMR) study and previous whole-organism assays. Ultimately, the 2-aminothiazole core compounds were found to not be …

The Indivisible System: Modeling The Metal-Pterin-Dithiolene System In Molybdenum And Tungsten Cofactors, Cassandra Gates

Bryn Mawr College Dissertations and Theses

Mo and W enzymes are ubiquitous in living organisms and crucial for sustaining life. Mo and W enzyme variety is diverse, but they contain a highly conserved aspect of functionality in these enzymes, the pyranopterin-dithiolene (PDT) ligand. A total of eight possible electron redox equivalents occurs between the metal center and PDT, making the molybdenum cofactor (Moco) and the tungsten cofactor (Tuco) the most redox rich cofactors in all of biology. This research focuses on the development of new pterin-dithiolene synthetic modeling systems for Moco. The knowledge gained from the characterization of these compounds is applied to the enzymes, furthering …

Enzymatic Electrochemical Biosensors For Neurotransmitters Detection: Recent Achievements And Trends, Zina Fredj, Baljit Singh Dr., Mohamed Bahri, Peiwu Qin, Mohamad Sawan

Articles

Neurotransmitters (NTs) play a crucial role in regulating the behavioral and physiological functions of the nervous system. Imbalances in the concentrations of NT have been directly linked to various neurological diseases (e.g., Parkinson’s, Huntington’s, and Alzheimer’s disease), in addition to multiple psychotic disorders such as schizophrenia, depression, dementia, and other neurodegenerative disorders. Hence, the rapid and real-time monitoring of the NTs is of utmost importance in comprehending neurological functions and identifying disorders. Among different sensing techniques, electrochemical biosensors have garnered significant interest due to their ability to deliver fast results, compatibility for miniaturization and portability, high sensitivity, and good controllability. …

Isolation And Identification Of Chlorate-Reducing Hafnia Sp. From Milk, William P. Mccarthy, Meghana Srinivas, Martin Danaher, Christine O'Connor, Tom F. O'Callaghan, Douwe Van Sinderen, John Kenny, John T. Tobin

Articles

Chlorate has become a concern in the food and beverage sector, related to chlorine sanitizers in industrial food production and water treatment. It is of particular concern to regulatory bodies due to the negative health effects of chlorate exposure. This study investigated the fate of chlorate in raw milk and isolated bacterial strains of interest responsible for chlorate breakdown. Unpasteurized milk was demonstrated to have a chlorate-reducing capacity, breaking down enriched chlorate to undetectable levels in 11 days. Further enrichment and isolation using conditions specific to chlorate-reducing bacteria successfully isolated three distinct strains of Hafnia paralvei . Chlorate-reducing bacteria were …

Design Of Block Copolymer With Tunable Hydrophobic/Hydrophilic/Fluorophilic Interactions, Tatiane De Fatima Dutra

Theses, Dissertations and Culminating Projects

Block copolymers (BCP) with balanced interactions and their resultant bulk-phase self-assembly have become increasingly important in advancing nanotechnology, separation, and energy applications. However, a few reports have addressed the synthesis challenge and bulk-phase self-assembly of such triblock copolymers. This thesis presents a facile route for preparing triblock copolymer via controlled radical and organocatalytic ring-opening polymerization that allows precise control over the incorporation of individual moieties in resultant polymer, responsible for balanced hydrophilic, hydrophobic/lipophilic, and fluorophilic interactions. Synthesized polymer with suggested self-assembled 2D lamellar nanostructure exhibits high-temperature stability. The long-term goal of this work is to selectively use this polymer class …

A Computational Study Of The Copper-Catalyzed Trifluoromethylation Of Boronic Acids, Kevin Nyhuis

Theses, Dissertations and Culminating Projects

This work is a computational study of a reaction mechanism for the trifluoromethylation of boronic acids. Three steps of the proposed reaction mechanism are studied, •CF₃ addition to a copper catalyst center, base promoted transmetalation between copper and aryl boronic acid, and bond forming reductive elimination in which the CF₃ and aryl substituent form a bond. Limited information is known about this mechanism. This study uses computational methods to attempt to elucidate the mechanism and provide the groundwork for potential improvement. Quantum chemical methods in conjunction with tight-binding based conformational sampling methods are used to investigate the possible …

Investigating The Roles Of Active Site Residues K59, K119 And E168 In M. Tuberculosis Indole-3-Glycerol Phosphate Synthase, Maryum M. Bhatti

Theses, Dissertations and Culminating Projects

Tuberculosis (TB) is a disease that is caused by a bacteria called Mycobacterium tuberculosis and primarily attacks the lungs but can spread to other areas of the body as well. TB can develop resistance to drugs that may be used to cure the disease. Multidrug resistant TB is especially a growing issue as it does not respond to the two most powerful anti-TB drugs, isoniazid and rifampicin. For this reason, finding new ways to target TB are critically needed. One possible way to do this is to target the enzymes in the tryptophan biosynthetic pathway of M. tuberculosis. Studies have …

Vibrational Spectroscopy For The Detection, Identification, And Differentiation Of Body Fluids And Fingermarks In Forensic Investigations, Samuel Joel Sears

Legacy Theses & Dissertations (2009 - 2024)

This thesis examines the recent literature that has explored the applications of vibrational spectroscopy in forensic science. Specifically, this thesis focuses on how vibrational spectroscopy has improved the detection, identification, and differentiation of body fluid and fingermark evidence in forensic investigations. It is here shown that novel, vibrational spectroscopic techniques have the potential to provide new insights to forensic investigators, and thus revolutionize the field of forensic science. This thesis has been adapted with permission from {Innovative Vibrational Spectroscopy Research for Forensic Application. Alexis Weber, Bailey Hoplight, Rhilynn Ogilvie, Claire Muro, Shelby R. Khandasammy, Luis Pérez-Almodóvar, Samuel Sears, and Igor …

Development Of New Mass Spectrometric Approaches For Biomarker Discovery: Application To Complex Biological Matrices For Tissue Characterization And Disease Diagnosis, Allix Marie Coon

Legacy Theses & Dissertations (2009 - 2024)

In this work, the newly developed technique laser ablation direct analysis in real – time high-resolution imaging mass spectrometry (LADI-MS) and the more established methods direct analysis in real time – high-resolution mass spectrometry (DART-HRMS) and two-dimensional gas chromatography – mass spectrometry (GC×GC-MS), were used to interrogate challenging plant- and human-derived complex matrices that have proven difficult to analyze by conventional methods, in order to extract heretofore inaccessible information that can be applied to the understanding of wood systems biology, ecophysiology, dendrochronology and natural product isolation of biologically relevant compounds (on the plant side), and explore the potential for discovery …

Development Of Ambient Ionization Mass Spectrometry Approaches For The Characterization And Quantification Of Psychoactive Small-Molecule Constituents In Complex Plant Matrices, Megan Isabella Chambers

Legacy Theses & Dissertations (2009 - 2024)

Drug chemistry sections of forensic crime laboratories are tasked with analyzing a variety of unknown materials, a subset of which are derived from plants. In comparison to the analysis of small-molecule drugs, these plant matrices are incredibly complex and present unique challenges. When traditional chromatographic approaches are used to interrogate these materials in forensic investigations, large amounts of time, resources, and funds are directed towards the extensive sample preparation steps required. Exacerbating the issue is that the matrix characteristics often result in instrument downtime to accomplish the maintenance required to address ingredients adhering to columns or clogging syringes, which are …

Dart-Hrms And Chemometric Analysis For Applications In Forensic Entomology, Amy Marie Osborne

Legacy Theses & Dissertations (2009 - 2024)

Forensic entomology, the utilization of insects in the course of legal investigations, is a broad field which encompasses three main branches: medico-legal, stored-product, and urban. This body of research focuses on the first two branches. The first branch, medico-legal forensic entomology, generally applies to death investigations. In death investigations it is imperative to establish the time since death (postmortem interval) and cause of death. Both of these queries can be difficult to assess for remains that are in mid- to late- stages of decay. Carrion insects found on and near the body can assist forensic investigators in this task, as …

Biomimetic Synthesis Of Hitorins A And B And Discovery Of Porous Metallopolymers, Tianran Zhai

Legacy Theses & Dissertations (2009 - 2024)

This work focuses on two research directions: the total synthesis of natural products hitorins A and B and the synthesis of porous metallopolymers/ metallooligomers and study of their properties. Nature has a good understanding and makes good use of cascade reactions to generate complex natural structures. The synthesis of hitorins A and B employed a radical cascade starting from a rare intermolecular alkoxy radical-olefin coupling reaction in our biomimetic synthetic strategy. A radical clock experiment was designed to reveal the mechanism for the key alkoxy radical-olefin coupling cascade. Microporous materials have many applications in diverse areas including gas separation, electronic …

Contrasting Seasonal Cycling Of Arsenic In A Series Of Subarctic Shield Lakes With Different Morphometric Properties, Jeremy Harbinson

Theses and Dissertations (Comprehensive)

The subarctic shield near Yellowknife, Northwest Territories (NWT), is populated with thousands of small lakes (<1.5 km²) and several large lakes. Historic mining activities in the region have left a legacy of environmental impacts and widespread arsenic (As) contamination in both aquatic and terrestrial environments. In particular, several small subarctic lakes near Yellowknife have been previously documented to be contaminated with high levels of As. Subarctic lakes are characterized by seasonal ice-cover that can persist for more than half of the year, yet little is known about the under-ice spatial and seasonal dynamics of As cycling. The objective of …

The Design And Characterization Of Gold Nanoclusters As Elementary Building Blocks, Heather Gaebler

Theses and Dissertations (Comprehensive)

Gold nanoclusters with diameters in the quantum size regime (< ~2 nm) are promising building blocks for the design of novel nanomaterials as they exhibit unique size-dependent properties that can be altered and fine-tuned. The research outlined in this PhD thesis employs density functional theory to construct and analyze small ligand-protected cage and rod-shaped nanoclusters. Chapter 2 reports stable halide-protected gold nanocages that were engineered to have a closed-shell valence electron count of 18. This study finds that nanocages comprised of 19 and 20 gold atoms can be converted into stable magic number species containing 18 valence electrons by modifying their charged states via adsorption of halide ligands to the cage’s surface. Chapter 3 reports stable ligand-protected gold nanoclusters with a tetrahedral Au₄ core that were engineered to have a closed-shell valence electron count of 2. This study investigates the structural and electronic effects of halide and alkoxy ligands on the tetrahedral nanocluster and concludes that the results support the broader conclusion that it’s possible to fine-tune the stability and electronic properties of small gold nanoclusters using appropriate ligands. Chapter 4 reports stable gold nanorods that have diameters in the quantum regime that were constructed from elementary building blocks that contain “halide-staples”. This study presents different orientations of the “halide-staple” motifs on …

Phosphorus Release And Recovery From Simulated Ferric Wastewater Sludge, Aseel Alnimer

Theses and Dissertations (Comprehensive)

Phosphorus (P) is a fundamental element necessary for all life forms and a key component in the fertilizer industry. Meanwhile, the excessive load of P to water bodies due to human activities has the potential to promote eutrophication. Wastewater treatment plants remove P either biologically or chemically and produce P rich sludge which could be a potential renewable source for P. At present, commercial technologies exist for P recovery from biological wastewater sludge. However, P recovery from chemical sludge particularly iron(III)-phosphate (Fe-P) sludge generated in chemical P removal plants that use iron(III) salts remains a challenge.

This study explored, in …

Investigating The Effect Of Poly (Ε-Caprolactone) Nanofibers Scaffolds With Random, Unidirectionally, And Radially Aligned Morphologies On The Fibroblast Cell?S Attachment And Growth Behavior, Saeed Nezari, Mohammadamin Sarli, Ahmad Hivechi, Hajir Bahrami, Peiman B. Milan, Noorahmad Latifi, Fatemeh Latifi, Tayyeb Ghadimi, S. Mohammad Amin Haramshahi, Soheila Naderi Gharahgheshlagh

Turkish Journal of Chemistry

In the last decade, significant progress in tissue engineering, repairing, and replacing organs has been achieved. The design and production of scaffolds for tissue engineering are one of the main areas which have attracted the researcher's interest. In this regard, electrospinning is one of the most popular methods of nanoscale scaffold similar to extracellular matrix production. This paper reports the fabrication of scaffolds consisting of radially aligned PCL nanofibers by utilizing a collector composed of a central point electrode and a peripheral ring electrode. The chemical and physical properties were compared using SEM, FTIR, XRD, and DSC experiments, as well …

Electrochemical Determination Of Aripiprazole Based On Aluminium Oxide Nanoparticles Modified Carbon Paste Electrode, Funda Öztürk, Eli̇f Yüksel, Pinar Esra Erden, Esma Kiliç

Turkish Journal of Chemistry

The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. …

Synthesis And Kinetic Analysis Of Poly(N-Acryloylmorpholine) Brushes Via Surface Initiated Raft Polymerization, Esma Mutlutürk, Tuncer Çaykara

Turkish Journal of Chemistry

Polymer brushes are promising many applications as smart materials and biocompatible surfaces. Surface-initiated reversible addition-fragmentation chain transfer (RAFT) polymerization is one of the most effective techniques for synthesis of well-defined polymer brushes. Herein, a biocompatible, uniform and stable poly(N-acryloylmorpholine)-silicon hybrid system was achieved using surface-initiated RAFT polymerization. Evidence of a well-controlled surface-initiated RAFT polymerization was confirmed by a linear increase of number average molecular weight (M$_{n}$) with overall monomer conversions. Water contact angle, ellipsometry, X-ray photoelectron spectroscopy and atomic force microscopy verified the presence of poly(N-acryloylmorpholine) (poly(NAM)) on silicon wafers. The grafting density (σ) and the average distance between grafting …

Promoting Antihepatocellular Carcinoma Activity Against Human Hepg2 Cells Via Pyridine Substituted Palladium Complexes: In Vitro Evaluation And Qsar Studies, Öğünç Meral, Fati̇h Mehmet Emen, Emi̇ne Kutlu, Ruken Esra Demi̇rdöğen, Nesli̇han Kaya Kinaytürk, Görkem Kismali, Şevki̇naz Doğan

Turkish Journal of Chemistry

Bis(4-(4-nitrobenzyl)pyridine)dichloropalladium(II), [PdCl$_{2}$L$^{1}$$_{2}$], bis(2-amino-5-bromopyridine)dichloropalladium(II), [PdCl$_{2}$L$^{2}$$_{2}$], bis(2,4-dimethylpyridine)dichloropalladium(II), [PdCl$_{2}$L$^{3}$$_{2}$], bis(3,4-dimethylpyridine)dichloropalladium(II), [PdCl$_{2}$L$^{4}$$_{2}$] were prepared. The spectroscopic techniques (FT-IR and $^{1}$H-NMR, $^{13}$C-NMR) were used to characterize the compounds. Theoretical calculations were used to validate the experimental results. The LanL2DZ-based DFT/B3LYP method was used to define the most stable possible molecular structure for the complexes. Potential energy distribution analysis was performed to determine the theoretical vibration bands of the complexes. Molecular electrostatic potential maps, boundary molecular orbitals and Mulliken charge distribution were used to determine the active sites of the molecules. The interaction mechanisms between the complexes and liver cancer protein were investigated via molecular docking. …

Inclusion Complexes Of Squalene With Beta-Cyclodextrin And Methyl-Beta-Cyclodextrin: Preparation And Characterization, Anh Van Nguyen, Victor Ivanovic Deineka, Anh Thi Ngoc Vu, Tuan Dinh Le, Hieu Tran Trung, Tien Anh Nguyen

Turkish Journal of Chemistry

The present work aimed to investigate inclusion complexes of squalene with various cyclodextrins (native ß-cyclodextrin and methyl-ß-cyclodextrin). The production of squalene-ß-cyclodextrin inclusion complex was obtained using Response Surface Methodology and obtained inclusion complexes were studied with FTIR spectroscopy, X-ray diffractometry, thermal analysis, and 1H-NMR spectrometry. At the same time, squalene content was determined by reversed-phase high-performance liquid chromatography. All results confirmed that squalene was successfully involved in the cyclodextrin cavities. Optimizing the condition in preparation for the squalen-ß-cyclodextrin inclusion complex yielded 54.3% with squalene content of 9.01%. The essential difference for the inclusion complex of squalene with methylated beta-cyclodextrin was …

Sars-Cov-2 Main Protease Targeting Potent Fluorescent Inhibitors: Repurposing Thioxanthones, Gönül Saadet Batibay, Eyüp Meti̇n

Turkish Journal of Chemistry

The coronavirus disease, COVID-19, is the major focus of the whole world due to insufficient treatment options. It has spread all around the world and is responsible for the death of numerous human beings. The future consequences for the disease survivors are still unknown. Hence, all contributions to understand the disease and effectively inhibit the effects of the disease have great importance. In this study, different thioxanthone based molecules, which are known to be fluorescent compounds, were selectively chosen to study if they can inhibit the main protease of SARS-CoV-2 using various computational tools. All candidate ligands were optimized, molecular …

Electrochemical Behavior, Antimicrobial Activities, And Effect Of Temperature On Micellization Of Imidazolium Monomeric Surfactants, Vinit Sharma, Tokuma Getahun, Manpreet Singh, Jaswinder Kaur, Nandita Thakur, Kamal Kishore

Turkish Journal of Chemistry

In the present study, we herein report the conductance behavior, effect of temperature, and chain-length of two environmentally friendly imidazolium cationic capric and stearic surfactants. The conductance behavior has been carried out in aqueous solvent (H2O) at four different temperatures such as 24 °C, 29 °C, 34 °C, and 39 °C. The normal micelles were formed in an aqueous solvent and critical micelle concentration (CMC) can be estimated through conductivity parameters. The expected dependency of the CMC on the alkyl chain length of the 3-(2-(decanoyloxy)ethyl)-1-methyl-1H-imidazol-3-ium-bromide and 3-(2-(octadecanoyloxy)ethyl)-1-methyl-1Himidazol- 3-ium-bromide was demonstrated. It was observed that the graphs of molar conduct activity …

Effect Of Size-Graded And Polydopamine-Coated Halloysite Nanotubes On Fundamental Properties Of Low-Density Polyethylene Nanocomposite Film, Cüneyt Erdi̇nç Taş

Turkish Journal of Chemistry

In this study, some of the critical fundamental properties, which are holding importance in usage areas, of low-density polyethylene (LDPE) film were studied by embedding size-graded and polydopamine-coated halloysite nanotubes into the polymer matrix. This concept evaluated the importance of the well-dispersion of nanoparticles in the composite system and interfacial adhesion between nanofiller and polymer matrix on the degree of crystallinity and mechanical properties. For this purpose, halloysite nanotubes, coated with polydopamine and size graded afterward, were integrated into the LDPE matrix by the twin-screw extrusion process, following which, nanocomposite films were prepared by film-blown technique. Both effects of halloysite …

Gan/Zno Hybrid Nanostructures For Improved Photocatalytic Performance: One-Step Synthesis, Tugay Üstün, Bi̇rcan Haspulat Taymaz, Volkan Eski̇zeybek, Handan Kamiş, Ahmet Avci

Turkish Journal of Chemistry

Nanostructured semiconductor materials are considered potential candidates for the degradation of textile wastewater via the photocatalytic process. This study aims to produce hexagonal gallium nitride (GaN) nanoplates and zinc oxide (ZnO) nanoparticles in a deionized water environment utilizing a one-step arc discharge process. Detailed characterization of samples has been completed via scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and UV visible spectroscopy methods. The hybrid nanostructure morphologies consist of nanoplates and nanorods of different sizes. The photoperformance of GaN/ZnO hybrid nanostructures was assessed via the malachite green (MG) dye degradation under …

Imaging Supermolecular Interactions Of The Pharmaceutical- Cocrystal Of Apigeninnicotinamide Binding With Serum Albumin, Yuting Sun, Ming Guo, Xiaoxue Zhao, Ronghui Wu

Turkish Journal of Chemistry

In this paper, a new pharmaceutical cocrystal was synthesized using apigenin (AP) and pharmaceutically acceptable conformer nicotinamide (Nico), and the drug delivery between AP-Nico pharmaceutical cocrystal and human serum albumin (HSA) in vivo was studied at atomic scale. The pharmaceutical cocrystal was characterized using Fourier-transform infrared (FTIR) spectroscopy, 1H NMR spectroscopy, differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD), and the self-assembling mechanism was explored. The dissolution and cumulative release in vitro were investigated. Molecular dynamic (MD) simulation combined with fluorescence spectroscopy was used to study the delivery mechanism of AP-Nico to HSA. The results showed that AP was …

Synthesis Of Copper Nano/Microparticles Via Thermal Decomposition And Their Conversion To Copper Oxide Film, Çağdaş Allahverdi̇

Turkish Journal of Chemistry

Copper nano/microparticles were synthesized in octadecene at 290 °C by thermal decomposition method. Copper acetate monohydrate, stearic acid, and 1-octadecanol were used as copper precursor, capping and mild reducing agents, respectively, at the synthesis. Borosilicate glass substrates submerged into the reaction solution during the synthesis were coated by copper nano/ microparticles. Thermal decomposition and coating techniques were combined in this study. Copper nano/microparticles were thoroughly characterised via X-ray powder diffraction, X-ray photoelectron, Raman, and attenuated total reflectance-Fourier transform infrared spectroscopies, and scanning and transmission electron microscopies. The average minimum Feret?s diameter of these synthesized copper particles was measured as ~87 …