Digital Commons Network^™

Dielectrophoretic Biomarkers For Cancer Detection And Cell Analysis: Integrating Microfluidics And Ai, Raphael Olumide Oladokun

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pancreatic ductal adenocarcinoma (PDAC) carries a five-year survival rate of 13%, driven largely by late-stage diagnosis and the absence of sensitive noninvasive screening tools. Current diagnostic methods lack the sensitivity to detect disease-associated systemic changes at early and precancerous stages, representing a critical clinical gap. This dissertation addresses the central hypothesis that PDAC and its pathological subtypes induce measurable, disease-associated electrophysiological changes in circulating PBMCs that can serve as correlative liquid-biopsy biomarkers. To test this hypothesis, this work asks: can dielectrophoresis (DEP), impedance and zeta potential analysis with AI-assisted classification distinguish benign pancreatic conditions (non-malignant control), precancerous lesions (primarily IPMNs), …

Elucidating Structure–Reactivity Relationships In Ni-Catalyzed Co2 Methanation, Majed Alam Abir

Graduate Theses, Dissertations, and Problem Reports (ETD)

The catalytic hydrogenation of carbon dioxide (CO₂) to methane represents a promising strategy for carbon utilization and renewable energy storage within power-to-gas systems. When coupled with hydrogen derived from renewable electricity, CO₂ methanation enables the conversion of intermittent energy sources into storable and transportable chemical fuels compatible with existing natural gas infrastructure. Nickel-based catalysts have emerged as leading candidates for this reaction due to their high activity towards CO₂ methanation, abundance, and cost. However, the performance and long-term stability of Ni catalysts are strongly influenced by catalyst support properties, Ni nanoparticle size, and promoter effect, and …

Plant-Wide Process Modeling, Techno-Economic Optimization, And Bayesian Uncertainty Quantification For Manufacturing Value-Added Products From Lignocellulosic Biomass, Poulomi Das

Graduate Theses, Dissertations, and Problem Reports (ETD)

For decades, many chemicals have been produced from fossil resources, contributing to resource depletion, pollution from extraction and refining, and hazardous byproducts. Growing environmental concerns and declining fossil reserves have intensified the search for sustainable sources of fuels, energy, and chemicals. Lignocellulosic biomass, the only abundant renewable carbon source, is therefore being explored as a feedstock for second-generation biofuels and high-value chemicals.

Currently, global wood-panel industry heavily depends on petroleum-derived commercial adhesives like phenol-formaldehyde, urea-formaldehyde, etc. These formaldehyde-based chemicals cause hazards to both human health and environment through emission of toxic volatile organic compounds. Typically, lignin is considered as one …

Supply Chain Optimization For Fertilizer Production From Wastewater, Ethan Clement Robey

Graduate Theses, Dissertations, and Problem Reports (ETD)

In West Virginia, approximately 27,000 tons of wastewater solids are generated annually, with nearly 75% being landfilled or alternatively disposed of in a non-beneficial manner. Over the past two decades, the amount of these solids being taken for beneficial uses, such as agricultural application, has declined by 25%, while landfilling has increased by more than 30%. This highlights issues related to eutrophication and disposal costs. This study aims to develop a supply chain optimization framework that addresses the conversion of wastewater solids into fertilizers to match local farm requirements, while determining processing facility locations that minimize transportation costs. To determine …

Made On Mars: Design And Manufacturing Of Structural Polymer-Regolith Composites, Pailey M. Vitale

Williams Honors College, Honors Research Projects

Human exploration of Mars is constrained by harsh environmental conditions and the prohibitive cost of transporting materials from Earth. Long-term sustainability requires the local production of mechanical and structural components using resources available on Mars, thereby minimizing payload mass. This project investigates polymer–regolith composites derived from atmospheric CO₂ and mineral-rich regolith as a pathway toward in-situ manufacturing. These composites, when compatible with additive manufacturing, could replace imported plastics, enable on-demand fabrication, and support closed-loop recycling systems. The objective is to design and evaluate polymer–regolith composites that maintain mechanical integrity and environmental resistance under Martian conditions, including extreme temperature swings, radiation …

Energy Efficient Windows Using Pvme, James S. Bronstrup

Williams Honors College, Honors Research Projects

This Honors Project aims to improve window energy efficiency using the thermoplastic polymer PVME (polyvinyl methyl ether), which displays temperature-dependent transparency that can be adjusted by mixing it with water and salt to reduce heat transfer through a window. The objective is to determine the optimal PVME water-salt ratios for placement inside a windowpane, evaluate energy savings compared to a traditional argon-filled window, and compare estimated costs. A small-scale model will test different concentrations for various climates, with heat transfer measured by temperature indicators via a LabQuest. Building on research by Yang Zhou at Nanyang Technological University, who used a …

Microscopic Insights On Shear Rheology Of Polyampholyte Ionomers Via Molecular Simulations, Kyle Vonscio

Williams Honors College, Honors Research Projects

Ionomers are polymers that contain a small fraction of charged groups. The ionic attraction of charged groups allows ionomers to act similarly to crosslinked polymers. Depending on the strength of electrostatic interactions and structure of the ionomers, different dynamics and rheological responses can be observed. With moderate attraction between ions, these noncovalent crosslinks can be broken when heated, allowing ionomers to flow and show the strength of a crosslinked network at low temperatures. Nonequilibrium molecular dynamics (NEMD) simulations will be performed under shear in the xy-plane and the macroscopic rheology and conformation of the polyampholyte ionomer will be determined. The …

Determining Critical Micelle Concentrations Of Standard Surfactants And Rhamnolipids, Kathryn E. Kunz

Williams Honors College, Honors Research Projects

My proposed project will study the critical micelle concentration (CMC) of rhamnolipids using the pendant-drop and drop-weight methods. First, the critical micelle concentrations of ionic and nonionic common surfactants will be tested. Sodium Dodecyl Sulfate (SDS) will be used as an ionic surfactant and Tween 20 will be used as a nonionic surfactant. The critical micelle concentrations will be determined using the pendant-drop and drop-weight methods. The experimental results from the standard surfactants compared to their accepted values will be tested to assist with determining a more suitable approach. Completing the tests will provide a better understanding of critical micelle …

Analyzing The Effect Of Network Properties On Self-Assembly Of Polymer Grafted Nanoparticles In Vitrimer Nanocomposites, Tyler Eakin

Williams Honors College, Honors Research Projects

This project aims to show the how polymer grafted nanoparticles behave in a vitrimer composite network. The effect of varying the network parameters such as the grafting density, the volume fraction of nanoparticles, and the ratio of polymer chain length : graft chain length will be studied. The assemblies formed by the polymer grafted nanoparticles will be visually analyzed and assigned one of 5 possible conformations. A phase diagram of grafting density vs network chain length / graft length will be constructed. The phase diagram will provide valuable insight into how nanoparticle self-assembly can be manipulated through changing network parameters

Effects Of Hofmeister Ions On Lower Critical Solution Temperatures Of Poly(N-Isopropylacrylamide) And Poly(Vinyl Methyl Ether), Joseph Joaquin

Williams Honors College, Honors Research Projects

The goal of this study is to compare how four different Hofmeister anions (Cl-, SCN-, F-, and I-) affect the Lower Critical Solution temperature (LCST) on two thermo-responsive polymers: poly(N-isopropylacrylamide) (pNIPAAM) and poly(vinyl methyl ether) (PVME). pNIPAAm is commonly used in the environmental applications such as monitoring, oil-water separations, or antifouling materials, and in medical industry from drug delivery to tissue engineering. When pNIPAAM or PVME reaches a temperature above their LCST, they become hydrophobic, and the polymer chains coiled, leading to their aqueous solutions turn opaque. PVME exhibits a similar LCST as that of pNIPAAM, so it can be …

Analysis Of Sessile Drop And Captive Bubble Contact Angle Measurements On Metallic And Hydrophobic Surfaces, Jack H. Darnell

Williams Honors College, Honors Research Projects

Contact angle measurements are widely used to characterize surface wettability and determine changes in surface energy, yet the choice of measurement technique can significantly influence the results. This study compares the sessile drop and captive bubble methods for measuring contact angles of sodium dodecyl sulfate (SDS) solutions on carbon steel, stainless steel, and a hydrophobic wafer. Additionally, the time‑dependent wetting behavior of water, SDS, polysorbate 20 (commercial name Tween 20), and rhamnolipids on a hydrophobic wafer was evaluated over a five‑minute period. Results show that the sessile drop method consistently produced higher contact angles than the captive bubble method on …

Surface Immobilization Of Stimuli-Responsive Polymers Using A Network Of Aminopropyltriethoxysilane, Walter Bungard, Ryan Nixon

Williams Honors College, Honors Research Projects

The goal of this honors project is to develop a cost-effective and accessible method for entrapping stimuli-responsive polymers onto solid substrates using aminopropyltriethoxysilane (APTES). The entrapment network process will first be replicated on glass or silicon using APTES and poly(N-isopropylacrylamide), involving spin coating and thermal annealing to chemically bond the polymer to the substrate. Once validated, the method will be applied to other stimuli-responsive polymers, including thermo-responsive, electroactive, and pH-sensitive types, with APTES as a control. For each sample, film stability, responsiveness, and surface behavior will be evaluated using contact angles, optical microscopy, and spectroscopic analysis, followed by statistical evaluation. …

Effects Of Coupling Agents On An Epoxy Coating And Consequent Corrosion Resistance Of Carbon Steel, Breck A. Mooney

Williams Honors College, Honors Research Projects

This project will include the determination of how coupling agents affect corrosion resistance on select carbon steel when combined with a polymer coating. This research will explore 2 different silane coupling agents: 3-aminopropyltriethoxysilane (APTES) and 3-glycidoxypropyl-trimethoxysilane (GPTMS). 1 polymer coating, Bispenol A diglicidyl ether (BADGE), will be explored as well. These coatings will be applied to select carbon steels in various ratios to determine their effects on corrosion.

Development Of A Signature Model For Predicting Normal Boiling Point Using Machine Learning, Mackenzie Karabin

Williams Honors College, Honors Research Projects

The goal of this project was to utilize the Signature molecular descriptor to construct a predictive model for computing the normal boiling point using a 4856-compound dataset. The final model intends to be applied to screening compounds whose experimental normal boiling point values are not readily available. Compounds were deconstructed into their height-1 atomic Signatures, resulting in 225 unique descriptors for the dataset, which were used as independent variables for creating the model. Machine learning (ML) techniques were employed to evaluate the applicability and accuracy of different ML models for predicting normal boiling point using the Regression Learner App in …

Computer-Aided Molecular Design To Identify More Environmentally Friendly Pfas, Melvin M. Keita

Williams Honors College, Honors Research Projects

The goal of this project is to inversely design alternatives to per- and polyfluoroalkyl substances (PFAS) using Computer-Aided Molecular Design (CAMD). PFAS, also described as “forever chemicals”, have been used in industry and consumer products since the 1940s. PFAS can be found in drinking water, food, food packaging, waste sites, and other sources. Exposure to different PFAS can lead to increased risks of some cancers, immune effects, and reproductive effects. Pulling from existing data, this project will use quantitative structure-property relationships (QSPRs) to design PFAS alternatives that possess optimal properties to prevent adsorption into drinking water and other potential sources …

C. Difficile Detection Method For First Responder Glove Application, Alli N. Senedak

Williams Honors College, Honors Research Projects

Clostridioides Difficile (C. diff) is a Anaerobic Gram-positive bacillus that is capable of spore formation, making it difficult to control its spread and duration in clinical environments. This phenomenon can provide danger to first responders, healthcare workers, and patients. The goal of this project is to create a biosensor capable of detecting C. diff in a clinical setting that can be applied to a glove apparatus. The project will involve the use of C. diff aptamers activated on the surface of an electrode. Once surface activation has been verified via surface analysis, the electrodes will be exposed to C. diff …

A Four-Step Thermocatalytic Route For Converting Co2 Into High-Purity Oxalic Acid, Hao Feng, Muhammad Kashif Khan, Lei Li, Hongyan Ma, Xinhua Liang

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

This research outlines a four-step methodology for transforming CO₂ into high-purity oxalic acid. CO2 was first sequestered as KHCO₃ through its reaction with aqueous KOH, followed by hydrogenation using a supported AgPd/CNT catalyst in a batch reactor at an initial H₂ pressure of 60 bar and a temperature of 150°C. The formate yield reached 91.8% at optimum conditions. Potassium formate in the solid state was thermally coupled in the presence of KOH at 400°C under N2 flow, yielding potassium oxalate of up to 76% yield. The final step was the selective precipitation of potassium oxalate with ferrous …

Brrbox, Shawn J. Myers, Lane Cline, Michael Davis, Christian Secrest

Williams Honors College, Honors Research Projects

This report details the project known as “The BRRBOX”, a reusable, insulated thermoelectric cooler developed to keep internal temperatures at refrigeration levels or cooler for at least 48 hours. The cooler will track its internal temperature during this period and be able to give the data at the end of its delivery cycle to keep up with food and pharmaceutical standards during delivery. The BRRBOX uses Peltier-based cooling alongside vacuum insulation panels and fans to achieve efficient thermal control. An onboard microcontroller will monitor temperature, record the data, and adjust the cooling output to minimize power consumption. The box will …

A Probabilistic Approach To Multiscale Simulation: Evaluating Machine-Learned Backmapping Models Of Diphenylalanine, Sage Paschall

2026 Research Poster Competition

Diphenylalanine (FF) has demonstrated the tendency to form several nanostructures, a subset of which are electrically conductive and have exciting potential applications in biotechnology and nanoelectronics. However, the exact mechanisms underlying this self-assembly process remain largely ambiguous. Atomistic-scale molecular dynamics (MD) simulations allow for the evaluation of atomic-level interactions crucial in understanding the driving thermodynamic forces behind self-assembly, but are too computationally expensive to span the necessary timescale to observe the self-assembly process in action. Coarse-grained (CG) models allow for simulation at the appropriate timescale but come at the cost of vital atomistic detail. It is therefore important to develop …

Rubric Enhanced Assessment Of Coursework And Teaching (React): Using Portfolios And Rubrics In An Engineering Classroom To Refocus From Grades To Learning, Nathan Lee Galinsky

2026 Scholarly Teaching Conference: Poster Session Papers

The goal of using rubrics in an engineering classroom is to make grading clearer for students and to enhance the learning efforts. Point based grading of work leaves students looking for the correct numerical solution or choice without thinking about their assumptions, process, or approximations. A rubric dissects grading to include the entire solution procedure emphasizing key steps in a solution procedure. Students also don’t have to wonder where partial credit will be focused or what emphasis a solution will be graded on when using rubrics. By combining the rubric assessment techniques with portfolios, students will be empowered to feel …

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Evaluation Of Chromium-Crosslinked Amps-Hpam Copolymer Gels: Effects Of Key Parameters On Gelation Time And Strength, Maryam Sharifi Paroushi, Baojun Bai, Thomas P. Schuman, Yin Zhang, Mingzhen Wei

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Controlling CO₂ channeling in heterogeneous reservoirs remains a major challenge for both enhanced oil recovery (EOR) and secure geological storage. AMPS-HPAM copolymers exhibit high-temperature resistance and brine tolerance compared with conventional HPAM gels, making them well suited for the harsh environments associated with CO₂ injection. Chromium-based crosslinkers (CrAc and CrCl₃) were investigated because sulfonic acid groups in AMPS can coordinate with trivalent chromium ions, enabling dual ionic crosslinking and the formation of a robust gel network. While organic crosslinked AMPS-HPAM gels have been widely studied, the behavior of chromium-crosslinked AMPS-containing systems, particularly their gelation kinetics under …

Effect Of Ionic Strength On Gelation Time And Strength Of Amps-Based Polymer Gels, Maryam Sharifi Paroushi, Xuyang Tian, Baojun Bai, Thomas P. Schuman, Yin Zhang, Mingzhen Wei

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Polymer gel treatment has been widely applied for improving sweep efficiency and controlling excessive water and gas production. Their performance depends on gelation time and final gel strength. In most studies, brine salinity is used to describe the effect of formation water on gel behavior. However, changing salinity also changes ionic strength and ion composition at the same time. Because of this coupling, it is difficult to identify the mechanisms controlling gelation, which has led to inconsistent trends in the literature. Increasing salinity has been reported to either slow or accelerate gelation and to weaken or strengthen gels depending on …

Eco-Friendly Solvent-Based Fabrication Of Single-Layer And Polydopamine-Modified Bilayer Pvdf-Hfp Membranes, Eesh M. Kulshrestha

Theses and Dissertations--Chemical and Materials Engineering

The growing global demand for clean drinking water has intensified the need for advanced water treatment technologies capable of efficiently removing contaminants while maintaining environmental sustainability. Polymeric membrane systems have emerged as an effective approach for water separations due to their high separation efficiency, simplicity, and adaptability to a wide range of water treatment applications. However, traditional membrane fabrication processes often rely on toxic organic solvents, such as N-methyl-2-pyrrolidone (NMP) and diemethylacetamide (DMAc), which pose environmental and health risks. These concerns have led to an increase in regulatory restrictions, primarily through the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) …

Investigation Of Succinylated Zwitterionic Polyethylenimine/Dna Complexes: Performance In Serum, Internalization, And Intracellular Fate, Levi Lampe

Theses and Dissertations--Chemical and Materials Engineering

Gene therapy has promised to revolutionize medicine since the earliest clinical trials, but a lack of delivery methods that are both safe and efficient has hampered progress. Gene therapy with viral vectors is effective at delivering nucleic acids to cells, but is associated with dangerous immunogenic responses and cancer-causing insertions into the genome. Viral vectors are also among the most prohibitively costly therapeutics in medicine. Polymeric vectors avoid these dangers and are made from inexpensive, off-the- shelf materials, but have been hindered by poor efficiency compared to viral vectors.

A benchmark polymer for in vitro nucleic acid delivery has been …

Aqueous Synthesis Of Luminescent Semiconductors For Opto-Electronic Applications, Saurabh Singh

Theses and Dissertations--Chemical and Materials Engineering

The advancement of opto-electronic and scintillation technologies relies heavily on developing low-temperature, eco-friendly, and scalable synthesis routes for high performance luminescent halide-based semiconductor materials. However, traditional synthesis methods for halide-based semiconductors, including hot-injection, solvothermal, solid-state reactions, Ligand-Assisted Reprecipitation (LARP), microwave-assisted synthesis, and thin film deposition techniques (spin coating, physical vapor deposition (PVD), chemical vapor deposition (CVD), etc.), often demand toxic organic/inorganic solvents, elevated processing temperatures, and high vacuum/inert environments. Such constraints limit their scalability, raise environmental concerns, and impede their commercial-level device integration. This research overcomes these long-standing challenges by employing water as a powerful crystallization-directing, and environmentally benign medium …

Effect Of Inter Electrode Distance On Electrochemical Mineralization Of Calcium Carbonate In Mildly Acidic Environments, Irene Walker, Ivy Wu, Steven Decaluwe, Robert Bell, Kerry Rippy

Reviews, Analyses, and Instructional Studies in Electrochemistry (RAISE)

The effect of inter electrode distance (IED) on electrochemical mineralization in a parallel plate cell with a stainless-steel working electrode is presented. Three IEDs were tested, 6.5 mm, 15.5 mm, and 22.0 mm, for their water reduction effectiveness to create a region of local alkalinity that stimulates calcium carbonate precipitation in mildly acidic conditions. Chronoamperometry at -1.6 V for 30 minutes with ex-situ optical microscopy and scanning electron microscopy (SEM) were used. At the smallest IEDs, crystal clusters formed in growth-favored regimes as compared to the largest IED, where nucleation dominated, leading to encasement of the SS mesh. Rapid precipitation …

Sustainable Textiles Through Electrospinning: Addressing Environmental Challenges, Nicole Sharples, Omid Doustdar, Miguel Carmona‐Cabello, Shayan Abrishami, Jose M. Herreros, Ali Sadaghiani, Karl D. Dearn

Research outputs 2022 to 2026

The textile industry, known for its significant environmental footprint, faces growing pressure to adopt sustainable practices. This review identifies the textile industry’s sustainability challenges and examines electrospinning as a promising technology to mitigate its environmental impact. Electrospinning enables the production of nanofibers with enhanced properties suitable for various textile applications, offering potential solutions to reduce resource consumption and waste generation. This review discusses the current uses of electrospinning in textile manufacturing and analyses emerging trends in textile recycling, emphasising the role of electrospinning in transforming waste textiles into value-added products. Prospects for advancing electrospinning techniques to achieve efficient textile recycling …

Towards Carbon Geosequestration: Comparing The Wettability Performance Of Western Australian Altered Basaltic Rock/Co2/Water Systems, Seyi Philemon Akanji, Rossen Sedev, Lionel Esteban, Ausama Giwelli, Trevor Beardsmore, Heather Howard, Joel Sarout, Alireza Keshavarz, Stefan Iglauer

Research outputs 2022 to 2026

Geosequestration of carbon dioxide in basaltic rock formations is considered to have the potential to safely and permanently store significant quantities of this greenhouse gas and thereby mitigate its potential global warming effect. The success of this storage method is primarily dependent on the wettability behaviour of the rock-water-CO2 system, which significantly affects fluid distribution, fluid transport, storage capacity and containment security. This study investigates the wettability performance of several Western Australian altered basaltic rocks, of similar geochemistry, porosity and inter-connection. The wettability behaviour of the basaltic materials is assessed using water containing ions that have been leached from the …

Tribological Properties Of Woven Carbon Fiber/Peek Composites From Ambient To 200 °C: Ultra-Low Wear And Performance Evolution, Zheng Bo Xu, Shu Qing Kou, Feng Qiu, Liang Yu Chen, Hong Yu Yang, Jun Nan Dai, Shi Li Shu, Ruifen Guo, Qi Chuan Jiang, Lai Chang Zhang

Research outputs 2022 to 2026

The limited mechanical and tribological stability of carbon fiber reinforced PEEK matrix composites at elevated temperatures remains a major obstacle to their widespread application in extreme service environments. In this work, stain-woven carbon fiber (60 wt%) reinforced PEEK composite (CP60) was fabricated via compression molding, and its temperature-dependent mechanical and wear performance was systematically evaluated. Friction and wear behavior were systematically investigated using pin-on-disc tests under dry sliding conditions. Experiments were conducted at two distinct temperatures (room temperature (RT) and 200 °C) with diverse loads (200–400 N) and sliding velocities (0.47 and 0.94 m/s). The composite exhibited lower average friction …