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Mc-02 Increased Wound Healing In P-Glycoprotein Deficient Intestinal Cells, Madison T. Mcneill, Scott Tanner
Mc-02 Increased Wound Healing In P-Glycoprotein Deficient Intestinal Cells, Madison T. Mcneill, Scott Tanner
SC Upstate Research Symposium
Inflammatory bowel disease (IBD) is an autoimmune disease of unknown cause and includes conditions such as Crohn’s disease and ulcerative colitis. With no cure and only palliative therapies available, many patients with these conditions struggle with diarrhea, abdominal pain, and other chronic symptoms. This study is interested in investigating the multidrug resistance gene (MDR) which encodes the small molecule pump P-glycoprotein (P-gp).
This gene is responsible for regulating drug absorption and accumulation in various parts of the body such as the intestines which is of particular interest to this study. Polymorphisms of the MDR1 gene (encoding p-glycoprotein) have consequently been …