Digital Commons Network^™

Pc-01 Synthesis Of Zinc Glycoconjugated Phthalocyanines As A Potential Phototherapeutic, Jessica A. Silva-Conejo, Katrina Mccarter, Tessa Greene, Joshua V. Ruppel

SC Upstate Research Symposium

Photodynamic Therapy (PDT) uses photosensitizers that are activated by light to produce singlet oxygen that can cause cell damage and potential cell death. Phthalocyanines are promising photosensitizers due to their absorption at clinically relevant wavelengths, meaning that they absorb at a wavelength that can penetrate deeper into tissues.

One challenge with using Phthalocyanines is that they have very low solubility in biological media. One potential approach to increase solubility is through glycoconjugation. Glycoconjugation can also be used as a strategy to increase selectivity toward targeted tissues. Glycoconjugated phthalocyanines can be synthesized using a copper catalyzed azide-alkyne cycloaddition reaction, otherwise known …

Be-03 Effects Of Dietary Iron On Taxonomic Composition And Function Of The Zebrafish Gut Microbiome, Megan D. Whisonant, Jeremiah L. Jackson, Sam L. Evans, Stuart Gordon Ph.D.

SC Upstate Research Symposium

A healthy gut microbiota is essential to promote host health and well-being, therefore, effects of dietary components on the gut microbiome are important to investigate as the gastrointestinal tract can be a major route of infection. Iron—an essential component of heme and iron-sulfur proteins—plays a central role in many biological activities, including oxygen transport and cellular respiration.

In particular, the iron homeostasis system is one of the best characterized due to iron's causative relationship with iron-deficiency anemia. Dietary iron supplementation is a commonly used treatment for iron deficiency anemia; however, the known direct impacts of iron on the gut microbiome …

Uh-02 A Case Report Of The Potential Link Between Pulmonary Fibrosis And Diabetes Mellitus, Bryson T. Rose, Isabella Nielson, Nnenna Igwe

SC Upstate Research Symposium

Pulmonary fibrosis is a chronic lung disease that is characterized by the progressive and irreversible scarring of the lung tissue. This scarring greatly diminishes the efficiency of pulmonary function. After being diagnosed with pulmonary fibrosis, patients live, on average, only three to five years. Diabetes mellitus is known to damage the tissue and blood vessels in organs such as the heart and kidneys due to increased intravascular pressure.

According to recent research, diabetes mellitus has also been linked to similar damage in the lungs. Additionally, a 2021 meta-analysis and systematic review of idiopathic pulmonary fibrosis suggests an association between diabetes …

Hi-03 Cultivated Words Of Chen Hongmou, Joe W. Stone, Professor Birney

SC Upstate Research Symposium

During the Qing dynasty, the Chinese Government appointed officials based on a man’s education and how he passed the imperial examinations. Chen Hongmou stands out among the many officials chosen during the eighteenth century.

Born October 10 1696 in Lingui, Guangxi, China, Chen spent his career as an official for several provinces. Based on his own experiences, Chen wrote texts on leadership and the duties of officials. He not only wrote to promote a system of good governance, he did so while espousing progressive ideals.

For example, he stated that women and “non Chinese” tribes should partake in the same …

Up-05 Comparing The Effects Of Pharmacological And Demographic Factors Between Male And Female Patients Diagnosed With Late-Onset And Early-Onset Alzheimer's Disease., Alyssa G. Miller, Thomas Nathaniel

SC Upstate Research Symposium

Objective: The current study investigates differences in men and women patients with Late-onset Alzheimer’s disease (LOAD) and Early-onset Alzheimer’s disease (EOAD)using pharmacological and demographic factors.

Method: Data for this study was collected from the Prisma Health Upstate Alzheimer’s patients registry between 2016-2021. Multivariate analysis was used to predict specific pharmacological and demographic factors associated with men and women with LOAD and EOAD.

Results: A total of 91.7% LOAD and 8.3% EOAD patients were identified. In the adjusted analysis, men AD patients that were administered memantine [OR=1.588, 95% CI, 1.175-2.145, p=0.003], and buspirone [OR = 1.971, 95% CI, 1.221-3.183, p=0.006] …

Mc-02 Increased Wound Healing In P-Glycoprotein Deficient Intestinal Cells, Madison T. Mcneill, Scott Tanner

SC Upstate Research Symposium

Inflammatory bowel disease (IBD) is an autoimmune disease of unknown cause and includes conditions such as Crohn’s disease and ulcerative colitis. With no cure and only palliative therapies available, many patients with these conditions struggle with diarrhea, abdominal pain, and other chronic symptoms. This study is interested in investigating the multidrug resistance gene (MDR) which encodes the small molecule pump P-glycoprotein (P-gp).

This gene is responsible for regulating drug absorption and accumulation in various parts of the body such as the intestines which is of particular interest to this study. Polymorphisms of the MDR1 gene (encoding p-glycoprotein) have consequently been …

Py-03 The Effect Of Notifications On Different Levels Of Processing Of Memory, Brandon Stiff, Sarah Connor Burns Phd

SC Upstate Research Symposium

Memory is a process that involves the acquiring, encoding, storing, and retrieving of information obtained from the environment. According to the levels of processing theory, proposed by Craik and Lockhart, the perception of stimuli requires analysis at various cognitive levels (1972). Processing things at greater “depth” involves more cognitive analysis and making connections with already known material. This deeper analysis is associated with longer retention and better performance on memory recall tasks (Craik & Lockhart, 1972).

To process the presence of a stimulus, you must first attend to it. According to Mulligan, divided attention results in worse performance on semantic …

Gh-05 Exploring Drug Efficacy In The Pediatric Population: Determining The Differences Among Various Drug Classes, William F. Gardner Ii, Brooks T. Mcphail

SC Upstate Research Symposium

Exploring Drug Efficacy in the Pediatric Population: Determining the Differences Among Various Drug Classes

William F. Gardner II¹, M. Jacob Wurst¹, Brooks McPhail, PhD^1,2

¹University of South Carolina School of Medicine Greenville, Greenville, SC,

²Cincinnati Children's Hospital Medical Center, Cincinnati, OH

Introduction: Pharmacodynamics is commonly defined as what the drug does to the body. The pharmacodynamic effects of a drug are required to determine its efficacy and safety. Due to the unique nature of pediatric development, and the challenges in doing research on children, the efficacy and safety of many drugs are …

Es-03 The Effects Of A Warmup Protocol Involving The Nordic Hamstring Exercise On Vertical Squat Jump Performance And Peak Muscular Activation, Reagan Hunter, Jeff Barfield

SC Upstate Research Symposium

Background: Vertical jumping is one of the most popular ways of assessing athleticism and power output of the lower body in both professional and recreational sport settings. Therefore, having access to an appropriate warmup protocol for enhancing this skill and the power output associated with it is essential for athletes whose success depends on the ability to perform it. Current literature demonstrates similar posterior kinetic chain muscle engagement during the vertical squat jump and during an exercise called the Nordic Hamstring Curl. The literature additionally demonstrates significant effects on strength and athleticism when the exercise is used in long-term training …

Uh-03 A Case Report Of Saint’S Triad And The Diagnostic Implications For Clinicians, Catalina S. Molina, Nnenna Igwe, Hannah Young

SC Upstate Research Symposium

Abstract

Study Design- Case Report

Background- In the process of dissecting a 78-year-old male cadaver, the body was found to have an enlarged heart, an aortic aneurysm, a hiatal hernia, the stomach protruding through the thoracic cavity. The discovery led to the suspicion of a disease known as Saint’s Triad. Saint’s Triad is a manifestation of a general connective tissue disorder, resulting in the formation of hernias, diverticula, aneurysms, or COPD. The objective is to raise awareness of the Saint’s Triad as a disease and demonstrate its relationship with connective tissue disorders. This study also aims to encourage medical professionals …

Up-02 Pharmacological And Non-Pharmacological Interventions For The Treatment Of Neonatal Abstinence Syndrome, Taylor Meetze, Reagan Bradley, Peyton Smith, Emily Sisk, Ryan Crawford

SC Upstate Research Symposium

Background: Newborns diagnosed with Neonatal Abstinence Syndrome (NAS) often experience extreme symptoms as their body’s withdrawals from substances. Pharmacological and non-pharmacological interventions are provided that aim to treat NAS. However, nurses should be aware of what treatment leads to better outcomes and shorter hospitalization.

Aim: The aim of the project was to compare the length of hospitalization of pharmacological and non-pharmacological interventions for newborns with mild NAS.

Methods: The team of researchers devised a research question to guide a search in the Cumulative Index of Nursing and Allied Health Literature (CINAHL) to identify relevant literature focused on pharmacological …

Up-03 Identifying The Determinants Of Pediatric Vaccine Uptake During The Covid-19 Pandemic, Colleen Phan, Brandon Mercardo, Justin Travis Ph.D., Ginny Webb Ph.D.

SC Upstate Research Symposium

COVID-19 has caused over a million deaths in the United States. Preventative measures such as masks, social distancing, and vaccination have been implemented to fight against the disease. Unfortunately, a large subset of Americans opposed these efforts.

SC DHEC reports that as of January 2023, only 53.9 % of eligible South Carolinians have been fully vaccinated against COVID-19. Previous studies have shown vaccine hesitancy is influenced largely by personal concerns about vaccine development, peer vaccination status, and general skepticism of immunization.

Hesitancy towards pediatric vaccination is particularly concerning because unvaccinated children can act as vessels to exponentially accelerate COVID-19 transmission. …

Bm-02 Spartanburg Methodist College: Evaluation Of Classroom Space Efficiency, Kahleag D. Terry, Drake A. Taber, Christina King-Johnson

SC Upstate Research Symposium

Spartanburg Methodist College: Evaluation of Classroom Space Efficiency

In 2019, Spartanburg Methodist College converted from a two-year to a four-year institution. As the college grows, more classrooms are needed to satisfy the course requirements for students. A research study was conducted to answer the following question: What is the best option to implement additional class times/locations for traditional undergraduate students for both student and faculty.

Through out the semester, the student researchers analyzed various types of data address the problems of space and later class time allocation opportunities. An evaluation of the last eight semesters class location and times were …

Gh-06 Human Trafficking Simulation With Senior Nursing Students, Stephanie Barnhill, Monique Jones

SC Upstate Research Symposium

This poster shares information on a human trafficking simulation that can be used in healthcare courses. It includes an overview of human trafficking, risk factors for victims, and a script that students follow to make decisions as a victim and see the choices this vulnerable population must make.

Thought-provoking quotations from victims involved in human trafficking are shared, as well as resources for debriefing and discussion of healthcare worker roles, biases, and human tracking choices.

Mc-01 Identification Of Genes In Blastocoel Fluid Associated With Successful Ivf Outcomes Of Women Of Advanced Maternal Age, Hannah C. Archer, Thao Nguyen, Carson Collins, Kayla Vaillant, Molly Riehs, Sarayu Bethi, Renee J. Chosed

SC Upstate Research Symposium

Introduction: A patient may seek the use of IVF technology when they are struggling to become pregnant. To improve IVF outcomes, much research is focused on identifying markers to allow embryologists to transfer embryos with the greatest chance of a successful pregnancy. Women of advanced maternal age, which is thirty-five years and older have a lower chance of success on a first attempt with IVF, women at the age of 40 have a 9% chance of a live birth with IVF. Therefore, identification of an additional biomarker during preimplantation embryo development that is associated with successful implantation in AMA patients, …

Py-05 Pediatric Vehicular Heatstroke: Analysis Of Cases That Children Gained Access To Vehicle, Emily N. Krull, Jennifer Gray Phd

SC Upstate Research Symposium

Since 1998, 937 children have died from Pediatric Vehicular Heatstroke (PVH), while this number is small regarding childhood mortality, it is still an important concern because the deaths of these children could have been prevented. Previous research has analyzed the deaths that occurred when children were left in the vehicle knowingly and unknowingly but does not discuss the cases where children gained access to the vehicle. The goal of this research is to determine what went wrong in the cases where children gained access to the vehicle and what parents were doing at the time of the incident, to understand …