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Feral Horses And Bison At Theodore Roosevelt National Park (North Dakota, United States) Exhibit Shifts In Behaviors During Drone Flights, Javier Lenzi, Christopher J. Felege, Robert Newman, Blake Mccann, Susan N. Ellis-Felege May 2022

Feral Horses And Bison At Theodore Roosevelt National Park (North Dakota, United States) Exhibit Shifts In Behaviors During Drone Flights, Javier Lenzi, Christopher J. Felege, Robert Newman, Blake Mccann, Susan N. Ellis-Felege

Biology Faculty Publications

Drone use has been rapidly increasing in protected areas in North America, and potential impacts on terrestrial megafauna have been largely unstudied. We evaluated behavioral responses to drones on two terrestrial charismatic species, feral horse (Equus caballus) and bison (Bison bison), at Theodore Roosevelt National Park (North Dakota, United States) in 2018. Using a Trimble UX5 fixed-wing drone, we performed two flights at 120 m above ground level (AGL), one for each species, and recorded video footage of their behaviors prior to, during, and after the flight. Video footage was analyzed in periods of 10 s intervals, and the occurrence …

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The Mitogenome Relationships And Phylogeography Of Barn Swallows (Hirundo Rustica), Gianluca Lombardo, Nicola Rambaldi Migliore, Giulia Colombo, Marco Rosario Capodiferro, Giulio Formenti, Manuela Caprioli, Elisabetta Moroni, Leonardo Caporali, Hovirag Lancioni, Simona Secomandi, Cristina Cereda, Valerio Carelli, Lauren Gillespie, Yang Liu, Yosef Kiat, Alfonso Marzal, Cosme López-Calderón, Javier Balbontín, Timothy Mousseau, Piotr Matyjasiak, Anders Pape Møller, Et. Al. May 2022

The Mitogenome Relationships And Phylogeography Of Barn Swallows (Hirundo Rustica), Gianluca Lombardo, Nicola Rambaldi Migliore, Giulia Colombo, Marco Rosario Capodiferro, Giulio Formenti, Manuela Caprioli, Elisabetta Moroni, Leonardo Caporali, Hovirag Lancioni, Simona Secomandi, Cristina Cereda, Valerio Carelli, Lauren Gillespie, Yang Liu, Yosef Kiat, Alfonso Marzal, Cosme López-Calderón, Javier Balbontín, Timothy Mousseau, Piotr Matyjasiak, Anders Pape Møller, Et. Al.

Faculty Publications

The barn swallow (Hirundo rustica) poses a number of fascinating scientific questions, including the taxonomic status of postulated subspecies. Here, we obtained and assessed the sequence variation of 411 complete mitogenomes, mainly from the European H. r. rustica, but other subspecies as well. In almost every case, we observed subspecies-specific haplogroups, which we employed together with estimated radiation times to postulate a model for the geographical and temporal worldwide spread of the species. The female barn swallow carrying the Hirundo rustica ancestral mitogenome left Africa (or its vicinity) around 280 thousand years ago (kya), and her descendants …

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Monitoring Avian Populations With Acoustic Indices In The Central Platte River Valley, Bethany Lynn Ostrom May 2022

Monitoring Avian Populations With Acoustic Indices In The Central Platte River Valley, Bethany Lynn Ostrom

Biology Theses, Dissertations, and Student Creative Activity

Acoustic indices are mathematical summaries of sound waves. Several researchers have tried to find relationships between them and vocal animal communities to use them as a passive monitoring method, as human-derived surveys are expensive, time-consuming, and suffer from observer bias. However, supplanting manual surveys with acoustic indices is a daunting task, considering effective indices for biological monitoring would need to differentiate biologically relevant sounds from the broader soundscape, including from human-derived (anthrophony) and earth-derived (geophony) sound. We collected avian community data and calculated six commonly used acoustic indices from acoustic recordings in the largest remaining intact lowland tallgrass prairie in …

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A Concise Synthetic Method For Constructing 3-Substituted Piperazine-2-Acetic Acid Esters From 1,2-Diamines, Srinivas Chamakuri, Sunny Ann Tang, Kevin A Tran, Shiva Krishna Reddy Guduru, Peter K Bolin, Kevin R Mackenzie, Damian W Young May 2022

A Concise Synthetic Method For Constructing 3-Substituted Piperazine-2-Acetic Acid Esters From 1,2-Diamines, Srinivas Chamakuri, Sunny Ann Tang, Kevin A Tran, Shiva Krishna Reddy Guduru, Peter K Bolin, Kevin R Mackenzie, Damian W Young

Faculty, Staff and Students Publications

We report a short synthetic route for synthesizing 2,3-substituted piperazine acetic acid esters. Optically pure amino acids were efficiently converted into 1,2-diamines that could be utilized to deliver the title 2,3-substituted piperazines in five steps with a high enantiomeric purity. The novel route facilitated, for the first time, the synthesis of 3-phenyl substituted-2-piperazine acetic acid esters that were difficult to achieve using other methods; however, in this case, the products underwent racemization.

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Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha May 2022

Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha

Michigan Tech Publications, Part 1

N95 respirator face masks serve as effective physical barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as filtration materials in N95 respirators via ultraviolet (UV)-initiated grafting of biocidal …

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Maf1, A Repressor Of Rna Polymerase Iii-Dependent Transcription, Regulates Bone Mass, Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson May 2022

Maf1, A Repressor Of Rna Polymerase Iii-Dependent Transcription, Regulates Bone Mass, Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson

Faculty, Staff and Students Publications

MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1 (Maf1-/- mice) produced a high bone mass phenotype. However, osteoblasts isolated from Maf1-/- mice showed reduced osteoblastogenesis ex vivo. Therefore, we determined the phenotype of mice overexpressing MAF1 in cells from the mesenchymal lineage (Prx1-Cre;LSL-MAF1 mice). These mice showed increased bone mass. Ex vivo, cells from these mice showed enhanced osteoblastogenesis concordant with their high …

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Evaluating The Brain-Enhancing Mitohormesis Of N-Propargylglycine, A Suicide Inhibitor Of Proline Dehydrogenase, To Offset The Proteotoxic Mechanisms Underlying Neurodegeneration In Huntington’S Disease And Evaluating The Phenotype Of A Mutant Pdia3 Knock-In Mouse Line As A Novel Genetic Model Of Neurological Disorders, Fadzai Teramayi May 2022

Evaluating The Brain-Enhancing Mitohormesis Of N-Propargylglycine, A Suicide Inhibitor Of Proline Dehydrogenase, To Offset The Proteotoxic Mechanisms Underlying Neurodegeneration In Huntington’S Disease And Evaluating The Phenotype Of A Mutant Pdia3 Knock-In Mouse Line As A Novel Genetic Model Of Neurological Disorders, Fadzai Teramayi

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Huntington’s Disease (HD) is characterized by atrophy of the striatal and cerebral cortical neurons producing a variety of severe, and life-shortening neurologic symptoms including motor dysfunction, cognitive decline, psychiatric disturbances, and weight loss. As with other life-threatening neurodegenerative disorders, HD has no effective treatment capable of preventing or mitigating its underlying hallmark, subcellular and pathogenetic mechanism, that is, proteotoxicity. While it has been suggested that inducing brain mitohormesis might offer a promising therapeutic strategy, to date, no brain-penetrating mitohormesis-inducing agent has yet been identified or tested in any neurodegenerative disease mouse model. Recently, N-propargylglycine (N-PPG) was shown …

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Noxious Cellular Injury Triggers An Oxidative Stress Gene Response, Shawyun Khoshneviszadeh May 2022

Noxious Cellular Injury Triggers An Oxidative Stress Gene Response, Shawyun Khoshneviszadeh

Master of Science in Integrative Biology Theses

Wound and regeneration involves a series of complex processes that can induce oxidative stress by elevating intracellular reactive oxygen species (ROS) levels. In this study, we used RNA-seq and qPCR to examine the molecular signature of Human Embryonic Kidney cells (HEK-293T) stimulated with Crotalus atrox (CA) venom. NGS data was assembled and annotated utilizing the Illumina paired-end RNA-seq approach with software packages HISAT2 and StringTie. Results showed 243 genes were differentially expressed (106 upregulated, 137 downregulated) between CA venom stimulated and non-stimulated cells (p<0.05). HEK-293T stimulated with CA venom for 4 hours showed an increase in the expression of oxidative stress response genes (e.g., TOMM6, EGR (1,2,3), HSP70 (1A, 1B), SPRY4, ETV5, and EMP1) (Fold-Change (fc) >2.0). Significantly downregulated genes were associated with many novel transcripts/proteins such as AC117378, AD000671, and AC023509. …

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Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes May 2022

Female Presence Does Not Increase Testosterone But Still Ameliorates Sickness Behaviours In Male Japanese Quail, Brenna M. G. Gormally, Kaelyn Bridgette, Aubrey Emmi, Delilah Schuerman, Patricia C. Lopes

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Infections can dramatically modify animal behaviour. The extent of these changes depends on an animal's environment. It has been proposed that testosterone modulates the suppression of behavioural symptoms of sickness under certain reproductive contexts. To further understand the role played by testosterone in modulating sickness behaviours under reproductive contexts, we studied a species, the Japanese quail, in which female exposure rapidly decreases circulating testosterone in males. Males received either an immune challenge (lipopolysaccharide – LPS) or a control injection and their behaviours, mass change and testosterone levels were quantified in the presence or absence of a female. Both the presence …

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Targeting Aberrant Replication And Dna Repair Events For Treating Breast Cancers, Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S R Nirzhor, Vijay Eedunuri, Tabrez A Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K Gupta, Benny A Kaipparettu, Jack L Arbiser, Manjeet K Rao May 2022

Targeting Aberrant Replication And Dna Repair Events For Treating Breast Cancers, Subapriya Rajamanickam, Jun Hyoung Park, Panneerdoss Subbarayalu, Santosh Timilsina, Kaitlyn Bates, Pooja Yadav, Saif S R Nirzhor, Vijay Eedunuri, Tabrez A Mohammad, Kwang Hwa Jung, Benjamin Onyeagucha, Nourhan Abdelfattah, Raymond Benevides, Grace Lee, Yidong Chen, Ratna Vadlamudi, Andrew Brenner, Virginia Kaklamani, Ismail Jatoi, John Kuhn, Robert Hromas, Yogesh K Gupta, Benny A Kaipparettu, Jack L Arbiser, Manjeet K Rao

Faculty, Staff and Students Publications

The major limitations of DNA-targeting chemotherapy drugs include life-threatening toxicity, acquired resistance and occurrence of secondary cancers. Here, we report a small molecule, Carbazole Blue (CB), that binds to DNA and inhibits cancer growth and metastasis by targeting DNA-related processes that tumor cells use but not the normal cells. We show that CB inhibits the expression of pro-tumorigenic genes that promote unchecked replication and aberrant DNA repair that cancer cells get addicted to survive. In contrast to chemotherapy drugs, systemic delivery of CB suppressed breast cancer growth and metastasis with no toxicity in pre-clinical mouse models. Using PDX and ex …

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Studying Tissue Specific Diversity Of Splicing Regulator Muscleblind, Davron Hanley May 2022

Studying Tissue Specific Diversity Of Splicing Regulator Muscleblind, Davron Hanley

Master of Science in Integrative Biology Theses

The muscleblind (mbl) family of RNA-binding proteins regulates alternative splicing, determining mRNA transcript composition for various types of tissue, and has been implicated in myotonic dystrophy. The mbl gene is subject to alternative splicing in Drosophila, leading to multiple isoforms, and has several paralogs in humans. Mbl proteins vary significantly in length, although the significance of such diversity and the role of specific isoforms have not been fully explored. Using immunofluorescence microscopy and polyclonal serum, we analyzed Mbl protein expression across adult Drosophila tissues. Mbl was detected in various locations, including the brain, gonads, muscle, and gut epithelium. Skeletal muscles …

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Our Past Creates Our Present: A Brief Overview Of Racism And Colonialism In Western Paleontology, Pedro M. Monarrez, Joshua B. Zimmt, Annaka M. Clement, William Gearty, John J. Jacisin, Kelsey M. Jenkins, Kristopher M. Kusnerik, Ashley W. Poust, Selina V. Robson, Judith A. Sclafani, Kelsey T. Stilson, Shamindri D. Tennakoon, Carmi Milagros Thompson May 2022

Our Past Creates Our Present: A Brief Overview Of Racism And Colonialism In Western Paleontology, Pedro M. Monarrez, Joshua B. Zimmt, Annaka M. Clement, William Gearty, John J. Jacisin, Kelsey M. Jenkins, Kristopher M. Kusnerik, Ashley W. Poust, Selina V. Robson, Judith A. Sclafani, Kelsey T. Stilson, Shamindri D. Tennakoon, Carmi Milagros Thompson

School of Biological Sciences: Faculty Publications

As practitioners of a historical science, paleontologists and geoscientists are well versed in the idea that the ability to understand and to anticipate the future relies upon our collective knowledge of the past. Despite this understanding, the fundamental role that the history of paleontology and the geosciences plays in shaping the structure and culture of our disciplines is seldom recognized and therefore not acted upon sufficiently. Here, we present a brief review of the history of paleontology and geology in Western countries, with a particular focus on North America since the 1800s. Western paleontology and geology are intertwined with systematic …

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Social And Ecological Drivers Of Life History Evolution In Wild Bees, Karen Kapheim May 2022

Social And Ecological Drivers Of Life History Evolution In Wild Bees, Karen Kapheim

Funded Research Records

No abstract provided.

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Understanding The Drivers And Limiting Factors Of Tui Chub In Pyramid Lake, Nv As The Most Important Food Source For Recovering Lahontan Cutthroat Trout, Phaedra Budy May 2022

Understanding The Drivers And Limiting Factors Of Tui Chub In Pyramid Lake, Nv As The Most Important Food Source For Recovering Lahontan Cutthroat Trout, Phaedra Budy

Funded Research Records

No abstract provided.

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Seasonal Migration Distance Varies With Natal Dispersal And Predicts Parasitic Infection In Song Sparrows, Tosha R. Kelly, Heather L. Macgillivray, Yanina Sarquis-Adamson, Matthew J. Watson, Keith A. Hobson, Elizabeth A. Macdougall-Shackleton May 2022

Seasonal Migration Distance Varies With Natal Dispersal And Predicts Parasitic Infection In Song Sparrows, Tosha R. Kelly, Heather L. Macgillivray, Yanina Sarquis-Adamson, Matthew J. Watson, Keith A. Hobson, Elizabeth A. Macdougall-Shackleton

Biology Publications

Seasonal migration and natal dispersal represent the major large-scale movements in the lives of animals. Individuals that are relatively prone to movement and exploration might thus be more likely to disperse and also to migrate farther. Such movement might be either negatively associated with parasitic infection (if infection prevents hosts from successful long-distance migration) or positively associated (e.g. if longer-distance migrants encounter more abundant or more diverse parasites). We examined whether natal dispersal tendency predicts seasonal migration distance in song sparrows (Melospiza melodia) and whether migration distance predicts infection with bloodborne parasites upon arrival at the breeding grounds. …

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Asset Values Of Trees Vary Among Age And Condition, Aidan Castricone May 2022

Asset Values Of Trees Vary Among Age And Condition, Aidan Castricone

Biology Student Scholarship

Trees are utilized everywhere for visual, physical or functional means with an example being on Providence College campus. We have 1,403 trees part of an inventory and management plan. As part of this plan that was updated this past December 2021 each tree has an asset value calculated with consideration of the size, species, condition, and location. What was not clear in the management plan was whether one factor held more weight in the calculated value compared to another factor. This research focuses on the influence that the age and condition of the tree have on the tree asset value. …

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The Impacts Of Ph On Biodiversity In Marine Environments, Matthew Rock May 2022

The Impacts Of Ph On Biodiversity In Marine Environments, Matthew Rock

Biology Student Scholarship

Climate change continues to impact each and every environment on Earth due to rising levels of greenhouse gasses. CO2 is the most pervasive of these gasses, and when mixed with seawater it creates carbonic acid increasing the pH of water. Ocean acidification has led to large-scale die-offs of more sensitive marine species like coral; therefore, this project serves to evaluate the interaction between pH and the biodiversity of coastal marine environments. BIO 340 final project

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Bird Nesting Trends In Massachusetts, Dieter Rodriguez May 2022

Bird Nesting Trends In Massachusetts, Dieter Rodriguez

Biology Student Scholarship

Bird nesting data has long been documented for various species across the United States. While trends between temperature changes or precipitation on bird nesting have been studied for particular species, studies done on the effects of temperature due to climate change on bird nesting on the broader state level are lacking. Using bird nesting data and average annual temperature data for Massachusetts collected over a ten year period, I assessed the effects of temperature changes over time on bird nesting attempts and total eggs laid for all documented species within the state. BIO 340 final project

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Climate Effects On Butterfly Species Richness, Isabelle Heron May 2022

Climate Effects On Butterfly Species Richness, Isabelle Heron

Biology Student Scholarship

The effects of climate change on the surrounding biodiversity lead scientists to argue an “insect apocalypse” is approaching. Butterflies, as poikilothermic animals, meaning their activity is closely controlled by weather, represent a useful indicator to studying climate change. Scientists can detect changes in butterfly abundance which result in changes in distribution and abundance over a short period of time. BIO 340 final project

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The Effect Of Temperature On Algal Blooms In New York State, Kylie Taylor May 2022

The Effect Of Temperature On Algal Blooms In New York State, Kylie Taylor

Biology Student Scholarship

Water shapes all flora and fauna. Urbanization, industrialization, and other human activities have negatively affected this important source. For example, algal blooms arise due to a combination of sunlight, warm temperatures, and excessive nutrient runoff. The nutrients are a result of fertilizer runoff which enters aquatic systems and cause algal blooms. Increased air temperatures cause increased water temperatures which creates ideal conditions for cyanobacteria growth which are responsible for blooms. Algal blooms affect the entire ecosystem by decreasing sunlight availability in the water. Decreased sunlight contributes to low oxygen dead-zones which negatively affect drinking water reservoirs. I examined the relationship …

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Environmental Toxins Disproportionately Affect Low Income And Minority Communities Along The Providence River, Jalynn Booker May 2022

Environmental Toxins Disproportionately Affect Low Income And Minority Communities Along The Providence River, Jalynn Booker

Biology Student Scholarship

The effects of environmental toxins emitted from the various industrial businesses along the Providence River and Allen’s Ave have been reported by residents to cause an incline in respiratory diseases and other illnesses in children and adults in nearby neighborhoods. Operations along Allen’s Ave consist of heavy toxin emitting practices such as hot asphalt mixing, fuels emissions, toxic runoff, gas leaks and piles of scrap metal. Many local news articles and blog posts have reported on the fact that this industrial waterfront has adversely impacted neighboring communities. However, there is little research explicitly comparing the socioeconomic differences between the east …

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Lyme Disease Cases Dependent On Annual Snowfall, Andrew Jordan May 2022

Lyme Disease Cases Dependent On Annual Snowfall, Andrew Jordan

Biology Student Scholarship

Ticks are parasitic arachnids that inhabit every region of the United States. Ticks can spread diseases through feeding on the blood of mammals and birds. Lyme disease is a bacterial infection you can get from the bite of a Blacklegged tick (deer tick), which can lead to long term health effects and can ultimately lead to fatality. Depending on location, up to 50% of ticks in the given area can carry Lyme disease. Lyme disease is a problem and climate change could make it even worse. Whether or not a tick dies in the winter depends on how deep they …

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Stinging The Predators: A Collection Of Papers That Should Never Have Been Published, Zen Faulkes May 2022

Stinging The Predators: A Collection Of Papers That Should Never Have Been Published, Zen Faulkes

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

This ebook collects academic papers and conference abstracts that were meant to be so terrible that nobody in their right mind would publish them. All were submitted to journals and conferences to expose weak or non-existent peer review and other exploitative practices. Each paper has a brief introduction. Short essays round out the collection.

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Alterations Of The Gut Microbial Community Structure And Function With Aging In The Spontaneously Hypertensive Stroke Prone Rat, Huanan Shi, James W Nelson, Sharon Phillips, Joseph F Petrosino, Robert M Bryan, David J Durgan May 2022

Alterations Of The Gut Microbial Community Structure And Function With Aging In The Spontaneously Hypertensive Stroke Prone Rat, Huanan Shi, James W Nelson, Sharon Phillips, Joseph F Petrosino, Robert M Bryan, David J Durgan

Faculty, Staff and Students Publications

Gut dysbiosis, a pathological imbalance of bacteria, has been shown to contribute to the development of hypertension (HT), systemic- and neuro-inflammation, and blood-brain barrier (BBB) disruption in spontaneously hypertensive stroke prone rats (SHRSP). However, to date individual species that contribute to HT in the SHRSP model have not been identified. One potential reason, is that nearly all studies of the SHRSP gut microbiota have analyzed samples from rats with established HT. The goal of this study was to examine the SHRSP gut microbiota before, during, and after the onset of hypertension, and in normotensive WKY control rats over the same …

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Genetically Explicit Model May Explain Multigenerational Control Of Emergent Turing Patterns In Hybrid Mimulus, Emily Simmons May 2022

Genetically Explicit Model May Explain Multigenerational Control Of Emergent Turing Patterns In Hybrid Mimulus, Emily Simmons

Biology and Medicine Through Mathematics Conference

No abstract provided.

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Cross-Modal Perception Of Identity By Sound And Taste In Bottlenose Dolphins, Jason N. Bruck, Sam F. Walmsley, Vincent M. Janik May 2022

Cross-Modal Perception Of Identity By Sound And Taste In Bottlenose Dolphins, Jason N. Bruck, Sam F. Walmsley, Vincent M. Janik

Faculty Publications

While studies have demonstrated concept formation in animals, only humans are known to label concepts to use them in mental simulations or predictions. To investigate whether other animals use labels comparably, we studied cross-modal, individual recognition in bottlenose dolphins (Tursiops truncatus) that use signature whistles as labels for conspecifics in their own communication. First, we tested whether dolphins could use gustatory stimuli and found that they could distinguish between water and urine samples, as well as between urine from familiar and unfamiliar individuals. Then, we paired playbacks of signature whistles of known animals with urine samples from either the same …

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Sodium Mediates Developmentally Plastic Responses In Plants And Herbivores, Luis Santiago-Rosario May 2022

Sodium Mediates Developmentally Plastic Responses In Plants And Herbivores, Luis Santiago-Rosario

LSU Doctoral Dissertations

Sodium plays a crucial role in organismal performance, trophic-level interactions, and eco-evolutionary dynamics. For plants, sodium impacts osmoregulation, growth, and water uptake. For animals, sodium is essential influencing osmoregulatory processes, muscle and neural development, and blood regulation. My dissertation aims to disentangle why sodium mismatch affects resource-consumer interactions and its influence on morphological and behavioral plasticity. First, I identified how sodium impacts plant performance and sodium accumulation strategies. I initially focused my research on understanding how increasing substrate sodium affects plant growth and tissue sodium accumulation strategies in controlled settings using a systematic review approach. I found that saltier plants …

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Mutant Microorganisms And Methods Of Making And Using, Raghuveer Singh, Derrick White, Paul Blum May 2022

Mutant Microorganisms And Methods Of Making And Using, Raghuveer Singh, Derrick White, Paul Blum

School of Biological Sciences: Faculty Publications

This disclosure describes methods that allow for the uncoupling of microbial growth from product formation, which allows for maximal use of raw material and optimal end product formation.

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Dyt-Prkra Mutation P222l Enhances Pact's Stimulatory Activity On Type I Interferon Induction, Lauren S. Vaughn, Kenneth Frederick, Samuel B. Burnett, Nutan Sharma, D. Cristopher Bragg, Sarah Camargos, Francisco Cardoso, Rekha C. Patel May 2022

Dyt-Prkra Mutation P222l Enhances Pact's Stimulatory Activity On Type I Interferon Induction, Lauren S. Vaughn, Kenneth Frederick, Samuel B. Burnett, Nutan Sharma, D. Cristopher Bragg, Sarah Camargos, Francisco Cardoso, Rekha C. Patel

Faculty Publications

DYT-PRKRA (dystonia 16 or DYT-PRKRA) is caused by mutations in the PRKRA gene that encodes PACT, the protein activator of interferon (IFN)-induced double-stranded (ds) RNA-activated protein kinase (PKR). PACT participates in several cellular pathways, of which its role as a PKR activator protein during integrated stress response (ISR) is the best characterized. Previously, we have established that the DYT-PRKRA mutations cause enhanced activation of PKR during ISR to sensitize DYT-PRKRA cells to apoptosis. In this study, we evaluate if the most prevalent substitution mutation reported in DYT-PRKRA patients alters PACT’s functional role in induction of type …

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Du Undergraduate Showcase: Research, Scholarship, And Creative Works: Abstracts, Emma Aggeler, Elena Arroway, Daisy T. Booker, Justin Bravo, Kyle Bucholtz, Megan Burnham, Nicole Choi, Spencer Cockerell, Rosie Contino, Jackson Garske, Kaitlyn Glover, Caroline Hamilton, Haley Hartmann, Madalyne Heiken, Colin Holter, Leah Huzjak, Alyssa Jeng, Cole Jernigan, Chad Kashiwa, Adelaide Kerenick, Emily King, Abigail Langeberg, Maddie Leake, Meredith Lemons, Alec Mackay, Greer Mckinley, Ori Miller, Guy Milliman, Katherine Miromonti, Audrey Mitchell, Lauren Moak, Megan Morrell, Gelella Nebiyu, Zdenek Otruba, Toni V. Panzera, Kassidy Patarino, Sneha Patil, Alexandra Penney, Kevin Persky, Caitlin Pham, Gabriela Recinos, Mary Ringgenberg, Chase Routt, Olivia Schneider, Roman Shrestha, Arlo Simmerman, Alec Smith, Tessa Smith, Nhi-Lac Thai, Kyle Thurmann, Casey Tindall, Amelia Trembath, Maria Trubetskaya, Zachary Vangelisti, Peter Vo, Abby Walker, David Winter, Grayden Wolfe, Leah York May 2022

Du Undergraduate Showcase: Research, Scholarship, And Creative Works: Abstracts, Emma Aggeler, Elena Arroway, Daisy T. Booker, Justin Bravo, Kyle Bucholtz, Megan Burnham, Nicole Choi, Spencer Cockerell, Rosie Contino, Jackson Garske, Kaitlyn Glover, Caroline Hamilton, Haley Hartmann, Madalyne Heiken, Colin Holter, Leah Huzjak, Alyssa Jeng, Cole Jernigan, Chad Kashiwa, Adelaide Kerenick, Emily King, Abigail Langeberg, Maddie Leake, Meredith Lemons, Alec Mackay, Greer Mckinley, Ori Miller, Guy Milliman, Katherine Miromonti, Audrey Mitchell, Lauren Moak, Megan Morrell, Gelella Nebiyu, Zdenek Otruba, Toni V. Panzera, Kassidy Patarino, Sneha Patil, Alexandra Penney, Kevin Persky, Caitlin Pham, Gabriela Recinos, Mary Ringgenberg, Chase Routt, Olivia Schneider, Roman Shrestha, Arlo Simmerman, Alec Smith, Tessa Smith, Nhi-Lac Thai, Kyle Thurmann, Casey Tindall, Amelia Trembath, Maria Trubetskaya, Zachary Vangelisti, Peter Vo, Abby Walker, David Winter, Grayden Wolfe, Leah York

DU Undergraduate Research Journal Archive

Abstracts from the DU Undergraduate Showcase.

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