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Association Of Human Leukocyte Antigen (Hla) Alleles With Atopic Dermatitis In The Uae Population, Suhib Ziad Abu Jwayed Nov 2023

Association Of Human Leukocyte Antigen (Hla) Alleles With Atopic Dermatitis In The Uae Population, Suhib Ziad Abu Jwayed

Theses

In the face of the increasing global prevalence of Atopic Dermatitis (AD), a chronic inflammatory skin condition, this thesis seeks to elucidate the genetic underpinnings of AD within the UAE population. Previous literature has underscored the ethnic-specific involvement of Human Leukocytes Antigen (HLA) genetic variations, especially within HLA-A and HLA-DRB1 genes, in the pathogenesis of various skin diseases, including AD. Leveraging this knowledge, our research specifically aimed to investigate the association between these HLA variants and AD in the UAE. Utilizing a comparative approach, the frequencies of HLA-A and HLA-DRB1 variants were assessed in AD patients vis-à-vis a control group. …

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Biochemical Charactrization Of A Fructosyltransferase Enzyme From A Halophilic Archaeon, Haloarcula Marismotui, For Biotechnological Applications, Ahlam Khalifa Al Ameri Nov 2023

Biochemical Charactrization Of A Fructosyltransferase Enzyme From A Halophilic Archaeon, Haloarcula Marismotui, For Biotechnological Applications, Ahlam Khalifa Al Ameri

Theses

Fructosyltransferase enzymes are involved in the production of fructans, which are polymers of fructose and naturally present in many foods like fruits, vegetables, legumes, and cereals. Fructans with short chain lengths are called Fructooligosaccharides (FOS), which are small dietary fibers having low caloric values and are known as “prebiotics”. Fructans have a broad range of applications in the food, pharmaceutical, cosmetics, and chemical industries. They have unique physiochemical properties and functionalities depending on the source of enzyme used for their production. The present study aimed at the utilization of a recently discovered unique fructosyltransferase enzyme from an extremely halophilic microorganism, …

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Population Structure And Genetic Diversity Of The Socotra Cormorant (Phalacrocorax Nigrogularis), Noura Mabkhout Almansoori Nov 2023

Population Structure And Genetic Diversity Of The Socotra Cormorant (Phalacrocorax Nigrogularis), Noura Mabkhout Almansoori

Theses

The Socotra cormorants (Phalacrocorax nigrogularis) are regional endemic seabirds restricted to the Arabian Gulf, Gulf of Oman, and the Arabian Sea. This species is classified as vulnerable by the IUCN Red List. However, no population genetic study has been conducted on P. nigrogularis in their range, and population structure, gene flow and connectivity between colonies is unknown. Likewise, genetic diversity of this species has not yet been characterized. Thus, the aim of this thesis was to fill these gaps by inferring population structure, assessing gene flow and genetic diversity of Socotra cormorant colonies in their known distribution range. …

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Foxo1 Promotes The Expression Of Canonical Wnt Target Genes In Examined Basal-Like Breast And Glioblastoma Multiforme Cancer Cells, Shania Pintor, Alma Lopez, David Flores, Brianda Lozoya, Bipul Soti, Rishi Pokhrel, Joaquin Negrete, Michael W. Persans, Robert Gilkerson, Bonnie Gunn, Megan Keniry Nov 2023

Foxo1 Promotes The Expression Of Canonical Wnt Target Genes In Examined Basal-Like Breast And Glioblastoma Multiforme Cancer Cells, Shania Pintor, Alma Lopez, David Flores, Brianda Lozoya, Bipul Soti, Rishi Pokhrel, Joaquin Negrete, Michael W. Persans, Robert Gilkerson, Bonnie Gunn, Megan Keniry

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Basal-like breast cancer (BBC) and glioblastoma multiforme (GBM) are aggressive cancers associated with poor prognosis. BBC and GBM have stem cell-like gene expression signatures, which are in part driven by forkhead box O (FOXO) transcription factors. To gain further insight into the impact of FOXO1 in BBC, we treated BT549 cells with AS1842856 and performed RNA sequencing. AS1842856 binds to unphosphorylated FOXO1 and inhibits its ability to directly bind to DNA. Gene Set Enrichment Analysis indicated that a set of WNT pathway target genes, including lymphoid enhancer-binding factor 1 (LEF1) and transcription factor 7 (TCF7), were …

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An Automated Respiratory Data Pipeline For Waveform Characteristic Analysis, Savannah Lusk, Christopher S Ward, Andersen Chang, Avery Twitchell-Heyne, Shaun Fattig, Genevera Allen, Joanna L Jankowsky, Russell S Ray Nov 2023

An Automated Respiratory Data Pipeline For Waveform Characteristic Analysis, Savannah Lusk, Christopher S Ward, Andersen Chang, Avery Twitchell-Heyne, Shaun Fattig, Genevera Allen, Joanna L Jankowsky, Russell S Ray

Faculty, Staff and Students Publications

Comprehensive and accurate analysis of respiratory and metabolic data is crucial to modelling congenital, pathogenic and degenerative diseases converging on autonomic control failure. A lack of tools for high-throughput analysis of respiratory datasets remains a major challenge. We present Breathe Easy, a novel open-source pipeline for processing raw recordings and associated metadata into operative outcomes, publication-worthy graphs and robust statistical analyses including QQ and residual plots for assumption queries and data transformations. This pipeline uses a facile graphical user interface for uploading data files, setting waveform feature thresholds and defining experimental variables. Breathe Easy was validated against manual selection by …

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Coordinated Regulation Of Myonuclear Dna Methylation, Mrna, And Mirna Levels Associates With The Metabolic Response To Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy In Female Mice, Ahmed Ismaeel, Nicholas T. Thomas, Mariah Mccashland, Sebastian Edman, Johanna T. Lanner, Vandré C. Figueiredo, Christopher S. Fry, John J. Mccarthy, Yuan Wen, Kevin A. Murach, Ferdinand Von Walden Nov 2023

Coordinated Regulation Of Myonuclear Dna Methylation, Mrna, And Mirna Levels Associates With The Metabolic Response To Rapid Synergist Ablation-Induced Skeletal Muscle Hypertrophy In Female Mice, Ahmed Ismaeel, Nicholas T. Thomas, Mariah Mccashland, Sebastian Edman, Johanna T. Lanner, Vandré C. Figueiredo, Christopher S. Fry, John J. Mccarthy, Yuan Wen, Kevin A. Murach, Ferdinand Von Walden

Health, Human Performance and Recreation Faculty Publications and Presentations

The central dogma of molecular biology dictates the general flow of molecular information from DNA that leads to a functional cellular outcome. In skeletal muscle fibers, the extent to which global myonuclear transcriptional alterations, accounting for epigenetic and post-transcriptional influences, contribute to an adaptive stress response is not clearly defined. In this investigation, we leveraged an integrated analysis of the myonucleus-specific DNA methylome and transcriptome, as well as myonuclear small RNA profiling to molecularly define the early phase of skeletal muscle fiber hypertrophy. The analysis of myonucleus-specific mature microRNA and other small RNA species provides new directions for exploring muscle …

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It’S All About Fishing: Robert Ellis Jenkins (1940-2023) And His Life Among Freshwater Fishes Of Virginia And The Redhorse Suckers, Eric J. Hilton Oct 2023

It’S All About Fishing: Robert Ellis Jenkins (1940-2023) And His Life Among Freshwater Fishes Of Virginia And The Redhorse Suckers, Eric J. Hilton

Southeastern Fishes Council Proceedings

Robert (Bob) Ellis Jenkins passed away in Salem, Virginia, on Wednesday, July 12, 2023. Bob was born February 9, 1940 in Brooklyn, New York. As a child, Bob took an early interest in natural history, and was a particularly avid fisherman. He attended Roanoke College (Salem, VA) as an undergraduate and entered into a Masters degree program at Virginia Tech (Blacksburg, VA), only to leave before finishing for a position at the NOAA Systematics Lab based at the Smithsonian Institution’s National Museum of Natural History. He eventually became faculty at his alma mater, Roanoke College, where he would spend virtually …

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Synaptic Proteins Involved In Reward-Based Plasticity, Cameron Martinez, Christian Wesselborg, Hey-Kyoung Lee Ph.D Oct 2023

Synaptic Proteins Involved In Reward-Based Plasticity, Cameron Martinez, Christian Wesselborg, Hey-Kyoung Lee Ph.D

Trick to the Treat of Internships and Research

My research focused on synaptic proteins involved in reward-based plasticity. More specifically, my aim sought to expand brain tissue in order to resolve the problem of distinguishing between synapses. This process involved using different biological assays.

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Clear Vision Center Of South Florida Biol 4990 - Independent Study In Biology, Bita Sabripour Oct 2023

Clear Vision Center Of South Florida Biol 4990 - Independent Study In Biology, Bita Sabripour

Trick to the Treat of Internships and Research

During my internship at Clear Vision Center of South Florida, I had the opportunity to shadow and work alongside Dr. Bita Sabripour to examine and provide eye care services to patients. I learned various clinical practices including taking patients' history, working the front desk, taking inventory, placing orders, selling frames, assisting patients, and keeping the office running. In addition, I ran the clinic's social media platforms and was in charge of communication with various manufacturers and sales representatives. I also volunteered with the associated nonprofit organization, See Your Future, which provides free eye care and services to the underprivileged and …

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Dietary Interventions During Chemotherapy Treatment: A Systematic Review Of Feasibility, Safety, And Efficacy, Shalet James, Alexie Oppermann, Amber S. Kleckner Oct 2023

Dietary Interventions During Chemotherapy Treatment: A Systematic Review Of Feasibility, Safety, And Efficacy, Shalet James, Alexie Oppermann, Amber S. Kleckner

Trick to the Treat of Internships and Research

Chemotherapy is a mainstay for cancer treatment. However, chemotherapy is associated with side effects that can significantly limit a person's physical and cognitive functioning, both reducing quality of life and leading to dose reductions of life-saving treatment. Dietary interventions may help manage and reduce the side effects of chemotherapy through biological and psychological mechanisms. While there is preliminary evidence supporting the importance of nutrition in cancer care, current guidelines are vague except for minimum calorie and protein intake to prevent malnutrition. The aim of this systematic review is to evaluate the feasibility, safety, and efficacy of dietary interventions on health …

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Minimum Blockers Of 123-Avoiding Permutation Matrices, Megan Bennett Oct 2023

Minimum Blockers Of 123-Avoiding Permutation Matrices, Megan Bennett

Trick to the Treat of Internships and Research

A blocker of 123-avoiding permutation matrices refers to the set of zeros contained within an 𝑛 × 𝑛 123-forcing matrix. Recently, Brualdi and Cao provided a characterization of all minimal blockers, which are blockers with a cardinality of 𝑛. Building upon their work, a new type of blocker, flag-shaped blockers, which can be seen as a generalization of the 𝐿-shaped blockers defined by Brualdi and Cao, are introduced. It is demonstrated that all flag-shaped blockers are minimum blockers, and the shifting of positions from these blockers is discussed. Lastly, the dimensions of subpolytopes that are defined by flag-shaped blockers are …

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Introduction To Protein Modeling, Jordan Nichole Carreras, Juhi Dalal, Ryan Luib, Omar Saleh, Pranav Neravetla, Shreya Averinini Oct 2023

Introduction To Protein Modeling, Jordan Nichole Carreras, Juhi Dalal, Ryan Luib, Omar Saleh, Pranav Neravetla, Shreya Averinini

Trick to the Treat of Internships and Research

HONR 1010G: Introduction to Protein Modeling is a course-based research opportunity focused on telling a “protein story” using a 3dprinted model developed by students working in research groups studying the literature and available protein database files. The course is open to honors students at all levels and majors. Throughout the semester, students work to develop a 3D printed model that explains how the protein works. This is done through using computational tools with protein database file published through the protein data bank (https://www.rcsb.org/) such as Jmol & Pymol, scientific literature and 3D protein models. In addition to creating the 3dprinted …

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Investigating The Gut Microbiota Of Skeleton Shrimp, Jason Rosales Oct 2023

Investigating The Gut Microbiota Of Skeleton Shrimp, Jason Rosales

Trick to the Treat of Internships and Research

No abstract provided.

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How Did The Covid-19 Pandemic Impact Anatomy And Physiology Education Worldwide, Sneh Patel, Sean Mahajan, Santanu De Oct 2023

How Did The Covid-19 Pandemic Impact Anatomy And Physiology Education Worldwide, Sneh Patel, Sean Mahajan, Santanu De

Trick to the Treat of Internships and Research

No abstract provided.

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Sea-Phages Research, Bianca Gonzalez Oct 2023

Sea-Phages Research, Bianca Gonzalez

Trick to the Treat of Internships and Research

Bacteriophages are viruses that infect and kill bacteria and there is an abundant amount of them in the world. They have been recently utilized in biotechnological applications including their use in combating antibiotic resistance and bioremediation of oil spills. Through the SEA-PHAGES program, my goal (along with my team) was to discover and isolate bacteriophages found in soil and analyze their full genome sequences

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Md Anderson Internship: Targeting Il-27rα In Ovarian Cancer, Meghana Kavarthapu Oct 2023

Md Anderson Internship: Targeting Il-27rα In Ovarian Cancer, Meghana Kavarthapu

Trick to the Treat of Internships and Research

We utilized a novel explainable artificial intelligence (XAI) approach to identify Interleukin-27 Receptor α (IL-27Rα) as a potential therapeutic target for high grade serous ovarian cancer (HGSC) patients based on the Cancer Genome Atlas (TCGA) dataset. High expression of IL-27Rα was found to be significantly correlated with poorer survival in HGSC patients. To investigate its therapeutic potential, we silenced IL-27Rα in murine HGSC cells lines using siRNA and assessed its impact on tumor proliferation, migration, invasion, and angiogenesis. Our results demonstrated that IL-27Rα siRNA effectively reduced its expression, as confirmed by Western Blot analysis, and significantly attenuated proliferation by clonogenic …

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Florida's Summer Institute In Biostatistics And Data Science Program Experience, David Giordano Oct 2023

Florida's Summer Institute In Biostatistics And Data Science Program Experience, David Giordano

Trick to the Treat of Internships and Research

The Summer Institute in Biostatistics and Data Science, sponsored by the NHLBI and NIAID, offers a comprehensive six to seven-week training program. This program provides classroom instruction, career mentoring, and hands-on data analysis using clinical study data related to infectious, immune-mediated, and chronic diseases. It's designed to address the increasing demand for biostatisticians and data scientists, targeting undergraduates and early graduate students to consider graduate programs in these fields. The curriculum includes intensive biostatistical training, introducing students to statistical methods' principles and applications in biomedical and clinical research.

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Pre-Health Professional Volunteer, Divya Papaiya Oct 2023

Pre-Health Professional Volunteer, Divya Papaiya

Trick to the Treat of Internships and Research

I participated in the esteemed Pre-Health Professional Volunteer Program at Penn Medicine Princeton Health over this summer from May to August. Through this program, I was able to rotate through various departments in the hospital ranging from – but not limited to – Radiation Oncology to the Pathology/Blood Bank Lab. Along with completing my rotations, I was a part of a close-knit cohort that was able to attend special lectures dedicated to a variety of healthcare topics such as medical treatment inequality and disparity, EMS services, organ donation, and medical examiner (autopsy) recognition cases. Despite being part of a specialized …

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Big 5 Conservation Internship, Bernhard Riegl Oct 2023

Big 5 Conservation Internship, Bernhard Riegl

Trick to the Treat of Internships and Research

The Discover Eden Big 5 Ecology and Conservation course is located in South Africa. Through a series of first-hand experiences and lectures, one learns much about Conservation and what it really is. By working with Ecologists, Conservationists, and Veterinarians, you gain insight into these professions and what they entail

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Summer 2023 Graz Internship, Eleanor Wind, Alex Pope Oct 2023

Summer 2023 Graz Internship, Eleanor Wind, Alex Pope

Trick to the Treat of Internships and Research

The summer 2023 Graz Internship was a comprehensive medical internship which exposed us to both surgical and clinical sides of medicine. Over the course of 6 weeks we were able to observe a variety of operations and even scrub in and assist. Clinical skills acquired included IV placement, phlebotomy, laparoscopy, suturing and surgical knot tying. In addition to experience gained in the hospital, we learned the basics of international travel, citywide navigation in multiple cities, European culture, and ate quite a bit of good food. We were fortunate enough to meet a network of medical students and doctors from other …

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Science Alive, Adam Sadik, Pranav Madadi, Mahalaxmi Some, Lohita Sunkara, Ashley Abad, Lickchina Jeanlis Oct 2023

Science Alive, Adam Sadik, Pranav Madadi, Mahalaxmi Some, Lohita Sunkara, Ashley Abad, Lickchina Jeanlis

Trick to the Treat of Internships and Research

Through the Science Alive outreach program, we work to bring the excitement of hands-on learning to grade-school children and the entire community. Science Alive promotes science education and interaction between the college and grade school community as “science buddies”. Group leaders can earn Science Alive internship credit and serve as volunteers with Broward County public schools. There are a variety of ways NSU students are involved in this internship program. We have a regular schedule of leading students once per week on Friday afternoons at Nova Blanche Elementary through NSU student-led activities to explore science. We also have been building …

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Evaluating The Utility Of S100a8/A9 As A Non-Invasive Biomarker, Leah Mellett Oct 2023

Evaluating The Utility Of S100a8/A9 As A Non-Invasive Biomarker, Leah Mellett

Arts & Sciences Graduate Student Theses and Dissertations

Biomarkers, a portmanteau of “biological markers”, are clinically relevant observations that can accurately and reproducibly indicate or predict patient outcomes. These objective measurements have vast clinical utility as they can aid clinicians with diagnoses, provide information about patient prognoses, and monitor changes in patient health statuses. While the discovery of several biomarkers are attributed to differential expression or concentration of genes or proteins within blood samples, biomarkers can be alternatively found in other bodily fluids or tissues depending on the associated condition. Recently, advances in urine proteomics have allowed for the identification of urine biomarkers that may eliminate the drawbacks …

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On The Origin Of Aids: Card8’S Role In Pathogenesis And Cure, Kolin Clark Oct 2023

On The Origin Of Aids: Card8’S Role In Pathogenesis And Cure, Kolin Clark

Arts & Sciences Graduate Student Theses and Dissertations

HIV infection remains a major global health burden with 1.7 million new acquisitions and 770,000 deaths in 2018 alone. While these numbers are declining due to antiretroviral therapy, only a handful of individuals have achieved complete remission from HIV. With the advent of antiretroviral therapy, HIV has turned a death sentence into a chronic, manageable condition. However, current antiretroviral therapies have only been studied on their ability to block infection and have not been able to clear the viral reservoir. Additionally, HIV cure strategies often rely upon sensing of highly variable epitopes such as the HIV envelope and have not …

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Multiple Light Signaling Pathways Control Solar Tracking In Sunflowers, Christopher J. Brooks, Hagop S. Atamian, Stacey L. Harmer Oct 2023

Multiple Light Signaling Pathways Control Solar Tracking In Sunflowers, Christopher J. Brooks, Hagop S. Atamian, Stacey L. Harmer

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Sunflowers are famous for their ability to track the sun throughout the day and then reorient at night to face east the following morning. This occurs by differential growth patterns, with the east sides of stems growing more during the day and the west sides of stems growing more at night. This process, termed heliotropism, is generally believed to be a specialized form of phototropism; however, the underlying mechanism is unknown. To better understand heliotropism, we compared gene expression patterns in plants undergoing phototropism in a controlled environment and in plants initiating and maintaining heliotropic growth in the field. We …

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Effects Of A Major Hurricane On Dynamics, Structure, And Composition Of Mississippi River Delta Forests, Lance C. Umlang Oct 2023

Effects Of A Major Hurricane On Dynamics, Structure, And Composition Of Mississippi River Delta Forests, Lance C. Umlang

LSU Doctoral Dissertations

Tropical cyclones recurrently influence coastal forests worldwide. Tree survival (resistance) and post-cyclone recruitment (resilience) can vary with cyclone intensity, producing differences in composition, arboreal structure, and dynamics among affected forests. Studies of tropical cyclone wind effects on coastal forests typically emphasize damage more than post-cyclone responses. We hypothesized that intense cyclones might produce large, stratum-dependent effects that prevent affected forests from returning to pre-storm conditions. We explored direct effects of major Hurricane Katrina and post-hurricane changes in oak-dominated bottomland and cypress/tupelo-dominated swamp forests within the inactive portion of the Mississippi River deltaic plain. Overall mortality was high (14-25%) but concentrated …

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Genome Sequences Of Six Cluster Ct And Two Cluster Dj Bacteriophages That Infect Gordonia Rubripertincta, Xavier F. Rodriguez, Daniel C. Williams, Catherine P. Chia Oct 2023

Genome Sequences Of Six Cluster Ct And Two Cluster Dj Bacteriophages That Infect Gordonia Rubripertincta, Xavier F. Rodriguez, Daniel C. Williams, Catherine P. Chia

School of Biological Sciences: Faculty Publications

We report the genome sequences of eight bacteriophages isolated using Gordonia rubripertincta NRRL B-16540-SEA. Based on gene content similarity to phages in the Actinobacteriophage database, six of the phages are assigned to phage cluster CT while two are assigned to cluster DJ.

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Examining The Role Of Microglia In Diabetic Retinopathy: Phenotypes, Mechanisms, And Therapies, Charles W. Pfeifer Oct 2023

Examining The Role Of Microglia In Diabetic Retinopathy: Phenotypes, Mechanisms, And Therapies, Charles W. Pfeifer

Arts & Sciences Graduate Student Theses and Dissertations

Retinal microglia activation and function is a pivotal component of ocular disease pathology, but their involvement in diabetic retinopathy, a complex neurovascular complication of diabetes, remains unclear. The purpose of this thesis work is to thoroughly examine features of microglia activation in DR, identify mechanistic underpinnings of their contributions to neuroinflammatory features of disease pathogenesis, and assess immunotherapeutic targeting of microglia as a potential approach to treating early-stage DR. Here, we show that chronic hyperglycemia elicits morphological, ultrastructural, and transcriptional changes in retinal microglia during early-stage DR while other elements of the retinal neurovascular unit remain unperturbed. Through chronic ablation …

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A Small-Molecule Inhibitor Of Topbp1 Exerts Anti-Myc Activity And Synergy With Parp Inhibitors, Fang-Tsyr Lin, Kang Liu, Lidija A Wilhelms Garan, Helena Folly-Kossi, Yongcheng Song, Shwu-Jiuan Lin, Weei-Chin Lin Oct 2023

A Small-Molecule Inhibitor Of Topbp1 Exerts Anti-Myc Activity And Synergy With Parp Inhibitors, Fang-Tsyr Lin, Kang Liu, Lidija A Wilhelms Garan, Helena Folly-Kossi, Yongcheng Song, Shwu-Jiuan Lin, Weei-Chin Lin

Faculty, Staff and Students Publications

We have previously identified TopBP1 (topoisomerase IIβ-binding protein 1) as a promising target for cancer therapy, given its role in the convergence of Rb, PI(3)K/Akt, and p53 pathways. Based on this, we conducted a large-scale molecular docking screening to identify a small-molecule inhibitor that specifically targets the BRCT7/8 domains of TopBP1, which we have named 5D4. Our studies show that 5D4 inhibits TopBP1 interactions with E2F1, mutant p53, and Cancerous Inhibitor of Protein Phosphatase 2A. This leads to the activation of E2F1-mediated apoptosis and the inhibition of mutant p53 gain of function. In addition, 5D4 disrupts the interaction of TopBP1 …

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To What Extent Do Physiological Tolerances Determine Elevational Range Limits Of Mammals?, Jay F. Storz, Graham R. Scott Oct 2023

To What Extent Do Physiological Tolerances Determine Elevational Range Limits Of Mammals?, Jay F. Storz, Graham R. Scott

School of Biological Sciences: Faculty Publications

A key question in biology concerns the extent to which distributional range limits of species are determined by intrinsic limits of physiological tolerance. Here, we use common-garden data for wild rodents to assess whether species with higher elevational range limits typically have higher thermogenic capacities in comparison to closely related lowland species. Among South American leaf-eared mice (genus Phyllotis), mean thermogenic performance is higher in species with higher elevational range limits, but there is little among-species variation in the magnitude of plasticity in this trait. In the North American rodent genus Peromyscus, highland deer mice (Peromyscus maniculatus …

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A Computational Study On The Impact Of Anchoring Groups On The Optical And Electronic Properties Of Triphenylamine-Based Dyes For Dye-Sensitized Solar Cell Applications, Geradius Deogratias, Grace Kinunda Oct 2023

A Computational Study On The Impact Of Anchoring Groups On The Optical And Electronic Properties Of Triphenylamine-Based Dyes For Dye-Sensitized Solar Cell Applications, Geradius Deogratias, Grace Kinunda

Tanzania Journal of Science

Anchoring groups are crucial for enhancing the performance of dye-sensitized solar cells (DSSCs). For instance, cyanoacrylic acid serves as the primary anchoring group in DSSC due to its crucial elements required for effective electron transport. However, it suffers from degradation. To address this limitation, this study proposes alternative cyano-based anchoring groups for sensitizers. Density functional theory (DFT) and time-dependent DFT were used to investigate the optical and electronic properties of the dyes. The studied dyes (excluding the dye containing OH group) displayed three absorption bands within the visible and NIR regions. Low-energy peaks ranged from 498 to 576 nm, corresponding …

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