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Full-Text Articles in Entire DC Network
Tim/Tam Receptors: A Potential Biomarker For Predicting Sensitivity To Zika Virus-Induced Oncolysis In Non-Small Cell Lung Cancers, Shankari Somasekar
Tim/Tam Receptors: A Potential Biomarker For Predicting Sensitivity To Zika Virus-Induced Oncolysis In Non-Small Cell Lung Cancers, Shankari Somasekar
Honors Undergraduate Theses
Non-small cell lung cancers (NSCLC) constitute 80-85% of lung cancers and are the leading cause of cancer-related deaths globally. The most common cause is prolonged smoking. Current treatment options for NSCLC include surgery, radiation, chemotherapy, targeted drug therapy, and immunotherapy. Although these medications are effective in the short term, patients often face issues of drug resistance and debilitating side effects with prolonged use. Currently, the use of Zika virus (ZIKV) is being researched as a possible alternative treatment for cancer, which minimizes side effects and the risk of drug resistance. TIM/TAM proteins are identified as the putative ZIKV receptors on …
Characterization Of Tonneau1 Recruiting Motif Proteins And Ton2 Signaling Functions, Tyler Falk
Characterization Of Tonneau1 Recruiting Motif Proteins And Ton2 Signaling Functions, Tyler Falk
Theses and Dissertations
Plants cells are fixed in place. As a result they have to carefully divide in order to function properly. Plants use a number of complex microtubule arrays to ensure proper division and orientation including the preprophase band (PPB) and the phragmoplast. The PPB orients the cell prior to division and marks the cortical division site, which is where the phragmoplast is guided to. The phragmoplast is a dynamic microtubule array that builds the cell plate which later becomes the cell wall that divides daughter cells. Proteins involved with PPB formation include Tonneau1 (TON1) and Tonneau2 (TON2) which localize to and …
Automatic Detection Of Birds In Images Acquired With Remotely Piloted Aircraft For Managing Wildlife Strikes To Civil Aircraft, Maurycio Rodrigues Oviedo, Flavio A. C. Mendonca Ph.D., Jose Cabrera, Cole A. Mcnall, Raymond Ayres, Ricardo Luís Barbosa, Rodrigo Gallis
Automatic Detection Of Birds In Images Acquired With Remotely Piloted Aircraft For Managing Wildlife Strikes To Civil Aircraft, Maurycio Rodrigues Oviedo, Flavio A. C. Mendonca Ph.D., Jose Cabrera, Cole A. Mcnall, Raymond Ayres, Ricardo Luís Barbosa, Rodrigo Gallis
International Journal of Aviation, Aeronautics, and Aerospace
Wildlife strikes represent a significant threat to aviation safety and economics, as evidenced by notable incidents such as the emergency landing of US Airways Flight 1549 in 2009. The Federal Aviation Administration (FAA) acknowledges this growing concern, as evidenced by its report on Wildlife Strikes to Civil Aircraft in the United States from 1990 to 2019.To address the need for improved risk management, airports conduct Wildlife Hazard Assessments (WHA), a laborious process typically relying on visual identification by Qualified Airport Wildlife Biologists (QAWB). However, technological advancements, such as Remotely Piloted Aircraft (RPA) and machine learning (ML), offer promising solutions to …
Complex Dynamics Of Coral Gene Expression Responses To Low Ph Across Species, Veronica Z. Radice, Ana Martinez, Adina Paytan, Donald C. Potts, Daniel J. Barshis
Complex Dynamics Of Coral Gene Expression Responses To Low Ph Across Species, Veronica Z. Radice, Ana Martinez, Adina Paytan, Donald C. Potts, Daniel J. Barshis
Biological Sciences Faculty Publications
Coral capacity to tolerate low pH affects coral community composition and, ultimately, reef ecosystem function. Low pH submarine discharges (‘Ojo’; Yucatán, México) represent a natural laboratory to study plasticity and acclimatization to low pH in relation to ocean acidification. A previous >2‐year coral transplant experiment to ambient and low pH common garden sites revealed differential survivorship across species and sites, providing a framework to compare mechanistic responses to differential pH exposures. Here, we examined gene expression responses of transplants of three species of reef‐building corals (Porites astreoides, Porites porites and Siderastrea siderea) and their algal endosymbiont communities …
Wild Sun Bears (Helarctos Malayanus) Exhibit Aseasonality In Parturition, Zachary A. David, Brian Crudge, Matt Hunt, Kirsty Officer, Vuthy Choun, Barbara Durrant, Megan A. Owen, Morokot Long, John P. Whiteman
Wild Sun Bears (Helarctos Malayanus) Exhibit Aseasonality In Parturition, Zachary A. David, Brian Crudge, Matt Hunt, Kirsty Officer, Vuthy Choun, Barbara Durrant, Megan A. Owen, Morokot Long, John P. Whiteman
Biological Sciences Faculty Publications
Seasonal reproduction can provide species with fitness advantages by allowing the birth of young to coincide with favorable environmental conditions, particularly in environments with high seasonal and intra-annual variation in these conditions. Seven of the eight species in the bear family (Ursidae) reproduce seasonally in both managed care and the wild; however, data for the eighth species, the sun bear (Helarctos malayanus), is unclear. Sun bears have been observed to reproduce throughout the year in managed care, yet currently there are no clear data of birth timing for wild sun bear cubs. Here we investigate the seasonality of …
Optimization Of An Immune Assay To Detect Binding Of Nod2 To Staphylococcus Aureus, Precious Mckenzie
Optimization Of An Immune Assay To Detect Binding Of Nod2 To Staphylococcus Aureus, Precious Mckenzie
All Student Theses and Dissertations
Staphylococcus aureus, a gram-positive, commensal bacterium, is the cause of a multitude of opportunistic diseases and infections. While S. aureus has evolved ways to escape innate immune responses in the host, the mechanisms are not fully understood. One area of active research involves mechanisms by which S. aureus avoids detection by Pattern Recognition Receptors (PRRs), such as Nuclear Oligomerization Domain 2 (NOD2), present on the surface of and inside innate immune cells. This study aimed to design and optimize an assay that can be utilized to investigate S. aureus components that contribute to the activation of NOD2 receptors. The …
Lighting Pathways To Success In Stem: A Virtual Laboratory Meeting Programme (Lamp) Mutually Benefits Mentees And Host Laboratories, Katie E. Lotterhos, Moisés A. Bernal, Megan Phifer-Rixey, Torrie Hanley
Lighting Pathways To Success In Stem: A Virtual Laboratory Meeting Programme (Lamp) Mutually Benefits Mentees And Host Laboratories, Katie E. Lotterhos, Moisés A. Bernal, Megan Phifer-Rixey, Torrie Hanley
Biology Faculty Publications
Developing robust professional networks can help shape the trajectories of early career scientists. Yet, historical inequities in science, technology, engineering, and mathematics (STEM) fields make access to these networks highly variable across academic programmes, and senior academics often have little time for mentoring. Here, we illustrate the success of a virtual Laboratory Meeting Programme (LaMP). In this programme, we matched students (mentees) with a more experienced scientist (mentors) from a research group. The mentees then attended the mentors’ laboratory meetings during the academic year with two laboratory meetings specifically dedicated to the mentee’s professional development. Survey results indicate that mentees …
Restricted Dispersal And Phenotypic Response To Water Depth In A Foundation Seagrass, Erik E. Sotka, Randall Hughes, Torrie Hanley, Cynthia G. Hays
Restricted Dispersal And Phenotypic Response To Water Depth In A Foundation Seagrass, Erik E. Sotka, Randall Hughes, Torrie Hanley, Cynthia G. Hays
Biology Faculty Publications
Species conservation and management benefit from precise understanding of natural patterns of dispersal and genetic variation. Using recent advances in indirect genetic methods applied to both adult plants and dispersed seeds, we find that the mean seed dispersal in a threatened marine foundation plant (the eelgrass Zostera marina) is approximately 100-200 m. This distance is surprisingly more similar to that of wind-dispersed terrestrial seeds (~10s to 100s of meters) than the passive dispersal of marine propagules via currents (~10s to 100s of kilometres). Because nearshore marine plants like Zostera are commonly distributed across strong selective gradients driven by bathymetry (depth) …
Forty Years Of Inferential Methods In The Journals Of The Society For Molecular Biology And Evolution, Claudia A.M. Russo, Adam Eyre-Walker, Laura A. Katz, Brandon S. Gaut
Forty Years Of Inferential Methods In The Journals Of The Society For Molecular Biology And Evolution, Claudia A.M. Russo, Adam Eyre-Walker, Laura A. Katz, Brandon S. Gaut
Biological Sciences: Faculty Publications
We are launching a series to celebrate the 40th anniversary of the first issue of Molecular Biology and Evolution. In 2024, we will publish virtual issues containing selected papers published in the Society for Molecular Biology and Evolution journals, Molecular Biology and Evolution and Genome Biology and Evolution. Each virtual issue will be accompanied by a perspective that highlights the historic and contemporary contributions of our journals to a specific topic in molecular evolution. This perspective, the first in the series, presents an account of the broad array of methods that have been published in the Society for Molecular Biology …
The Larval Preference Of An Invasive Bryozoan (Watersipora 'New Species') For Copper-Based Antifouling Paints, Alexander K. Strawhand
The Larval Preference Of An Invasive Bryozoan (Watersipora 'New Species') For Copper-Based Antifouling Paints, Alexander K. Strawhand
Cal Poly Humboldt theses and projects
The bryozoan Watersipora subtorquata and its cryptic congener Watersipora ‘new species’ are now globally invasive species. Previous studies have found this species complex to have a high tolerance to copper-based antifouling paints, which represent a large portion of the mitigation effort toward preventing hull fouling by invasive invertebrates. Tolerance alone, however, is unlikely to explain the full extent of Watersipora’s massive and rapid worldwide invasion success. The aim of this research was to move beyond tolerance, and test whether larvae of Watersipora ‘new species’ exhibit a preference for copper-coated settlement surfaces in both laboratory and field settings. For the laboratory …
A Case Of Incipient Budding Speciation In The California Floristic Province, Infraspecific Divergence In Abronia Villosa, Eli J. Allen
A Case Of Incipient Budding Speciation In The California Floristic Province, Infraspecific Divergence In Abronia Villosa, Eli J. Allen
Cal Poly Humboldt theses and projects
Physical barriers to gene flow are the traditional evidence for species divergence. Conversely, there has been increasing acknowledgment of speciation in the face of gene flow as an evolutionary process. Budding speciation involves peripheral populations adapting to local ecological conditions, thereby budding off from a widespread progenitor species. Budding speciation is distinguished by ecological divergence and is generally evidenced by asymmetrical range size and nested phylogenetic relationships of sister species. The narrow endemic Abronia villosa var. aurita is adapted to montane sandy washes adjacent to its widespread sister variety, the desert dwelling var. villosa. Here, I tested the hypothesis …
Tetrodotoxin, Fungal Pathogen Infection, And Bacterial Microbiome Associations Are Variable In The Skin Microecosystems Of Two Taricha Newt Species, Talon B. Jost
EWU Masters Thesis Collection
Chytridiomycosis is an amphibian disease linked to population declines and species extinctions, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd). While chytridiomycosis can result in host death, some amphibians are less susceptible to severe infections through intrinsic factors including host-associated skin microbes aiding defense through resource competition and antifungal metabolite production. Amphibians can also release toxins in response to stress cues to defend against disease, parasitism, and predation. Tetrodotoxin (TTX) is a potent low molecular weight neurotoxin found in genus Taricha, and despite a previously observed negative relationship between differential levels of TTX concentration and Bd infection presence within a …
Bird Predation On Coho Salmon (Oncorhynchus Kisutch) In Humboldt Bay, Colton J. Dixon
Bird Predation On Coho Salmon (Oncorhynchus Kisutch) In Humboldt Bay, Colton J. Dixon
Cal Poly Humboldt theses and projects
Coho Salmon (Oncorhynchus kisutch) populations along the west coast of the United States are declining. In Humboldt County, located in northwestern California, Coho Salmon have been in decline since their federal listing as threatened in 1997, primarily due to habitat loss from logging, agriculture, and urban development. Although these anthropogenic factors caused salmon populations to decline, bird predation may also be hindering population recovery, as evidenced by the recovery of Passive Integrated Transponder (PIT) tags, originally implanted in Coho Salmon, from bird colonies in Humboldt Bay. This study examines predation by Double-crested Cormorants (Phalacrocorax auritus), Caspian …
Interactions Between New Zealand Mud Snails (Potamopyrgus Antipodarum) And Toxic Cyanoabacteria (Anabaena) In Baduwa’T (Mad River), Humboldt County, California, Cecilia F. Kennelly
Interactions Between New Zealand Mud Snails (Potamopyrgus Antipodarum) And Toxic Cyanoabacteria (Anabaena) In Baduwa’T (Mad River), Humboldt County, California, Cecilia F. Kennelly
Cal Poly Humboldt theses and projects
Invasive species in freshwater systems are circulated around the globe, wreaking havoc on natural communities. The New Zealand mud snail (Potamopyrgus antipodarum) is a very successful aquatic invader that has established populations in freshwater streams, lakes, and rivers around the globe. The goal of this project was to evaluate the interactions of invasive New Zealand mud snails (NZMS) and toxic cyanobacteria Anabaena in the Mad River in Humboldt County, California. These two species of concern are found in similar habitats along the river, but their whether NZMS consume Anabaena or affect toxin production is unknown. First, I conducted …
Shifting Soil Fungal Communities In Response To Fire And Weed Management In Urban Banksia Woodlands, Aaron Justin Brace
Shifting Soil Fungal Communities In Response To Fire And Weed Management In Urban Banksia Woodlands, Aaron Justin Brace
Theses: Doctorates and Masters
This research aims to fill the knowledge gap in soil fungi in the Banksia woodland and emphasizes considering holistic ecosystem dynamics in invasive species management strategies. This is accomplished by surveying soil fungi under different fire regime across the Swan Coastal Plain, and within both in and ex situ herbicide application trials. This is the first such study to investigate the fungal component of the Banksia woodland so thoroughly. Chapter 2 quantified and analysed changes in soil fungal community composition and functional groups over a 50-year fire chronosequence in fire-prone Banksia woodland in southwestern Australia. Effects were variable, but fungal …
Characterizing Leaf Endophyte Composition In The Dune Grass Ammophila Breviligulata, Nabaa Majeed, Sarah Hobbs, Sarah Emery, Connor Morozumi, Natalie Christian
Characterizing Leaf Endophyte Composition In The Dune Grass Ammophila Breviligulata, Nabaa Majeed, Sarah Hobbs, Sarah Emery, Connor Morozumi, Natalie Christian
Undergraduate Research Events
Microorganisms living within plants play crucial roles in their health and function, yet these diverse communities that make up the plant microbiome remain poorly understood. The dune grass Ammophila breviligulata. is an ecosystem engineer which helps to build and stabilize dune ecosystems effectively acting as a buffer against storms to coastal communities. It is currently unknown whether the Ammophila microbiome plays a role in this plant species’ ability to transform dune ecosystems.. In this study, we assessed fungal diversity of endophytes—microbes living within plant tissues— in Ammophila leaves collected from Leelanau State Park, MI along the eastern shores of Lake …
Ecosystem Functions And Services Landscaping For Water Quality – April 30, 2024 Sunapee, Nh, Julia Peterson
Ecosystem Functions And Services Landscaping For Water Quality – April 30, 2024 Sunapee, Nh, Julia Peterson
UNH Cooperative Extension
No abstract provided.
Tarantula Toxin Transcripts And Toxin Structure Prediction By Alphafold, Christine Vega, Rebekkah Sepulveda, Ying Jia
Tarantula Toxin Transcripts And Toxin Structure Prediction By Alphafold, Christine Vega, Rebekkah Sepulveda, Ying Jia
School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)
Tarantula venom predominantly comprises peptides and small proteins (venom toxins). To explore this further, we generated a combined gland cDNA library from five different tarantula species. Subsequently we randomly sequenced 752 clones, which led to the identification of sixteen distinct toxin groups, including one novel group. Each group consists of a minimum of three identical sequences. A comprehensive analysis of these toxin groups was carried out, and we simulated the 3D structures of certain predicted toxins. These transcripts can be used to the production of venom toxins through recombinant techniques, offering promising applications in various biomedical applications.
Investigating The Role Of The Mammalian Dsrnai Pathway In Preventing Infection By Respiratory Syncytial Virus And Human Coronavirus, Iliana Portelli
Investigating The Role Of The Mammalian Dsrnai Pathway In Preventing Infection By Respiratory Syncytial Virus And Human Coronavirus, Iliana Portelli
Theses and Dissertations (Comprehensive)
dsRNA interference (dsRNAi) is an antiviral innate immune response that uses long dsRNA (>40bp) to inhibit gene expression through the RNA interference (RNAi) pathway. dsRNAi is an important antiviral defense mechanism in plants, invertebrates, and fungi. However, its use as an antiviral mechanism in vertebrates is not well understood. Evidence proving the significance of dsRNAi in vertebrate cells does exist, but there is still a lack of research in this area, particularly with the use of long dsRNA. Respiratory Syncytial Virus (RSV) and human coronaviruses (HCoVs) are two single stranded RNA (ssRNA) viruses that infect airway cells. This study …
Role Of Interferon Induced Transmembrane Protein 3 (Ifitm3) And Neural Precursor Cell Expressed Developmentally Down Regulated Protein 4 (Nedd4) In Seneca Virus A (Sva) Replication, Shamiq Aftab
Electronic Theses and Dissertations
In this study, we studied the role of IFITM3 in SVA replication in vitro by silencing the endogenous IFITM3 in NCI-H1299 cells. An average of 1.94-fold increase in SVA VP2 expression and an average of 4.4-fold increase in supernatant virus titer was observed after 24h SVA isolate SD15-26 infection. We have indeed observed an increase in viral mRNA copies by an average of 5-fold in IFITM3 silenced NCI-H1299 cells at 8 hpi indicating that IFITM3 restricts SVA replication post virus attachment and entry. A positive correlation between interferon-alpha induced IFITM3 upregulation and reduced SVA replication was observed. To further confirm …
Translation Of: Trembley À Réaumur, Abraham Trembley, Morgan Mclaughlin
Translation Of: Trembley À Réaumur, Abraham Trembley, Morgan Mclaughlin
Biology: Student Scholarship & Creative Works
While examining a jar filled with aquatic plants and animals, Abraham Trembley, a young tutor working for Count William Bentinck in the Netherlands, noticed tiny, green, tube-shaped organisms attached to aquatic plants. Uncertain whether they were plants or animals, he devised a brilliant series of experiments to understand their biology. He observed them contract when disturbed and take steps towards a light, gathering in front of a chevron-shaped opening in a piece of cardboard. Nearly convinced they were animals, he cut one in half expecting to see it die. Instead, it regenerated two perfectly formed bodies from the severed halves. …
Coleoptera Of Brazil: What We Knew Then And What We Know Now. Insights From The Catálogo Taxonômico Da Fauna Do Brasil, Edilson Caron, Marcela L. Monné, Geoffrey Morse, Et Al.
Coleoptera Of Brazil: What We Knew Then And What We Know Now. Insights From The Catálogo Taxonômico Da Fauna Do Brasil, Edilson Caron, Marcela L. Monné, Geoffrey Morse, Et Al.
Biology: Faculty Scholarship
In 2000, Cleide Costa published a paper presenting the state of knowledge of the Neotropical Coleopte ra, with a focus on the Brazilian fauna. Twenty-four years later, thanks to the development of the Coleoptera section of the Taxonomic Catalog of the Brazilian Fauna (CTFB - Catálogo Taxonômico da Fauna do Brasil) through the collaboration of 100 coleopterists from all over the globe, we can build on Costa’s work and present an updated overview of the state of knowledge of the beetles from Brazil. There are currently 35,699 species in 4,958 genera and 116 families known to occur in the country, …
An Overview Of The Brazilian Chrysomelidae (Insecta: Coleoptera): The Most Species-Rich Beetle Family In Brazil, Adelita M. Linzmeier, Luciano De A. Moura, Cibele S. Ribeiro-Costa, Daiara Manfio, Federico Agrain, Maria L. Chamorro, Geoffrey Morse, Renato Regalin, Lukáš Sekerka
An Overview Of The Brazilian Chrysomelidae (Insecta: Coleoptera): The Most Species-Rich Beetle Family In Brazil, Adelita M. Linzmeier, Luciano De A. Moura, Cibele S. Ribeiro-Costa, Daiara Manfio, Federico Agrain, Maria L. Chamorro, Geoffrey Morse, Renato Regalin, Lukáš Sekerka
Biology: Faculty Scholarship
The leaf beetles (Chrysomelidae) are one of the most species-rich family of herbivorous beetles with about 45,000 species worldwide. Based on the contributions of chrysomelidologists to the Taxonomic Catalog of the Brazilian Fauna - CTFB, the family comprises 6,079 species in 562 genera of which 951 species are endemic to Brazil, standing out as the most diverse, representing 4.8% of the Brazilian fauna and 17.1% of the beetle species. Chrysomelidae has twelve subfamilies with nine reported to Brazil: Galerucinae, the richest with 1,916 species in 202 genera, followed by Cassidinae, Eumolpinae, Cryptocephalinae, Chrysomelinae, Bruchinae, Criocerinae, Lamprosomatinae and Sagrinae - this …
How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck
How Does A Global Climate Cycle Affect The Reproductive Output Of A Neotropical Migratory Bird?, Abby K. Bressette, Emma Cummings, Daniel Albrecht-Mallinger, Lesley Bulluck
UROP Posters
El-Niño Southern Oscillation (ENSO) causes regional changes in climate and has been found to have varying effects on the survival, fecundity, and recruitment of migratory songbirds. This study seeks to better understand the effect of ENSO on the fecundity of Virginia-breeding Prothonotary warbler (Protonotaria citrea; PROW), a neotropical migratory songbird. PROW breed in the Eastern United States and spend the non-breeding season primarily in Panama and Colombia. Ongoing research in Virginia has found a positive relationship between spring precipitation and predicted number of PROW fledgelings during La Niña, but the opposite during El Niño. To better understand this relationship, we …
Carry-Over Effects Of Climate On Prothonotary Warbler (Protonotaria Citrea) Feather Quality, Alyssa N. Spasic, Dan Albrecht-Mallinger, Lesley Bulluck
Carry-Over Effects Of Climate On Prothonotary Warbler (Protonotaria Citrea) Feather Quality, Alyssa N. Spasic, Dan Albrecht-Mallinger, Lesley Bulluck
UROP Posters
Avian species have inspired numerous studies on ornamentation, exploring its role in intra- and intersexual selection as a marker for individual quality. Male birds have been the focus of most of these studies while females, which can also display ornamentation, have been studied less. Coloration achieved through molt, particularly carotenoid-based pigments, requires energy derived from food resources. As climate affects insect abundance, there may be a link between climate conditions during molt and feather quality the following season. We assessed the relationship between temperature and precipitation during molt and female Prothonotary Warbler (Protonotaria citrea) breast and crown feather reflectance metrics …
Improving Growth Models Of Cultivated Sugar Kelp, Saccharina Latissima, By Accounting For Intraspecific Variation In Thermal Tolerance, Ruby Krasnow, Sara Gonzalez, Scott Lindell
Improving Growth Models Of Cultivated Sugar Kelp, Saccharina Latissima, By Accounting For Intraspecific Variation In Thermal Tolerance, Ruby Krasnow, Sara Gonzalez, Scott Lindell
Student Publications [Scholarly]
Dynamic models of sugar kelp (Saccharina latissima) growth are used to estimate the production potential of seaweed aquaculture in many regions around the world. These models do not currently account for the existence of S. latissima ecotypes that are adapted to regional environmental conditions, particularly temperature. We tested the hypothesis that recalibrating the temperature parameters of a dynamic energy budget model using literature data for S. latissima from regions with a similar climate to the region of interest would result in more accurate predictions than using a general species-wide temperature response curve. Calibrating the model using data from warm regions …
Cerebellar Feedback Effects On Responses To Conspecific Signals Of Different Frequencies In The Electrosensory System, Elora K. Shinn
Cerebellar Feedback Effects On Responses To Conspecific Signals Of Different Frequencies In The Electrosensory System, Elora K. Shinn
Graduate Theses, Dissertations, and Problem Reports (ETD)
Sensory systems in animals have evolved to translate physical stimuli into neural representations that, in turn, guide behavior. Feedback is critical in these processes, allowing organisms to filter redundant information and respond effectively to relevant stimuli. In humans, for example, the cerebellar flocculus provides feedback to the vestibulo-ocular reflex to stabilize eye movements during body rotation. In bats, the feedback during echolocation helps prioritize essential signals from the environment. In weakly electric fish, cerebellar feedback helps filter out redundant low-frequency modulations caused by conspecifics, enabling them to detect prey and other relevant signals. However, the influence of cerebellar feedback on …
Remediating Fibrosis To Restore Salivary Gland Function, Jennifer Morrissey
Remediating Fibrosis To Restore Salivary Gland Function, Jennifer Morrissey
Electronic Theses & Dissertations (2024 - present)
Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposition of extracellular matrix components including collagen. In the case of persistent injury or autoimmunity, as in Sjogren’s Disease, the ECM persists. Fibrosis can be studied in multiple animal models. Our lab has published the use of a mouse submandibular salivary gland partial resection model. In this procedure 40% of the left distal tip of the submandibular salivary gland (SMG) is excised. This leads to a chronic sustained fibrotic response in a localized region. The use of the non-obese diabetic mouse (NOD) has …
Klebsiella Pneumoniae Carbapenemase Variant 44 Acquires Ceftazidime-Avibactam Resistance By Altering The Conformation Of Active-Site Loops, Zhizeng Sun, Hanfeng Lin, Liya Hu, Neetu Neetu, Banumathi Sankaran, Jin Wang, B V Venkataram Prasad, Timothy Palzkill
Klebsiella Pneumoniae Carbapenemase Variant 44 Acquires Ceftazidime-Avibactam Resistance By Altering The Conformation Of Active-Site Loops, Zhizeng Sun, Hanfeng Lin, Liya Hu, Neetu Neetu, Banumathi Sankaran, Jin Wang, B V Venkataram Prasad, Timothy Palzkill
Faculty, Staff and Students Publications
Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistance as it can hydrolyze and inactivate virtually all β-lactam antibiotics. KPC-2 is potently inhibited by avibactam via formation of a reversible carbamyl linkage of the inhibitor with the catalytic serine of the enzyme. However, the use of avibactam in combination with ceftazidime (CAZ-AVI) has led to the emergence of CAZ-AVI-resistant variants of KPC-2 in clinical settings. One such variant, KPC-44, bears a 15 amino acid duplication in one of the active-site loops (270-loop). Here, we show that the KPC-44 variant exhibits higher catalytic efficiency in hydrolyzing ceftazidime, lower …
Inhibition Of Src-3 As A Potential Therapeutic Strategy For Aggressive Mantle Cell Lymphoma, Imani Bijou, Yang Liu, Dong Lu, Jianwei Chen, Shelby Sloan, Lapo Alinari, David M Lonard, Bert W O'Malley, Michael Wang, Jin Wang
Inhibition Of Src-3 As A Potential Therapeutic Strategy For Aggressive Mantle Cell Lymphoma, Imani Bijou, Yang Liu, Dong Lu, Jianwei Chen, Shelby Sloan, Lapo Alinari, David M Lonard, Bert W O'Malley, Michael Wang, Jin Wang
Faculty, Staff and Students Publications
Mantle cell lymphoma (MCL) has a poor prognosis and high relapse rates despite current therapies, necessitating novel treatment regimens. Inhibition of SRC-3 show effectiveness in vivo and in vitro in other B cell lymphomas. Additionally, previous studies have shown that SRC-3 is highly expressed in the lymph nodes of B cell non-Hodgkin's lymphoma patients, suggesting SRC-3 may play a role in the progression of B cell lymphoma. This study aimed to investigate novel SRC-3 inhibitors, SI-10 and SI-12, in mantle cell lymphoma. The cytotoxic effects of SI-10 and SI-12 were evaluated in vitro and demonstrated dose-dependent cytotoxicity in a panel …