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Articles 3931 - 3960 of 39329
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Fishes In Murky Waters: Effects Of Total Suspended Solids On Fish Gills And Performance, Xena Montoya
Fishes In Murky Waters: Effects Of Total Suspended Solids On Fish Gills And Performance, Xena Montoya
Theses and Dissertations (Comprehensive)
Total suspended solids (TSS) naturally occur in aquatic habitats, but climate change and other anthropogenic disturbances can lead to increased levels. Exposure to high levels of TSS has the potential to damage fish gills through abrasion, leading to impairment of gill function and fish physiology. However, little work has been done exploring the linkages between TSS-induced gill damage and animal performance. Therefore, we tested the hypothesis that TSS damages gill structure, causing gill dysfunction and reducing swimming performance. We exposed salmonids (rainbow trout, brook trout and cutthroat trout) and non-salmonids (fathead minnow and longnose dace) to different TSS concentrations (0-1000 …
Characterizing The Targeting Pathway Of Chloroplast Outer Membrane Protein Oep18 In Arabidopsis Thaliana And Other Targeting Signals Utilized By Outer Envelope Membrane Proteins, Ceaira Hiemstra
Theses and Dissertations (Comprehensive)
Approximately 95% of chloroplast proteins are encoded by nuclear DNA and are post-translationally targeted to the chloroplast. Over half of the 138 known or predicted chloroplast outer membrane (OM) proteins are predicted to utilize four non-canonical targeting pathways. The first two pathways are characterized by containing a single α-helical transmembrane domain (TMD) within the first or last 50 amino acids (AAs), the third pathway is utilized by β-barrels, and the last requires an N-terminal cleavable transit peptide (TP). Recently, a fifth novel pathway called Toc159-like (TOC159L) has been characterized by the presence of a C-terminal reverse TP in Toc159. Subsequent …
Elucidating Mechanisms Of Enhanced Dsrna-Nanophytoglycogen Innate Immune Responses In Healthy Human Cells, Nicholas Jadaa
Elucidating Mechanisms Of Enhanced Dsrna-Nanophytoglycogen Innate Immune Responses In Healthy Human Cells, Nicholas Jadaa
Theses and Dissertations (Comprehensive)
Immunostimulatory nucleic acids, such as long double-stranded RNA (ds)RNA, can stimulate innate immune responses in a non-sequence specific manner. These molecules are recognized by pattern-recognition receptors in the cytoplasm, endosome, and on the cell surface. Activation leads to the production of mediators of innate immune pathways, including type I interferon and proinflammatory cytokines. Although these receptors are present in all cells, their role in non-immune cells is often overlooked due to their lower level of responsiveness. Nanocarriers can enhance these nucleic acid-mediated responses, allowing for exploration of innate immune pathways in non-immune cells. Nanoparticles as carriers of nucleic acids can …
Effect Of Rare Earth Element Mixtures On Daphnia Magna, Celine Do
Effect Of Rare Earth Element Mixtures On Daphnia Magna, Celine Do
Theses and Dissertations (Comprehensive)
Rare earth elements (REEs) are increasingly being used in modern technologies and as such, there is an increasing concern for the potential environmental risk associated with anthropogenic contamination. In addition to there being very little data available for individual REEs, there is also a lack of knowledge concerning mixtures. The objective of my study was to investigate the chronic effects of lanthanum (La) and yttrium (Y) as well as the acute effects of neodymium (Nd), praseodymium (Pr) and Y as a single metal and as a mixture to Daphnia magna. Standard 21-d chronic tests and 48-h single metal acute …
Evaluating The Risk Posed By Gadolinium In The Grand River Watershed, Johann Memmel
Evaluating The Risk Posed By Gadolinium In The Grand River Watershed, Johann Memmel
Theses and Dissertations (Comprehensive)
Gadolinium (Gd) is a rare earth element (REE), primarily used in contrast agents for magnetic resonance imaging (MRI), with additional applications in metallurgy, phosphors, neutron shielding, and other niche applications. Both Gd and Gd-based contrast agents (GBCAs, the form used for MRIs) have been detected downstream of wastewater effluent discharges and there is currently little research into the risk this poses to aquatic ecosystems. This study investigated the potential environmental risks of Gd and GBCAs using the Grand River watershed (GRW) in southwestern Ontario as a model ecosystem due to it containing a variety of land uses (urban, industrial, agricultural) …
The Effects Of Warmer Temperatures On The Physiology Of Invasive Sea Lamprey And Imperiled Populations Of Lake Sturgeon In The Laurentian Great Lakes, Milica Koledin
Theses and Dissertations (Comprehensive)
Invasive sea lamprey (Petromyzon marinus) contributed to massive declines in fisheries in the Laurentian Great Lakes due to their parasitism of large-bodied salmonid fishes in the 20th century. Chemical control measures, which involve the application of 3-trifluoromethyl-4-nitrophenol (TFM) into rivers containing larval sea lamprey, were successfully implemented approximately 60 years ago to control populations. Recently, however, it was discovered that TFM tolerance increases in sea lamprey with a rise in temperature for reasons which are incompletely understood. Nor is it understood how sea lamprey will respond to warmer temperatures due to climate change, which could affect their …
Impacts Of Environmental Stressors On Mummichog (Fundulus Heteroclitus) Growth And The Gh-Igf1 Pathway Using A Laboratory Bioassay, Olena Kuntyj
Theses and Dissertations (Comprehensive)
Using a flow-through laboratory bioassay, experiments investigated the effects of limited feeding, increased temperature, ammonium chloride (NH4Cl), and 17α-ethinylestradiol (EE2) on juvenile mummichog (Fundulus heteroclitus) growth. Weight measurements were taken every three days as the apical growth endpoint. Gene expression was examined by qPCR for genes in the GH (growth hormone)-IGF1 (insulin-like growth factor 1) pathway, including gh, igf1, and their receptors (ghra, ghrb, igf1ra, igf1rb). In Experiment 1, juvenile mummichog were exposed to excess or limited feed for 21 days. The limited-fed mummichog weighed less, were …
Assessing Stormwater Management Pond Water Quality, Function, And The Potential Biotic Effects To Receiving Waters, Mitchell Elstone
Assessing Stormwater Management Pond Water Quality, Function, And The Potential Biotic Effects To Receiving Waters, Mitchell Elstone
Theses and Dissertations (Comprehensive)
The use of stormwater management ponds (SWMPs) has been increasing over the past five decades. However, an in-depth understanding of the daily performance of SWMPs and functionality during cold periods is limited. This is in part because mandated monitoring is relatively infrequent, and the assumption that SWMPs are inactive between storm events and during the winter. The goals of this research were to better understand daily stormwater (SW) characteristics, the performance of SWMPs based on current forms of evaluation and assess the potential for SWMP effluent to impact downstream biota. Influent and effluent samples from two SWMPs were collected daily …
A Comparative In Vitro Investigation Of Rainbow Trout Vig-3 And Human Isg15, Kristof Jenik, Sarah J. Poynter, Shanee Herrington-Krause, Kayla Samms, Nichole Sanchez Diaz, Stephanie J. Dewitte-Orr, Tania Rodriguez-Ramos, Brian Dixon, Adebisi Sanyaolu, Tamiru Alkie, Bryce M. Warner, Nikesh Tailor, Shawna Semple
A Comparative In Vitro Investigation Of Rainbow Trout Vig-3 And Human Isg15, Kristof Jenik, Sarah J. Poynter, Shanee Herrington-Krause, Kayla Samms, Nichole Sanchez Diaz, Stephanie J. Dewitte-Orr, Tania Rodriguez-Ramos, Brian Dixon, Adebisi Sanyaolu, Tamiru Alkie, Bryce M. Warner, Nikesh Tailor, Shawna Semple
Theses and Dissertations (Comprehensive)
The aquaculture industry is a big part of the global economy, supplying food and supporting many livelihoods, yet it faces formidable challenges from diverse aquatic pathogens, especially viruses. Effective antiviral treatments are lacking for both humans and economically significant farmed fish like rainbow trout (Oncorhynchus mykiss). When viruses invade host cells, pattern recognition receptors detect viral components, initiating intracellular signaling and type I interferon (IFN-I) production. IFN-I triggers interferon-stimulated genes (ISGs) that establish an antiviral state in infected and nearby cells, curbing viral spread. In rainbow trout, a particularly understudied ISG is viral hemorrhagic septicemia virus (VHSV)-induced gene 3 (vig-3), …
Notes On Patagium Morphology In The Gliding Flat-Tailed House Gecko (Hemidactylus Platyurus), Amber M. Petty, Tony Gamble, Aaron H. Griffing
Notes On Patagium Morphology In The Gliding Flat-Tailed House Gecko (Hemidactylus Platyurus), Amber M. Petty, Tony Gamble, Aaron H. Griffing
Biological Sciences Faculty Research and Publications
Several species of geckos have independently evolved patagia, membranous features that facilitate gliding. Detailed morphological investigations of gecko patagia have largely been limited to gliding members of the genus Gekko (formerly in the genus Ptychozoon). Herein we describe the morphology of gliding patagia of the Flat-tailed House Gecko (Hemidactylus platyurus), a species with an independent evolutionary origin of gliding patagia from Gekko and an important species for researching gliding biomechanics. We compared morphology of H. platyurus with a closely related non-gliding species, the Common House Gecko (Hemidactylus frenatus). Using external examination and histological techniques, we …
Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice
Ai Is A Viable Alternative To High Throughput Screening: A 318-Target Study, Martin St. Maurice
Biological Sciences Faculty Research and Publications
High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, …
Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova
Bacillus Subtilis-Derived Peptides Disrupt Quorum Sensing And Biofilm Assembly In Multidrug-Resistant Staphylococcus Aureus, Kyle R. Leistikow, Daniel S. May, Won Se Suh, Gabriel Vargas Asensio, Adam J. Schaenzer, Cameron R. Currie, Krassimira R. Hristova
Biological Sciences Faculty Research and Publications
Multidrug-resistant Staphylococcus aureus is one of the most clinically important pathogens in the world, with infections leading to high rates of morbidity and mortality in both humans and animals. The ability of S. aureus to form biofilms protects cells from antibiotics and promotes the transfer of antibiotic resistance genes; therefore, new strategies aimed at inhibiting biofilm growth are urgently needed. Probiotic species, including Bacillus subtilis, are gaining interest as potential therapies against S. aureus for their ability to reduce S. aureus colonization and virulence. Here, we search for strains and microbially derived compounds with strong antibiofilm activity against multidrug-resistant S. …
Season Influences Interspecific Responses Of Canopy-Forming Kelps To Future Warming And Acidification At High Latitude, Lauren E. Bell, Lily Westphal, Evan O' Brien, Jason A. Toy, Haleigh Damron, Kristy J. Kroeker
Season Influences Interspecific Responses Of Canopy-Forming Kelps To Future Warming And Acidification At High Latitude, Lauren E. Bell, Lily Westphal, Evan O' Brien, Jason A. Toy, Haleigh Damron, Kristy J. Kroeker
Biological Sciences Faculty Publications
Variability in primary producers' responses to environmental change may buffer higher trophic levels against shifts in basal resource composition. Then again, in instances where there is a lack of functional redundancy because consumers rely on a few species to meet their energetic requirements at specific times of the year, altered community production dynamics may significantly impact food web resilience. In high-latitude kelp forests, a complementary annual phenology of seaweed production supports coastal marine consumers' metabolic needs across large seasonal variations in their environment. Yet, marine consumers in these systems may face significant metabolic stress under the pronounced low pH conditions …
Targeting Ocean Conservation Outcomes Through Threat Reduction, Joseph A. Turner, Malcolm Starkey, Nicholas K. Dulvy, Frank Hawkins, Louise Mair, Adeline Serckx, Thomas Brooks, Beth Polidoro, Stuart H. M. Butchart, Kent Carpenter, Minna Epps, Rima W. Jabado, Nicholas B. W. Macfarlane, Leon Bennun
Targeting Ocean Conservation Outcomes Through Threat Reduction, Joseph A. Turner, Malcolm Starkey, Nicholas K. Dulvy, Frank Hawkins, Louise Mair, Adeline Serckx, Thomas Brooks, Beth Polidoro, Stuart H. M. Butchart, Kent Carpenter, Minna Epps, Rima W. Jabado, Nicholas B. W. Macfarlane, Leon Bennun
Biological Sciences Faculty Publications
Nations have committed to reductions in the global rate of species extinctions through the Sustainable Development Goals 14 and 15, for ocean and terrestrial species, respectively. Biodiversity loss is worsening despite rapid growth in the number and extent of protected areas, both at sea and on land. Resolving this requires targeting the locations and actions that will deliver positive conservation outcomes for biodiversity. The Species Threat Abatement and Restoration (STAR) metric, developed by a consortium of experts, quantifies the contributions that abating threats and restoring habitats in specific places offer towards reducing extinction risk based on the IUCN Red List …
A Taxonomic Revision Of The Genus Hydnora (Hydnoraceae), Sebastian A. Hatt, Chris J. Thorogood, J. F. Bolin, Lytton J. Musselman, Duncan D. Cameron, Olwen M. Grace
A Taxonomic Revision Of The Genus Hydnora (Hydnoraceae), Sebastian A. Hatt, Chris J. Thorogood, J. F. Bolin, Lytton J. Musselman, Duncan D. Cameron, Olwen M. Grace
Biological Sciences Faculty Publications
A systematic monograph is presented for Hydnora (Hydnoraceae), a poorly known genus of holoparasitic plants distributed across Africa, Madagascar and southern Arabia. Species of Hydnora are characterised by their underground habit, unusual fleshy flowers and complete absence of leaves or photosynthetic tissue. This is the first detailed monograph of the genus Hydnora since 1935 and is informed by a comprehensive survey of herbarium specimens and literature. Detailed descriptions, full synonymy, distribution maps and discussion concerning confusable taxa are provided for each species, along with notes on ethnobotany, ecology and conservation. We place particular emphasis on the taxonomic value of osmophore …
When And Where Can Coastal Wetland Restoration Increase Carbon Sequestration As A Natural Climate Solution, Scott F. Jones, Ariane Arias-Ortiz, Dennis Baldocchi, Meagan Eagle, Daniel A. Friess, Catrina Gore, Greg Noe, Stefanie Nolte, Patty Oikawa, Adina Paytan, Jacqueline L. Raw, Brian J. Roberts, Kerrylee Rogers, Charles Schutte, Camille L. Stagg, Karen M. Thorne, Eric J. Ward, Lisamarie Windham-Myers, Erik S. Yando
When And Where Can Coastal Wetland Restoration Increase Carbon Sequestration As A Natural Climate Solution, Scott F. Jones, Ariane Arias-Ortiz, Dennis Baldocchi, Meagan Eagle, Daniel A. Friess, Catrina Gore, Greg Noe, Stefanie Nolte, Patty Oikawa, Adina Paytan, Jacqueline L. Raw, Brian J. Roberts, Kerrylee Rogers, Charles Schutte, Camille L. Stagg, Karen M. Thorne, Eric J. Ward, Lisamarie Windham-Myers, Erik S. Yando
Biological Sciences Faculty Publications
Coastal wetlands are hotspots of carbon sequestration, and their conservation and restoration can help to mitigate climate change. However, there remains uncertainty on when and where coastal wetland restoration can most effectively act as natural climate solutions (NCS). Here, we synthesize current understanding to illustrate the requirements for coastal wetland restoration to benefit climate, and discuss potential paths forward that address key uncertainties impeding implementation. To be effective as NCS, coastal wetland restoration projects will accrue climate cooling benefits that would not occur without management action (additionality), will be implementable (feasibility) and will persist over management-relevant timeframes (permanence). Several issues …
Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth
Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth
Biological Sciences Faculty Publications
Globally, climate change is causing shifts in precipitation patterns. Shifting precipitation patterns can be a stressor for many species. One species that is experiencing such stress is Helenium amarum Raf (H. Rock). H. amarum, thrives in dry upland pastures and low-lying grassy and sandy habitat in the mid-Atlantic (USA), where it persists despite storm-driven standing water. Helenium amarum is a species that is toxic to livestock and has been found outside its native range. Temperature and light impacts on germination are already known, but the role of water availability and potential ameliorating effects of mycorrhizae during water stress have …
Abalones At Risk: A Global Red List Assessment Of Haliotis In A Changing Climate, Howard Peters, Gina M. Ralph, Laura Rogers-Bennett
Abalones At Risk: A Global Red List Assessment Of Haliotis In A Changing Climate, Howard Peters, Gina M. Ralph, Laura Rogers-Bennett
Biological Sciences Faculty Publications
There is increasing awareness that marine invertebrates such as abalones are at risk from the combined stressors of fishing and climate change. Abalones are an important marine fishery resource and of cultural importance to Indigenous and non-Indigenous people. A highly priced marine delicacy, they are inherently vulnerable: individuals are slow-growing and long-lived and successful reproduction requires dense assemblages. However, their global conservation status is poorly understood. Using IUCN Red List methodology, we assessed the extinction risk to all 54 species of abalone (genus Haliotis). Of the 21 fished commercially for human consumption either now and/or in the past, 15 …
Environmental Implications Of Modern Food Production: An Analysis For The Conscious Consumer, Jessica T. Coming
Environmental Implications Of Modern Food Production: An Analysis For The Conscious Consumer, Jessica T. Coming
Cal Poly Humboldt theses and projects
This project explores the pathways by which agriculture affects the environment and determines which foods have the greatest climate, water, and land impacts. Agricultural effects on the environment are extensive, from loss of habitat and declines in regional biodiversity to disruption of global nutrient cycles and climate change. Global food production accounts for 26-34% of annual anthropogenic greenhouse gas emissions, makes up 38-46% of habitable land, and is responsible for 70% of freshwater extraction. The effect of agriculture on the environment is most significantly dictated by what type of food is being produced. Animal-based food products consistently have the highest …
Characterization Of Host Cell Specific Interactions During Spotted Fever Group Rickettsiae Infection, Emerson Towey
Characterization Of Host Cell Specific Interactions During Spotted Fever Group Rickettsiae Infection, Emerson Towey
Graduate Theses, Dissertations, and Problem Reports (ETD)
Vector-borne diseases have been increasing over the past few years due to changes in climate and disturbances in the vectors’ natural environment. To mitigate the risks of these diseases, it is necessary to understand pathogen biology and how it interacts with a host to cause disease. Here we focus our attention on the tick-borne pathogen, Rickettsia rickettsii. R. rickettsii is a member of the spotted fever group (SFG) Rickettsiae and is the etiological agent of Rocky Mountain spotted fever (RMSF), a fatal human disease that is lacking an effective vaccine. Members of the bacterial genus Rickettsia are obligate intracellular endoparasites …
Investigating Changing Macronutrient Dynamics At A Plant, Microbe And Plant-Microbe Interactions Scale, Emel Kangi
Investigating Changing Macronutrient Dynamics At A Plant, Microbe And Plant-Microbe Interactions Scale, Emel Kangi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Nutrient limitation drives forest ecosystem processes by altering net primary production, belowground (C) investments, and microbial activity. As such, the availability of essential macronutrients, such as nitrogen (N) and phosphorus (P), can severely impact plant growth, microbial decomposition, and the strength of plant-microbial interactions. However, our understanding of plant and microbe responses to changing nutrient availability, and the extent to which nutrient availability affects plant-microbe interactions, remains somewhat limited. Therefore, in this dissertation, I aimed to investigate nutrient limitation on a plant, microbe, and plant-microbe interaction level. First, to connect the phenotypic responses of nutrient-limited plants to key molecular mechanisms, …
Estimating Steelhead Smolt Abundance From A Mixed Resident/Anadromous Oncorhynchus Mykiss Population, Gabriel Temple
Estimating Steelhead Smolt Abundance From A Mixed Resident/Anadromous Oncorhynchus Mykiss Population, Gabriel Temple
All Master's Theses
Effective management of fish populations in inland waters requires, at the most fundamental level, a basic understanding of population abundance. This is especially important for critically depressed species having high conservation value. Unfortunately, due to their critically depressed abundance, the anadromous form of Oncorhynchus mykiss, known as Steelhead Trout, has high conservation value in the upper Yakima Basin located in central Washington State. However, the resident form of O. mykiss, known as Rainbow Trout, are numerous in the watershed. We used a juvenile tagging study coupled with a long-term population monitoring study to disaggregate this mixed O. mykiss …
Conceptualising Project Environmental Impact Assessment For Enhancement: No Net Loss, Net Gain, Offsetting And Nature Positive, Angus Morrison-Saunders, Luis Sánchez
Conceptualising Project Environmental Impact Assessment For Enhancement: No Net Loss, Net Gain, Offsetting And Nature Positive, Angus Morrison-Saunders, Luis Sánchez
Research outputs 2022 to 2026
With declining biodiversity worldwide, the need for development proposals to deliver positive, not negative, environmental outcomes is clear. Arguably, this is a long-standing goal of environmental impact assessment (EIA). This article explores the extent to which current project EIA practice can achieve enhancement, no net loss or a net gain of biodiversity and Nature Positive goals. Using reflexivity, a conceptual approach is applied to policies and examples from practice. The environmental enhancement goal of EIA is explained. The mitigation hierarchy is applied to a hypothetical mining example for accomplishing no net loss/net gain of biodiversity through offsets. Nature Positive is …
Screening H3 Histone Acetylation In A Wild Bird, The House Sparrow (Passer Domesticus), Daniella Ray
Screening H3 Histone Acetylation In A Wild Bird, The House Sparrow (Passer Domesticus), Daniella Ray
College of Graduate Studies: Theses & Dissertations
Epigenetic mechanisms are increasingly understood to have major impacts across ecology. However, one molecular epigenetic mechanism, DNA methylation, currently dominates the literature. A second mechanism, histone modification, is likely important to ecologically relevant phenotypes and thus warrants investigation, especially because molecular interplay between methylation and histone acetylation can strongly affect gene expression. There are a limited number of histone acetylation studies on non-model organisms, yet those that exist show that it can impact gene expression and phenotypic plasticity. Wild birds provide an excellent system to investigate histone acetylation, as free-living individuals must rapidly adjust to environmental change. Here, we screen …
Mammalian Biodiversity On Greenways Across An Urban-To-Rural Gradient, Brooklyn C. Zwinklis
Mammalian Biodiversity On Greenways Across An Urban-To-Rural Gradient, Brooklyn C. Zwinklis
College of Graduate Studies: Theses & Dissertations
Large-scale urbanization is one of the leading causes of biodiversity loss on a global scale due to habitat loss and fragmentation. This has created a need to investigate ways to mitigate the damage caused by urban development, such as studying whether green spaces in urban areas can serve as means of preserving mammalian biodiversity in cities. This study specifically focused on greenways as they are understudied when compared to other green spaces, such as parks and cemeteries. Greenways are linear tracts of paved land, usually designed for human recreational activities. However, their benefits to wildlife have not been well researched. …
Calcium Permeability Of Rat Trpv1 In A Close State When Expressed In Xenopus Laevis Oocytes, Zinnia Adhikary
Calcium Permeability Of Rat Trpv1 In A Close State When Expressed In Xenopus Laevis Oocytes, Zinnia Adhikary
Theses and Dissertations
Transient Receptor Potential V1 (TRPV1) is a nonselective cation channel, which is expressed in nociceptors/ pain detecting receptors. Activated by a wide variety of exogenous and endogenous physical and chemical stimuli such as heat, TRPV1 is involved in temperature detection, body temperature regulation, and pain perception. It is generally accepted that TRPV1's conductance to cations, including Ca2+, depends on its conformational change from a closed to an open state following gating. In the current study, I observed that the plasma membrane of Xenopus laevis oocytes, upon exogenous expression of rat TRPV1, exhibited weak permeability to Ca2+, as evidenced by the …
Searching For Novel Mutations That Regulates The Mouse Polycystin-2 (Trpp2) Ion Channel, Akhilraj Rajan Pillai
Searching For Novel Mutations That Regulates The Mouse Polycystin-2 (Trpp2) Ion Channel, Akhilraj Rajan Pillai
Theses and Dissertations
Polycystin-2 (PC2) is an ion channel belonging to the polycystin subfamily of the transient receptor potential (TRP) cation channel superfamily. Mutations in PC2 are associated with autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases in humans. Despite extensive studies over the past decades, the role of PC2 in normal and ADPKD kidneys remains largely unknown, and the activation and regulation of this ion channel are elusive. To gain a better understanding of the structure and function of the mouse PC2 channel, this study focused on generating five pore mutations in a gain-of-function (GOF) mutant of …
Long Term Trends In Mortality Rates Of A Smallmouth Bass Population, Caleb D. Anderson
Long Term Trends In Mortality Rates Of A Smallmouth Bass Population, Caleb D. Anderson
Journal of Earth and Life Science
Smallmouth bass Micropterus dolomieu are known as a popular sport fish for anglers. When a known smallmouth bass fishery appears to have a dwindling population, it raises questions about the population health. A common indicator of the health of the population is the mortality rate. By comparing mortality, conclusions can be made on whether smallmouth bass are dying at a different rate in the system over time. Therefore, the objective of this study was to see if there had been a significant change in smallmouth bass mortality over a span of thirty years in Round Lake (DOW:010204), Aitkin County, Minnesota. …
Relationship Between Northern Pike And Walleye Cpue In Minnesota Lakes, Simon Oslund
Relationship Between Northern Pike And Walleye Cpue In Minnesota Lakes, Simon Oslund
Journal of Earth and Life Science
Northern pike Esox lucius and walleye Sander vitreus are both top predators in freshwater systems. Due to their predatorial nature, high populations of one species can prohibit populations of the other species from thriving, specifically northern pike foraging on walleye. This information is tracked by the Minnesota Department of Natural Resources through catch per unit effort (CPUE). CPUE data was gathered for all lakes in Beltrami County, Minnesota, and a regression analysis was done to test for a relationship between pike and walleye. It was found that the relationship between northern pike and walleye CPUE was significant (P = 0.02). …
The Effects Of Length, Weight, Age, And Gender On Mercury Concentrations In Burbot In North-Central Minnesota Lakes, Liam Hanley
The Effects Of Length, Weight, Age, And Gender On Mercury Concentrations In Burbot In North-Central Minnesota Lakes, Liam Hanley
Journal of Earth and Life Science
Burbot Lota lota in north-central Minnesota lakes have the potential to reach large sizes and consume large volumes of prey. This caveat may make burbot susceptible to higher rates of biocontamination, bioaccumulation and biomagnification. The objective of this study was to determine how changes in age, length, gender, weight, and lake affect total mercury concentrations in burbot. In this experiment 28 burbot were angled from three lakes: Cass (n = 17), Winnibigoshish (n = 4), and Bad Medicine (n = 7). Then tissue samples were taken from each fish and were lyophilized and homogenized. Homogenized tissue samples were analyzed by …