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Articles 3211 - 3240 of 39322
Full-Text Articles in Entire DC Network
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Annual Killifish: Eye Development And Retinal Cell Regeneration, Carmen Z. Rodriguez
Student Research Symposium
Vertebrate eye development is highly conserved. Current models have allowed the understanding of gene expression patterns that support eye development, but lack the context of extreme environmental conditions that challenge these fundamental programs. Typical vertebrate life spans can be years, but annual killifish, Austrofundulus limnaeus, are able to complete their entire adult lifespan in only weeks. Thus, A. limnaeus is a strong model for age-related macular degeneration. A. limnaeus also experiences embryonic diapause; a period of developmental dormancy. Developing/diapausing embryos of A. limnaeus are resistant to environmental stresses such as hypoxia/anoxia that would cause irreparable damage to vital organs, such …
Dragon Pseudoscorpions Shed Light On Ancient Climate History In The Pacific Northwest, Joshua W. Hootman
Dragon Pseudoscorpions Shed Light On Ancient Climate History In The Pacific Northwest, Joshua W. Hootman
Student Research Symposium
Pseudoscorpions are an ancient and diverse group of understudied arachnids, and there is much to be learned about their relationships to each other. Pseudoscorpions are one of many leaf-litter dwelling and low dispersing invertebrates that inhabit the forests of the Pacific Northwest. Previous phylogeographic studies of Pacific Northwest taxa have shed light on some of the climatic and geologic events that have shaped the area's flora and fauna. One purpose of this study is to determine if there is similar genetic structuring within the pseudoscorpion populations present in the study area, or if there is even more structure likely influenced …
Crossing The Ocean: The Importance Of Gene Flow In Island Evolution, Ethan F. Gyllenhaal
Crossing The Ocean: The Importance Of Gene Flow In Island Evolution, Ethan F. Gyllenhaal
Biology ETDs
Islands have long been a critical arena for the development of ecological and evolutionary theory, particular due to persistent open-water gaps between them. In this dissertation I demonstrates how these caps are permeable, which can be leveraged to understand evolution on islands and more broadly. The first chapter develops this connection between ongoing, overwater gene flow and island biogeographic theory, and tests it on an archipelago species. The second take a three-pronged approach in demonstrating how over-water gene flow can bias phylogenetic inference, and how many phylogeographic metrics in islands are likely shaped by long-term gene flow. The final two …
Evaluating Pathological Tau Spread In Early Alzheimer Disease: Developing A Metric For Tau Positron Emission Tomography Quantifying Tau Spatial Spread, Stephanie Sierra Doering
Evaluating Pathological Tau Spread In Early Alzheimer Disease: Developing A Metric For Tau Positron Emission Tomography Quantifying Tau Spatial Spread, Stephanie Sierra Doering
Arts & Sciences Graduate Student Theses and Dissertations
The overall goal of this dissertation is to gain a better understanding of how pathological tau burden and tau spread are related at early stages of Alzheimer Disease, and whether each tau component is uniquely informative to key elements of AD progression. A spatiotemporal pattern of tau pathological progression is observed in AD and is highly correlated to regional neurodegeneration and domain-specific cognitive impairment. This progression is reflective of two biological processes: the aggregation of tau neurofibrillary tangles in early brain regions (tau burden) as well as the transmission of pathological tau to additional brain regions (tau spread). Positron emission …
Tracking And Mitigating Imprint Erasure During Human Pluripotent State Transitions, Laura A. Fischer
Tracking And Mitigating Imprint Erasure During Human Pluripotent State Transitions, Laura A. Fischer
Arts & Sciences Graduate Student Theses and Dissertations
Early human embryogenesis is difficult to study due to practical and ethical limitations, but the successful culture of “naïve” human pluripotent stem cells (hPSCs) has expanded our ability to model cells akin to the pre-implantation epiblast. Naïve hPSCs are readily obtained through in vitro resetting of “primed” hPSCs, cells which model the post-implantation epiblast. Naïve hPSCs offer the advantages of modeling the pre-implantation transcriptome and epigenome, the ability to form embryonic and extraembryonic tissues, and the capacity to self-organize into integrated human embryo models. However, a persistent drawback of naïve hPSCs is the loss of parent-specific epigenetic marks, called imprints. …
Understanding Mechanisms Of Local Adaptation In White Clover (Trifolium Repens L.): Insights From A Phenotypic Cline And Population Genomics, Wen-Hsi Kuo
Arts & Sciences Graduate Student Theses and Dissertations
Rapid global climate change threatens food production and natural ecosystems. Knowledge of the mechanisms by which species adapt to local climates can inform future agriculture and conservation efforts and help to ensure sustainability and resilience of both cultivated and wild species. The overarching goal of this dissertation is to investigate the broad range of adaptive traits and their underlying genetics in wild populations of a widely distributed and polyploid forage plant, white clover. White clover is an ideal system because of its genetic diversity, widespread distribution, and its ability adapt to various environmental stresses through mechanisms that include its well-studied …
Antimicrobial Mechanisms Of Human Lipocalin-2, Lindsey Steinberg
Antimicrobial Mechanisms Of Human Lipocalin-2, Lindsey Steinberg
Arts & Sciences Graduate Student Theses and Dissertations
Lipocalin-2 (Lcn2, also known as siderocalin or neutrophil gelatinase-associated lipocalin) is an innate immune protein released by neutrophils and epithelial cells at sites of infection. It is understood to limit bacterial growth by restricting access to iron, an essential nutrient, but it does not avidly bind iron in isolation. At least two iron restricting Lcn2 mechanisms are described in the literature. In the prototypical mechanism, Lcn2 binds and prevents uptake of enterobactin, a high affinity iron chelator secreted by E. coli and closely related Enterobacterales. Sequestration of this bacterial siderophore prevents nutritional iron delivery to these pathogens. However, the narrow …
Microbial Community Composition And Assembly In Diverse Environmental Systems, Rhiannon Celeste Vargas
Microbial Community Composition And Assembly In Diverse Environmental Systems, Rhiannon Celeste Vargas
Arts & Sciences Graduate Student Theses and Dissertations
Analyzing microbial community responses across systems, particularly in coordinated ways, is critical to informing meaningful community ecology patterns. In Chapter 1, I provide historical contexts to the field of microbial community ecology. In Chapter 2 I have investigated a specific opportunistic pathogen, Staphyloccocus pseudintermedius, by utilizing whole genome sequencing to understand the genomic architecture that contributes to the community structures of S. pseudintermedius found in different environmental niches. We found that unlike other Staphylococcal pathogens, S. pseudintermedius niches are indistinguishable by core and accessory gene architecture. Rather, niches are resolved through the encoding of antimicrobial resistances such as those isolates …
Autism Risk Gene Cul3 Alters Neuronal Morphology Via Caspase-3 Activity In Mouse Hippocampal Neurons, Qiang-Qiang Xia, Anju Singh, Jing Wang, Zhong Xin Xuan, Jeffrey D. Singer, Craig M. Powell
Autism Risk Gene Cul3 Alters Neuronal Morphology Via Caspase-3 Activity In Mouse Hippocampal Neurons, Qiang-Qiang Xia, Anju Singh, Jing Wang, Zhong Xin Xuan, Jeffrey D. Singer, Craig M. Powell
Biology Faculty Publications and Presentations
Autism Spectrum Disorders (ASDs) are neurodevelopmental disorders (NDDs) in which children display differences in social interaction/communication and repetitive stereotyped behaviors along with variable associated features. Cul3, a gene linked to ASD, encodes CUL3 (CULLIN-3), a protein that serves as a key component of a ubiquitin ligase complex with unclear function in neurons. Cul3 homozygous deletion in mice is embryonic lethal; thus, we examine the role of Cul3 deletion in early synapse development and neuronal morphology in hippocampal primary neuronal cultures. Homozygous deletion of Cul3 significantly decreased dendritic complexity and dendritic length, as well as axon formation. Synaptic spine density significantly …
Functions Of Cdc1 In Mediating Cd4+ Help For Cd8+ T Cells, Renee Wu
Functions Of Cdc1 In Mediating Cd4+ Help For Cd8+ T Cells, Renee Wu
Arts & Sciences Graduate Student Theses and Dissertations
Classical dendritic cells (cDCs) are specialized antigen presenting cells that comprise distinct subsets distinguished by transcriptional developmental differences and in the types of immune responses they initiate. Classical type 1 dendritic cells (cDC1) are thought to perform antigen cross-presentation, which is required to prime CD8 T cells, whereas cDC2 have been suggested to be specialized for priming CD4 T cells. CD4 T cell help for CD8 T cell responses has been proposed to be mediated by CD40-dependent licensing of antigen-presenting cells. cDC1 have been suggested as the target of CD4 T cell help on the basis of in vitro analysis …
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Role Of Integrase-Pp2a Interaction In Human T-Cell Leukemia Virus Type-1 Replication And Pathogenesis, Shayna Turbin
Senior Honors Papers / Undergraduate Theses
Human T-cell leukemia virus type-1 (HTLV-1) is an oncogenic retrovirus that causes multiple disorders, including adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. HTLV-1 retroviral integrase binds to the regulatory B’56γ subunit of the host cell Protein Phosphatase 2A (PP2A). Integrase contains a highly conserved LxxIxE motif that is essential for binding, which increases integration efficiency and facilitates HTLV-1 hijack of host cell machinery. We aim to understand how mutations introduced in the highly conserved binding site can affect viral particle production and infectivity. We transfected 729B human lymphoblastoid cells and 293T cells with mutant and wildtype virus. Mutations L213A, …
Identification And Characterization Of Ube3a Gain Of Function Variants As A Driver Of Neurodevelopmental Disease, Kellan Phoebe Weston
Identification And Characterization Of Ube3a Gain Of Function Variants As A Driver Of Neurodevelopmental Disease, Kellan Phoebe Weston
Arts & Sciences Graduate Student Theses and Dissertations
UBE3A is a HECT (homologous to E6AP-Terminus) domain E3 ubiquitin ligase that targets substrate proteins for polyubiquitination and subsequent degradation through the ubiquitin-proteasome pathway. The UBE3A gene is of unique interest for its gene dosage-dependent effect in the developing brain: deletion of the maternal copy of UBE3A causes a severe intellectual disability known as Angelman syndrome; meanwhile, duplication or triplication of the genomic region containing UBE3A is linked to a prevalent syndromic form of autism known as Dup15q syndrome. However, little is known about the effects of missense variants which cause a single amino acid change in the resulting UBE3A …
Regulation Of Neuronal Cell-Type-Specific Transcription By Non-Cg Methylation And Mecp2, James Russell Moore
Regulation Of Neuronal Cell-Type-Specific Transcription By Non-Cg Methylation And Mecp2, James Russell Moore
Arts & Sciences Graduate Student Theses and Dissertations
Modulation of gene expression is fundamental to the exceptional complexity and diversity of cells in the nervous system. Within that last decade, evidence has emerged that neurons utilize unique forms of DNA methylation to regulate transcriptional programs, with multiple types of neurons displaying high levels of cytosine methylation in a non-CG context compared to non-neural cells. This non-CG methylation primarily occurs at CA dinucleotides (mCA) and is read out by methyl-CpG binding protein 2 (MeCP2). Inactivation of MeCP2 results in Rett Syndrome (RTT), a severe neurodevelopmental disorder, while overexpression of MeCP2 results in MeCP2 duplication syndrome, an autism spectrum disorder. …
Identification Of Potent Pan-Ephrin Receptor Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Chandrashekhar Madasu, Zian Liao, Sydney E Parks, Kiran L Sharma, Kurt M Bohren, Qiuji Ye, Feng Li, Murugesan Palaniappan, Zhi Tan, Fei Yuan, Chad J Creighton, Suni Tang, Ramya P Masand, Xiaoming Guan, Damian W Young, Diana Monsivais, Martin M Matzuk
Identification Of Potent Pan-Ephrin Receptor Kinase Inhibitors Using Dna-Encoded Chemistry Technology, Chandrashekhar Madasu, Zian Liao, Sydney E Parks, Kiran L Sharma, Kurt M Bohren, Qiuji Ye, Feng Li, Murugesan Palaniappan, Zhi Tan, Fei Yuan, Chad J Creighton, Suni Tang, Ramya P Masand, Xiaoming Guan, Damian W Young, Diana Monsivais, Martin M Matzuk
Faculty, Staff and Students Publications
EPH receptors (EPHs) are highly sought-after drug targets owing to their essential roles in maintaining appropriate cellular functions in both physiological and disease conditions. However, limited potency and specificity pose significant obstacles to the development of small-molecule inhibitors for EPHs. Here, using high-throughput DNA-encoded chemical library screenings, we developed potent and selective inhibitors of the EPH receptor kinase family. Our results also emphasize the therapeutic potential of our EPH inhibitors in cancer and endometriosis, a global health concern that causes chronic pain and often leads to infertility in women. This study showcases the robust pipeline of using DNA-encoded chemistry technology …
Investigating The Involvement Of Gabaergic Interneurons And A Gene Therapy Strategy For Epilepsy In Cln2 Disease, Keigo Takahashi
Investigating The Involvement Of Gabaergic Interneurons And A Gene Therapy Strategy For Epilepsy In Cln2 Disease, Keigo Takahashi
Arts & Sciences Graduate Student Theses and Dissertations
The neuronal ceroid lipofuscinoses (NCLs) are a group of neurodegenerative lysosomal storage disorders affecting children and young adults. CLN2 disease, or classic late infantile neuronal ceroid lipofuscinosis, is one of the most common forms of NCL and is caused by a deficiency of tripeptidyl peptidase 1 (TPP1). Although an FDA-approved enzyme replacement therapy for CLN2 disease now exists, a poor understanding of pathophysiology has hampered the development of more effective and persistent therapy. While Cln2R207X/R207X knock-in mice which carry one of the most common pathogenic mutations in human patients were developed in 2017, this genetically accurate mouse model for CLN2 …
Measuring The Effects Of Selenium Exposure On Batrachochytrium Dendrobatidis (Bd) Growth In Vivo In Larval American Bullfrogs (Rana Catesbeiana)., Taylor Morrison
Measuring The Effects Of Selenium Exposure On Batrachochytrium Dendrobatidis (Bd) Growth In Vivo In Larval American Bullfrogs (Rana Catesbeiana)., Taylor Morrison
Honors Thesis
Most amphibians in today’s world are exposed to a variety of environmental stressors. This project’s main objective was to determine any effects of selenium on Batrachochytrium dendrobatidis (Bd) and infection levels in South Dakota amphibians. I selected American bullfrogs (Rana catesbeiana) as they are susceptible to Bd and are found throughout eastern South Dakota. The secondary objective of this project was to measure any impact of Bd and selenium, combined, on growth measures of the frogs. The third objective was to see if survival rates were reduced when amphibians were exposed to Bd and selenium. Tadpoles were collected (n=225) from …
Lmpact Of Salmonella Enterica Effector Proteins On Plant Physiology And Immunity, Sara Qader
Lmpact Of Salmonella Enterica Effector Proteins On Plant Physiology And Immunity, Sara Qader
Honors Theses
Salmonella enterica serovar Typhimurium are primarily recognized as pathogens associated with foodborne illnesses in humans. Salmonella also can colonize plant tissue effectively. The pathogen relies on type III secretion systems (T3SS) to infect mammals and plants successfully and counteract the immune response. Understanding the molecular mechanisms underlying Salmonella’s interactions with plants is essential for developing effective strategies to reduce its impact on human health and agriculture. Effector proteins, known for their role in modulating host-pathogen interactions, have been implicated in the virulence and pathogenicity of Salmonella. However, their specific functions and contributions to Salmonella’s interactions with plants remain largely unknown. …
Open Resources For Biology Education (Orbe): A Resource Collection, Sanah Ahmed, Tiffany Adjei-Opong, Ashley B. Heim, Keenan Noyes, Kelly Schmid, Brian A. Couch, Mackenzie R. Stetzer, Lillian G. Senn, Erin Vinson, Michelle K. Smith, Kira Treibergs
Open Resources For Biology Education (Orbe): A Resource Collection, Sanah Ahmed, Tiffany Adjei-Opong, Ashley B. Heim, Keenan Noyes, Kelly Schmid, Brian A. Couch, Mackenzie R. Stetzer, Lillian G. Senn, Erin Vinson, Michelle K. Smith, Kira Treibergs
School of Biological Sciences: Faculty Publications
In undergraduate life sciences education, open educational resources (OERs) increase accessibility and retention for students, reduce costs, and save instructors time and effort. Despite increasing awareness and utilization of these resources, OERs are not centrally located, and many undergraduate instructors describe challenges in locating relevant materials for use in their classes. To address this challenge, we have designed a resource collection (referred to as Open Resources for Biology Education, ORBE) with 89 unique resources that are primarily relevant to undergraduate life sciences education. To identify the resources in ORBE, we asked undergraduate life sciences instructors to list what OERs they …
Regulation Of Intracellular Sorting Of The Bruno Protein In Drosophila Flight Muscles, Travis Main
Regulation Of Intracellular Sorting Of The Bruno Protein In Drosophila Flight Muscles, Travis Main
Master's Theses
Understanding mechanisms of intracellular sorting is a fundamental inquiry of cell biology. We used the B-body and protein Bruno (Bru) as a model to study the formation of nuclear domains that are membraneless organelles inside the cell nucleus. Specifically, we sought to identify protein sequences that regulate Bru's affinity to B-bodies and protein aggregation. We generated various Bru mutants and subsequently tested them in vivo using fluorescence microscopy. We found that the protein solubility of Bru is determined through an interplay of RNA recognition motifs (RRMs) and intrinsically disordered regions (IDRs). Using truncation analysis, we identified a 31-amino acid region …
Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose
Investigating The Electrostatics Of Mucins As Key Contributors To Mucus Stasis In Cystic Fibrosis, Elex Skylar Rose
All ETDs from UAB
Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which encodes a channel responsible for the transport of chloride and bicarbonate ions across the apical cell surface. In the respiratory tract, defective CFTR results in viscous and adherent mucus that becomes static within the airway, which leads to chronic infections, progressive lung damage, and early mortality. Historically, CF mucus stasis has been attributed to significant airway dehydration; however, growing evidence has demonstrated that aberrant electrostatic properties of mucins also contribute to mucus stasis in CF. Mucins are large, polymeric glycoproteins …
Mammalian Roadkill Trends In Central Georgia, Lucy Beck
Mammalian Roadkill Trends In Central Georgia, Lucy Beck
Biology Theses
Wildlife-vehicle collisions are a global concern for both wildlife conservation and driver safety, and knowledge of spatiotemporal trends are required in order to effectively mitigate these consequences. This study documents species composition and spatiotemporal trends in terrestrial mammalian roadkill using ten-years of data recorded along a 12.8 mile stretch of State Route 212 in Baldwin and Putnam Counties, Georgia. From January 1 2012 to December 31 2021, 2,263 roadkilled vertebrates were observed on the survey route, and terrestrial mammals accounted for 84% of the observations. Two methods of hotspot identification indicated a non-random spatial distribution of roadkill associated with physical …
Comparing Oxidative Balance Of Summer And Winter Acclimatized Birds, Olivia R. Gulseth
Comparing Oxidative Balance Of Summer And Winter Acclimatized Birds, Olivia R. Gulseth
Honors Thesis
The oxidative stress system allows air-breathing animals to deal with the potentially harmful byproducts of metabolism. How this system reacts to the increasing thermoregulatory demands in winter for birds from cold winter climates is poorly understood. The purpose of this project was to compare the oxidative balance of summer (warm acclimatized) and winter (cold acclimatized) phenotypes of overwintering songbirds in South Dakota to determine if there is a significant difference between the seasonal phenotypes and among species. Seasonal differences in oxidative balance were expected due to the increased metabolic costs of elevating metabolism to maintain body temperature during winter. Blood …
Beating The Heat: The Use Of Coral-Benefitting Bacteria For Heat-Stressed Anemones And Inspiring Future Biologists, Navah Eshraghi
Beating The Heat: The Use Of Coral-Benefitting Bacteria For Heat-Stressed Anemones And Inspiring Future Biologists, Navah Eshraghi
Undergraduate Honors Theses
The warming of ocean temperatures has caused mass coral-bleaching events characterized by the expulsion of vital algal symbionts from coral tissues. However, the possibility of algal reuptake and existence of bacteria that support coral-algal symbiosis are two avenues of potential restoration efforts. Using the sea anemone Exaiptasia diaphana as a model for corals, I tested whether the coral-benefitting bacterium Endozoicomonas montiporae could enhance algal uptake under ambient (27°C) and heat-stressed (32°C) conditions. I then turned acquired results into an article modeled after National Geographic Kids to introduce the experiment to younger ages. While temperature was a larger determinant of algal-uptake …
Assessing The Effects Of Cold Storage Regimes Of North American Bombus Gynes, Thuy Tien T. Lindsay, Marcia M. Hagen, Joyce N. Knoblett, Joseph P. Rinehart, Karen M. Kapheim, James P. Strange
Assessing The Effects Of Cold Storage Regimes Of North American Bombus Gynes, Thuy Tien T. Lindsay, Marcia M. Hagen, Joyce N. Knoblett, Joseph P. Rinehart, Karen M. Kapheim, James P. Strange
Biology Faculty Publications
Bumble bees are the primary commercial pollinators for greenhouse-grown crops and managing them requires insight into the Bombus life cycle. However, some aspects of the life cycle are not fully understood. Once mated, adult Bombus gynes can be stored for a short term at a constant low temperature (CLT). However, survival rates for some species are low during CLT, particularly when storage periods exceed a month. To address this, we tested the hypothesis that Bombus gynes stored in a fluctuating thermal regime (FTR) have increased survival compared to gynes stored in CLT. Specifically, the FTR had a baseline temperature of …
The First Draft Genome Of Cold-Water Octocoral Anthothela Grandiflora, The Great Flowerbud Coral, Laurel Humphrey
The First Draft Genome Of Cold-Water Octocoral Anthothela Grandiflora, The Great Flowerbud Coral, Laurel Humphrey
Honors Scholar Theses
Cold-water corals are important sources of ocean biodiversity, yet populations are increasingly threatened by human activity and climate change. Soft octocorals may endure higher ocean acidification levels in comparison to stony hexacorals, although the mechanisms of octocoral biomineralization are less understood. Building genomic resources for cold-water octocorals could help to close information gaps by elucidating the evolutionary history of octocoral calcification and provide a reference for future studies of adaptation to acidified waters. This report describes the first reference genome for the cold-water octocoral species Anthothela grandiflora found throughout the Atlantic Ocean. Sequencing using Oxford Nanopore Technologies generated 43.6 Gb …
Dual Modes Of Dopamine Underly Distinct Facets Of Impulsive Actions, Tzvia Pinkhasov
Dual Modes Of Dopamine Underly Distinct Facets Of Impulsive Actions, Tzvia Pinkhasov
Arts & Sciences Graduate Student Theses and Dissertations
During the pursuit of basic needs, animals sometimes fail to suppress actions that are maladaptive and counterproductive to their survival. In humans, these actions are often called impulsive because they can incur negative consequences. Impulsivity is ubiquitous across psychiatric disorders and related to debilitating outcomes such as substance abuse, crime and suicidality. Despite its risks, a lack of a neural mechanism understanding of impulsive actions impedes the development of effective treatments.In this dissertation, I set out to bridge the knowledge gained from the parallel fields of neuropsychopharmacology, experimental psychology, and systems neuroscience to uncover neural mechanisms of impulsive actions. Clinicians …
Neuroepigenetic Mechanisms Of Brain Development: From Technology To Biological Insights, Allen Yen
Neuroepigenetic Mechanisms Of Brain Development: From Technology To Biological Insights, Allen Yen
Arts & Sciences Graduate Student Theses and Dissertations
Each cell in the brain has the same genomic sequence, yet they can have vastly different phenotypes and function. This diversity is a result of complex genetic and signaling pathways, and knowing how these are regulated is key to understanding physiological development and how pathogenic dysfunctions arise. Genomic methods such as chromatin immunoprecipitation followed by sequencing (ChIP-seq) and assay for transposase-accessible chromatin with sequencing (ATAC-seq) have played pivotal roles in dissecting these processes. However, a key limitation is that the cells are destroyed upon observation of their molecular states, which preclude our ability to correlate historical epigenetic information with future …
Integrating Dna Methylation And 3d-Genome Architecture To Identify Functional Regulatory Sequences In Idh-Mutant Aml, Elisabeth Wilson
Integrating Dna Methylation And 3d-Genome Architecture To Identify Functional Regulatory Sequences In Idh-Mutant Aml, Elisabeth Wilson
Arts & Sciences Graduate Student Theses and Dissertations
Acute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease. Recurrent mutations in genes involved in epigenetic pathways are common in AML and are thought to contribute to this variability by disrupting epigenetic patterns relative to normal hematopoietic cells. The most well-studied epigenetic modification in AML is DNA methylation. Although methods for studying DNA methylation have improved significantly in the past decade, the landscape of methylation changes in AML and how they relate to chromatin architecture and gene regulation is still not fully understood. This thesis is focused on the DNA methylation phenotype of IDH1 or IDH2 mutations in …
Whale Harvest Through Time: Unveiling The Hemispheric Contrasts In Whaling, Laura Mooney '24
Whale Harvest Through Time: Unveiling The Hemispheric Contrasts In Whaling, Laura Mooney '24
Biology Student Scholarship
Whales have been long known for their oils and rich blubber which has been a dish in many countries in both the Northern and Southern hemispheres. Some species were being hunted to near extinction. The earliest whaling began in 3000BC by Native American but commercial whaling began by the Basques in the 17th century with a huge increase in the 18th,19th and 20th centuries. This study examines how whale harvest has changed over time in years between 1900 and 1999 in both the Northern and Southern hemispheres. I analyzed the data collected by Jr. Robert(2015) and looked to see if …
Sea Surface Temperature Influence On Tropical Storms And Hurricanes, Elise Leroux '26
Sea Surface Temperature Influence On Tropical Storms And Hurricanes, Elise Leroux '26
Biology Student Scholarship
Hurricanes are both dangerous and difficult to predict because of the various factors that influence the size and intensity of storms, where sea surface temperature (SST) is one of the most relevant variables. As temperatures are increasingly rising due to climate change, the effect on storm size, intensity, and frequency is going to be greater. There have been many studies how individual storms are affected, but less so on the overall frequency of hurricanes. This study assesses the number of hurricanes each year in comparison to the SST and the average wind speed of each hurricane. I predict that years …