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Articles 1831 - 1860 of 39284
Full-Text Articles in Entire DC Network
Analysis Of Cd36 Variants Associated With Heart Disease, Elaine Vanterpool, Lemanisha Adams
Analysis Of Cd36 Variants Associated With Heart Disease, Elaine Vanterpool, Lemanisha Adams
Student Posters
Cardiovascular Disease (CVD) affects an estimated 47-54% of Black adults in America. CVD is characterized when coronary arteries struggle to supply the heart with enough blood, oxygen, and nutrients. CVD refers to a various disorders affecting the heart and blood vessels, which includes disease like stroke, coronary artery disease, and heart failure. Risk factors can include diabetes, high cholesterol, and hypertension. Some symptoms include chest pain, shortness of breath, pain in the neck, numbness, weakness, or coldness in the arms or legs, dizziness or fainting, and fatigue or exhaustion. Unfortunately, Heart disease remains one of the leading causes of mortality …
Ctsc Gene Correlation With Dental Disease Periodontitis, Elaine Vanterpool, Misiel Garcia
Ctsc Gene Correlation With Dental Disease Periodontitis, Elaine Vanterpool, Misiel Garcia
Student Posters
Periodontitis is a chronic inflammatory and non-communicable disease that poses a major public health challenge worldwide. In the United States alone, approximately 50% of adults are affected by this condition. It results from bacterial infection and dental plaque buildup, leading to gum inflammation, bleeding, bone loss, and, if left untreated, tooth loss. Beyond its effects on oral health, periodontitis is linked to systemic diseases such as cardiovascular disease and diabetes, making it a significant health concern. Treatment involves professional dental care, including oral hygiene education, deep cleaning of root surfaces, and reducing risk factors like smoking. In addition to environmental …
Three Reference Genomes For Freshwater Diatom Ecology And Evolution, Wade R. Roberts, Andrew J. Alverson
Three Reference Genomes For Freshwater Diatom Ecology And Evolution, Wade R. Roberts, Andrew J. Alverson
Biological Sciences Faculty Publications and Presentations
Diatoms are an important component of marine and freshwater ecosystems. Although the majority of described diatom species live in freshwater systems, genome sequencing efforts have focused primarily on marine species. Genomic resources for freshwater species have the potential to improve our understanding of diatom ecology and evolution, particularly in the context of major environmental shifts. We used long- and short-read sequencing platforms to assemble reference genomes for three freshwater diatom species, all in the order Thalalassiosirales, which are abundant in the plankton of oceans, lakes, reservoirs, and rivers worldwide. We targeted three species that cover the breadth of phylogenetic diversity …
A Bioinformatic Analysis Of Foxo3 And Tgfb3 Variants: Possible Pathways To Survivin Expression, Elaine Vanterpool, Jordon Vanterpool
A Bioinformatic Analysis Of Foxo3 And Tgfb3 Variants: Possible Pathways To Survivin Expression, Elaine Vanterpool, Jordon Vanterpool
Student Posters
Worldwide, cancer is a major medical concern. Cancer may spread to your bones or organs through the lymphatic or circulatory systems. To have the best chance of recovery, it is crucial to get examined for cancer early. Numerous forms of cancer exist including breast, bone, brain, prostate, colon cancer, and etc. Survivin is a small inhibitor for apoptosis. Scientist consistently identify survivin being expressed in high tumor grade cancers by using molecular profiling analysis. Survivin has the potential to avail diagnosis. The goal of this study is to identify and investigate potential variants that are associated with the increased expression …
Hydin Gene Variants: Implications In Primary Ciliary Dyskinesia And Other Diseases, Elaine Vanterpool, Sharie Angus
Hydin Gene Variants: Implications In Primary Ciliary Dyskinesia And Other Diseases, Elaine Vanterpool, Sharie Angus
Student Posters
The HYDIN gene, also known as CILD5, HYDIN1, HYDIN2, and PPP1R31, encodes a protein that plays a role in cilia motility. Mutations in HYDIN are associated with autosomal recessive primary ciliary dyskinesia-5 (PCD5), a disorder characterized by cerebrospinal fluid accumulation in the brain’s ventricles. A duplicate copy of this gene has also been identified on chromosome 1 in humans. Research indicates that HYDIN loss of-function mutations contribute to asthenoteratozoospermia, leading to structural defects in sperm flagella, disassembly of the acrosome and neck, and subsequent male infertility. Intracytoplasmic sperm injection (ICSI) has been proposed as a potential treatment for sperm immobility …
Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Ashlee Simpson
Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Ashlee Simpson
Student Posters
Hypertension is abnormally high blood pressure in the arteries, the blood vessels that carry blood from the heart to the rest of the body. Many individuals do not know they have the condition. However, it is a major risk factor for a multitude of health problems. The heart and arteries having to work harder than normal thickens the muscles of the heart and arteries and hardens and damages artery walls. Flow of blood and oxygen is also reduced which directly results in heart disease. This study focuses on how the ABCA3 gene is associated with hypertension. The membrane-associated protein encoded …
Mutations In The Mmp20 Gene In Association With Amelogenesis Imperfecta, Elaine Vanterpool, Alicia Myrie
Mutations In The Mmp20 Gene In Association With Amelogenesis Imperfecta, Elaine Vanterpool, Alicia Myrie
Student Posters
Amelogenesis Imperfecta or AI is a group of disorders that affect enamel formation and result in enamel abnormalities. One of the genes associated with these disorders is the MMP20 gene, which has instructions encoding for the protein enamelysin. Enamelysin, a predominant amelogenin-processing enzyme coded by MMP20 forms enamel by cleaving other proteins involved in its formation, making them easier to remove once they are no longer needed. These include: Amelogenin, Ameloblastin, and enamelin. Amelogenin makes up most of the enamel's extracellular matrix. Amelobastin deals with adhesion and cell signaling, along with aiding in structure. Enamelin is the largest protein in …
Chek2 In Cancer Suppression: Investigating Genetic Variants And Their Impact, Elaine Vanterpool, Nicevarlyn Philippe
Chek2 In Cancer Suppression: Investigating Genetic Variants And Their Impact, Elaine Vanterpool, Nicevarlyn Philippe
Student Posters
Cancer develops when cells grow uncontrollably, often due to mutations in genes that maintain genome stability. One such gene is CHEK2 (Checkpoint Kinase 2), a tumor suppressor activated in response to DNA damage. CHEK2 halts the cell cycle to allow for DNA repair, stabilizes TP53, and phosphorylates BRCA1 , all of which help prevent the spread of mutations. CHEK2 belongs to the CDS1 family of serine/threonine kinases and contains an FHA domain that facilitates interaction with other DNA damage response proteins. Upon activation, CHEK2 inhibits CDC25C phosphatase, preventing premature mitosis, and contributes to G1 arrest through p53 stabilization. Itsrole in …
Eed Gene Variants And Irritable Bowel Syndrome: A Genetic Approach To Understanding Ibs, Elaine Vanterpool, Ted Howard
Eed Gene Variants And Irritable Bowel Syndrome: A Genetic Approach To Understanding Ibs, Elaine Vanterpool, Ted Howard
Student Posters
Irritable Bowel Syndrome is a disease associated with the gastrointestinal tract that can cause abdominal discomfort, bloating, and alterations in the digestive tract. Its etiology remains complex, involving both genetic and environmental factors. Recent studies suggest that genetic variations may contribute to the pathogenesis of IBS. One such gene, the EED (Embryonic Ectoderm Development) gene, has been implicated in regulating various biological processes, including gene expression, cellular development, and gastrointestinal functions. In this research, we explore the potential relationship between the EED gene and IBS, with a focus on the variation rs798256, documented in the ClinVar database. We examine how …
An Analysis Of Pon1 Variants Associated With Cardiovascular Disease (Cvd), Elaine Vanterpool, Adaiah Murray
An Analysis Of Pon1 Variants Associated With Cardiovascular Disease (Cvd), Elaine Vanterpool, Adaiah Murray
Student Posters
The PON1 gene encodes for paraoxonase 1, an enzyme that plays a crucial role in the breakdown of organophosphates and the prevention of oxidative damage to lipids, particularly those in low-density lipoprotein (LDL). PON1 is primarily associated with high-density lipoprotein (HDL), often called "good cholesterol," and is involved in antioxidant defense mechanisms. Cardiovascular Disease (CVD): The relationship between PON1 and cardiovascular disease has been a subject of considerable research. Variations in the PON1 gene and its product, paraoxonase 1, are important in modulating the risk of cardiovascular disease. The gene’s polymorphisms and their impact on enzyme activity may influence individual …
The Analysis Of Thra Variants In Hypothyroidism, Elaine Vanterpool, Anaiah Mills
The Analysis Of Thra Variants In Hypothyroidism, Elaine Vanterpool, Anaiah Mills
Student Posters
Hypothyroidism is a chronic disease that lacks the production of thyroid hormones. If this disease is not treated with the proper care, it can lead to some serious health effects, or even become fatal. In hypothyroidism levels of thyroid hormones are low. The thyroid gland is a very pivotal part of the endocrine system located at the front of The protein encoded by this gene is the nuclear hormone receptor triiodothyronine. The consequences of untreated or inadequately treated hypothyroidism include infertility, cardiovascular disease, and neurological and musculoskeletal symptoms. Environmental iodine deficiency is the most common cause of thyroid disorders, including …
The Analysis Of The Comt Gene Contribution To Schizophrenia, Elaine Vanterpool, Caelyn Mukorombindo
The Analysis Of The Comt Gene Contribution To Schizophrenia, Elaine Vanterpool, Caelyn Mukorombindo
Student Posters
The COMT gene, also known as the catechol-O-methyltransferase gene, plays a role in breaking down the neurotransmitters in the brain, like dopamine. Dopamine plays a role in behavior and mood; as a result, the COMT gene can influence traits like mental illnesses and disorders. COMT has a variation called Val158Met, where a change in the DNA sequence affects the efficiency of dopamine breakdown. Those who have the variant have lower COMT activity, which results in dopamine levels being high in the brain, which affects their ability to deal with stress and to show signs of aggressive behavior. This gene has …
Bioinformatic Analysis Of Epcam Variants Associated With Colorectal Cancer, Elaine Vanterpool, Taylor Hall
Bioinformatic Analysis Of Epcam Variants Associated With Colorectal Cancer, Elaine Vanterpool, Taylor Hall
Student Posters
Colorectal cancer is the uncontrolled cell growth on the first and largest part of the intestine, the colon. Colorectal cancer, known as the “silent disease”, is easily undetected, especially in its early stages. It can be asymptomatic for years, and without the proper diagnosis, it can become fatal. Once symptoms start to appear, a patient can have rectal bleeding, fatigue, weight loss, changes in bowel habits, and more. Comprehending the pathogenesis of Colorectal cancer and enquiring about preventative measures against this disease requires awareness of the variants that play a part in this cancer. To start this study, we first …
An Analysis Of Lamb3 Variants Associated With Amelogenesis Imperfecta, Elaine Vanterpool, Aaliyah Ruddock
An Analysis Of Lamb3 Variants Associated With Amelogenesis Imperfecta, Elaine Vanterpool, Aaliyah Ruddock
Student Posters
The disease researched in this study was Amelogenesis Imperfecta. Those infected may experience mild to extreme the enamel formation which results in tooth brittleness and discoloration (brown and yellow). Being an X-linked recessive inherited disease, it is more detrimental to males than that of females. Individuals with this disease are also more susceptible to dental caries caused by bacteria such as streptococcal mutans. Overtime, this bacteria can demineralize the teeth by metabolizing sugars that can produce acids. These acids can cause severe unrepairable damage to the tooth. This disease can also result in psychological issues including mental health disorders due …
Analysis Of Rest Gene Variants Associated With Gingival Fibromatosis, Elaine Vanterpool, Daniellw Mills
Analysis Of Rest Gene Variants Associated With Gingival Fibromatosis, Elaine Vanterpool, Daniellw Mills
Student Posters
Gingival fibromatosis is a genetic disorder that affects cell proliferation of the gum tissue leading to excessive, benign growth of tissue in the mouth (1) . Like all genetic disorders this disease results from mutations in specific gene sequences responsible for proper protein expression (2). Geneticists are increasingly interested in studying the genes responsible for various diseases and the mutations that cause them (2). While significant study has been devoted to Gingival fibromatosis and the mutations that lead to it , there remains research to be done in alternate effects of various mutations in the genes responsible for the disease. …
Genetic Insights Into Glaucoma: The Impact Of Tkb1 Mutations On Glaucoma, Elaine Vanterpool, Kelli-An Kindell
Genetic Insights Into Glaucoma: The Impact Of Tkb1 Mutations On Glaucoma, Elaine Vanterpool, Kelli-An Kindell
Student Posters
Glaucoma is a neurodegenerative eye disorder that can cause vision loss or permanent blindness due to damage in the optic nerve. Research has helped identify various genetic variants associated with this disease, including TBK1 (TANK-binding kinase 1). TBK1encodes for an enzyme serine/threonine which plays a role in innate immunity antiviral responses. This enzyme helps the immune system fight off infections by turning on specific signals in the body like IRF3/7 and NF-kB which regulate cytokine production and inflammatory response. Beyond immunity TBK1 is involved in crucial cellular processes including autophagy, mitochondrial energy production and cellular proliferation. TBK1 was linked to …
An Analysis Of Dagla Variants Associated With Adhd, Elaine Vanterpool, Zahra Dulan
An Analysis Of Dagla Variants Associated With Adhd, Elaine Vanterpool, Zahra Dulan
Student Posters
The human genome is largely responsible for each individual’s unique physical and physiological development. It contains thousands of genes with multiple alleles that code for proteins with various functions. Mutations in these genes have the potential to lead to the development of human diseases and disorders. Therefore, properly analyzing mutated genes is essential to understanding their potential pathogenicity in various diseases and disorders. It may also provide a basis for the development of new therapies. The DAGLA gene encodes a protein called diacylglycerol lipase alpha. This enzyme is involved in the biosynthesis of 2-arachidonoyl-glycerol, a key player in the endocannabinoid …
Analysis Of Tert Gene Associated With Melanoma, Elaine Vanterpool, Laila Prentice
Analysis Of Tert Gene Associated With Melanoma, Elaine Vanterpool, Laila Prentice
Student Posters
Melanoma is a type of skin cancer that arises when melanocytes, the pigment-producing cells in the skin, begin to proliferate uncontrollably. It can develop from a preexisting mole or previously unblemished skin. Melanoma is considered one of the most aggressive forms of skin cancer, known for its rapid proliferation and resistance to treatment. This malignancy poses a significant health risk to the elderly, who may be more susceptible due to cumulative sun exposure and age-related immune system decline. There are several subtypes of melanoma, including superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral melanoma. Its development is strongly …
An Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Lisa-Faith Dieujuste
An Analysis Of Abca3 Variants Associated With Hypertension, Elaine Vanterpool, Lisa-Faith Dieujuste
Student Posters
blood pressure in the body is too high. A medical condition that is well known to be one of the major causes of premature deaths worldwide. Affecting an estimation of 1.28 billion adults . ABCA3 is a protein that is involved in the development of hypertension. ABCA3 is part of the ATP-binding cassette transporter family. It is a multi-membrane spanning protein meaning it has to do with the transporting, signaling and structure of cells. It plays a crucial role in the regulation of pulmonary surfactant homeostasis, but its main objective is to provide instruction to make protein that is involved …
An Analysis Of Capn-10 Variants Associated With Polycystic Ovarian Syndrome, Elaine Vanterpool, Azaria Carey
An Analysis Of Capn-10 Variants Associated With Polycystic Ovarian Syndrome, Elaine Vanterpool, Azaria Carey
Student Posters
Calpain 10 (CAPN-10): A calcium independent protein in the calpain family involved in cell structure, signaling, and metabolism. oKey Functions: Regulates sugar metabolism, energy production, and insulin release, making it crucial for metabolic health. oType 2 Diabetes: CAPN-10 was the first gene linked to T2DM in the early 2000s. oGestational Diabetes: CAPN-10 variations contribute to insulin release and pancreas function, increasing risks for both mother and child. oPolycystic Ovary Syndrome (PCOS): CAPN-10 changes may exacerbate PCOS-related issues like insulin resistance, weight gain, and heart disease. o Purpose: to further clarify the role of CAPN-10 mutations in PCOS and their broader …
Analysis Of Alzheimer's Associated Adam10 Mutations, Elaine Vanterpool, Addie Mciver
Analysis Of Alzheimer's Associated Adam10 Mutations, Elaine Vanterpool, Addie Mciver
Student Posters
Alzheimer’s Disease (AD) is characterized by a loss of short-term memory and deterioration of the brain through a decrease in neuron connection and damage to the cerebral cortex. The main symptoms of AD are confusion and a loss of memory, reasoning, and social behavior, partially believed to be caused by neuritic plaque accumulation. This debilitating disease is associated with 28 genes and 515 variants. One of the rarer genes, ADAM10, is a cell surface protein/ protease that is part of the alpha secretase family, commonly associated with AD. These genes, present in all mammals, code for others in the ADAM …
Analysis Of Mapt On Alzheimer’S Disease, Elaine Vanterpool
Analysis Of Mapt On Alzheimer’S Disease, Elaine Vanterpool
Student Posters
There are multiple factors that contribute to the onset of Alzheimer’s disease. These include genetic causes, environmental factors, and lifestyle choices. Microtubule-Associated Protein Tau. (MAPT) is a gene that is associated with the onset of Alzheimer’s disease. There are 2 main alleles of the APOE gene: H1 haplotype and H2 haplotype. H1 haplotype is the more common variant and is associated with an increased risk of developing tau-related neurodegenerative diseases.H2 haplotype is less common and is thought to have originated from an ancient inversion on chromosome 17q21. It may have some protective effects against certain tauopathies. The H1 haplotype is …
Analysis Of Mutations Of Hydin Gene Associated With Hypertension, Elaine Vanterpool, Savania Simms
Analysis Of Mutations Of Hydin Gene Associated With Hypertension, Elaine Vanterpool, Savania Simms
Student Posters
Hypertension also called “High Blood Pressure” is a disorder caused by factors such as old age, genetics, weight, physical activeness, and diet. Today hypertension affects 1.28 billion adults aged 30–79 years worldwide (Mayo Clinic, 2024). When hypertension is in the range of 180/120 it can cause symptoms such as headache, chest pain, dizziness, blurred vision, and other symptoms . It is important to study the genes associated with this disorder because it helps to identify what genetic risk factors cause this as well as it helps develop more treatments for it. The gene HYDIN associated with hypertension has 51 variants …
Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool, Mya St. Louis, Josel Bryant, Kennedi Ewan, Taylor Hall, Leah Marcelle, Mayah Seal
Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool, Mya St. Louis, Josel Bryant, Kennedi Ewan, Taylor Hall, Leah Marcelle, Mayah Seal
Student Posters
Serratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Collagenase is an enzyme that breaks down collagen, while also playing a key role in the extracellular matrix. Collagenase uses zinc to operate that helps it break down the peptide bonds in collagen. Testing Agents ❖ Metronidazole is an antimicrobial drug used to treat infections caused by different anaerobic bacteria, such as infections in the blood, liver, bones, joints, and meninges. ❖ Vanillin is …
Silver Nanoparticles And Natural Compounds Can Modulate Proteolytic Activities Of Escherichia Coli, Elaine Vanterpool, Simone Chotan, Wendolyn Johnson, Emilee Duany, Antonio Ward
Silver Nanoparticles And Natural Compounds Can Modulate Proteolytic Activities Of Escherichia Coli, Elaine Vanterpool, Simone Chotan, Wendolyn Johnson, Emilee Duany, Antonio Ward
Student Posters
Investigating the impact of antibacterial agents on Escherichia coli (E. coli) protease activity is vital for advancing new approaches to combat bacterial infections. Proteases are crucial enzymes in bacterial physiology that contribute to immune system evasion, biofilm development, and host tissue degradation. Due to these enzymes being directly involved in E. coli virulence, understanding how antibacterial compounds affect protease function may lead to innovative treatment strategies. E. coli is a gram-negative, facultatively anaerobic bacterium that exists both as a harmless intestinal commensal and a significant human pathogen. Many lives have been negatively affected by severe E. coli infections in the …
Analyzing The Inhibition Of Chemical Compounds On Protease In P. Aeruginosa, Elaine Vanterpool, Micah Andrews, Marielle Cooper, Mitspah Eshette, Anaya Moodie-Lee, Jayda Russell, Jordon Vanterpool
Analyzing The Inhibition Of Chemical Compounds On Protease In P. Aeruginosa, Elaine Vanterpool, Micah Andrews, Marielle Cooper, Mitspah Eshette, Anaya Moodie-Lee, Jayda Russell, Jordon Vanterpool
Student Posters
Pseudomonas aeruginosa is a gram-negative, bacillus-shaped opportunistic pathogen, notorious for invading immunocompromised individual leading to secondary infections. These opportunistic microbes typically are implicated mild to more severe infections including burn or wound infections to more serious systemic infections. The bacterium Ps. aeruginosa utilizes a variety of virulence factors to enhance the pathogenicity of the organism. Virulence factors secreted by Ps. aeruginosa include its pili, adhesins, capsule, exotoxin A, and lipopolysaccharide (LPS). The proteases produced by Ps. aeruginosa are powerful virulence factors that can lead to tissue destruction and immune invasion. It is imperative that we find ways of regulating the …
Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool, Jayden Vanterpool, Ayanna Liburd, Andrew Mcintosh, Cayden Pyform, Cameron Scott, Jea Joseph Msie
Improving Biocompatibility And Structural Integrity Of Decellularized Biomaterials, Elaine Vanterpool, Jayden Vanterpool, Ayanna Liburd, Andrew Mcintosh, Cayden Pyform, Cameron Scott, Jea Joseph Msie
Student Posters
Venous grafting using synthetic and biomaterials has been one of the forefront issues of the scientific community. For years, in vitro experimentation of both bio and synthetic materials has been carried out with the hope of treating issues like chronic venous insufficiency, heart attacks, artery blockage, etc. Within these issues, there has been much success. Numerous cases have made it to clinical trials with grafts lasting as long as two years within the patient. Nonetheless, some common and persistent issues occur within all the cases observed. Despite extensive experimentation and development of the most prestigious technology, thrombosis, negative immune response, …
Using Secreted Biomarkers In The Development Of The Detection Of Advanced Cancer Screening System, Elaine Vanterpool, Jaydan Vanterpool, Jordon Vanterpool, Robert Lister, Shania Swain, Enock Ngoga, Jovaughn Redley, Imani Shields, Dalen Jones, Santiago Moreno, Ronnie Nichalson, Jea Joseph Msie
Using Secreted Biomarkers In The Development Of The Detection Of Advanced Cancer Screening System, Elaine Vanterpool, Jaydan Vanterpool, Jordon Vanterpool, Robert Lister, Shania Swain, Enock Ngoga, Jovaughn Redley, Imani Shields, Dalen Jones, Santiago Moreno, Ronnie Nichalson, Jea Joseph Msie
Student Posters
As of 2020, there were an estimated 19.3 million new cancer cases and almost 10 million cancer deaths. Among the different types of cancers in the world, the most prevalent cancer, lung cancer, accounted for 23% of all cancer deaths (CDC) and has been relatively steady since 1999. However, by using Detection of Advanced Cancer Screening (D.A.C.S), many patients with cancer cases would receive efficient, reliable treatment in a timely manner. According to Cancer.gov, multiple participants reported being screened for cancer, “After they had ‘aged out of the recommended range for routine cancer screening”. (Dr. Moss) “We found that over …
Mutations In The Pms1 Gene Associating With Ovarian Cancer, Elaine Vanterpool, Erin Hough
Mutations In The Pms1 Gene Associating With Ovarian Cancer, Elaine Vanterpool, Erin Hough
Student Posters
Ovarian cancer occurs when abnormal cells in the ovaries grow and divide uncontrollably, destroying healthy body tissue. Common symptoms of ovarian cancer include weight loss, fatigue, discomfort in the pelvic area, or changes in bowel habits. This study focuses on how ovarian cancer is related to the PMS1 gene. The PMS1 gene encodes MLH1, a protein involved in DNA mismatch repair (MMR) system. MMR helps connect errors that occur during DNA replication, preventing mutations and potential cancer development. When this gene is mutated, there is an increased risk of developing ovarian and other endometrial cancer. Bioinformaic softwares allow us to …
Impact Of Msx1 And Irf6 Gene Variants On Orofacial Cleft And Facial Development, Elaine Vanterpool, Lisa Banks
Impact Of Msx1 And Irf6 Gene Variants On Orofacial Cleft And Facial Development, Elaine Vanterpool, Lisa Banks
Student Posters
A cleft lip or palate is a congenital anomaly that occurs when a baby's mouth doesn’t form properly during pregnancy. It happens when the tissues that shape the upper lip or roof of the mouth fail to join during development. It is among the most common birth defects associated with genetic conditions or syndromes. Orofacial cleft can be caused by a combination of genes and other factors like the mother's exposure to environmental things, diet, and medications during pregnancy. Examining the genes involved and making connections that provide insight into the improper formations of the maxillary tissues during fetal stages …