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A Review Of Sars-Cov-2, Responsible For Covid-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks And How An Alternate Rbd Vaccine Is Safer?, Zmg Sarwar Jahangir, Arleta Helena Marnik Jan 2021

A Review Of Sars-Cov-2, Responsible For Covid-19: History, Biology, Infection Mechanism, Antigenic Vaccines, Their Risks And How An Alternate Rbd Vaccine Is Safer?, Zmg Sarwar Jahangir, Arleta Helena Marnik

Publications and Research

The SARS (severe acute respiratory syndrome)-CoV (Coronavirus)-2 S(spike)-protein mRNA/cDNA currently being used as vaccines are antigenic but not antigens against SARS-CoV-2, that causes COVID (Coronavirus Disease) -19. Furthermore, the mRNA and cDNA antigenic vaccines also have potentials for homologous as well as heterologous recombination, primarily into the somatic cell DNA of the vaccine recipients. On the contrary, a SARS-CoV-2 RBD-protein antigen, a part of the S-protein, will directly stimulate antibody production against SARS-CoV-2. Hence, a vaccine composed of SARS-CoV-2 RBD-protein as a safer, fast acting, and effective vaccine against SARS-CoV-2 and thus against COVID-19. This is also useful for some …

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The Influence Of Infant Formula On The Growth Of Commensal And Pathogenic Streptococcus Species In The Infant Oral Cavity, Geneva Waynick Jan 2021

The Influence Of Infant Formula On The Growth Of Commensal And Pathogenic Streptococcus Species In The Infant Oral Cavity, Geneva Waynick

Undergraduate Honors Theses

The oral microbiome is a complex community of microorganisms that can both reflect and greatly influence the health of the human host. A number of diseases are associated with dysbiotic oral microflora in infants and children, including dental (e.g. dental caries, gingivitis, and periodontal disease), and gastrointestinal diseases (e.g. pediatric appendicitis, celiac disease, and pediatric inflammatory bowel disease). A variety of factors can influence the composition of the oral microbial community in infants, including gestation length, mode of delivery, feeding method, and diet. This study focuses on the effects of diet on the growth of a commensal bacterium (Streptococcus …

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Investigating The Protective Effects Of Intestinal Gaba[Subscript A] Receptor Activation On An Animal Model Of Multiple Sclerosis, Hannah M. Kohl Jan 2021

Investigating The Protective Effects Of Intestinal Gaba[Subscript A] Receptor Activation On An Animal Model Of Multiple Sclerosis, Hannah M. Kohl

EWU Masters Thesis Collection

Gamma aminobutyric acid (GABA) is an inhibitory neurotransmitter, produced by neurons in the central nervous system (CNS) and by some species of intestinal bacteria. GABAA receptors are found not only in the CNS, but also in T cells and within the intestines. Past studies have indicated that GABA can have an anti-inflammatory effect and production of GABA by gut bacteria decreases in patients with multiple sclerosis (MS). We examined whether administration of a positive allosteric GABAA receptor modulator, farnesol, ameliorates the progression of experimental autoimmune encephalomyelitis (EAE), a murine model of MS and whether those effects correlated with a decrease …

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Effects Of Salt Runoff On Aquatic Macroinvertebrate Colonies, Kendra Fink Jan 2021

Effects Of Salt Runoff On Aquatic Macroinvertebrate Colonies, Kendra Fink

Journal of Earth and Life Science

Aquatic macroinvertebrates bridge the gap in part between primary and secondary consumers, making them ecologically important for most aquatic systems. They are used as biotic indicators for water quality due to their sensitivity to pollutants and may be affected, specifically, by chloride ion concentrations in the water. Water quality can be evaluated by looking at species compositions and their respective tolerance values. To determine long-term effects of road salt on macroinvertebrate colonies, a total of 338 identified macroinvertebrates of 10 families (two generalized to class) at 9 sites were collected from before, after, and between three bridges on Turtle River …

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Characterizing The Cellular Dynamics Of Nup155 And A Clinically Identified Variant, Emily Storm Jan 2021

Characterizing The Cellular Dynamics Of Nup155 And A Clinically Identified Variant, Emily Storm

Dissertations and Theses

The nuclear pore complex (NPC) is a highly conserved, yet dynamic structure within the cell. As the sole point of communication between the nucleus and cytoplasm, maintenance of its function and composition is essential. Recent studies have shown that both NPCs and their constitutive components, nucleoporins (NUPs), can have diverse roles separate from canonical transport. In addition, mutations in individual NUPs have been linked to a wide variety of clinical diseases, however, the exact mechanism by which they cause pathology is often unclear. Recently, a point mutation in NUP155, R391H, was identified specifically in patients with familial atrial fibrillation. We …

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Strategies For Successful Mangrove Living Shoreline Stabilizations In Shallow Water Subtropical Estuaries, Rebecca Fillyaw Jan 2021

Strategies For Successful Mangrove Living Shoreline Stabilizations In Shallow Water Subtropical Estuaries, Rebecca Fillyaw

Electronic Theses and Dissertations, 2020-2023

Mangrove living shorelines are an effective alternative to hard-armoring, which combat erosion while also increasing habitat. To improve the success of future mangrove deployments, an experimental Rhizophora mangle living shoreline was deployed within Mosquito Lagoon, FL. A factorial design was used to test the impact of mangrove age, breakwater presence, and mangrove placement on mangrove survival and growth. Environmental factors were monitored to isolate the reason for mangrove mortalities. Mangrove age was represented by 3 developmental stages: "seedlings" at 11-months-old, "transitionals" at 23-months-old, and "adults" between 35 and 47-months-old. Mixed mangrove age groups were included to identify if seedling survival …

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Dirofilaria Immitis Prevalence In Canis Latrans In Kentucky, Melanie Ann Brandon Jan 2021

Dirofilaria Immitis Prevalence In Canis Latrans In Kentucky, Melanie Ann Brandon

Murray State Theses and Dissertations

Dirofilaria immitis (canine heartworm) was found in forty-two (42) of the two hundred seventy-five (275) Canis latrans (coyote) necropsied in the state of Kentucky from November 27, 2019 through March 3, 2021. Thirty-five (35) of the positive cases were from western Kentucky region with the other seven spread across the state. With this group of coyotes, one hundred fifty-eight (158) were male and the other one hundred six-teen (116) were female. The estimated age ranged from a pup to senior dogs. A little over forty percent of the dogs were obtained through coyote/predator tournaments; the remaining were acquired from pest …

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Identification Of Loci Influencing Teosinte Crossing Barrier 1 (Tcb1) Efficacy In Maize By Quantitative Trait Loci (Qtl) Mapping And Genome-Wide Association Study (Gwas), Namrata Maharjan Jan 2021

Identification Of Loci Influencing Teosinte Crossing Barrier 1 (Tcb1) Efficacy In Maize By Quantitative Trait Loci (Qtl) Mapping And Genome-Wide Association Study (Gwas), Namrata Maharjan

Electronic Theses and Dissertations

Pollen cross-contamination has been a major problem for maize breeders. Various mechanical methods applied to avoid the contaminations are ineffective. The genetic factors related to maize fertilization can be used to develop an effective method to prevent pollen contamination. Pollen rejection ability controlled by Teosinte crossing barrier 1 (Tcb1) is such a genetic system. Silks possessing dominant Tcb1-s reject pollen possessing the recessive allele (tcb1). Successful fertilization occurs when Tcb1-s pollen falls upon tcb1 silks. The efficacy of dominant Tcb1-s was, however, reduced when repeatedly backcross with maize inbred lines, which suggests that there are modifiers to Tcb1-s. To find …

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Pollinator Ecology In Agroecosystems Of Eastern South Dakota, Isabela Beatriz Vilella-Arnizaut Jan 2021

Pollinator Ecology In Agroecosystems Of Eastern South Dakota, Isabela Beatriz Vilella-Arnizaut

Electronic Theses and Dissertations

Community structure contributes to ecosystem persistence and stability. To understand the mechanisms underlying pollination and community stability of natural areas in a human influenced landscape, a better understanding of the interaction patterns between plants and pollinators in disturbed landscapes is needed. Furthermore, understanding the potential conservation value in green spaces such as botanical gardens could assist in preserving and bolstering plant-pollinator interactions. Our study takes place in the Northern Great Plains which still retains extensive tracts of remnant temperate grassland habitat within a matrix of varying land-uses. First, we used a network-based approach to quantify how temperate grassland attributes and …

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Electrical Sensing In Non-Excitable Cells To Promote Galvanotaxis And Tissue Survival, Anyesha Sarkar Jan 2021

Electrical Sensing In Non-Excitable Cells To Promote Galvanotaxis And Tissue Survival, Anyesha Sarkar

Electronic Theses and Dissertations

Weak DC fields have been shown to induce polarity, cell migration and cell proliferation in 2D cultures in vitro. To understand the mechanism by which non-excitable cells sense such weak EFs, we have investigated the mechanism of cathode-directed water flow (electro-osmosis) in the boundary layer of cells by reducing it with neutral, viscous polymers. Our results indicate that low molecular weight polymers decrease cathodal migration and promote anodal migration in a concentration dependent manner. High molecular weight polymers do not affect directionality and can be explained using porosity and hydraulic permeability between the polymers. These results provide the first evidence …

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The Effects Of Food Supply On Reproductive Hormones And Timing Of Reproduction In An Income-Breeding Seabird, Shannon Whelan, Scott A. Hatch, Z. Morgan Benowitz-Fredericks, Charline Parenteau, Olivier Chastel, Kyle Elliott Jan 2021

The Effects Of Food Supply On Reproductive Hormones And Timing Of Reproduction In An Income-Breeding Seabird, Shannon Whelan, Scott A. Hatch, Z. Morgan Benowitz-Fredericks, Charline Parenteau, Olivier Chastel, Kyle Elliott

Faculty Journal Articles

Current food supply is a major driver of timing of breeding in income-breeding animals, likely because increased net energy balance directly increases reproductive hormones and advances breeding. In capital breeders, increased net energy balance increases energy reserves, which eventually leads to improved reproductive readiness and earlier breeding. To test the hypothesis that phenology of income-breeding birds is independent of energy reserves, we conducted an experiment on food-supplemented (“fed”) and control female black-legged kittiwakes (Rissa tridactyla). We temporarily increased energy costs (via weight handicap) in a 2 × 2 design (fed/unfed; handicapped/unhandicapped) during the pre-laying period and observed movement …

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Genomic Analysis Of The Only Blind Cichlid Reveals Extensive Inactivation In Eye And Pigment Formation Genes, Matthew L. Aardema, Melanie L.J. Stiassny, S. Elizabeth Alter Jan 2021

Genomic Analysis Of The Only Blind Cichlid Reveals Extensive Inactivation In Eye And Pigment Formation Genes, Matthew L. Aardema, Melanie L.J. Stiassny, S. Elizabeth Alter

Department of Biology Faculty Scholarship and Creative Works

Trait loss represents an intriguing evolutionary problem, particularly when it occurs across independent lineages. Fishes in light-poor environments often evolve “troglomorphic” traits, including reduction or loss of both pigment and eyes. Here, we investigate the genomic basis of trait loss in a blind and depigmented African cichlid, Lamprologus lethops, and explore evolutionary forces (selection and drift) that may have contributed to these losses. This species, the only known blind cichlid, is endemic to the lower Congo River. Available evidence suggests that it inhabits deep, low-light habitats. Using genome sequencing, we show that genes related to eye formation and pigmentation, as …

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A Baraminological Analysis Of The Landfowl (Aves: Galliformes), Timothy R. Brophy Jan 2021

A Baraminological Analysis Of The Landfowl (Aves: Galliformes), Timothy R. Brophy

Faculty Publications and Presentations

We performed a baraminological analysis on 60 extant landfowl taxa (Aves: Galliformes) using 102 morphological characters. Both baraminic distance correlation analysis and multidimensional scaling suggest the possibility of four holobaramins within the landfowl order: Megapodiidae, Cracidae, Numididae, and the remaining Phasianoidea. Hybridization, however, connects three of these holobaramins (six of the currently recognized families). Considering both sets of evidence, we conclude that the landfowl are composed of two holobaramins: Megapodiidae and [Phasianoidea + Cracidae]. The five currently recognized families in the superfamily Phasianoidea have, until recently, been considered subfamilies in a more broadly conceived family Phasianidae, so it should not …

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Effects Of Wastewater Effluent On Fish Fin Morphology Of Larval Fathead Minnows (Pimephales Promelas) And Swimming Performance Of Smallmouth Buffalo (Ictiobus Bubalus), Seth Michael Bogue Jan 2021

Effects Of Wastewater Effluent On Fish Fin Morphology Of Larval Fathead Minnows (Pimephales Promelas) And Swimming Performance Of Smallmouth Buffalo (Ictiobus Bubalus), Seth Michael Bogue

Masters Theses

The Sangamon River flows across central Illinois and is mostly free flowing except in the city of Decatur where it is impounded to form Lake Decatur. The Sanitary District of Decatur (SDD) is located approximately three miles downstream of the Lake Decatur dam. For a significant portion of the year, the stretch of the Sangamon River downstream of SDD is dominated by effluent due to limited discharge from the Lake Decatur dam. This has resulted in heavy nutrient loading, most notably phosphorus, and elevated levels of nickel and other compounds in the downstream section of the river. Smallmouth buffalo ( …

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Vertebrate Subfossil Localities In Taylorsville Metropark, Montgomery County, Ohio, Usa, Ryan Shell, Kristin Zimmerman, David Peterman, Charles Ciampaglio, Lauren Fuelling, Stephen J. Jacquemin Jan 2021

Vertebrate Subfossil Localities In Taylorsville Metropark, Montgomery County, Ohio, Usa, Ryan Shell, Kristin Zimmerman, David Peterman, Charles Ciampaglio, Lauren Fuelling, Stephen J. Jacquemin

Biological Sciences Faculty Publications

Karst features in the Silurian dolomites of Taylorsville MetroPark (Dayton Metropolitan Area, Ohio, United States) were explored from 2017 to 2018 to identify sites of paleontological interest. Initial landscape surveys recovered 124 skeletal elements (from 12 sites) that were attributed to 17 vertebrate species--including evidence of such extirpated animals as bobcats (Lynx rufus) and rattlesnakes (Crotalus sp.). Of the 12 sites, 9 sites contained remains from the historical era and 3 sites contained much older remains (n = 17) that were radiocarbon dated to approximately 1,400 years before present (YBP). Human remains at one site, butchered bones at another, and …

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Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff Jan 2021

Use Of Lymesim 2.0 To Assess The Potential For Single And Integrated Management Methods To Control Blacklegged Ticks (Ixodes Scapularis; Acari: Ixodidae) And Transmission Of Lyme Disease Spirochetes, Shravani Chitineni, Elizabeth R. Gleim, Holly D. Gaff

Undergraduate Honors Theses

Annual Lyme disease cases continue to rise in the U.S. making it the most reported vector-borne illness in the country. The pathogen (Borrelia burgdorferi) and primary vector (Ixodes scapularis; blacklegged tick) dynamics of Lyme disease are complicated by the multitude of vertebrate hosts and varying environmental factors, making models an ideal tool for exploring disease dynamics in a time- and cost-effective way. In the current study, LYMESIM 2.0, a mechanistic model, was used to explore the effectiveness of three commonly used tick control methods: habitat-targeted acaricide (spraying), rodent-targeted acaricide (bait boxes), and white-tailed deer targeted acaricide (4-poster …

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Quantifying The Effects Of Early Competition On Niche Specialization: A Natural Experiment In A Restored System, Christy Nicole Wails Jan 2021

Quantifying The Effects Of Early Competition On Niche Specialization: A Natural Experiment In A Restored System, Christy Nicole Wails

Graduate Research Theses & Dissertations

Islands support the greatest numbers of endemic species but are highly vulnerable to human activities. In particular, the introduction of invasive, predatory mammals (e.g., rodents) has resulted in sharp declines of island fauna due to a lack of evolved behavioral capacities to avoid depredation. Because of this, invasive species are considered to be one of the most detrimental impacts to biodiversity. To combat this biodiversity loss, the eradication of invasive mammals is now a primary conservation tool, with > 700 attempts globally. However, mammal eradications are predicated on the assumption that islands will naturally return to their pre-invaded condition. Yet many …

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Chemical Niche Divergence In Sympatric Lemurs: Understanding Species' Food Selection, Chloe Nicole Marie Gherardi Jan 2021

Chemical Niche Divergence In Sympatric Lemurs: Understanding Species' Food Selection, Chloe Nicole Marie Gherardi

Graduate Research Theses & Dissertations

The integration of nutritional ecology into primatology has provided considerable insight into the feeding strategies of primates, and the ecological factors limiting populations - critical knowledge in a world of rapidly changing habitats. The eastern rainforest of Madagascar is home to one of the world’s most diverse primate communities, often hosting over 12 sympatric lemur species; however, the ecological mechanisms by which these species are able to coexist are not well understood. Two species within this community that have been especially understudied are the nocturnal and folivorous Avahi laniger and Lepilemur mustelinus. My research team observed and collected feeding data …

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Lynn Margulis And Boris Kozo-Polyansky: How The Symbiogenesis Was Translated From Russian, Victor Fet Jan 2021

Lynn Margulis And Boris Kozo-Polyansky: How The Symbiogenesis Was Translated From Russian, Victor Fet

Biological Sciences Faculty Research

This contribution details the complex history of the early work by Boris Kozo-Polyansky (1924) that became available in English translation 86 years after it was published in Russian. The great American naturalist Lynn Margulis—whose serial endosymbiosis theory was presciently predated by Kozo-Polyansky by four decades—was instrumental in organizing this resurrection and ‘horizontal transfer’ of knowledge, forgotten by that time even in Russia.

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The Relationship Between Population Dynamics And Dietary Preferences Within Two Snake Genera (Storeria And Thamnophis), Molly M. Dixon Jan 2021

The Relationship Between Population Dynamics And Dietary Preferences Within Two Snake Genera (Storeria And Thamnophis), Molly M. Dixon

Master's Theses and Doctoral Dissertations

Amidst massive losses in biodiversity, it is vital to identify the factors driving species declines. The main objective of this research was to assess dietary differences between Storeria dekayi and Thamnophis sirtalis and their less abundant and more geographically restricted sister species, Storeria occipitomaculata and Thamnophis butleri, in Illinois and Michigan. I hypothesized that greater abundance and more cosmopolitan distribution are associated with consuming a wide variety of prey and more nonnative prey. To assess diets, I conducted field surveys of Storeria and Thamnophis and analyzed DNA metabarcoding data from fecal samples. I found no significant difference in the …

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Studies Of Insect Temporal Trends Must Account For The Complex Sampling Histories Inherent To Many Long-Term Monitoring Efforts, Ellen A.R. Welti, Anthony Joern, Aaron M. Ellison, David C. Lightfoot, Sydne Record, Nicholas Rodenhouse, Emily H. Stanley, Michael Kaspari Jan 2021

Studies Of Insect Temporal Trends Must Account For The Complex Sampling Histories Inherent To Many Long-Term Monitoring Efforts, Ellen A.R. Welti, Anthony Joern, Aaron M. Ellison, David C. Lightfoot, Sydne Record, Nicholas Rodenhouse, Emily H. Stanley, Michael Kaspari

Biology Faculty Research and Scholarship

Crossley et al. (2020)1 examine patterns of change in insect abundance and diversity across US Long-Term Ecological Research (LTER) sites, concluding “a lack of overall increase or decline”. This is notable if true, given mixed conclusions in the literature regarding the nature and ubiquity of insect declines across regions and insect taxonomic groups2–6. The data analyzed, downloaded from and collected by US LTER sites, represent unique time series of arthropod abundances. These long-term datasets often provide critical insights, capturing both steady changes and responses to sudden unpredictable events. However, a number of the included datasets are not …

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A Test Of Species Distribution Model Transferability Across Environmental And Geographic Space For 108 Western North American Tree Species, Noah D. Charney, Sydne Record, Beth E. Gerstner, Cory Merow, Phoebe L. Zarnetske, Brian J. Enquist Jan 2021

A Test Of Species Distribution Model Transferability Across Environmental And Geographic Space For 108 Western North American Tree Species, Noah D. Charney, Sydne Record, Beth E. Gerstner, Cory Merow, Phoebe L. Zarnetske, Brian J. Enquist

Biology Faculty Research and Scholarship

Predictions from species distribution models (SDMs) are commonly used in support of environmental decision-making to explore potential impacts of climate change on biodiversity. However, because future climates are likely to differ from current climates, there has been ongoing interest in understanding the ability of SDMs to predict species responses under novel conditions (i.e., model transferability). Here, we explore the spatial and environmental limits to extrapolation in SDMs using forest inventory data from 11 model algorithms for 108 tree species across the western United States. Algorithms performed well in predicting occurrence for plots that occurred in the same geographic region in …

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Ecocomdp: A Flexible Data Design Pattern For Ecological Community Survey Data, Margaret O'Brien, Colin A. Smith, Eric R. Sokol, Corinna Gries, Nina Lany, Sydne Record, Max C. N. Castorani Jan 2021

Ecocomdp: A Flexible Data Design Pattern For Ecological Community Survey Data, Margaret O'Brien, Colin A. Smith, Eric R. Sokol, Corinna Gries, Nina Lany, Sydne Record, Max C. N. Castorani

Biology Faculty Research and Scholarship

The idea of harmonizing data is not new. Decades of amassing data in databases according to community standards - both locally and globally - have been more successful for some research domains than others. It is particularly difficult to harmonize data across studies where sampling protocols vary greatly and complex environmental conditions need to be understood to apply analytical methods correctly. However, a body of longterm ecological community observations is increasingly becoming publicly available and has been used in important studies. Here, we discuss an approach to preparing harmonized community survey data by an environmental data repository, in collaboration with …

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The Iron-Responsive Genome Of The Chiton Acanthopleura Granulata, Rebecca M. Varney, Daniel Isaac Speiser, Carmel Mcdougall, Bernard M. Degnan, Kevin M. Kocot Jan 2021

The Iron-Responsive Genome Of The Chiton Acanthopleura Granulata, Rebecca M. Varney, Daniel Isaac Speiser, Carmel Mcdougall, Bernard M. Degnan, Kevin M. Kocot

Faculty Publications

Molluscs biomineralize structures that vary in composition, form, and function, prompting questions about the genetic mechanisms responsible for their production and the evolution of these mechanisms. Chitons (Mollusca, Polyplacophora) are a promising system for studies of biomineralization because they build a range of calcified structures including shell plates and spine- or scale-like sclerites. Chitons also harden the calcified teeth of their rasp-like radula with a coat of iron (as magnetite). Here we present the genome of the West Indian fuzzy chiton Acanthopleura granulata, the first from any aculiferan mollusc. The A. granulata genome contains homologs of many genes associated …

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Fishes Of The Cypress Creek System, Tennessee River Drainage, Jeffery M. Ray, Mitchell S. Lovell, Benjamin S. Wilson, Stuart W. Mcgregor, Gary A. Hastert Jan 2021

Fishes Of The Cypress Creek System, Tennessee River Drainage, Jeffery M. Ray, Mitchell S. Lovell, Benjamin S. Wilson, Stuart W. Mcgregor, Gary A. Hastert

Biology

Cypress Creek is a northern tributary to the Tennessee River (Pickwick Lake) in Lauderdale County, Alabama, and Wayne County, Tennessee, with a drainage area of 214 square miles. Although repeatedly sampled for fishes such as Slackwater Darter, Etheostoma boschungi, Tuscumbia Darter, E. tuscumbia, and Flame Chub, Hemitremia flammea, over the past several decades, the last comprehensive fish survey of the watershed was conducted in 1971, and changes in the fish fauna and community composition may have occurred. Historical data (1845‐ 2019) containing 5,105 records was compiled for 109 species reported at least once from the Cypress Creek system. Samples from …

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Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka Jan 2021

Intrabodies Reveal Critical Steps Involved In Ricin's Interactions With The Ribosome, Timothy Francis Czajka

Legacy Theses & Dissertations (2009 - 2024)

Ricin is a highly lethal protein toxin derived from the seeds of the castor plant, Ricinus communis. It is a Type II ribosome inactivating protein (RIP), meaning it is a heterodimer with one subunit, ricin toxin B (RTB), that mediates cell surface attachment and intracellular trafficking and a second subunit, ricin toxin A (RTA), that irreversibly shuts down protein synthesis in the cytosol. During trafficking, RTA and RTB necessarily separate in the endoplasmic reticulum, wherein RTA unfolds and translocates into the cytosol where it refolds into an enzymatically active conformation. RTA is remarkably fast acting and efficient, with few molecules …

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Study Of Primary Cilium Structure And Intraflagellar Transport, Shufeng Sun Jan 2021

Study Of Primary Cilium Structure And Intraflagellar Transport, Shufeng Sun

Legacy Theses & Dissertations (2009 - 2024)

Primary cilia are hair-like protrusions that stem from the basal bodies in the cytoplasm and extend into the extracellular space to sense signals. Intraflagellar transport (IFT) functions to transport cargo molecules into and out of the ciliary compartment to assemble, maintain, and disassemble the cilia. Accurate knowledge of the three-dimensional (3D) structure of primary cilia and precise details of the IFT profile is the foundation for understanding the sensory functions of primary cilia. This work covers three aspects of primary cilia. Firstly, we obtained and analyzed the overall 3D architecture of the complete primary cilia axoneme region using serial section …

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Residual Spatial Autocorrelation In Macroecological And Biogeographical Modeling: A Review, Guetchine Gaspard Jan 2021

Residual Spatial Autocorrelation In Macroecological And Biogeographical Modeling: A Review, Guetchine Gaspard

Theses and Dissertations--Geography

Macroecological and biogeographical modelers have predicted the distribution of species across space relying on the relationship between biotic processes and environmental variables. Such a method employs data associated, for instance, with species abundance or presence/absence, climate, geomorphology, and soils. Statistical analyses found in previous studies have highlighted the importance of accounting for the effects of spatial autocorrelation (SAC), which indicates a level of dependence between pairs of nearby observations. A consensus has existed that residual spatial autocorrelation (rSAC) can substantially impact modeling processes and inferences. However, more emphasis should be put on identifying the sources of rSAC and the degree …

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Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi Jan 2021

Identification Of Differentially Expressed Micrornas In Primary Esophageal Achalasia By Next-Generation Sequencing, Mahin Gholipour, Javad Mikaeli, Seyed Javad Mowla, Mohammad Reza Bakhtiarzadeh, Marie Saghaeian Jazi, Naeme Javid, Narges Fazlollahi, Masoud Khoshnia, Naser Behnampour, Abdolvahab Moradi

Turkish Journal of Biology

Molecular knowledge regarding the primary esophageal achalasia is essential for the early diagnosis and treatment of this neurodegenerative motility disorder. Therefore, there is a need to find the main microRNAs (miRNAs) contributing to the mechanisms of achalasia. This study was conducted to determine some patterns of deregulated miRNAs in achalasia. This case-control study was performed on 52 patients with achalasia and 50 nonachalasia controls. The miRNA expression profiling was conducted on the esophageal tissue samples using the next-generation sequencing (NGS). Differential expression of miRNAs was analyzed by the edgeR software. The selected dysregulated miRNAs were additionally confirmed using the quantitative …

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Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng Jan 2021

Analyzing Differentially Expressed Genes And Pathways Of Bex2-Deficient Mouse Lung Via Rna-Seq, Noor Bahadar, Hanif Ullah, Salah Adlat, Rajiv Kumar Sah, May Zun Zaw Myint, Zin Mar Oo, Fatoumata Binta Bah, Farooq Hayel Nagi, Hsu Htoo, Ahmad Ud Din, Xuechao Feng, Yaowu Zheng

Turkish Journal of Biology

Bex2 is well known for its role in the nervous system, and is associated with neurological disorders, but its role in the lung's physiology is still not reported. To elucidate the functional role of Bex2 in the lung, we generated a Bex2 knock-out (KO) mouse model using the CRISPR-Cas9 technology and performed transcriptomic analysis. A total of 652 genes were identified as differentially expressed between Bex2-/- and Bex2+/+ mice, out of which 500 were downregulated, while 152 were upregulated genes. Among these DEGs, Ucp1, Myh6, Coxa7a1, Myl3, Ryr2, RNaset2b, Npy, Enob1, Krt5, Myl2, Hba-a2, and Nrob2 are the most prominent …

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