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The Effects Of Roadways On The Spatial And Temporal Movement Patterns Of Timber Rattlesnakes (Crotalus Horridus), Anna F. Tipton, Dominic L. Desantis

Graduate Research Showcase

Roadways are among the most widespread and disruptive anthropogenic land use features that influence the behavior and movement of wildlife. Negative impacts include vehicle-induced mortality, habitat destruction and fragmentation, and creating barriers to movement which can have far-reaching sub-lethal effects. In an effort to improve upon historical methods of evaluating the influence of prominent landscape features, such as roads, on the movement of small and secretive wildlife, we are using a novel integration of emerging spatial analyses and tri-axial accelerometry in Timber Rattlesnakes (Crotalus horridus) from central Georgia. We used dynamic Brownian Bridge Movement Models to estimate motion …

Validating An Automated Classification System For Snake Movement Behavior: Refining And Extending The Radio Telemetry-Accelerometry Framework, Dominic L. Desantis

College of Arts and Sciences

An animal’s behavioral decisions, such as when, why, and how individuals move through their environment, are mediated by a complex interplay between internal (e.g., sex, physiological state, motivational state) and external (e.g., environmental conditions, predation, competition) factors. A detailed understanding of the causes and consequences of these decisions for many species has historically been precluded by methodological constraints. However, a recent wave of advancements in sensor technologies circumvents many of these traditional limitations and has spurred the emerging field of biologging science. Animal-attached dataloggers (or biologgers) give researchers the ability to remotely monitor an individual’s physiology and behavior in the …

Soil Macroinvertebrate Responses To Wildfires In The Blue Ridge Mountains, Usa, Madeline Nicole Olliff, Bruce Snyder, Mac Callaham Jr., Melanie K. Taylor

Graduate Research Showcase

Title: Soil Macroinvertebrate Responses to Wildfires in the Blue Ridge Mountains, USA Authors: 1Madeline N. Olliff, 1Bruce A. Snyder, 2Melanie K. Taylor, and 2Mac A. Callaham

1Georgia College and State University, Milledgeville, Georgia, USA; 2USDA Forest Service, Southern Research Station, Athens, Georgia, USA

Abstract: Wildfires are of increasing concern in light of climate change, more frequent late summer droughts, and increasing incidence of human ignitions. There have been few studies examining the effects of wildland fires on soil macroinvertebrates in the Blue Ridge Mountains, in spite of the importance of these animals to soil processes, and their contributions to the …

What Common Factors May Influence The Success Of Dental Implant?, Yehuda Taavar

The Science Journal of the Lander College of Arts and Sciences

The aim of this study is to investigate the common factors that may influence the success of dental implants. Addressing these factors may potentially aid experts in the field in delivering dental implants without approaching or decreasing the number of failures. Smoking, diabetes, implant maintenance, age, and implant size have significantly influenced implant success. It is suggested that patients are advised to quit smoking at least one week before surgery to minimize risk factors. Inadequate glycemic control also contributes to periodontal destruction and is associated with the severity of peri-implant complications. However, if patients maintain good glycemic control, dental implants …

Exploring Microbiome Functional Dynamics Through Space And Time With Trait-Based Theory, Leonora S. Bittleston, Zachary B. Freedman, Jessica R. Bernardin, Jacob J. Grothjan, Erica B. Young, Sydne Record, Benjamin Baiser, Sarah M. Gray

Biology Faculty Research and Scholarship

Microbiomes play essential roles in the health and function of animal and plant hosts and drive nutrient cycling across ecosystems. Integrating novel trait-based approaches with ecological theory can facilitate the prediction of microbial functional traits important for ecosystem functioning and health. In particular, the yield-acquisition-stress (Y-A-S) framework considers dominant microbial life history strategies across gradients of resource availability and stress. However, microbiomes are dynamic, and spatial and temporal shifts in taxonomic and trait composition can affect ecosystem functions. We posit that extending the Y-A-S framework to microbiomes during succession and across biogeographic gradients can lead to generalizable rules for how …

The Dual Nature Of Metacommunity Variability, Thomas Lamy, Nathan I. Wisnoski, Riley Andrade, Max C. N. Castorani, Aldo Compagnoni, Nina Lany, Luca Marazzi, Sydne Record, Christopher M. Swan, Jonathan D. Tonkin, Nicole Voelker, Shaopeng Wang, Phoebe L. Zarnetske, Eric R. Sokol

Biology Faculty Research and Scholarship

There is increasing interest in measuring ecological stability to understand how communities and ecosystems respond to broad-scale global changes. One of the most common approaches is to quantify the variation through time in community or ecosystem aggregate attributes (e.g. total biomass), referred to as aggregate variability. It is now widely recognized that aggregate variability represents only one aspect of communities and ecosystems, and compositional variability, the changes in the relative frequency of species in an assemblage, is equally important. Recent contributions have also begun to explore ecological stability at regional spatial scales, where interconnected local communities form metacommunities, a key …

Harnessing The Neon Data Revolution To Advance Open Environmental Science With A Diverse And Data-Capable Community, R. Chelsea Nagy, Jennifer K. Balch, Erin K. Bissell, Megan E. Cattau, Nancy F. Glenn, Benjamin S. Halpern, Nayani Ilangakoon, Brian Johnson, Maxwell B. Joseph, Sergio Marconi, Catherine O'Riordan, Sydne Record

Biology Faculty Research and Scholarship

It is a critical time to reflect on the National Ecological Observatory Network (NEON) science to date as well as envision what research can be done right now with NEON (and other) data and what training is needed to enable a diverse user community. NEON became fully operational in May 2019 and has pivoted from planning and construction to operation and maintenance. In this overview, the history of and foundational thinking around NEON are discussed. A framework of open science is described with a discussion of how NEON can be situated as part of a larger data constellation—across existing networks …

Propranolol Sensitizes Vascular Sarcoma Cells To Doxorubicin By Altering Lysosomal Drug Sequestration And Drug Efflux, Jhuma Saha, Jong Hyuk Kim, Clarissa N. Amaya, Caleb M. Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Erin B. Dickerson

Faculty Publications

Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance. We previously identified a subset of doxorubicin-resistant cells in human angiosarcoma and canine hemangiosarcoma cell lines that exhibit high lysosomal accumulation of doxorubicin. Hydrophobic, weak base chemotherapeutics, like doxorubicin, are known to sequester within lysosomes, promoting resistance by limiting drug accessibility to cellular targets. Drug synergy between the beta adrenergic receptor (β-AR) antagonist, propranolol, and multiple chemotherapeutics has been documented in vitro, and …

Rna Splicing In Neuron Physiology And Neurodegenerative Diseases, Md Faruk Hossain

Theses and Dissertations

Gene expression is regulated at multiple levels, including transcription, RNA editing, pre-mRNA splicing, mRNA export, translation, and posttranslational modifications. Alternative splicing is a process by which exons can be included or excluded, giving rise to multiple mRNA isoforms from the same transcript. Alternative splicing is an important mechanism in developmental, tissue- and cell-specific control of gene expression, and it is key for expanding proteomic diversity and complexity from a limited number of genes. Moreover, more than 95% of multiexon genes undergo alternative splicing in humans, and about half of all disease-causing point mutations in humans affect pre-mRNA splicing, including neurological …

Repeatability Of Foraging Behavior Following A Simulated Predation Attempt Depends On Color Morph, Sex, And Foraging Metric In Red-Backed Salamanders (Plethodon Cinereus), Brian P. Waldron*, Marissa C. Ganzfried*, Cari-Ann M. Hickerson, Carl D. Anthony

2021 Faculty Bibliography

Behavioral repeatability greatly affects the capacity of an individual to respond to varying environments. When multiple behaviors within individuals are repeatable and correlated across time or across contexts, it is termed a behavioral syndrome. However, not all behaviors exhibit the same level of repeatability, and relatively few studies have examined repeatability in amphibians. We examined the repeatability of foraging behavior in the Eastern Red-backed salamander (Plethodon cinereus), a color-polymorphic terrestrial salamander, following a simulated predation attempt. We tested several hypotheses: (1) Simulated predation would negatively affect foraging, increasing latency to feed and decreasing the number of prey items eaten in …

New Piperidine Alkaloids From Fire Ants Are Not Sequestered By The Green And Black Poison Frog ( Dendrobates Auratus ), Ian Davison, Ralph Saporito, Lisa M. Shulte, Kyle Summers

2021 Faculty Bibliography

Neotropical poison frogs possess alkaloid-based antipredator defenses which they sequester from a diet of arthropods such as oribatid mites and myrmicine ants. Alkaloid sequestration is still poorly understood and although several studies have examined its uptake, most experiments directly feed alkaloids to the frogs. Here, we examined the alkaloid uptake system in the poison frog species Dendrobates auratus by feeding it an alkaloid-containing prey item, the red imported fire ant Solenopsis invicta (Formicidae, Myrmicinae). Captive bred frogs were either fed live ants or fruit flies dusted with powdered ants for 4 months. Using GC–MS, we confirm that S. invicta contain …

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A New Species Of Cryptic Cyanobacteria Isolated From The Epidermis Of A Bottlenose Dolphin And As A Bioaerosol, Amber O. Brown, Caitlin S. Romanis, Petr Dvorak, Amanda J. Foss, Quincy A. Gibson, Chelsea D. Villaneuva, Wendy N. Durden, Anyssa D. Garvey, Phillip Jenkins, Petr Hasler, Jeffrey R. Johansen, Brett A. Neilan, Dale A. Casamatta

2021 Faculty Bibliography

No abstract provided.

The Crazy Critter Club - Lesson Plans, Caitlin Flynn Copenhaver, Audrey Anderson

Honors Program: Expanded Learning Clubs

This curriculum covers the lesson plans for the 2021 "Cool Critter Club". It is focused on teaching students about animals and the environment, especially at a local level. This club engages students through the use of games, art, and spending time outside.

Assessing Pace-Of-Life: Comparing Metabolism And Behavior In Tarantulas, Haley Vanscoyoc

Master's Theses and Doctoral Dissertations

Pace-of-Life Syndrome (PoLS) links physiology, behavior, and life history to understand how an organism lives and is under-researched in many invertebrate groups. In this study I used five tarantula species to assess if they follow the predictions of PoLS. I compared individual species as well as Old- and New-World lineages and solitary and sub-social species. I predicted that Old- World and sub-social species would have higher resting metabolic rates (RMRs) and activity levels compared to New-World and solitary species. RMRs were measured using an open-flow respirometry system, and a classic open-arena test was used to assess activity level. Spearman’s correlation …

Dung Beetle (Scarabaeinae) Diversity Of The Highest Elevation In West Africa: The Nimba Mountain Range, Jacob Bowen

Mahurin Honors College Capstone Experience/Thesis Projects

The Nimba Mountain Range in Guinea, Ivory Coast, and Liberia is within the Upper Guinean Forests, a critical biodiversity hotspot highly threatened by various human activities. The region is home to many endemic species including the viviparous Nimba toad, Nimba otter-shrew, and the discrete Bossou chimpanzee population. Dung beetles can act as a focal taxon from which extrapolation to the diversity of other taxa and ecosystem health can be made. Elevational trends in dung beetle diversity were investigated on the Nimba Mountain Range and in the nearby Bossou Chimpanzee reserve in Guinea. Dung beetle species diversity surveys aimed to document …

Acoustic Communication In The Atlantic Mudskipper, Periopthalmus Barbarus, Seth Hoffman

Mahurin Honors College Capstone Experience/Thesis Projects

Mudskippers are intertidal fishes that can survive both in and out of the water. They are territorial and exhibit behaviors to attract mates and defend against competitors. Recently, it has been shown that vibrations are produced and transmitted through the mud during such displays in one species, Periophthalmodon septemradiatus. To see if similar vibrations are produced in other species of mudskippers, I recorded the behavioral interactions of pairs of the mudskipper Periophthalmus barbarus via digital video and acoustic signals via accelerometer. Comparative analysis of fish mass, sex, contest length, and contest outcome coupled with acoustic characteristics within dyadic pairings …

A Comparison Of Bee Abundance And Species Richness In Three Managed Grassland Types, Emily Russ

Mahurin Honors College Capstone Experience/Thesis Projects

Bees are threatened by environmental changes, pathogens, and pesticides (Pettis, 2012, Meeus et al., 2018). The goal of the study is to compare and evaluate the bee abundance and species richness in three different field types. My hypothesis is that bees would favor the fields planted for their benefit, and that the tall grass dominated plantings would be preferred over mowed fescue. My findings have low power considering few replicates and the use of relative abundance and relative species richness for statistical analyses. Bee abundance and species richness had an overall positive relationship of varying degrees across habitat types. Relative …

Antibiotic Resistant Gene Concentrations In Bacteria In Groundwater From Agricultural Waste, Koji Barnaby

Mahurin Honors College Capstone Experience/Thesis Projects

The overuse of antibiotics has led to an increase in antibiotic resistant bacteria since some antibiotics are sent into the wastewater system by waste produced by both humans and agriculture, making exposure to these bacteria more likely. The evolution of these bacteria in groundwater is of particular concern, as groundwater is used as a source of drinking water, and infections by these bacteria would be more difficult to treat. There are no policies in place to monitor or regulate antibiotic resistance bacteria in groundwater, leaving the threat to public health unknown. The study area of Crumps Cave in Smiths Grove, …

Effect Of Acute Sleep Fragmentation Upon Inflammatory Response Of Brown And White Adipose Tissue In Male Mice, Zach Wriedt

Mahurin Honors College Capstone Experience/Thesis Projects

Sleep is an important process required for vertebrates, including humans, to function. When sleep is disrupted, it leads to deleterious effects such as inflammatory responses throughout the body. Past studies have shown that acute (24 h) sleep fragmentation (SF) leads to an inflammatory response in white adipose tissue. However, whether brown adipose tissue responds in a similar fashion is unknown. Male adult (>8 weeks of age) C57BL/6j mice were subjected to SF for 24 h using a cage outfitted with a bar that moves horizontally across the cage every 2 min to periodically awaken mice (N =10). Controls were …

Understanding Pathophysiology Of Nonsyndromic Autism By Examining And Extrapolating From Syndromic Variants, Alexander Labkowsky

The Science Journal of the Lander College of Arts and Sciences

Autism spectrum disorder (ASD) is a broad, heterogeneous neurodevelopmental disorder encompassing a range of presentation and severity. The common characteristics include communication deficits, impaired social skills, dependency on routine, sensitivity to environmental change, and stereotyped behavior (DSM-5, 2013). When ASD is accompanied by a host of other symptoms it is often referred to as syndromic autism. Syndromic autism is usually severe and can usually be traced to deletions or duplications on a specific gene. These monogenic disorders are by definition easier to diagnose and are good candidates for study since specific biological markers can be assessed and tracked. There have …

The Role Of Immunotherapy In Treating High-Risk Neuroblastoma, Mollie Raczkowski

The Science Journal of the Lander College of Arts and Sciences

Neuroblastoma originates from the cells in the neural crest. High-risk neuroblastoma, patients have poor outcomes even with the multi-step treatment plans, including immunotherapy maintenance treatment. Researchers in developmental biology search for unique antigens in neuroblastoma cells to utilize monoclonal antibodies (mAbs). Currently, GD2 is the most effective antigen that scientists have isolated in the tumor; these anti-GD2 mAbs are administered in the forms of Dinutuximab or Dinutuximab beta to attack the tumor. Monoclonal antibodies are currently administered in neuroblastoma instead of CAR T (that has seen success in curing different types of leukemias) due to the heterogeneity of this tumor. …

A Study Of Bone Histology Procedures And Applications, Breanna Smith

Student Research Poster Presentations 2021

Bone histology paired with ontogeny can allow for discovery of the way in which an individual grows. “Bone” umbrellas so many types and patterns which are all linked to both environmental and genetic influences. Vascular patterns allow for the differentiation of growth rates and growth periods. Veracious usage of terminology and proper specimen selection can lead to these explanations.

Aquatic Coleoptera Of Northern Negros, Philippines, Marc Ryan Sabordo, Carl Michael Buyco, Gwendalyn Henares, Jessica Pacalioga, Hendrik Freitag

Biology Faculty Publications

The water beetle fauna of northern Negros Island has not been comprehensively studied. In this study, aquatic Coleoptera of northern Negros have been compiled from various collections. Specimens were sampled through manual sampling and light trap. Twenty-six (26) species were recorded including 21 which are Philippine endemics. Nine genera and three known species are recorded for the first time from Negros.. Notes on distribution, ecology and identification are provided. Possible new species, future potential discoveries as well as current significance in terms of conservation are discussed.

Crippling Rapid Evolution Of Metastasis And Drug Resistance In A549 Non-Small Cell Lung Cancer Cells With The Clinically Relevant Hsp90 Inhibitor Auy922, Nickolas Anthony Bacon

Theses, Dissertations and Capstones

The ability for species to evolve new features in response to changing circumstances in order to survive and propagate is a ubiquitous observation on both the macroscopic and microscopic levels of living systems. It should be no surprise, then, that diseases such as cancer utilize their own forms of adaptation to perpetuate themselves when exposed to external threats. Indeed, concepts drawn from Darwinian evolution are now widely accepted to help explain certain aspects of carcinogenesis and malignant progression, the sum of which have come to be known as the theory of tumor evolution. Since metastasis and drug resistance are features …

Comparing The Condition Of Deformed And Non-Deformed Walleyes In Long Lake, Mn, Clayton Beck

Journal of Earth and Life Science

Walleye Sander vitreus is a popular game fish in Minnesota. Walleye’s have become such a popular game fish for anglers that it has led agencies to raise Walleye in rearing ponds. Farm raised fish can show deformities due to environmental, genetic, nutritional, infectious, and toxic factors. Due to this phenomenon, the purpose of this study was to determine if the condition of the Walleye differed between those with and without deformities in Long Lake, MN. Angling was the method of capture during the months of September 2020 through July 2021. There was no evidence to suggest condition differed between non-deformed …

Occurrence Of Tick-Borne Diseases And Parasites Of American Black Bears In Lakewood And Hiles, Wisconsin, Daniela Mathieu

Undergraduate Honors College Theses 2016-

We conducted a study of 159 American Black Bears (Ursus Americanus) to establish the occurrence rates of Lyme disease, Rocky Mountain spotted fever (RMSF), babesiosis, Ehrlichiosis, and anaplasmosis as well as the presence of their vectors Dermacentor variabilis and Rhipicephalus sanguineus. There are many factors that influence the prevalence of not only the ticks, but tick-borne diseases as well including seasonal and environmental changes, interactions between humans and their domestic animals, as well as changes observed in the tick and host species themselves. We studied the effects of sex, location, and the presence of fecal parasites based on the tick …

Using Audio Recording Devices And Multiseason Occupancy Modelling To Evaluate Clark's Nutcracker (Nucifraga Columbiana) Occurrence In Whitebark Pine Habitats Of Washington's Cascade Mountains, Lauren Taracka

Undergraduate Honors Theses

The Clark’s nutcracker (Nucifraga columbiana) and whitebark pine (Pinus albicaulis), both native to the harsh subalpine habitats of Washington’s Cascade Mountains, are being negatively impacted by white pine blister rust (Cronartium ribicola), the mountain pine beetle (Dendroctonus ponderosae), and climate change. As temperatures continue to warm, while many species at lower elevations can move upward in elevation to suit their temperature needs, subalpine species do not have that option. Whitebark pine is a keystone tree species - numerous animals consume its high fat, high energy seeds; it’s a nurse tree, providing shelter …

Protein Prenylation In The Moss Physcomitrium Patens, Zayna H. Qaissi, Anam F. Ahmed, Katherine V. Brown, Mark P. Running

Undergraduate Arts and Research Showcase

Protein prenylation is the addition of a 15 or 20 carbon lipid to a cysteine near carboxyl terminus of target proteins. Prenylation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction. Protein prenylation is generally conserved among eukaryotes, and mutations in genes that carry out prenylation are lethal in animals and yeast. In plants prenylation mutations are not always lethal, but they do affect development, disease resistance, biofuel production, and drought response, among other processes of agricultural interest. To understand the evolutionary and developmental implications of plant protein prenylation, we used the sequenced, annotated, and translated genome of the moss …

Estrogen Disruption Of Hypothalamic Neural Activity, Princess Dickson

Cal Poly Humboldt theses and projects

The brain is highly dependent on the endocrine system for proper neurodevelopment, as it plays a key role in many biological processes. Bisphenol A is a chemical found in plastics that has the potential to mimic the effects of Estrogen in the body, at least weakly. People interact with plastic that contains BPA regularly, and people are at risk for exposure even before being born. The abundance of BPA, along with other exogenous estrogens, makes examining the relationship between early exposure and changes in brain activity imperative. The current study aims to establish a relationship between disrupted estrogen function and …

Phylogeography, Diversification, And Historical Demography Of The White-Toothed Rats (Berylmys) In Indochina, Kristy Lee Tuttle

Graduate Research Theses & Dissertations

Berylmys, the White-toothed rats, and other members of the Rattus sl (Rattus, Maxomys, Leopoldamys, Niviventer, Bandicota, and Sundamys) evolved from 3-5 million years ago during a period of dynamic landscape change in Indochinese south Asia wherein climatically stable, warm forests of Miocene and Pliocene Indochina transitioned to a modern landscape regime. From the late Pliocene through the terminal Pleistocene, climate changes, ecological shifts, rising and falling sea levels, and tectonic uplift drove adaptive radiation within Rattus sl, in complex interactions that are still not completely understood. The goal of this study is to understand species relationships and population structure in …