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Investigating The Efficacy Of Jak2/Stat3 And Pi3k/Mtor Inhibitory Therapy On Glioblastoma And Basal Breast Cancer Cell Lines, Neftali Vazquez
Investigating The Efficacy Of Jak2/Stat3 And Pi3k/Mtor Inhibitory Therapy On Glioblastoma And Basal Breast Cancer Cell Lines, Neftali Vazquez
Theses and Dissertations
The JAK2/STAT3 and PI3K/mTOR pathways are upregulated in cancer cells. STAT3 promotes a positive feedback loop for the stem program whereas PI3K inhibits FOXOs tumor suppressor role and mTOR promotes tumorigenic advancement. Particularly GBM and BBC are aggressive cancers that have a stem cell population that makes them difficult to treat and metastatic. We investigate the effects of a combination therapy that inhibits JAK2/STAT3 and PI3K/mTOR output aiming to lower stem cell expression and promote apoptosis. Our collected data indicates that the dual inhibition induced apoptosis, but it also increased the stem cell signature. The findings pave way for the …
Social Influences On Vocal Development In A Wild Parrot, Caleb Michael Mand Arellano
Social Influences On Vocal Development In A Wild Parrot, Caleb Michael Mand Arellano
Theses and Dissertations
The Social Intelligence Hypothesis (SIH) proposes that navigating complex societies requires increased neural processing to monitor shifting relationships. SIH evolutionary focus of brain size variation in adults originally ignored the developmental frameworks leading to increased sociality. I studied the ontogeny of early sibling interactions in wild Green‐rumped Parrotlets (Forpus passerinus) in a Venezuelan population that exhibited large variation in brood size and engaged in elaborate social interactions and complex social learning during nestling development. To test if nests of varying brood sizes exhibit differences in social complexity, I quantified the number and strength of sibling play partnerships, as a proxy …