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Articles 151 - 172 of 172
Full-Text Articles in Entire DC Network
The Optimization Of A One-Pot Heteroconjugate Addition-Oxidation-Diels-Alder Reaction, Christina Vivelo
The Optimization Of A One-Pot Heteroconjugate Addition-Oxidation-Diels-Alder Reaction, Christina Vivelo
Honors Theses
Ynoate esters are ideal reagents for one-pot reactions due to their ability to undergo multiple addition reactions in one flask. Ethyl propiolate undergoes a heteroconjugate addition reaction with aromatic thiol nucleophiles, producing an enoate which is then oxidized by m-CPBA and is able to undergo a Diels–Alder reaction with cyclopentadiene. The work presents the optimization of a three-step heteroconjugate addition-oxidation-Diels–Alder reaction to yield cyclic compounds favoring endo stereochemistry, which may be used in further synthesis of biologically active compounds such as (+)-Methyl-5-epi-Shikimate or Deipeptyl-IV-Peptidase inhibitor.
The Relationship Between Live Coral And Macroalgae In South Caicos As Influenced By Herbivorous Fishes, Sarah Byce
The Relationship Between Live Coral And Macroalgae In South Caicos As Influenced By Herbivorous Fishes, Sarah Byce
Honors Theses
Marine life is the basis for most industries in the Turks and Caicos Islands, located on the outskirts of the Caribbean Sea. Few studies have been carried out to assess the current status of reefs in this region, especially those off the shore of South Caicos Island. The AGRRA v.4.0 methodologies were employed create baseline assessments of stony corals, macroalgae and associated fishes and to explore the relationships between these key reef organisms. This study was based on 10 different locations both inside and outside of Marine Protected Areas (MPAs) and including exposed and sheltered reefs in proximity to South …
Co-Crystallization And Polymorphism Of Naturally Occurring Peptide Derivatives, Kevin Crowley
Co-Crystallization And Polymorphism Of Naturally Occurring Peptide Derivatives, Kevin Crowley
Honors Theses
Carnosine is a dipeptide compound that is found in many dietary supplements and food products. Carnosine has many functions in the body, such as alleviating oxidative stress on tissues by acting as an antioxidant compound. Carnosine, therefore, has important anti-aging properties. Carnosine is also capable of forming protective sequestration structures around heavy metal ions; this process of chelating metals ions in solutions is very beneficial for maintaining the well-being of cells in the body. Thus, carnosine could be useful in pharmaceutical products for creating anti-aging drugs that would reduce tissue stress and promote a healthy cellular environment. I attempted to …
The Impact Of Tricaine Methanesulfonate, 2-Phenoxyethanol, And Carvone-Methyl Salicylate On The Innate Immune Response Of Zebrafish (Danio Rerio), Charles R. Wulff
The Impact Of Tricaine Methanesulfonate, 2-Phenoxyethanol, And Carvone-Methyl Salicylate On The Innate Immune Response Of Zebrafish (Danio Rerio), Charles R. Wulff
Honors Theses
Anesthesia plays a vital role in the maintenance of aquaculture species, where it is used to minimize stress during complex handling tasks such as transport, assessment, and harvesting. However, anesthetics have been shown to suppress the innate immune response, which could impact immunity and increase risk of infection. Tricaine methanesulfonate (MS-222) and 2-Phenoxyethanol (2-PE) represent two of the most commonly used anesthetics in aquaculture, with R-(+)-carvone, in the form of carvone-methyl salicylate (CMS) has recently been proposed as an alternative anesthetic for food fish. These three anesthetics were used to assess the influence of anesthetics on the immune system of …
Increasing Lipoxygenase Solubility Through Fusion Of Highly Acidic Peptides, Rachel Fabacher
Increasing Lipoxygenase Solubility Through Fusion Of Highly Acidic Peptides, Rachel Fabacher
Honors Theses
No abstract provided.
Patterns Of Apoptotic Poly(Adp-Ribose) Polymerase Cleavage Induced By Laromustine And Its Analogs, Adam N. Paine
Patterns Of Apoptotic Poly(Adp-Ribose) Polymerase Cleavage Induced By Laromustine And Its Analogs, Adam N. Paine
Honors Theses
The anticancer prodrug Laromustine (VNP40101M) has produced promising remission rates in clinical trials among leukemic patients relative to currently available chemotherapeutics. Such improvements demand that the agent’s mechanism of action be elucidated. This study aimed to determine the role of poly(ADP-ribose) polymerase (PARP) in Laromustine-induced cell death. Previous studies indicated that the methyl isocyanate produced upon activation of Laromustine is largely responsible for its effective induction of apoptosis. Results reported herein strongly support the activation of a PARP-dependent apoptotic pathway by Laromustine’s carbamoylating and chlorethylating subspecies. Furthermore, it is evident that the Laromustine-induced PARP-dependent apoptosis is primarily attributable to methyl …
Characterization Of The Catalytic Mechanism Of The Carboxyltransferase Component Of Escherichia Coli Acetyl-Coa Carboxylase Leading To Rational Inhibitor Identification And The Development Of Enzymatic Mimics, Nabil K. Thalji
Honors Theses
No abstract provided.
Toxic Gene Expression In Escherichia Coli Using Trpl As A Repressor, Ian Primm
Toxic Gene Expression In Escherichia Coli Using Trpl As A Repressor, Ian Primm
Honors Theses
No abstract provided.
Early Stage Detection Of Marine Oil Oxidation, Loren Lapointe
Early Stage Detection Of Marine Oil Oxidation, Loren Lapointe
Honors Theses
A method involving overnight stir bar sorptive extraction (SBSE) headspace gas chromatography/mass spectrometry (GC/MS) in negative ion chemical ionization (NICI) mode was developed to determine the presence of aldehydes (cis-4-heptenal, trans,trans-2,4-heptadienal, trans-2-octenal, cis-6-nonenal, trans-2-cis-6-nonadienal, trans-2-nonenal, and trans,trans-2,4-decadienal) in fresh and aged commercial fish oil (untreated and treated with antioxidant blends). Aldehyde standards were quantifiable to >100ppb levels using this method. Only trans,trans-2,4-heptadienal was shown to be present in the commercial fish oil and its presence was used to compare the performance of the two different antioxidant treatments in the fish oil. Includes Powerpoint.
The Purification Of Helicobacter Pylori Urease Β Subunit Protein And Dna For Vaccine Production, Alyson Moll
The Purification Of Helicobacter Pylori Urease Β Subunit Protein And Dna For Vaccine Production, Alyson Moll
Honors Theses
No abstract provided.
The Identification And Isolation Of A Full Length Beta Carbonic Anhydrase Cdna In Arabidopsis Thaliana, Lisa Michelle Ballard
The Identification And Isolation Of A Full Length Beta Carbonic Anhydrase Cdna In Arabidopsis Thaliana, Lisa Michelle Ballard
Honors Theses
No abstract provided.
The Modulation And Cross-Talk Between Stat 5 And Socs-3 In Insulin And Growth Hormone Signaling In 3t3-L1 Adipocytes., David James Story
The Modulation And Cross-Talk Between Stat 5 And Socs-3 In Insulin And Growth Hormone Signaling In 3t3-L1 Adipocytes., David James Story
Honors Theses
No abstract provided.
The Characterization Of A Novel Petite Phenotype In Transgenic Arabidopsis Thaliana And The Examination Of The Expression Patterns Of A Gamma Carbonic Anhydrase Homologue In Arabidopsis Thaliana, Sumeet K. Asrani
Honors Theses
No abstract provided.
The Examination Of The Expression Patterns Of A Gamma Carbonic Anhydrase Homologue In Arabidopsis Thaliana, Eric Thomas Dane Nielsen Iii
The Examination Of The Expression Patterns Of A Gamma Carbonic Anhydrase Homologue In Arabidopsis Thaliana, Eric Thomas Dane Nielsen Iii
Honors Theses
No abstract provided.
Comparison Of The Mutant Frequency And Mutation Spectra Of Three Non-Genotoxic Carcinogens Oxazepam, Phenobarbital, And Wyeth 14,643 At The Λcii Locus In Big Blue Transgenic Mice, Vijaypreet K. Singh
Comparison Of The Mutant Frequency And Mutation Spectra Of Three Non-Genotoxic Carcinogens Oxazepam, Phenobarbital, And Wyeth 14,643 At The Λcii Locus In Big Blue Transgenic Mice, Vijaypreet K. Singh
Honors Theses
No abstract provided.
Oligosaccharides From Cell Surface Glycoproteins Of Thermoplasma Acidophilum, An Archae, Gitanjali Srivastava
Oligosaccharides From Cell Surface Glycoproteins Of Thermoplasma Acidophilum, An Archae, Gitanjali Srivastava
Honors Theses
No abstract provided.
Evidence That Cys230 And Lys238 Of Biotin Carboxylase Do Not Act As An Acid-Base Pair To Deprotonate Biotin, Robert Brett Lloyd
Evidence That Cys230 And Lys238 Of Biotin Carboxylase Do Not Act As An Acid-Base Pair To Deprotonate Biotin, Robert Brett Lloyd
Honors Theses
No abstract provided.
Identification Of The Catalytic Residue In Rabbit Muscle Phosphofructokinase By Site-Directed Mutagenesis, Wenjue Hu
Honors Theses
No abstract provided.
Biosynthesis Of Galactose Β-(1–>4)-Mannose, A Novel Disaccharide, Through Loosened Acceptor Specificity Of Bovine Galactosyltransferase, Darren Schmidt
Biosynthesis Of Galactose Β-(1–>4)-Mannose, A Novel Disaccharide, Through Loosened Acceptor Specificity Of Bovine Galactosyltransferase, Darren Schmidt
Honors Theses
No abstract provided.
The Effects Of Unpaired Bases In An Oligo Deoxy (A) * Deoxy (T) Tract On Dna Bending, Vasavi Malineni
The Effects Of Unpaired Bases In An Oligo Deoxy (A) * Deoxy (T) Tract On Dna Bending, Vasavi Malineni
Honors Theses
No abstract provided.
The Role Of Tocopherol, Cholesterol, And Oleic Acid In Lipid Peroxidation, Jherie Jean Demouy Blazier
The Role Of Tocopherol, Cholesterol, And Oleic Acid In Lipid Peroxidation, Jherie Jean Demouy Blazier
Honors Theses
No abstract provided.
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Honors Theses
Sodium dodecyl sulfide (SDS) non-acrylamide gel-filled capillary columns are a new technology being used for analysis and separation of biotechnology-derived proteins. This research was to compare this new technology to the current methods of SDS polyacrylamide gel electrophoresis (SDS-PAGE) and high-performance size-exclusion chromatography (HPSEC). The molecular mass of four different recombinant proteins were determined by two commercialized SDS non-acrylamide gel-filled capillary columns, SDS-PAGE, and HPSEC. The data obtained showed that the SDS non-acrylamide gel-filled capillary columns were compatible with the SDS-PAGE technique for molecular mass determination. HPSEC was shown to be unreliable for molecular weight determination. SDS non-acrylamide gel-filled capillary …