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Full-Text Articles in Social and Behavioral Sciences
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …
Serum Levels Of Polyunsaturated Fatty Acids Are Low In Chinese Men With Metabolic Syndrome, Whereas Serum Levels Of Saturated Fatty Acids, Zinc And Magnesium Are High, Yinghua Yu, Z. Cai, Jusheng Zheng, J-Z Chen, Xu Zhang, Xu-Feng Huang, Duo Li
Serum Levels Of Polyunsaturated Fatty Acids Are Low In Chinese Men With Metabolic Syndrome, Whereas Serum Levels Of Saturated Fatty Acids, Zinc And Magnesium Are High, Yinghua Yu, Z. Cai, Jusheng Zheng, J-Z Chen, Xu Zhang, Xu-Feng Huang, Duo Li
Xu-Feng Huang
The purpose of this study was to examine the hypothesis that serum levels of phospholipid (PL) fatty acids (FA) and minerals are associated with the components of metabolic syndrome (MetS) in the Chinese population and the profiles of changes may differ from patients with MetS from Western countries. The levels of serum PL, FA, and minerals were examined in 201 subjects (52 with MetS and 149 healthy controls without any MetS components) in China. The saturated FA proportion in serum was significantly higher, whereas the proportion of total polyunsaturated FA (PUFA), n-3 and n-6 PUFA (22:6n-3: −16%, P = .006; …
Energy-Restricted Pair-Feeding Normalizes Low Levels Of Brain-Derived Neurotrophic Factor/Tyrosine Kinase B Mrna Expression In The Hippocampus, But Not Ventromedial Hypothalamic Nucleus, In Diet-Induced Obese Mice, Xu-Feng Huang, Qing Wang, Yinghua Yu
Energy-Restricted Pair-Feeding Normalizes Low Levels Of Brain-Derived Neurotrophic Factor/Tyrosine Kinase B Mrna Expression In The Hippocampus, But Not Ventromedial Hypothalamic Nucleus, In Diet-Induced Obese Mice, Xu-Feng Huang, Qing Wang, Yinghua Yu
Xu-Feng Huang
Brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase B (TrkB) are closely associated with the regulation of energy homeostasis, but their roles in diet-induced obesity have not been explored. Using dietary interventions, this study examined regional changes of BDNF and TrkB mRNA expression in different brain regions of diet-induced obese (DIO) and resistant (DR) mice in response to high-fat (HF), energy-restricted pair-feeding and low fat (LF) diets. Using in situ hybridization, DIO mice had significantly decreased levels of BDNF mRNA expression (ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÿ32% to ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÿ37%) and TrkB (ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÿ21% to ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÿ23%) in the hippocampus compared to DR mice on an HF …