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Full-Text Articles in Social and Behavioral Sciences
Short-Term Effects Of Fish And Fish Oil Consumption On Total And High Molecular Weight Adiponectin Levels In Overweight And Obese Adults, Elizabeth P. Neale, Beverly Muhlhausler, Yasmine C. Probst, Marijka J. Batterham, Francesca Fernandez, Linda C. Tapsell
Short-Term Effects Of Fish And Fish Oil Consumption On Total And High Molecular Weight Adiponectin Levels In Overweight And Obese Adults, Elizabeth P. Neale, Beverly Muhlhausler, Yasmine C. Probst, Marijka J. Batterham, Francesca Fernandez, Linda C. Tapsell
Dr Marijka Batterham
Objective: Fish or fish oil consumption may increase levels of total and high molecular weight (HMW) adiponectin, a hormone associated with anti-inflammatory and insulin-sensitising effects, however it is not known if the effects of the food and supplement are the same. The aim of this study was to compare the effect of consuming fish and fish oil supplements on plasma total and HMW adiponectin concentrations in overweight human participants. Materials/Methods: 29 overweight and obese participants underwent a two week run-in period, followed by a four week isocaloric dietary intervention which provided 1.8g of long chain omega-3 polyunsaturated fatty acids (LC …
Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell
Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell
Dr Marijka Batterham
Background We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1st degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH−) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+. Methods Normoglycaemic participants were categorised either FH+ (≥1 1st degree relative with T2DM, 50F/30M, age 45±14 (SD) yr) or FH− (71F/51M, age 43±14 yr). Log-transformed anthropometric measurements (height, hip and waist circumferences) and lean, bone and fat mass …
Brief Report: Can Men Do Better If They Try Harder: Sex And Motivational Effects On Emotional Awareness, Joseph Ciarrochi, Nadia Crittenden, Keiren Hynes
Brief Report: Can Men Do Better If They Try Harder: Sex And Motivational Effects On Emotional Awareness, Joseph Ciarrochi, Nadia Crittenden, Keiren Hynes
joseph Ciarrochi
No abstract provided.
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
No abstract provided.
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
The effects of three different meat-containing breakfast meals (pork, beef or chicken) on acute satiety and appetite regulatory hormones were compared using a within-subjects study design. Thirty fasting non-smoking pre-menopausal women attended a research centre on three test days to consume, a meat-containing meal matched in energy (kJ) and protein content, palatability, and appearance. No difference was found between meat groups for either energy intake or macronutrient profile of food consume data subsequent ad libitum buffet lunch, or over the rest of the day. Visual Analogue Scale(VAS) ratings for hunger and satiety over an 180min period did not differ between …
Cholesterol-Lowering Effects Of B-Glucan Containing Breakfast Cereals And Snack Bars, Karen Charlton, Linda Tapsell, Marijka Batterham, Jane O'Shea, Rebecca Thorne, Qingsheng Zhang, Eleanor Beck
Cholesterol-Lowering Effects Of B-Glucan Containing Breakfast Cereals And Snack Bars, Karen Charlton, Linda Tapsell, Marijka Batterham, Jane O'Shea, Rebecca Thorne, Qingsheng Zhang, Eleanor Beck
Qingsheng Zhang
No abstract provided.
Independent Effects Of Local And Global Binocular Disparity On The Perceived Convexity Of Stereoscopically Presented Faces In Scenes, Harold Matthews, Harold Hill, Stephen Palmisano
Independent Effects Of Local And Global Binocular Disparity On The Perceived Convexity Of Stereoscopically Presented Faces In Scenes, Harold Matthews, Harold Hill, Stephen Palmisano
Harold Hill
No abstract provided.
Self-Reported Side Effects Of Breast Cancer Treatment: A Cross-Sectional Study Of Incidence, Associations, And The Influence Of Exercise, Sheridan A. Gho, Julie R. Steele, Sandra C. Jones, Bridget J. Munro
Self-Reported Side Effects Of Breast Cancer Treatment: A Cross-Sectional Study Of Incidence, Associations, And The Influence Of Exercise, Sheridan A. Gho, Julie R. Steele, Sandra C. Jones, Bridget J. Munro
Sandra Jones
Purpose Side effects as a result of breast cancer treatment may have a lasting detrimental impact on quality of life. Exercise has been shown to be an effective intervention in post-treatment care. This study aimed to gain a better understanding of breast cancer treatment-related side effects through identifying potential patient characteristic associations, including current levels of exercise. Methods Four hundred and thirty-two breast cancer patients completed an online survey covering their treatment and demographic background, current exercise levels, and self-reported treatment side effects. Side effects were considered in a binary logistic regression against age, surgery, currently undergoing treatment, and exercise …
Saving Lives Or Raising Revenue: Analysing Media Coverage Of The Alcopops Tax In Light Of The Evidence On Its Effects, Sandra C. Jones, Laura Robinson
Saving Lives Or Raising Revenue: Analysing Media Coverage Of The Alcopops Tax In Light Of The Evidence On Its Effects, Sandra C. Jones, Laura Robinson
Sandra Jones
The Australian Government increased the tax on ready-to-drink (RTD) alcohol beverages in 2008, in order to address concerns about increasing alcohol consumption among young people. This decision resulted in significant debate and discussion in the media, and in academic circles. The aim of the current study was to examine media coverage of the debate – and particularly the arguments posed in favour of and against the tax – now that we have objective evidence of its impact. We find that business owners and industry groups were vocal in the media, raising a number of arguments in opposition to the tax; …
Anthropogenic Effects In A Coastal Lagoon: Geochemical Characterization Of Burrill Lake, Nsw, Australia, Brian Jones, Hannah Killian, Bryan Chenhall, Craig Sloss
Anthropogenic Effects In A Coastal Lagoon: Geochemical Characterization Of Burrill Lake, Nsw, Australia, Brian Jones, Hannah Killian, Bryan Chenhall, Craig Sloss
B. G. Jones
Burrill Lake, a small coastal lagoon on the south coast of New South Wales, developed as an impounded drowned river valley following the post-glacial marine transgression. Marine sand fills the entrance to the lagoon whereas the back-barrier basin has accumulated organic-rich mud and sandy bayhead deltas. The bilobate form of the estuary coincides with two different catchment lithologies and land use patterns. The northern lobe drains an agricultural catchment and has a much larger bayhead delta than the southern lobs that drains natural and state forest. Sedimentation rates within the muddy lagoonal deposits are about 1.7 mm/yr. The distributions of …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Karen E. Charlton
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Long-Term Effects Of Increased Dietary Polyunsaturated Fat From Walnuts On Metabolic Parameters In Type Ii Diabetes, Cassandra Quick, Marijka Batterham, Linda Tapsell, Lynda Gillen, Karen Charlton, Sze Yen Tan, Grigorijs Teuss, Sayne Mam Dalton
Karen E. Charlton
Background/Objectives: Most dietary interventions have metabolic effects in the short term, but long-term effects may require dietary fat changes to influence body composition and insulin action. This study assessed the effect of sustained high polyunsaturated fatty acids (PUFA) intake through walnut consumption on metabolic outcomes in type II diabetes.Subjects/Methods: Fifty overweight adults with non-insulin-treated diabetes (mean age 54±8.7 years) were randomized to receive low-fat dietary advice ±30 g per day walnuts targeting weight maintenance (around 2000 kcal, 30% fat) for 1 year. Differences between groups were assessed by changes in anthropometric values (body weight, body fat, visceral adipose tissue) and …
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Appetite Regulatory Hormone Responses, Karen E. Charlton, Linda C. Tapsell, Marijka Batterham, Jane E. O'Shea, Rebecca L. Thorne, Qingsheng Zhang, Eleanor Beck
Karen E. Charlton
No abstract provided.
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Pork, Beef And Chicken Have Similar Effects On Acute Satiety And Hormonal Markers Of Appetite, Karen Charlton, Linda Tapsell, Marijka Batterham, Rebecca Thorne, Jane O'Shea, Qingsheng Zhang, Eleanor Beck
Karen E. Charlton
The effects of three different meat-containing breakfast meals (pork, beef or chicken) on acute satiety and appetite regulatory hormones were compared using a within-subjects study design. Thirty fasting non-smoking pre-menopausal women attended a research centre on three test days to consume, a meat-containing meal matched in energy (kJ) and protein content, palatability, and appearance. No difference was found between meat groups for either energy intake or macronutrient profile of food consume data subsequent ad libitum buffet lunch, or over the rest of the day. Visual Analogue Scale(VAS) ratings for hunger and satiety over an 180min period did not differ between …
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
The Effects Of Phencyclidine Treatment On The Nmdar-Nrg1 Signalling Pathway In Rats, T Morosin, T Du Bois, K Newell, Xu-Feng Huang
Xu-Feng Huang
No abstract provided.
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Effects Of Dopamine D2 Receptor Partial Agonist Bifeprunox On Body Weight Gain, Food And Water Intake In Male Rats, M De Santis, Xu-Feng Huang, C Deng
Xu-Feng Huang
An abstract of a poster presentation that presented at Australian Neuroscience Society 32nd Annual meeting.
Environmental Effects Of Ozone Depletion And Its Interactions With Climate Change: Progress Report, 2011, Anthony L. Andrady, Pieter J. Aucamp, Amy T. Austin, Alkiviadis F. Bais, Carlos L. Ballare, Lars Olof Bjorn, Janet F. Bornman, Martyn Caldwell, Anthony P. Cullen, David J. Erickson, Frank R. De Gruijl, Donat-P Hader, Walter Helbling, Mohammad Ilyas, Janice Longstreth, Robyn Lucas, Richard L. Mckenzie, Sasha Madronich, Mary Norval, Nigel D. Paul, Halim Redhwi, Sharon Robinson, Min Shao, Keith R. Solomon, Barbara Sulzberger, Yukio Takizawa, Xiaoyan Tang, Ayako Torikai, Jan C. Van Der Leun, Craig Williamson, Stephen R. Wilson, Robert C. Worrest, Richard G. Zepp
Environmental Effects Of Ozone Depletion And Its Interactions With Climate Change: Progress Report, 2011, Anthony L. Andrady, Pieter J. Aucamp, Amy T. Austin, Alkiviadis F. Bais, Carlos L. Ballare, Lars Olof Bjorn, Janet F. Bornman, Martyn Caldwell, Anthony P. Cullen, David J. Erickson, Frank R. De Gruijl, Donat-P Hader, Walter Helbling, Mohammad Ilyas, Janice Longstreth, Robyn Lucas, Richard L. Mckenzie, Sasha Madronich, Mary Norval, Nigel D. Paul, Halim Redhwi, Sharon Robinson, Min Shao, Keith R. Solomon, Barbara Sulzberger, Yukio Takizawa, Xiaoyan Tang, Ayako Torikai, Jan C. Van Der Leun, Craig Williamson, Stephen R. Wilson, Robert C. Worrest, Richard G. Zepp
Sharon Robinson
The parties to the Montreal Protocol are informed by three panels of experts. One of these is the Environmental Effects Assessment Panel (EEAP), which deals with two focal issues. The first focus is the effects of increased UV radiation on human health, animals, plants, biogeochemistry, air quality, and materials. The second focus is on interactions between UV radiation and global climate change and how these may affect humans and the environment. When considering the effects of climate change, it has become clear that processes resulting in changes in stratospheric ozone are more complex than believed previously. As a result of …
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Structural Contributions Of Antipsychotic Drugs To Their Therapeutic Profiles And Metabolic Side Effects, Somayeh Jafari, Francesca Fernandez-Enright, Xu-Feng Huang
Xu-Feng Huang
Antipsychotic drugs have various neuropharmacological properties as a result of their structural diversity. Despite their therapeutic benefits, most of the prescribed atypical antipsychotics can induce severe side effects, including weight gain, type II diabetes mellitus, and cardiovascular diseases. Among the developed atypical antipsychotic agents, tetracyclic dibenzodiazepine and thienobenzodiazepine compounds, particularly clozapine and olanzapine, are associated with the greatest weight gain and metabolic disturbances. However, the unique chemical structure of these compounds causes the low risk of side effects reported for typical antipsychotics (e.g. extrapyramidal symptoms and tardive dyskinesia). This report reviews the recent discovery of the potential role of the …
Effects Of Ice Hockey Facial Protectors On The Response Time And Kinematics In Goal-Directed Tasks, P M. Dowler, D J. Pearsall, P J. Stapley
Effects Of Ice Hockey Facial Protectors On The Response Time And Kinematics In Goal-Directed Tasks, P M. Dowler, D J. Pearsall, P J. Stapley
Dr Paul J Stapley
Ice hockey facial protectors are essential to prevent eye (and, in some cases, dental) injuries but must also not encumber vision and, in turn, playersapos; performance. The purpose of this study was to investigate the effects of three different facial protection conditions on temporal and kinematic parameters in a goal-directed pointing task: helmet (control), visor, and cage. Start and end target switches captured temporal estimates (reaction time (RT), movement time, (MT), and response time (RT+MT)), while a 13-light target array and 6-camera Vicon Mx system were used to collect upper-body kinematics data (head and thorax orientation, shoulder and elbow joint …
A Randomized Controlled Trial Investigating The Effects Of A Low-Glycemic Index Diet On Pregnancy Outcomes In Gestational Diabetes Mellitus, Jennie Brand-Miller, Jimmy Chun Yu Louie, Peter Petocz, Tania Markovic, Nimalie Perera, Deborah Foote, Glynis Ross
A Randomized Controlled Trial Investigating The Effects Of A Low-Glycemic Index Diet On Pregnancy Outcomes In Gestational Diabetes Mellitus, Jennie Brand-Miller, Jimmy Chun Yu Louie, Peter Petocz, Tania Markovic, Nimalie Perera, Deborah Foote, Glynis Ross
Jimmy Chun Yu Louie
OBJECTIVE: The prevalence of gestational diabetes mellitus (GDM) is rising. There is little evidence to demonstrate the effectiveness of one dietary therapy over another. We aimed to investigate the effect of a low-glycemic index (LGI) versus a conventional high-fiber diet on pregnancy outcomes, neonatal anthropometry, and maternal metabolic profile in GDM.RESEARCH DESIGN AND METHODS: Ninety-nine women (age 26-42 years; mean ñ SD prepregnancy BMI 24 ñ 5 kg/mò) diagnosed with GDM at 20-32 weeks' gestation were randomized to follow either an LGI (n = 50; target glycemic index [GI] ~50) or a high-fiber moderate-GI diet (HF) (n = 49; target …
"A Spoonful Of Sugar": Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, F Atkinson, P Petocz, J Brand-Miller
"A Spoonful Of Sugar": Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, F Atkinson, P Petocz, J Brand-Miller
Jimmy Chun Yu Louie
No abstract provided.
Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, Fiona Atkinson, Peter Petocz, Jennie Brand-Miller
Delayed Effects Of Coffee, Tea And Sucrose On Postprandial Glycemia In Lean, Young, Healthy Adults, Jimmy Chun Yu Louie, Fiona Atkinson, Peter Petocz, Jennie Brand-Miller
Jimmy Chun Yu Louie
In observational studies, habitual coffee consumption has been linked to a lower risk of type 2 diabetes. We hy-pothesized that the mechanism may be related to delayed effects on postprandial glycemia. The aim of this study is to investigate the glycemic and insulinemic effects of consumption of caffeinated and decaffeinated coffee, sweetened and unsweetened, tea and sucrose, 1 h prior to a high carbohydrate meal. On separate occasions in random order, lean young healthy subjects (n = 8) consumed a potato-based meal 1 hour after consumption of 250 mL of black coffee (COF), black coffee sweetened with 10 g of …
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Effects Of Simvastatin And 6-Hydroxydopamine Lesion On Histaminergic H1 Receptor Binding In Rat Brains, C H. Hu, C Deng, Xu-Feng Huang, J Chen, Q Wang
Xu-Feng Huang
No abstract provided.
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Xu-Feng Huang
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Short Term Effects Of Energy Restriction And Dietary Fat Sub-Type On Weight Loss And Disease Risk Factors, Linda C. Tapsell, Marijka Batterham, Xu-Feng Huang, Sze Yen Tan, Grigorijs Teuss, Karen E. Charlton, Jane E. O'Shea, Eva M. Warensjo
Xu-Feng Huang
Background and aims: Decreasing energy intake relative to energy expenditure is the indisputable tenet of weight loss. In addition to caloric restriction modification of the type of dietary fat may provide further benefits. The aim of the present study was to examine the effect of energy restriction alone and with dietary fat modification on weight loss and adiposity, as well as on risk factors for obesity related disease. Methods and results: One-hundred and fifty overweight men and women were randomized into a 3 month controlled trial with four low fat (30% energy) dietary arms: (1) isocaloric (LF); (2) isocaloric with …
Effects Of Diets High In Whey, Soy, Red Meat And Milk Protein On Body Weight Maintenance In Diet-Induced Obesity In Mice, Xu-Feng Huang, Y Liu, Gita Rahardjo, Peter Mclennan, Linda Tapsell, William Buttemer
Effects Of Diets High In Whey, Soy, Red Meat And Milk Protein On Body Weight Maintenance In Diet-Induced Obesity In Mice, Xu-Feng Huang, Y Liu, Gita Rahardjo, Peter Mclennan, Linda Tapsell, William Buttemer
Xu-Feng Huang
This study examined the effects of different food sources of protein on energy intake, body weight maintenance, and on the responses of plasma leptin, insulin and adiponectin in chronic high-fat diet-induced obese mice. Obesity was induced in 47 mice with a high-fat diet for 20 weeks. They were divided into five diet groups to test the effects of a higher protein proportion (30% energy), achieved at the expense of carbohydrate. For the next eight weeks, four of the groups were fed diets of chow formulated with whey, soy, red meat or milk while the control group continued on their high-fat …
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
This study examined regional changes of peptide YY (PYY) binding densities in the rat brain after chronic administration of olanzapine (1.2 mg/kg/day and haloperidol (2.0 mg/kg/day)for 36 days. PYY binding densities and distributions were detected by [125I] binding autoradiography after ratswere sacrificed either 2 h or 48 h after the last drug administration to examine both immediate and delayed effects following the drugwithdrawal. Following 2 h of drug administration, it showed that olanzapine administration significantly decreased PYY binding densities, predominantly in the posterodorsal part of medial amygdaloid nucleus (52 percent, pb0.05), dorsal part of medial geniculate nucleus (56 percent, pb0.05), …
Effects Of Antipsychotic Medication On Muscarinic M1 Receptor Mrna Expression In The Rat Brain, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng, Mei Han
Effects Of Antipsychotic Medication On Muscarinic M1 Receptor Mrna Expression In The Rat Brain, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou, Chao Deng, Mei Han
Xu-Feng Huang
Alterations in muscarinic M1 receptor protein and mRNA expression have been revealed in post-mortem brains of schizophrenia patients. Most patients had been treated with antipsychotics, so medication effects cannot be excluded as a possible explanation for these results. With in situ hybridization, this study investigated M1 receptor mRNA expression in rats treated with the typical antipsychotic haloperidol (0.3 mg/kg/day) and the atypical antipsychotics olanzapine (1.5 mg/kg/day) and aripiprazole (2.25 mg/kg/day) for 1 or 12 weeks. Compared with the control group, haloperidol significantly increased (13-21%, P < 0.05) M1 mRNA expression in the CA1, CA2, and CA3 regions of the hippocampus after both 1 and 12 weeks of treatment, and it also increased (17%, P < 0.01) M1 mRNA expression in the substantia nigra compacta after 1 week of treatment. Olanzapine significantly increased (14-22%, P < 0.05) M1 mRNA expression in the hippocampus (CA1, CA2, and CA3) and substantia nigra compacta after 12 weeks of treatment, but not after 1 week. Aripiprazole significantly increased (17%, P < 0.01) M1 mRNA expression in the hippocampus (CA1) after both 1 and 12 week treatments and increased (12%, P < 0.05) M1 mRNA expression in the nucleus accumbens after 1 week of treatment. Despite their different affinities for muscarinic M1 receptors, all three antipsychotic medications induced a similar trend of change in M1 mRNA expression in selected brain regions. These data suggest that the decreased M1 receptor protein and mRNA expression observed in schizophrenia patients is unlikely to be a consequence of drug treatments and implicates muscarinic M1 receptors in the pharmacotherapy of the disease. ÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂÃÂé 2007 Wiley-Liss, Inc.