Social and Behavioral Sciences Commons^™

Effects Of Early-Life Stress On 5-Ht1a Receptors In Juvenile Rhesus Monkeys Measured By Pet, Simona Spinelli, Svetlana Chefer, Richard E. Carson, Elaine Jagoda, Lixin Lang, Markus Heilig, Christina S. Barr, Stephen J. Suomi, J. Dee Higley, Elliot A. Stein

Faculty Publications

Background—Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin1A receptor (5-HT1AR) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.

Methods—To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography (PET) to measure in vivo 5- HT1AR density and apparent dissociation constant (KD app) in the brain of juvenile rhesus monkeys exposed to the early-life stress of peer-rearing.

Results—In general, 5-HT1AR density and KD app were decreased in peer-reared …