Social and Behavioral Sciences Commons^™

A Look At The Causes Of Gender Identity With The Help Of Four Core Genotype Mice, Evan Serio Friedenberg

Scripps Senior Theses

The purpose of this project is to better understand the influences underlying gender differences in the brain using Four Core Genotype mice. Four Core Genotype mice are transgenic mice in which the SRY gene has been translocated from the Y chromosome to another location. This enables separation of the genetic sex and gonadal sex. For example, there are female mice based on sexual organs but their chromosomes are XY(UY- in mice). This allows us to determine whether sexual differentiation in the brain is due to genes or hormones. In this project, I looked at a sexually dimorphic area of the …