Social and Behavioral Sciences Commons^™

Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie

Jimmy Chun Yu Louie

In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …

Health Care Reform And Women's Insurance Coverage For Breast And Cervical Cancer Screening, Alice R. Levy, Brian K. Bruen, Leighton C. Ku

Health Policy and Management Faculty Publications

INTRODUCTION:

The Patient Protection and Affordable Care Act of 2010 (ACA) will increase insurance coverage for US citizens and for breast and cervical cancer screening through insurance expansions and regulatory changes. The primary objective of this study was to estimate the number of low-income women who would gain health insurance after implementation of the ACA and thus be able to obtain cancer screening. A secondary objective was to estimate the size and characteristics of the uninsured low-income population and the number of women who would still need National Breast and Cervical Cancer Early Detection Program (NBCCEDP) services.

METHODS:

We used …

Breast Cancer Patients' Preferences For Information: Different Sources At Different Times?, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Introduction: Information given to breast cancer patients may not universally reduce anxiety and assist treament compliance. One possible reason could be that patient preferences for specific information sources may change over time.Objectives: To compare breast cancer patients' preferred formats for receiving education about their disease and treatment soon after diagnosis versus about two years after that time.Methods: An anonymous survey of 253 breast cancer patients' evaluations of alternative information formats was conducted within one month of diagnosis, and data were compared to those collected in a previous study from patients who were abut two years post-diagnosis.Results: There were discrepancies between …

Variability In Anxiety And Depression Over Time Following Diagnosis In Patients With Prostate Cancer, Christoper Sharpley, David Christie, Vicki Bitsika

Vicki Bitsika

To determine the presence and nature of variability in anxiety and depression in patients with prostate cancer (PCa) over 3 years following diagnosis, 442 patients with PCa completed standardized anxiety and depression inventories via survey between 1 and 36 months after receiving their initial diagnosis. Data were analyzed from a series of 3-month cohorts, and results indicated that total scores and incidence of clinically significant anxiety and depression varied over time, but that this variability was restricted to specific subfactors of anxiety and depression. Provision of effective psychological treatment to patients with PCa is discussed.

Incidence And Nature Of Anxiety-Depression Comorbidity In Prostate Cancer Patients, Christoper Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Background: The aim of this study was to measure the incidence of anxiety-depression comorbidity among a sample of prostate cancer (PCa) patients and to investigate the total score, factor score and scale item differences across subgroups defined according to the presence of anxiety and/or depression. Methods: 491 PCa patients who had received their initial diagnosis between 1 and 113 months previously completed a survey of background variables, as well as the Zung Self-Rating Anxiety and Depression Scales (SAS, SDS). Results: Incidence of anxiety-depression comorbidity was nearly 16%, and higher than that previously reported in other samples. Although the directional differences …

Reliability And Validity Of The Outcome Questionnaire In A Heterogeneous Cancer Population, Laura Testerman

Loma Linda University Electronic Theses, Dissertations & Projects

The Institute of Medicine (IOM) and National Cancer Comprehensive Network (NCCN) now require integration of psychosocial care into the treatment of cancer patients to identify, monitor, and treat psychosocial distress. Despite the widespread use of Patient Reported Outcomes (PRO) for these purposes, no gold standard PRO for assessing distress exists for psycho-oncology research and clinical practice. This study examined the reliability, validity, and preliminary treatment effects of the Outcome Questionnaire, a PRO never before been used or validated with heterogeneous cancer patients. Adult cancer survivors were recruited nationwide to participate in an online support group (N=187) and randomly assigned to …

Examining Cancer And Cardiovascular Risk Behaviours In People Attending Residential Substance Abuse Treatment, Peter Kelly, A Baker, Frances Kay-Lambkin, Frank Deane, Billie Bonevski

Peter Kelly

No abstract provided.

Depression And Quality Of Life In Cancer Survivors: Is There A Relationship With Physical Activity?, Nancy Humpel, Donald Iverson

Don C. Iverson

Background Evidence is growing on the benefit of physical activity to improve well-being following a cancer diagnosis. This study examined changes in physical activity from pre to post diagnosis and explored this relationship with quality of life and depression. Methods Participants were recruited by posters and by letter of invitation. The questionnaire was completed by 59 prostate and 32 breast cancer survivors. Results Physical activity decreased by 72 minutes per week from pre to post diagnosis, although 20.9% reported having increased activity post diagnosis. Over 30% were considered depressed. Breast cancer participants who increased physical activity post diagnosis reported higher …

Review And Critique Of The Quality Of Exercise Recommendations For Cancer Patients And Survivors, Nancy Humpel, Donald Iverson

Don C. Iverson

The benefit of exercise for cancer patients is starting to become recognized. The purposes of this paper were to review the literature to examine whether research findings are being converted into guidelines for patients and survivors and to examine the quality of evidence on which they were based. A computer search of major health databases was conducted for peer-reviewed literature and books on exercise and cancer, and an Internet search was conducted for cancer websites reporting any exercise guidelines/recommendations for cancer patients. Seven peer-reviewed articles, eight books and eight cancer websites were identified that suggested exercise guidelines for cancer patients …

School-Based Cancer Education Programs: An Opportunity To Affect The National Cancer Problem, Donald Iverson, J Scheer

Don C. Iverson

No abstract provided.

The Danger Of Applying Uniform Clincal Policies Across Populations: The Case Of Breast Cancer In American Indians, Paul Nutting, Ned Calonge, Donald Iverson, Larry Green

Don C. Iverson

OBJECTIVES. This study examined the implications of annual screening mammography for cost and mortality in American Indian populations with differing baseline breast cancer rates. METHODS. A decision tree compared annual screening mammography and screening clinical breast examination with referral for diagnostic mammography when appropriate. The decision tree was constructed to examine the effect of different base-line cancer rates, stage at diagnosis, and stage-specific survival. Outcomes included 5-year relative survival, deaths prevented at 5 years, cost per death prevented, and total costs. RESULTS. The findings suggest that the total cost of breast cancer is 3.6 times higher with the screening mammography …

Workgroup Iv: Public Education. Uicc International Workshop On Facilitating Screening For Colorectal Cancer, Oslo, Norway 2002, R Hiatt, J Wardle, S Vernon, J Austoker, L Bistanti, S Fox, R Gnauck, Donald Iverson

Don C. Iverson

The Workgroup on public education was brought together to formulate an international perspective on public education for the important public health challenge of increasing colorectal cancer screening. The focus of the group did not include professional education, which is an important channel for public education, since another Workgroup covered that topic. The results of the Workgroup represent an expression of expert opinion and did not include a comprehensive review of the literature. However, the recommendations for further research may stimulate a more in-depth examination of the literature in some areas and generate ideas for investigation.

Involving Providers And Patients In Cancer Control And Prevention Efforts. Barriers To Overcome, Donald Iverson

Don C. Iverson

Although progress has been made in providing cancer prevention and control services to the population, there remain sizeable segments of the population that are either uninvolved or underinvolved with national and state efforts. One method of reaching most of the population, including those segments currently not involved or underinvolved, is through primary care clinicians. Effective, albeit imperfect, strategies to increase the involvement of primary care clinicians in cancer prevention and control are available, and there is emerging evidence that these strategies are making a difference. Unfortunately, the progress made to date is at risk of being lost because of economic …

Feasibility Studies Of Low-Fat Diet To Prevent Or Retard Breast Cancer, P Greenwald, C Clifford, R Butrum, Donald Iverson

Don C. Iverson

No abstract provided.

Sleep Quality, Fatigue And Physical Activity Following A Cancer Diagnosis, Nancy Humpel, Donald Iverson

Don C. Iverson

Research on physical activity for cancer survivors suggests a relationship with improved quality of life. The aim of this study was to explore if there was also a relationship of physical activity with sleep difficulties and fatigue, common effects of cancer and its treatments. Recruitment was by posters and flyers in medical waiting rooms and by letter of invitation. Thirty-two breast and 59 prostate cancer survivors completed the questionnaire. Poor sleep quality was reported by 57.8%. A greater proportion of breast cancer (36.7%) than prostate cancer survivors (15.5%) reported poor sleep latency, and sleep disturbance (48.4% vs. 17.2%). The mean …

Australian Women's Awareness Of Breast Cancer Symptoms And Responses To Potential Symptoms, Sandra Jones, Parri Gregory, Caroline Nehill, Lance Barrie, Karen Luxford, A. Nelson, Helen Zorbas, Donald Iverson

Don C. Iverson

Poor awareness of breast cancer symptoms has been associated with patient delay in seeking help; thus reduced survival, more aggressive treatment, and fewer treatment choices. The aim of this study was to develop a representative picture of Australian women’s knowledge of symptoms, experienced potential symptoms, and behavioral responses. A general population sample of approximately 3,000 women aged 30–69 completed a telephone survey; results were compared to previous surveys conducted in 1996 and 2003. The most commonly cited potential symptom of breast cancer was a lump in the breast, identified by 86% of respondents (an increase from 75% in 2003). Other …

Prostate Cancer Screening In The Midst Of Controversy: Canadian Men's Knowledge, Beliefs, Utilization, And Future Intentions, Shawna Mercer, Vivek Goel, Isra Levy, F Ashbury, Donald Iverson, Neill Iscoe

Don C. Iverson

Despite controversy about prostate cancer screening, administrative data show that the use of prostate specific antigen (PSA) testing in Canada has increased. This study sought to determine awareness and knowledge of prostate cancer and screening, use to date, and future intentions to have a digital rectal examination (DRE) and PSA test among Canadian men aged 40 and over. Data were collected through a Canada-wide cross-sectional random digit dial telephone survey of 629 men. Awareness of DRE and PSA, use to date, and future intended use varied with age and education. Although only 9% of respondents had had PSA testing for …

Defining Research Priorities For Pancreatic Cancer In Australia: Results Of A Consensus Development Process, Monica Robotin, Sandra Jones, Andrew Biankin, Louise Waters, Donald Iverson, Helen Gooden, Bruce Barraclough, Andrew Penman

Don C. Iverson

Introduction: Pancreatic cancer (PC) is the sixth leading cause of cancer death in Australia and the fourth in the United States, yet research in PC is lagging behind that in other cancers associated with a high disease burden. In the absence of agreed processes to reliably identify research areas which can deliver significant advances in PC research, the Cancer Council NSW established a strategic partnership with the NSW Pancreatic Cancer Network to define critical research issues and opportunities that could accelerate progress in this field in Australia. Materials and methods: The process consisted of five distinct stages: a literature review …

Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas

Don C. Iverson

Background Numerous studies have shown that the majority of women overestimate both their own risk and the populations’ risk of developing breast cancer. A number of factors have been found to correlate with perceived risk. Methods This paper reports on a telephone survey of a nationally representative sample of approximately 3,000 Australian women aged 30 to 69 years, conducted in 2007, and compares the findings with those of a similar survey conducted in 2003. Results There was a clear tendency for respondents to overestimate the proportion of women who will develop breast cancer during their lifetime. Approximately half the respondents …

Seeking Cancer Information: An Appalachian Perspective, Robin C. Vanderpool, Bin Huang, Brent J. Shelton

Journal of Health Disparities Research and Practice

There are noted disparities by ethnicity, race, age, gender, and socioeconomic status in the reported use of and access to cancer information. Missing from this list of variables that predict these disparities are specific geographic locales, such as Appalachia, a region recognized as a medically underserved, “special population”. Through a secondary analysis of NCI’s 2003 HINTS dataset, we are able to describe the cancer information-seeking behaviors of Appalachians as compared to non-Appalachians with a focus on actual versus preferential information-seeking behaviors, information-seeking experiences, and demographics. In general, Appalachians and non-Appalachians do not significantly differ in their cancer information-seeking behaviors and …

Talking Glossary Of Genomics Terminology: A Genomics Education Module For American Indian Communities, Jill Peters, Pauline Davies, Naomi Lane, Kathryn Coe

Journal of Health Disparities Research and Practice

This paper describes the development of an audio visual genomics glossary that was designed as an education tool for American Indian communities. This “Talking Glossary of Genomics Terminology” is a multimedia DVD that was modeled on the “Talking Glossary of Genetics,” which was developed by the National Human Genome Research Institute (NHGRI). The NHGRI Glossary was modified and expanded with content designed to increase awareness among American Indians about cancer, genomics, and personalized medicine. Partners on the project include the Inter Tribal Council of Arizona, Inc., Phoenix Indian Medical Center, Arizona Cancer Center at the University of Arizona, the Translational …

Young Adult Cancer Survivors' Satisfaction With Interpersonal Life Changes, Kelly J. Foy

Honors Scholar Theses

This study looked at the life satisfaction of young adult cancer survivors in comparison to adult cancer survivors. Satisfaction was focused on three separate domains: romantic relationships, fertility and sexuality, and family and friendships. 292 participants completed the survey, which included measures such as the Zebrack Cancer Impact Scale, the Ferrans and Powers Quality of Life Index, the Post-Traumatic Growth Scale, and a new measure developed for this study. Bivariate correlation analyses were used to identify significant relationships among the domains. It was determined that there was no significant difference between young adult cancer survivors and adult cancer survivors in …

Update - February 2012, Loma Linda University Center For Christian Bioethics

Update

In this issue:

-- Cancer Stories: An Argument for Narrative Ethics
-- Dual-Degree Masters of Arts in Bioethics
-- From the Director
-- Finding a Voice for Seventh-day Adventist Ethics in the Radical Reformation?

Dispositional Mindfulness In People Diagnosed With Cancer: The Relationship To Depressive Symptoms And Well-Being, Karen Kersting

Theses and Dissertations

Coping with a cancer diagnosis is known to be a stressful experience that can be related to declines in personal well-being and increases in distress. Dispositional mindfulness is known to be related to depressive symptoms and well-being. The primary purpose of this study was to examine the relationship between mindfulness and experiences of depressive symptoms and well-being in people recently diagnosed with cancer. Seventy-four participants who were diagnosed with cancer in the last 12 months completed an initial self-report survey, and 43 of those completed another survey 3 months later. Cross-sectional regression analysis showed that higher levels of mindfulness were …

Children's Cancer And Transplant Hospital: A Micro Town Within A Bubble, Kimia Samimi

Masters Theses 1911 - February 2014

As the greatest considerations in health-care design have traditionally been functional —hygiene, efficiency, and flexibility for changing technology— hospitals have evolved to become dehumanizing spaces. In this thesis two specific groups of chronically ill children who have among the longest inpatient stays are studied: cancer and organ transplant patients. Being under immunosuppressive drugs, these children are physically vulnerable thus are kept completely isolated. These long stays and isolation can be very depressing for them.

This thesis undertakes the challenge of designing a fully isolated space that doesn’t feel like one or in other words “a micro-town within a bubble”. The …

Sociological Impact On Cancer, Michelle Little

A with Honors Projects

Demographics of cancer and other sociological impacts on cancer.

The Sociological Impact Of Cancer: Cancer Among The World, Jenna Kooy

A with Honors Projects

Cancer among ethnic groups and in high income/low income regions.

Telomere Dynamics And Homeostasis In A Transmissible Cancer, Beata Ujvari, Anne-Maree Pearse, Robyn Taylor, Stephen Pyecroft, Cassandra Flanagan, Sara Gombert, Anthony T. Papenfuss, Thomas R. Madsen, Katherine Belov

Faculty of Science - Papers (Archive)

Background: Devil Facial Tumour Disease (DFTD) is a unique clonal cancer that threatens the world's largest carnivorous marsupial, the Tasmanian devil (Sarcophilus harrisii) with extinction. This transmissible cancer is passed between individual devils by cell implantation during social interactions. The tumour arose in a Schwann cell of a single devil over 15 years ago and since then has expanded clonally, without showing signs of replicative senescence; in stark contrast to a somatic cell that displays a finite capacity for replication, known as the "Hayflick limit". Methodology/Principal Findings: In the present study we investigate the role of telomere length, measured as …

Effectiveness Of 'Signs And Symptoms' Campaigns For Lun G Cancer: A Rapid Review, Ross Gordon, Christopher Magee, Sandra Jones, Lyn Phillipson, Lance Barrie

Faculty of Social Sciences - Papers (Archive)

Early diagnosis of lung cancer may be important in improving the survival rate and patients' quality of life. This Evidence Check review assessed the effectiveness of 'signs and symptoms' campaigns in influencing knowledge, attitudes, beliefs and help-seeking behaviour in the general community and at-risk groups. Interventions may be effective, but the evidence is limited overall, and very limited for at risk groups. Social marketing frameworks may provide a structure for future interventions.

Improving Cancer Outcomes Among Culturally And Linguistically Diverse Communities: A Rapid Review Of The Literature, Lyn Phillipson, Karen Larsen-Truong, Sandra Jones, Leissa Pitts

Faculty of Social Sciences - Papers (Archive)

This Evidence Check review examined the knowledge, attitudes and beliefs of Chinese, Vietnamese and Arabic speaking communities in Australia in relation to cancer, its causes, screening, treatments, perceptions of susceptibility, and perceived outcomes. The review explores fear, stigma, taboos, and the role of family, as well as the evidence of effectiveness of cancer prevention, detection and treatment interventions. There are significant gaps in the evidence base.