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Full-Text Articles in Social and Behavioral Sciences
A Neurocomputational Account Of Cognitive Deficits In Parkinson's Disease, Sébastien Hélie, Erick J. Paul, F Gregory Ashby
A Neurocomputational Account Of Cognitive Deficits In Parkinson's Disease, Sébastien Hélie, Erick J. Paul, F Gregory Ashby
Department of Psychological Sciences Faculty Publications
Parkinson’s disease (PD) is caused by the accelerated death of dopamine (DA) producing neurons. Numerous studies documenting cognitive deficits of PD patients have revealed impairments in a variety of tasks related to memory, learning, visuospatial skills, and attention. While there have been several studies documenting cognitive deficits of PD patients, very few computational models have been proposed. In this article, we use the COVIS model of category learning to simulate DA depletion and show that the model suffers from cognitive symptoms similar to those of human participants affected by PD. Specifically, DA depletion in COVIS produced deficits in rule-based categorization, …
Simulating The Effect Of Dopamine Imbalance On Cognition: From Positive Affect To Parkinson's Disease, Sebastien Helie, Erick J. Paul, F Gregory Ashby
Simulating The Effect Of Dopamine Imbalance On Cognition: From Positive Affect To Parkinson's Disease, Sebastien Helie, Erick J. Paul, F Gregory Ashby
Department of Psychological Sciences Faculty Publications
Cools (2006) suggested that prefrontal dopamine levels are related to cognitive stability whereas striatal dopamine levels are related to cognitive plasticity. With such a wide ranging role, almost all cognitive activities should be affected by dopamine levels in the brain. Not surprisingly, factors influencing brain dopamine levels have been shown to improve/worsen performance in many behavioral experiments. On the one hand, Nadler and his colleagues (2010) showed that positive affect (which is thought to increase cortical dopamine levels) improves a type of categorization that depends on explicit reasoning (rule-based) but not a type that depends on procedural learning (informationintegration). On …