Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
- Publication
Articles 1 - 6 of 6
Full-Text Articles in Social and Behavioral Sciences
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Aripiprazole Differentially Affects Mesolimbic And Nigrostriatal Dopaminergic Transmission: Implications For Long-Term Drug Efficacy And Low Extrapyramidal Side-Effects, Xu-Feng Huang, Chao Deng, Mei Han
Xu-Feng Huang
Aripiprazole has been used effectively to treat schizophrenia in the clinic ; however, its mechanisms ofaction are not clear. This study examined how short- and long-term aripiprazole treatment affects dopaminergic transmission in mesolimbic and nigrostriatal pathways. For comparison, the effects of haloperidol and olanzapine treatment were also examined. Aripiprazole significantly increased D2 receptor mRNA expression and decreased tyrosine hydroxylase (TH) mRNA expression in the ventral tegmental area (VTA) after 1- and 12-wk treatment, but had no effect in substantia nigra (SN) and nucleus accumbens (NAc). Aripiprazole also decreased dopamine transporter (DAT) binding density in NAc (for 1- and 12- wk …
Lifestyle-Gene-Drug Interactions In Relation To The Metabolic Syndrome, Leonard Storlien, Xu-Feng Huang, Linda Tapsell, Cecilia Karlsson, Maria Niklasson, John Pears, Bjorn Cl Carlsson
Lifestyle-Gene-Drug Interactions In Relation To The Metabolic Syndrome, Leonard Storlien, Xu-Feng Huang, Linda Tapsell, Cecilia Karlsson, Maria Niklasson, John Pears, Bjorn Cl Carlsson
Xu-Feng Huang
No abstract provided.
Predictors Of Burnout Amongst Australian Drug And Alcohol Workers, M Dimartino, Peter Kelly, Frank Deane
Predictors Of Burnout Amongst Australian Drug And Alcohol Workers, M Dimartino, Peter Kelly, Frank Deane
Peter Kelly
No abstract provided.
Exploring Spiritual Growth And Forgiveness In Drug And Alcohol Recovery, Geoffrey Lyons, Frank Deane, Peter Kelly
Exploring Spiritual Growth And Forgiveness In Drug And Alcohol Recovery, Geoffrey Lyons, Frank Deane, Peter Kelly
Peter Kelly
No abstract provided.
Staff Attitudes Towards Evidence Based Practice In A Residential Drug And Alcohol Rehabilitation Service, M Lovett, Peter Kelly, Frank Deane, Trevor Crowe
Staff Attitudes Towards Evidence Based Practice In A Residential Drug And Alcohol Rehabilitation Service, M Lovett, Peter Kelly, Frank Deane, Trevor Crowe
Peter Kelly
No abstract provided.