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Articles 1 - 11 of 11
Full-Text Articles in Social and Behavioral Sciences
Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell
Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell
Faculty of Health and Behavioural Sciences - Papers (Archive)
School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …
The Impact Of Complex Survey Design On Prevalence Estimates Of Intakes Of Food Groups In The Australian National Children's Nutrition And Physical Activity Survey, Sandy Burden, Yasmine Probst, David G. Steel, Linda C. Tapsell
The Impact Of Complex Survey Design On Prevalence Estimates Of Intakes Of Food Groups In The Australian National Children's Nutrition And Physical Activity Survey, Sandy Burden, Yasmine Probst, David G. Steel, Linda C. Tapsell
Faculty of Health and Behavioural Sciences - Papers (Archive)
No abstract provided.
Activity And Molecular Dynamics Relationship Within The Family Of Human Cholinesterase, Judith Peters, Marie Trovaslet, Marcus Trapp, Florian Nachon, Flynn Hill, Etienne Royer, Frank Gabel, Lambert Van Eijck, Patrick Masson, Moeava Tehei
Activity And Molecular Dynamics Relationship Within The Family Of Human Cholinesterase, Judith Peters, Marie Trovaslet, Marcus Trapp, Florian Nachon, Flynn Hill, Etienne Royer, Frank Gabel, Lambert Van Eijck, Patrick Masson, Moeava Tehei
Faculty of Science - Papers (Archive)
The temperature dependence of the dynamics of recombinant human acetylcholinesterase (hAChE) and plasma human butyrylcholinesterase (hBChE) is examined using elastic incoherent neutron scattering. These two enzymes belong to the same family and present 50% amino acid sequence identity. However, significantly higher flexibility and catalytic activity of hAChE when compared to the ones of hBChE are measured. At the same time, the average height of the potential barrier to the motions is increased in the hBChE, e.g. more thermal energy is needed to cross it in the latter case, which might be the origin of the increase in activation energy and …
Selective Reduction Of Hydroperoxyeicosatetraenoic Acids To Their Hydroxy Derivatives By Apolipoprotein D: Implications For Lipid Antioxidant Activity And Alzheimer's Disease, Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin Scott Kim, Paul Else, Aaron J. Oakley, Brett Garner
Selective Reduction Of Hydroperoxyeicosatetraenoic Acids To Their Hydroxy Derivatives By Apolipoprotein D: Implications For Lipid Antioxidant Activity And Alzheimer's Disease, Surabhi Bhatia, Bianca Knoch, Jenny Wong, Woojin Scott Kim, Paul Else, Aaron J. Oakley, Brett Garner
Faculty of Science - Papers (Archive)
ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown. Specific methionine residues may inhibit lipid peroxidation by reducing radical-propagating L-OOHs (lipid hydroperoxides) to non-reactive hydroxides via a reaction that generates MetSO (methionine sulfoxide). Since apoD has three conserved methionine residues (Met49, Met93 and Met157), we generated recombinant proteins with either one or all methionine residues replaced by alanine and assessed their capacity to reduce HpETEs (hydroperoxyeicosatetraenoic acids) to their HETE (hydroxyeicosatetraenoic acid) derivatives. ApoD, apoDM49-A and apoDM157-A all catalysed the reduction of HpETEs to …
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Synthesis And Anti-Leukaemic Activity Of Pyrrolo[3,2,1-Hi]Indole-1,2- Diones, Pyrrolo[3,2,1-Ij]Quinoline-1,2-Diones And Other Polycyclic Isatin Derivatives, Lidia Matesic, Julie M. Locke, Kara Vine, Marie Ranson, John B. Bremner, Danielle Skropeta
Faculty of Science - Papers (Archive)
To further expand the structure–cytotoxic activity relationships of isatin derivatives and to reduce flexibility in substituent groups at nitrogen, 20 analogues incorporating a ring system between the N1 and C7 atoms of isatin were prepared using a variety of synthetic strategies. This yielded pyrroloindole-, pyrroloquinoline-, pyrroloacridine-, pyrrolophenanthridine- and benzopyrrolophenanthridine-based systems with embedded isatin moieties, the latter possessing a novel carbon skeleton. These compounds were subsequently assessed for their in vitro cytotoxicity against human U937 lymphoma cells, with the brominated pyrroloacridine dione 27 showing the most promising activity (IC50 3.01 μM) after 24 h.
The Relationship Between Particulate Pollution Levels In Australian Cities, Meteorology, And Landscape Fire Activity Detected From Modis Hotspots, Owen F. Price, Grant J. Williamson, Sarah B. Henderson, Fay Johnston, David M. J. S Bowman
The Relationship Between Particulate Pollution Levels In Australian Cities, Meteorology, And Landscape Fire Activity Detected From Modis Hotspots, Owen F. Price, Grant J. Williamson, Sarah B. Henderson, Fay Johnston, David M. J. S Bowman
Faculty of Science - Papers (Archive)
Generally, sigmoid curves are used to describe the growth of animals over their lifetime. However, because growth rates often differ over an animal's lifetime a single curve may not accurately capture the growth. Broken-stick models constrained to pass through a common point have been proposed to describe the different growth phases, but these are often unsatisfactory because essentially there are still two functions that describe the lifetime growth. To provide a single, converged model to age animals with disparate growth phases we developed a smoothly joining two-phase nonlinear function (SJ2P), tailored to provide a more accurate description of lifetime growth …
Phytochemical And Biological Activity Studies Of The Bhutanese Medicinal Plant Corydalis Crispa, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan
Phytochemical And Biological Activity Studies Of The Bhutanese Medicinal Plant Corydalis Crispa, Phurpa Wangchuk, Paul A. Keller, Stephen G. Pyne, Thanapat Sastraruji, Malai Taweechotipatr, Roonglawan Rattanajak, Aunchalee Tonsomboon, Sumalee Kamchonwongpaisan
Faculty of Science - Papers (Archive)
The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibitedsignificant anti-inflammatory (p < 0.01) activity against TNF-alpha production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.
Structural Insights Into The Dehydroascorbate Reductase Activity Of Human Omega-Class Glutathione Transferases, Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, Aaron J. Oakley
Structural Insights Into The Dehydroascorbate Reductase Activity Of Human Omega-Class Glutathione Transferases, Huina Zhou, Joseph Brock, Dan Liu, Philip G. Board, Aaron J. Oakley
Faculty of Science - Papers (Archive)
The reduction of dehydroascorbate (DHA) to ascorbic acid (AA) is a vital cellular function. The omega-class glutathione transferases (GSTs) catalyze several reductive reactions in cellular biochemistry, including DHA reduction. In humans, two isozymes (GSTO1-1 and GSTO2-2) with significant DHA reductase (DHAR) activity are found, sharing 64% sequence identity. While the activity of GSTO2-2 is higher, it is significantly more unstable in vitro. We report the first crystal structures of human GSTO2-2, stabilized through site-directed mutagenesis and determined at 1.9Å resolution in the presence and absence of glutathione (GSH). The structure of a human GSTO1-1 has been determined at 1.7Å resolution …
An Indoor Localisation And Motion Monitoring System To Determine Behavioural Activity In Dementia Afflicted Patients In Aged Care, Matthew D'Souza, Montserrat Ros, Mohanraj Karunanithi
An Indoor Localisation And Motion Monitoring System To Determine Behavioural Activity In Dementia Afflicted Patients In Aged Care, Matthew D'Souza, Montserrat Ros, Mohanraj Karunanithi
Faculty of Health and Behavioural Sciences - Papers (Archive)
Dementia is highly prevalent among the older population. Most patients with dementia are admitted to an aged care facility due to wandering behaviour which tends to result in dangerous scenarios such as straying away from the facility and being seriously injured. Due to the decreasing availability of carers in aged care, there is a need to prioritise monitoring of patients that have a severe case of wondering. The challenge is to allow carers to monitor the status of such patients in terms of position localisation and motion behavioural status, in real-time. The long term behavioural analysis of such patients would …
Physical Activity And Energy Expenditure In Haemodialysis Patients: An International Survey, Carla Maria Avesani, Stanislas Trolonge, Patrik Deleaval, Flavia Baria, Denise Mafra, Gerd Faxen-Irving, Phillipe Chauveau, Daniel Teta, Maria Ayako Kamimura, Maria Chan, Lilian Cuppari, Olof Heimburger, Denis Fouque
Physical Activity And Energy Expenditure In Haemodialysis Patients: An International Survey, Carla Maria Avesani, Stanislas Trolonge, Patrik Deleaval, Flavia Baria, Denise Mafra, Gerd Faxen-Irving, Phillipe Chauveau, Daniel Teta, Maria Ayako Kamimura, Maria Chan, Lilian Cuppari, Olof Heimburger, Denis Fouque
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background. The assessment of physical activity and energy expenditure is relevant to the care of maintenance haemodialysis (MHD) patients. In the current study, we aimed to evaluate measurements of physical activity and energy expenditure in MHD patients from different centres and countries and explored the predictors of physical activity in these patients. Methods. In this cross-sectional multicentre study, 134MHD patients from four countries (France, Switzerland, Sweden and Brazil) were included. The physical activity was evaluated for 5.0 6 1.4 days (mean 6 SD) by a multisensory device (SenseWear Armband) and comprised the assessment of number of steps per day, activity-related …
Influence Of 18ghz Microwave Radiation On The Enzymatic Activity Of Escherichia Coli Lactate Dehydrogenase And Cytochrome C Oxidase, Yuri Shamis, Alex Traub, Rodney J. Croft, Russell Crawford, Elena Ivanova
Influence Of 18ghz Microwave Radiation On The Enzymatic Activity Of Escherichia Coli Lactate Dehydrogenase And Cytochrome C Oxidase, Yuri Shamis, Alex Traub, Rodney J. Croft, Russell Crawford, Elena Ivanova
Faculty of Health and Behavioural Sciences - Papers (Archive)
The catalytic activity of two common bacterial enzymes, lactate dehydrogenase (LDH) and cytochrome c oxidase (COX) from Escherichia coli, was examined following bacterial exposure to microwave (MW) radiation under well-defined experimental conditions. The experiments were conducted in a specialised microwave processing apparatus, with an exposure frequency of 18 GHz, and a temperature profile that was restricted to below 40oC to avoid thermal degradation of the bacteria. The absorbed power was calculated to be 1500 kW/m3 and the electric field was determined to be 300 V/m. Both values were theoretically confirmed using Computer Simulation Technology (CST) Microwave Studio 3D Electromagnetic Stimulation …