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Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Simvastatin Prevents Dopaminergic Neurodegeneration In Experimental Parkinsonian Models: The Association With Anti-Inflammatory Responses, Junqiang Yan, Yunqi Xu, Cansheng Zhu, Limin Zhang, Aimin Wu, Yu Yang, Zhaojun Xiong, Chao Deng, Xu-Feng Huang, Midori A. Yenari, Yuan-Guo Yang, Weihai Ying, Qing Wang
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background: In addition to their original applications to lowering cholesterol, statins display multiple neuroprotective effects. N-methyl-D-aspartate (NMDA) receptors interact closely with the dopaminergic system and are strongly implicated in therapeutic paradigms of Parkinson’s disease (PD). This study aims to investigate how simvastatin impacts on experimental parkinsonian models via regulating NMDA receptors. Methodology/Principal Findings: Regional changes in NMDA receptors in the rat brain and anxiolytic-like activity were examined after unilateral medial forebrain bundle lesion by 6-hydroxydopamine via a 3-week administration of simvastatin. NMDA receptor alterations in the post-mortem rat brain were detected by [3H]MK-801(Dizocilpine) binding autoradiography. 6-hydroxydopamine treated PC12 was applied …
Revealing Indigenous Indonesian Traditional Medicine: Anti-Infective Agents, Paul A. Keller, Ari Satia Nugraha
Revealing Indigenous Indonesian Traditional Medicine: Anti-Infective Agents, Paul A. Keller, Ari Satia Nugraha
Faculty of Science - Papers (Archive)
Indonesia is rich in medicinal plants which the population has used traditionally from generation to generation for curing diseases. Our interest in the treatment of infectious diseases has lead to the investigation of traditional Indonesian treatments. In this review, we present a comprehensive review of ethnopharmacologically directed screening in Indonesian medicinal plants to search for new anti-viral, antimalarial, anti-bacterial and anti-fungal agents. Some potent drug leads have been isolated from Indonesian medicinal plants. Further research is still required for the lead development as well as the search for new bioactive compounds from the enormous medicinal plant resources.
Anti-Representationalism: Not A Well-Founded Theory Of Cognition, Michael Kirchhoff
Anti-Representationalism: Not A Well-Founded Theory Of Cognition, Michael Kirchhoff
Faculty of Arts - Papers (Archive)
This article argues for the conclusion that anti-representationalism in the cognitivesciences is not a well-founded theory of cognition. This conclusion is supported by the observationthat the link between the sceptical demonstrations and the anti-representational conclusion is tooweak for the demonstrations to justify anti-representationalism in general. Rather than denying theneed for internal representation, this article aim to establish that representational explanation -reconstructed within a dynamical agent-environment characterization - serves a necessary epistemicand ontological aim: It enables us to demarcate activities that presuppose intentionality andbehavioral autonomy from activities that are merely reactive and situation-determined.
Initiatives On Ip Enforcement Beyond Trips: The Anti-Counterfeiting Trade Agreement And The International Medical Products Anti-Counterfeiting Task Force, Christoph Antons, Gabriel Garcia
Initiatives On Ip Enforcement Beyond Trips: The Anti-Counterfeiting Trade Agreement And The International Medical Products Anti-Counterfeiting Task Force, Christoph Antons, Gabriel Garcia
Dr Gabriel Garcia
No abstract provided.