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Social and Behavioral Sciences Commons™
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Articles 1 - 4 of 4
Full-Text Articles in Social and Behavioral Sciences
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
The Schizophrenia Susceptibility Gene Neuregulin 1 Modulates Tolerance To The Effects Of Canabinoids, Aurelie Boucher, Glenn E. Hunt, Jacques Micheau, Xu-Feng Huang, Iain Mcgregor, Tim Karl, Jonathon Arnold
Faculty of Health and Behavioural Sciences - Papers (Archive)
Cannabis increases the risk of schizophrenia in genetically vulnerable individuals. In this study we aim to show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice. Nrg1 heterozygous (HET) and wild-type (WT) mice were treated daily for 15 d with the synthetic analogue of D9-tetrahydrocannabinol, CP55,940 (0.4 mg/kg). We measured the impact of this exposure on locomotor activity, anxiety, prepulse inhibition (PPI), body temperature and FosB/DFosB immunohistochemistry. Tolerance to CP55,940-induced hypothermia and locomotor suppression developed more rapidly in Nrg1 HET mice than WT mice. Conversely in the light-dark test, while tolerance to …
Cerebellar White-Matter Changes In Cannabis Users With And Without Schizophrenia, N Solowij, M Yucel, C Respondek, S Whittle, E Lindsay, C Pantelis, D I. Lubman
Cerebellar White-Matter Changes In Cannabis Users With And Without Schizophrenia, N Solowij, M Yucel, C Respondek, S Whittle, E Lindsay, C Pantelis, D I. Lubman
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background. The cerebellum is rich in cannabinoid receptors and implicated in the neuropathology of schizophrenia. Long-term cannabis use is associated with functional and structural brain changes similar to those evident in schizophrenia, yet its impact on cerebellar structure has not been determined. We examined cerebellar grey and white matter in cannabis users with and without schizophrenia. Method. Seventeen patients with schizophrenia and 31 healthy controls were recruited ; 48% of the healthy group and 47% of the patients were long-term heavy cannabis users (mean 19.7 and 17.9 years near daily use respectively). Cerebellar measures were extracted from structural 3-T magnetic …
Quality Of Life Among People With Schizophrenia In Saudi Arabia, Amira Ali Alshowkan, Janette Curtis, Yvonne White
Quality Of Life Among People With Schizophrenia In Saudi Arabia, Amira Ali Alshowkan, Janette Curtis, Yvonne White
Faculty of Health and Behavioural Sciences - Papers (Archive)
Research aims: To provide a profile of the quality of life of people with schizophrenia in Saudi Arabia. To investigate the relationships between Socio-demographic characteristics and their quality of life.
The Quality Of Life Of People With Schizophrenia Living In The Community In Al-Khobar, Saudi Arabia, Amira Ali Alshowkan, Janette Curtis, Yvonne White
The Quality Of Life Of People With Schizophrenia Living In The Community In Al-Khobar, Saudi Arabia, Amira Ali Alshowkan, Janette Curtis, Yvonne White
Faculty of Health and Behavioural Sciences - Papers (Archive)
No abstract provided.