Social and Behavioral Sciences Commons^™

Quantitative Template For Subtyping Primary Progressive Aphasia, Marsel Mesulam, Christina Wieneke, Emily Rogalski, Derin J. Cobia, Cynthia Thompson, Sandra Weintraub

Faculty Publications

Objective—To provide a quantitative algorithm for classifying primary progressive aphasia (PPA) into agrammatic (PPA-G), semantic (PPA-S) and logopenic (PPA-L) variants, each of which is known to have a different probability of association with Alzheimer’s disease (AD) versus frontotemporal lobar degeneration (FTLD).

Design—Prospectively and consecutively enrolled 16 PPA patients tested with neuropsychological instruments and magnetic resonance imaging (MRI).

Setting—University medical center. Participants—PPA patients recruited nationally in the USA as part of a longitudinal study.

Results—A two-dimensional template, reflecting performance on tests of syntax (Northwestern Anagram Test) and lexical semantics (Peabody Picture Vocabulary Test), classified all 16 patients in concordance with a …

Provide Visual Structure For Students With Asd, Tina Taylor

Faculty Publications

World renowned animal scientist and autism self-advocate Temple Grandin said, "People on the autism/Asperger spectrum have uneven skills. They are often good at one type of learning and bad at another. Educators need to work on building up the area of strength." She explains that three cognitive areas of strength are those who are visual thinkers, pattern thinkers, and word thinkers. Visual thinkers are more inclined to think in pictures rather than words. They may excel in graphic design, industrial design, animation, geometry, or trigonometry. Pattern thinkers have abstract visual thoughts where they can see patterns and relationships between numbers. …

Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry

Faculty Publications

A powerful convergence of genetics, neuroimaging and epidemiological research has identified biological pathways mediating individual differences in complex behavioral processes and related risk for disease. Orthologous genetic variation in non-human primates represents a unique opportunity to characterize the detailed molecular and cellular mechanisms which bias behaviorally- and clinically-relevant brain function. We report that a rhesus macaque orthologue of a common polymorphism of the serotonin transporter gene (rh5-HTTLPR) has strikingly similar effects on behavior and brain morphology to those in humans. Specifically, the rh5- HTTLPR Short allele broadly impacts cognitive choice behavior and brain morphology without observably affecting 5-HT transporter or …

Social Relationships And Mortality Risk: A Meta-Analytic Review, Timothy B. Smith, Julianne Holt-Lunstad, J. Bradley Layton

Faculty Publications

Background: The quality and quantity of individuals' social relationships has been linked not only to mental health but also to both morbidity and mortality. Objectives: This meta-analytic review was conducted to determine the extent to which social relationships influence risk for mortality, which aspects of social relationships are most highly predictive, and which factors may moderate the risk. Data Extraction: Data were extracted on several participant characteristics, including cause of mortality, initial health status, and pre-existing health conditions, as well as on study characteristics, including length of follow-up and type of assessment of social relationships. Results: Across 148 studies (308,849 …

Tackling Sleeplessness: Psychological Treatment Options For Insomnia In Older Adults, Joseph C. Dzierzewski, Erin M. O’Brien, Daniel Kay, Christina S. Mccrae

Faculty Publications

This paper provides a broad review of the extant literature involving the treatment of sleeplessness in older adults with insomnia. First, background information (including information regarding key issues in late-life insomnia and epidemiology of late-life insomnia) pertinent to achieving a general understanding of insomnia in the elderly is presented. Next, theories of insomnia in older adults are examined and discussed in relation to treatment of insomnia in late-life. With a general knowledge base provided, empirical evidence for both pharmacological (briefly) and psychological treatment options for insomnia in late-life are summarized. Recent advances in the psychological treatment of insomnia are provided …

Married With Children: The Influence Of Parental Status And Gender On Ambulatory Blood Pressure, Wendy C. Birmingham, Julianne Holt-Lunstad, Adam M. Howard, Dustin Thoman

Faculty Publications

Background Although there is substantial evidence that social relationships and marriage may influence both psychological and physical health, little is known about the influence of children. Purpose This study examined the competing predictions regarding the directional influence of parental status and its interaction with gender—given that mothers are typically disproportionately more responsible for everyday care of children—on cardiovascular functioning. Method We examined ambulatory blood pressure (ABP) over 24 hours among 198 married males and females. Results Couples without children had significantly higher ambulatory SBP and DBP than those with children. Moreover, we found a significant interaction between parental status and …

Empathy And Error Processing, Scott A. Baldwin, Michael J. Larson, Joseph E. Fair, Daniel A. Good

Faculty Publications

Recent research suggests a relationship between empathy and error processing. Error processing is an evaluativecontrol function that can be measured using post-error response time slowing and the error-related negativity (ERN)and post-error positivity (Pe) components of the event-related potential (ERP). Thirty healthy participants completedtwo measures of empathy, the Interpersonal Reactivity Index (IRI) and the Empathy Quotient (EQ), and a modifiedStroop task. Post-error slowing was associated with increased empathic personal distress on the IRI. ERN amplitudewas related to overall empathy score on the EQ and the fantasy subscale of the IRI. The Pe and measures of empathywere not related. Results remained consistent …

Multiple Pathways To Functional Impairment In Obsessive–Compulsive Disorder, Scott A. Baldwin, Yeraz Markarian, Michael J. Larson, Mirela A. Aldea, Daniel Good, Arjan Berkeljon, Tanya K. Murphy, Eric E. Storch, Dean Mckay

Faculty Publications

Obsessive–compulsive disorder (OCD) is a chronic and debilitating condition that is relatively common in both children and adults, and it is associated with a wide range of functional impairments. Mental health researchers and practitioners have placed considerable attention on OCD over the past two decades, with the goal of advancing treatment and understanding its etiology. Until recently, it was unknown to what extent this disorder was associated with functional impairment. However, recent research shows that the condition has significant social and occupational liabilities. This article discusses etiology, common symptom presentations (including comorbid and ancillary symptoms), basic OCD subtypes, neuropsychological functioning, …

Temporal Stability Of The Error-Related Negativity (Ern)And Post-Error Positivity (Pe): The Role Of Number Of Trials, Scott A. Baldwin, Michael J. Larson, Daniel A. Good, Joseph E. Fair

Faculty Publications

The error-related negativity (ERN) and post-error positivity (Pe) components of the event-related potential (ERP) arerelatively stable over time. The current study further assessed the temporal reliability of ERN and Pe amplitudes forrandom samples of 2 to 14 trials per participant and the grand mean over a 2-week retest interval. In a replication ofprevious results, intraclass and zero-order correlations revealed moderate to good temporal stability for participants’(N520) grand mean ERN and Pe component amplitudes. Adding trials increased test–retest reliabilities; however, thetemporal stability of ERN and Pe amplitudes with 14 or fewer trials were modest at best and considerably lower thanthat for …

Use Of The Patient Care Monitor To Screen For Depressionin Adult Cancer Patients Interviewed With The Structuredclinical Interview For Dsm-Iv, Scott A. Baldwin, Arthur C. Houts, Damon Lipinski, James P. Olsen, Murad Hasan

Faculty Publications

Objective: To evaluate the Patient Care Monitor (PCM1.0) Acute Distress and DespairnormalizedTscores as indicators of a diagnosis of Major Depression according to theStructured Clinical Interview for DSM-IV Axis I Disorders (SCID).Methods: Subjects were 21 adult cancer patients identified by treating communityoncologists as having significant emotional distress matched on age, cancer type, treatmenthistory, and sex to 21 patients not having significant distress. All completed e/tablet PCM 1.0and SCID administered by trained interviewers. Unweighted kappa and receiver operatingcharacteristics (ROC) analyses were used to assess scale properties.Results: Agreement between SCID Major Depression and Acute Distress and Despair(TX65) were kappa50.751 and 0.755, respectively. ROC …

Alcohol Response And Consumption In Adolescent Rhesus Macaques: Life History And Genetic Influences, Melanie L. Schwandt, Stephen G. Lindell, Scott Chen, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr

Faculty Publications

The use of alcohol by adolescents is a growing problem and has become an important research topic in the etiology of the alcohol use disorders. A key component of this research has been the development of animal models of adolescent alcohol consumption and alcohol response. Due to their extended period of adolescence, rhesus macaques are especially well-suited for modeling alcoholrelated phenotypes that contribute to the adolescent propensity for alcohol consumption. In this review, we discuss studies from our laboratory that have investigated both the initial response to acute alcohol administration and the consumption of alcohol in voluntary self-administration paradigms in …

Effects Of Early-Life Stress On 5-Ht1a Receptors In Juvenile Rhesus Monkeys Measured By Pet, Simona Spinelli, Svetlana Chefer, Richard E. Carson, Elaine Jagoda, Lixin Lang, Markus Heilig, Christina S. Barr, Stephen J. Suomi, J. Dee Higley, Elliot A. Stein

Faculty Publications

Background—Traumatic experiences in early childhood are associated with increased risk for developing mood and anxiety disorders later in life. Low serotonin1A receptor (5-HT1AR) density during development has been proposed as a trait-like characteristic leading to increased vulnerability of stress-related neuropsychiatric disorders.

Methods—To assess the relationship between early-life stress and alterations in the serotonin system during development, we used positron emission tomography (PET) to measure in vivo 5- HT1AR density and apparent dissociation constant (KD app) in the brain of juvenile rhesus monkeys exposed to the early-life stress of peer-rearing.

Results—In general, 5-HT1AR density and KD app were decreased in peer-reared …

Are Older Adults Less Or More Physiologically Reactive? A Meta-Analysis Of Age-Related Differences In Cardiovascular Reactivity To Laboratory Tasks, Wendy C. Birmingham, Bert N. Uchino, Cynthia A. Berg

Faculty Publications

In this meta-analytic review of 31 laboratory studies, we examined if relatively older adults showed lower or higher cardiovascular reactivity compared with relatively younger adults. Results revealed that age was associated with lower heart rate reactivity but higher systolic blood pressure (SBP) reactivity during emotionally evocative tasks. Consistent with the predictions of dynamic integration theory, the result for SBP was moderated by the degree of task activation. These data are discussed in light of existing self-regulatory models and important future research directions.

Self-Regulation As A Mediator Between Sibling Relationship Quality And Early Adolescents’ Positive And Negative Outcomes, Laura M. Padilla-Walker, James M. Harper, Alexander C. Jensen Phd

Faculty Publications

The current study examined the role of adolescents’ self-regulation as a mediator between sibling relationship quality and adolescent outcomes, after controlling for the quality of the parent-child relationship. Participants were 395 families (282 two parent; 113 single parent) with an adolescent child (M age of child at Time 1 = 11.15, SD = .96, 49% female) who took part in [project name masked for blind review] at both Time 1 and Time 2. Path analysis via structural equation modeling suggested that sibling affection was longitudinally and positively related to self-regulation and prosocial behaviors, and negatively related to externalizing behaviors; while …