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Administration Of A Cannabinoid Receptor Antagonist Following Chronic ∆9-Tetrahydrocannabinol Induces Physical Withdrawal In The Absence Of A Dysphoric State, Brittany Ford

Theses and Dissertations (Comprehensive)

The selective cannabinoid CB1 receptor antagonist SR141716 has been shown to precipitate physical signs of withdrawal in ∆⁹-tetrahydrocannabinol (THC)-dependent rats; however, the affective state associated with this withdrawal state has not yet been well characterized. Thus, the aim of present study was to examine the physical and affective consequences of SR141716-precipitated THC withdrawal in male Sprague-Dawley rats. Rats were injected with THC (5 mg/kg, i.p.) or its vehicle twice daily for 13 consecutive days, and challenged with SRI 41716 (1 mg/kg, i.p.) or its vehicle 1 h later on days 3, 5, 7, 9, 11, and 13. Consistent …