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Effects Of Acute And Chronic Endurance Exercise On Intracellular Nitric Oxide In Putative Endothelial Progenitor Cells: Role Of Napdh Oxidase, Nathan T. Jenkins, Sarah Witkowski, Espen E. Spangenburg, James M. Hagberg

Exercise and Sport Studies: Faculty Publications

We sought to delineate the effects of acute and chronic exercise on the regulation of intracellular nitric oxide (NOi) production in putative endothelial progenitor cells (EPCs). Putative EPC colony-forming units (CFUEC) were cultured from blood drawn before and after 30 min of treadmill exercise at 75% of maximal oxygen uptake in active (n = 8) and inactive (n = 8) men. CFU-EC were similar between groups at baseline, but increased after exercise in active men only (P = 0.04). CFU-EC expressed lower NADPH oxidase subunit gp91 phox mRNA and elevated endothelial nitric oxide synthase mRNA in active relative to inactive …