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Social and Behavioral Sciences Commons™
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Articles 1 - 3 of 3
Full-Text Articles in Social and Behavioral Sciences
Activity In Both Hippocampus And Perirhinal Cortex Predicts The Memory Strength Of Subsequently Remembered Information, Y. Schrager, C. Brock Kirwan, L. R. Squire
Activity In Both Hippocampus And Perirhinal Cortex Predicts The Memory Strength Of Subsequently Remembered Information, Y. Schrager, C. Brock Kirwan, L. R. Squire
Faculty Publications
An influential idea about memory and medial temporal lobe function suggests that hippocampal activity predicts subsequent recognition success only when decisions are based on recollection, whereas perirhinal activity predicts subsequent recognition success when decisions are based on familiarity. An alternative idea is that hippocampal and perirhinal activity are both sensitive to the level of overall memory strength. Using functional magnetic resonance imaging, we have tested the relationship between brain activity during learning and subsequent memory strength. Activity in a number of cortical regions (including regions within what has been termed the default network) was negatively correlated with subsequent memory strength, …
Clinical Application Of Standardized Cognitive Assessment Using Fmri. Ii. Verbal Fluency, Mark D. Allen, Alina K. Fong
Clinical Application Of Standardized Cognitive Assessment Using Fmri. Ii. Verbal Fluency, Mark D. Allen, Alina K. Fong
Faculty Publications
In this study, we describe an fMRI version of the verbal fluency test. This is the second in a series of fMRI adaptations of classical neuropsychological tests, for which normative samples of functional activation have been collected from unimpaired control subjects and structured in a manner that makes individual patient evaluation possible in terms of familiar z-score distributions. This fMRI protocol is shown to have strong convergent validity with the FAS phonemic fluency test and to elicit activation patterns highly consistent with a large body of previous neuroimaging studies of verbal fluency. We also present a case study, in which …
Clinical Application Of Standardized Cognitive Assessment Using Fmri. I. Matrix Reasoning, Mark D. Allen, Alina K. Fong
Clinical Application Of Standardized Cognitive Assessment Using Fmri. I. Matrix Reasoning, Mark D. Allen, Alina K. Fong
Faculty Publications
Functional MRI is increasingly recognized for its potential as a powerful new tool in clinical neuropsychology. This is likely due to the fact that, with some degree of innovation, it is possible to convert practically any familiar cognitive test into one that can be performed in the MRI scanning environment. However, like any assessment approach, meaningful interpretation of fMRI data for the purpose of patient evaluation crucially requires normative data derived from a sample of unimpaired persons, against which individual patients may be compared. Currently, no such normative data are available for any fMRI-based cognitive testing protocol. In this paper, …