Social and Behavioral Sciences Commons^™

An Analysis Of Metabotropic Glutamate Receptors 2/3 And 5 In Schizophrenia, Major Depression And Bipolar Disorder From The Stanley Neuropathology Consortium, N Matosin, E Frank, F Fernandez, C Deng, J Wong, Xu-Feng Huang, K A. Newell

Xu-Feng Huang

Purpose: Metabotropic glutamate receptors (mGluRs) are proposed novel therapeutic targets for a variety of brain disorders such as schizophrenia (SZ), bipolar disorder (BP) and major depression (MD). Despite their potential, the involvement of these receptors in these pathological processes is uncertain. This information is crucial to understand the efficiency of drugs that target these receptors. Methods: Using post-mortem human brains, mGluR2/3 and mGluR5 binding densities were measured in the anterior cingulate cortex of SZ, BP, MD and matched controls (CT) (n=15/group) by receptor autoradiography. Results: Whilst preliminary analyses indicated no diagnostic effect in mGluR2/3 or mGluR5 binding densities, mGluR2/3 binding …

Psychometric Analysis Of The Swedish Translation Of The Who Well-Being Scales, Jesper Löve, Crystal Moore, Lena Andersson, Gunnel Hensing

Crystal Moore

Purpose

The purpose of this study is to validate the Swedish translation of the WHO (Ten) and WHO (Five) Well-Being Questionnaires among three samples of Swedes.

Methods

Baseline data collected in 2008 from the Health Assets Project are the data source consisting of three cohorts of Swedes aged 19–64 years: (1) a randomized general population cohort (n = 4,027); (2) employees sick-listed reported by the employer (n = 3,310); and (3) self-certified sick-listed individuals (n = 498). The psychometric properties of the scales are assessed using factor analysis, Cronbach’s alpha, and examination of the relationship between scale …

Measuring Depression In Prostate Cancer Patients: Does The Scale Used Make A Difference?, Christopher Sharpley, Vicki Bitsika, David Christie, Myra Hunter

Vicki Bitsika

This study investigated differences in the scores, relative severity and major depressive disorder (MDD) and subsyndromal depression status from three standardised self-report scales for depression in prostate cancer (PCa) patients. The Hospital Anxiety and Depression Scale Depression subscale (HADS-D), the Self-rating Depression Scale (SDS) and the Patient Health Questionnaire (PHQ-9) for depression were administered to a sample of 138 PCa patients via mail-out self-reports in Queensland, Australia during May 2014. Despite significant correlations between the total scores from the three scales, severity classification differed across the three scales and there was evidence of considerable underestimation of depression by the HADS-D …

Differences In The Prevalence, Severity And Symptom Profiles Of Depression In Boys And Adolescents With An Autism Spectrum Disorder Versus Normally Developing Controls, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

The prevalence, severity and symptom profiles for major depressive disorder (MDD) were compared in samples of boys and adolescents with and without an autism spectrum disorder (ASD). Self-reports were obtained on the Depression subscale of the Child and Adolescent Symptoms Inventory (CASI-D) with 70 ASD and 50 non-ASD male participants between the ages of 8 and 18 from Queensland, Australia who were matched for age and IQ. Results indicated that the ASD participants had significantly higher total CASI-D scores, a greater proportion of participants who qualified for a diagnosis of MDD, and over 50% higher scores for 8 of the …

Researching Depression In Prostate Cancer Patients: Factors, Timing, And Measures., Christopher Sharpley, Vicki Bitsika, David Christie, James Denham, Gillian Duchesne, Jeremy Couper

Vicki Bitsika

Background: Due to the pressing need to understand the causal and associative factors of depression among prostate cancer (PCa) patients, a comprehensive research protocol for investigating depression in prostate cancer patients is suggested as a way of furthering the collection of data in consistent and informative ways. Methods: A detailed review of a range of predictors of, and buffers against, depression, plus methods of assessing depressive symptomatology and optimum time to collect data were used to develop a model for a comprehensive research protocol. Results: A model protocol is described that includes socioeconomic, genetic, endocrinal, immunological, physiological, psychological, relationship, and …

Body Dissatisfaction And Surveillance, Exercise Frequency, Depression And Self-Esteem In A University Population, Peta Stapleton, Natalie Dzodz

Peta B. Stapleton

The purpose of the present study was to explore the relationship between body dissatisfaction and body surveillance, exercise frequency, depression and self-esteem in 121 university students from various Australian tertiary institutions aged between 17 to 45 years old population. This study also aimed to observe gender differences in the experience of body dissatisfaction. Inconsistent with previous research and the present hypothesis, no significant relationship was found between body dissatisfaction and exercise frequency or body surveillance. However, a significant relationship was found between body dissatisfaction and depression, as well as with self-esteem. Gender was also found to significantly predict body dissatisfaction, …

Measuring Individual Burden Of Illness For Depression Among Prostate Cancer Patients, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Objective: This study aims to develop and test three potential models of Individual Burden of Illness for Depression (IBI-D) in prostate cancer patients. Methods: Responses to three sets of scales measuring depressive symptoms, functional impairment, and quality of life satisfaction were collected from 191 prostate cancer patients and analysed via principal components analysis to obtain weightings for each of the scales within the three sets of measures. These weightings were then used to form IBI-D Indices, and these were then compared with depressive symptoms alone for their overlap. Results: Single-factor solutions were found for each of the three IBI-D models, …

Variability In Depressive Symptoms Of Cognitive Deficit And Cognitive Bias During The First 2 Years After Diagnosis In Australian Men With Prostate Cancer, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

The incidence and contribution to total depression of the depressive symptoms of cognitive deficit and cognitive bias in prostate cancer (PCa) patients were compared from cohorts sampled during the first 2 years after diagnosis. Survey data were collected from 394 patients with PCa, including background information, treatments, and disease status, plus total scores of depression and scores for subscales of the depressive symptoms of cognitive bias and cognitive deficit via the Zung Self-Rating Depression Scale. The sample was divided into eight 3-monthly time-since-diagnosis cohorts and according to depression severity. Mean scores for the depressive symptoms of cognitive deficit were significantly …

Differences In Major Depressive Disorder And Generalised Anxiety Disorder Symptomatology Between Prostate Cancer Patients Receiving Hormone Therapy And Those Who Are Not, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie

Vicki Bitsika

Objective: The aim of this study is to explore the associations between hormone treatment variables and depression, and the nature of depression in prostate cancer (PCa) patients by comparing the severity and symptom profile of anxiety and depression in men who were currently receiving hormone therapy (HT) versus those who were not. Method: Self-reports of anxiety and depression on standardized scales of GAD and major depressive disorder (MDD) were collected from 156 PCa patients across two recruitment sites in Australia. Patients who were currently receiving HT were compared with patients not receiving HT for their severity and symptom profiles on …

Predictors Of Depression In Prostate Cancer Patients: A Comparison Of Psychological Resilience Versus Pre-Existing Anxiety And Depression, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie

Vicki Bitsika

Background: Previous anxiety and depression can influence current anxiety and depression, and psychological resilience may be a buffer against current anxiety and depression. However, despite the relevance of these two sets of predictors of anxiety and depression, and their potential in treatment planning, no reports have been published on their role in post-diagnosis anxiety and depression among prostate cancer (PCa) patients. Therefore, this study aimed to determine the roles of these predictors in a sample of men with prostate cancer. Method: Retrospective self-reports of anxiety and depression for how they were before receiving their diagnosis of PCa and at the …

Are You A Perfectionist And Does It Matter? Depression And Perfectionism In Australian University Students, Maryke Mead, Richard Hicks

Richard Hicks

This study examined the relationships that exist between depression and adaptive and maladaptive perfectionism among university students. There has been earlier evidence that depression in a general population is related to maladaptive perfectionism, but first, would this be the case among university students and second, would adaptive perfectionism be related positively to wellbeing (i.e., be related negatively to depression). This current study examined these questions in a sample of 215 university students across three Australian states. The links between maladaptive perfectionism and poorer mental health were confirmed, but there was no significant relationship found between adaptive perfectionism and depression or …

Depression Symptoms Improve After Successful Weight Loss With Emotional Freedom Techniques, Peta Stapleton, Dawson Church, Terri Sheldon, Brett Porter, Cassandra Carlopio

Peta B. Stapleton

Participants crossed over to the EFT group upon completion of wait period. Degree of food craving, perceived power of food, restraint capabilities, and psychological symptoms were assessed at pretreatment, posttreatment and at 12-month follow-up for combined EFT groups. Significant improvements in weight, body mass index, food cravings, subjective power of food, craving restraint and psychological coping for EFT participants from pretreatment to 12-month follow-up (𝑃 < 0.05) were reported. The current paper isolates the depression symptom levels of participants, as well as levels of eight other psychological conditions. Significant decreases from pre- to posttreatment were found for depression, interpersonal sensitivity, obsessive-compulsivity, …

Does Resilience 'Buffer' Against Depression In Prostate Cancer Patients? A Multi-Site Replication Study, Christopher Sharpley, Vicki Bitsika, Addie Wootten, David Christie

Vicki Bitsika

Although psychological resilience has been shown to 'buffer' against depression following major stressors, no studies have reported on this relationship within the prostate cancer (PCa) population, many of whom are at elevated risk of depression, health problems and suicide. To investigate the effects of resilience upon anxiety and depression in the PCa population, postal surveys of 425 PCa patients were collected from two sites: 189 PCa patients at site 1 and 236 at site 2. Background data plus responses to depression and resilience scales were collected. Results indicated that total resilience score was a significant buffer against depression across both …

Mental Health Risk Factors Associated With Childhood Language Brokering, Robert Morrison

Robert Morrison

Do Patient-Reported Androgen-Deprivation Therapy Side Effects Predict Anxiety And Depression Among Prostate Cancer Patients Undergoing Radiotherapy? Implications For Psychosocial Therapy Interventions, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Antiandrogen therapy (AAT) is a common adjunct treatment for prostate cancer (PCa) patients and has shown significant benefits to long-term outcomes from radiation or surgery. Although AAT has some adverse side effects and data from breast cancer patients indicate that such side effects from hormonal therapies may contribute to anxiety and depression and may also hinder AAT treatment compliance, this issue has not been investigated within a sample of PCa patients. This study explores the incidence of AAT side effects in a sample of PCa patients, the links between those side effects and anxiety and depression, the possible ways in …

Do Prostate Cancer Patients Suffer More From Depressed Mood Or Anhedonia?, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Objective: This study aimed to compare the prevalence of depressed mood and anhedonia in a sample of men with prostate cancer (PCa) and to determine which of these key symptoms contributed most to the overall depressive status of that sample. Method: From Zung Self-rating Depression Scale (SDS) responses collected on 526 PCa patients, direct comparisons were made between the prevalence of the first two DSM-IV-TR symptoms of Major Depressive Episode. These symptoms were then tested for their predictive power on depression total score and Zung’s criteria for ‘clinically significant’ depression. Results: Mean scores for anhedonia were significantly higher than for …

Comorbidity Of Anxiety-Depression Among Australian University Students: Implications For Student Counsellors, Vicki Bitsika, Christopher Sharpley

Vicki Bitsika

The incidence, factor structure and scale item differences in anxiety-depression comorbidity were investigated in a sample of Australian university students defined according to the presence of anxiety and/or depression. The incidence of anxiety-depression comorbidity was over 32%, about four times that for anxiety or depression alone. Participants with comorbidity had significantly higher Selfrating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) total and factor scores than those with anxiety or depression alone. The major differences between the comorbid and unitary disordered subgroups were for self-disintegration and autonomic arousal. Comorbidity of anxiety and depression is a more serious disorder than either …

Differences In Neurobiological Pathways Of Four "Clinical Content" Subtypes Of Depression, Christopher Sharpley, Vicki Bitsika

Vicki Bitsika

Although often considered as a mental disorder, depression is best described as a behavioural-neurobiological phenomenon. In addition, although usually reported as a unitary diagnosis, Major Depressive Episode is composed of a range of different symptoms that can occur in nearly 1,500 possible combinations to fulfil the required diagnostic criterion. To investigate and describe the underlying behavioural and neurobiological substrates of these symptoms, they were clustered into "clinical content" subtypes of depression according to their predominant common behavioural characteristics. These subtypes were then found to possess different neurobiological pathways that argue for different treatment approaches.

Coping Skill Acquisition During Computer-Based Cbt For Co-Occurring Substance Dependence And Depression, A Mitchell, Peter Kelly, Frank Deane, Frances Kay-Lambkin, A Baker

Peter Kelly

No abstract provided.

Metabotropic Glutamate Receptor Subtype 5 Is Reduced In Schizophrenia Subjects With Comorbid Major Depression And Unchanged Following Antipsychotic Drug Treatment, N Jimenez, Xu-Feng Huang, C Deng, K Newell

Xu-Feng Huang

Abstract of a paper that presented at the Australian Neuroscience Society 32nd Annual meeting.

The Interplay Between Depression, Anxiety, Interpersonal Problems And Self-Weighing On The Overall Eating Styles Of University Students, Peta Stapleton, Sheree Empson

Peta B. Stapleton

The world is facing an epidemic of obesity. As a result, it is vital that the contributing factors of this issue are identified and addressed. The aim of this study was to investigate the interplay between overall eating style scores in University students with depression, anxiety, interpersonal problems and self-weighing. The present study consisted of 170 participants (73% female). The results indicated that when social desirability, gender and race were controlled for, depression, interpersonal problems, and self-weighing significantly negatively contributed to overall eating style scores. When self-weighing and interpersonal problems were accounted for, anxiety was found to not significantly predict …

Dealing With Uncertainty In Life Commitment: Deciding On A Career, Victoria Alexander, Richard Hicks, Dee Bartrum

Richard Hicks

Resilience and resourcefulness are needed in dealing with major life issues. One such issue faced by all young people is that of career choice, because the effects are life-long in terms of satisfaction, wellbeing and lifestyle choice. This chapter looks at how resilient young people feel (degree of career certainty or uncertainty , or indecision), and what internal resources there are that help or hinder them in those choices. Resourcefulness is thought to be related to optimism and emotional intelligence, and to emotional wellbeing and stability. The situation which young people face represents challenges for them, as they are often …

The Impact Of Students' 'Internally' Versus 'Externally' Oriented Coping Strategies Upon Anxiety And Depression: Implications For Counselling Processes, Vicki Bitsika, Christopher Sharpley, Aspasia Aroutzidis, Dimity Smith

Vicki Bitsika

As a preliminary investigation of the implications for counselling practice of Purpose in Life (PIL), Search for Neotic Goals (SONG) and Conscientiousness (CON) as potential buffers against anxiety and depression among university student clients, 398 students from a university in eastern Australia completed measures of these constructs. Results indicated that, although having a clear PIL and being conscientious were negatively associated with anxiety and depression, SONG was positively linked with these disorders. More importantly for counselling processes, up to 10% of those students whose anxiety and depression would make them most likely to seek counselling showed inverse relationships between PIL, …

Variability In Anxiety And Depression Over Time Following Diagnosis In Patients With Prostate Cancer, Christoper Sharpley, David Christie, Vicki Bitsika

Vicki Bitsika

To determine the presence and nature of variability in anxiety and depression in patients with prostate cancer (PCa) over 3 years following diagnosis, 442 patients with PCa completed standardized anxiety and depression inventories via survey between 1 and 36 months after receiving their initial diagnosis. Data were analyzed from a series of 3-month cohorts, and results indicated that total scores and incidence of clinically significant anxiety and depression varied over time, but that this variability was restricted to specific subfactors of anxiety and depression. Provision of effective psychological treatment to patients with PCa is discussed.

Incidence And Nature Of Anxiety-Depression Comorbidity In Prostate Cancer Patients, Christoper Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Background: The aim of this study was to measure the incidence of anxiety-depression comorbidity among a sample of prostate cancer (PCa) patients and to investigate the total score, factor score and scale item differences across subgroups defined according to the presence of anxiety and/or depression. Methods: 491 PCa patients who had received their initial diagnosis between 1 and 113 months previously completed a survey of background variables, as well as the Zung Self-Rating Anxiety and Depression Scales (SAS, SDS). Results: Incidence of anxiety-depression comorbidity was nearly 16%, and higher than that previously reported in other samples. Although the directional differences …

What Stresses University Students: An Interview Investigation Of The Demands Of Tertiary Studies, Vicki Bitsika, Christoper Sharpley, Vira Rubenstein

Vicki Bitsika

Although several previous scales have been developed to measure the presence and effects of the stressful demands encountered by university students, most of these have been validated with samples drawn from US universities, commonly using only undergraduate psychology students. In addition, many of the items used are from scales designed for application within general adult populations, with little focus upon the specific stressors met by students. In order to identify what are the major changes these students encounter that they find stressful, a sample of 32 university students from different degree areas within an Australian university was individually interviewed using …

'What Made Me Unhappy'. Experiences Of, And Responses To, Lifestyle Changes In Breast Cancer Patients, Vicki Bitsika, Christoper Sharpley, David Christie

Vicki Bitsika

Sixteen breast cancer patients were interviewed about any lifestyle changes they had experienced and their reactions to those changes. Data were collected and analysed via content analysis and then summary tabulations of patient responses until replication of responses was verified across patients. Results indicated that most patients suffered a reduction in recreation activities, unpleasant physical side effects from treatment and loss of feminine appearance characteristics, all of which were seen as decreases in previously available and valuable sources of social support and self-esteem. In response to these losses, patients reported a common coping strategy of avoidance or escape similar to …

Causal 'Mapping' Of Depression And Anxiety Among Prostate Cancer Patients: A Preliminary Interview Study, Christopher Sharpley, Vicki Bitsika, David Christie

Vicki Bitsika

Background: Men with prostate cancer experience elevated levels of anxiety and depression, with some previous data suggesting that this is due to loss of previously-available social and personal reinforcing pleasant activities and abilities. Little is currently known about the range of activities/abilities that these patients lose, leaving open the question of how to best target lifestyle changes designed to help them overcome these negative effects on their mental health. This study used personal interviews to gather details of the pattern of lost activities/abilities from a sample of men with prostate cancer so that a self-report questionnaire might be developed for …

The Contribution Of Anxiety And Depression To Fatigue Among A Sample Of Australian University Students: Suggestions For University Counsellors, Vicki Bitsika, Christopher Sharpley, Ryan Bell

Ryan Bell

Responses to the Zung Self-Rating Anxiety Scale (SAS: Zung, W. (1971). A rating instrument for anxiety disorders. Psychosomatics, 12, 371-379), the Self-Rating Depression Scale (SDS: Zung, W. (1973). From art to science: The diagnosis and treatment of depression. Archives of General Psychiatry, 29, 328-337) and the Fatigue Severity Scale (FSS) developed by Krupp and colleagues (Krupp, L.B., LaRocca, N.G., Muir-Nash, J., & Steinberg, A.D. (1989). The fatigue severity scale: Application to patients with multiple sclerosis and systemic lupus erythematosus. Archives of Neurology, 46, 1121-1123) were collected from 200 Australian university students to explore the links between these three disorders. Reliability …

Positive (But Not Negative) Punishment Predicts Anxiety And Depression Among Prostate Cancer Patients: An Exploration Of The Behaviour Analytic Model Of Depression, Vicki Bitsika, Christopher Sharpley, David Christie

Vicki Bitsika

The relative power of Positive and Negative Punishment as predictors of anxiety and depression was investigated within the gender-specific population of Prostate Cancer patients. As well as being a more powerful predictor of total test scores, Positive Punishment was also a stronger predictor of the presence of clinical levels of anxiety and depression. Examination of the particular Positive Punishment events that were significantly associated with clinical anxiety and depression showed considerable overlap, supporting the concept of a combined anxiety-depression disorder. Suggestions for behavioural interventions with this patient group are made.