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Articles 1 - 11 of 11
Full-Text Articles in Social and Behavioral Sciences
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Short- And Long-Term Effects Of Antipsychotic Drug Treatment On Weight Gain And H1 Receptor Expression, Kelly Newell, Xu-Feng Huang, Chao Deng, Tom Burne, Mei Han
Xu-Feng Huang
The present study investigated body weight gain, food intake, open-field activity and brain histamine H1 receptor mRNA and protein expression in rats treated with three types of antipsychotics. Rats were divided into eight groups and treated with aripiprazole (2.25mg/kg/day), olanzapine (1.5mg/kg/day), haloperidol (0.3mg/kg/day) or vehicle (as control) for 1 or 12 weeks. Administration of olanzapine for 1 week led to a threefold increase in body weight gain and a 35% increase in fat deposits compared to controls (p<0.05). In the 12-week olanzapine treatment group, accumulative food intake was significantly higher in the first 7 weeks of treatment compared to …
Effect Of Chronic Treatment With Clozapine And Haloperidol On 5- Ht2a And 2c Receptor Mrna Expression In The Rat Brain, Xu-Feng Huang, Qing Wang, Yean Yeow Tan
Effect Of Chronic Treatment With Clozapine And Haloperidol On 5- Ht2a And 2c Receptor Mrna Expression In The Rat Brain, Xu-Feng Huang, Qing Wang, Yean Yeow Tan
Xu-Feng Huang
No abstract provided.
Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin
Chronic Treatment With Simvastatin Upregulates Muscarinic M1/4 Receptor Binding In The Rat Brain, Kelly Newell, P Wong, Xu-Feng Huang, Qing Wang, Wilfred Yeo, P Wang, Weihai Ying, Midori Yenari, Ayse Zengin
Xu-Feng Huang
Statins are increasingly being used for the treatment of a variety of conditions beyond their original indication for cholesterol lowering. We previously reported that simvastatin affected the dopaminergic system in the rat brain. This study aims to investigate regional changes of muscarinic M1/4 receptors in the rat brain after 4-week administration of simvastatin (1 or 10 mg/kg/day). M1/4 receptor distribution and alterations in the post-mortem rat brain were detected by [3H]pirenzepine binding autoradiography. Simvastatin (1 mg/kg/day) increased [3H]pirenzepine binding, predominantly in the prefrontal cortex (171%, P<0.001), primary motor cortex (153%, P=0.001), cingulate cortex (109%, P<0.001), hippocampus (138%, P …
Short And Long Term Changes In Nmda Receptor Binding In Mouse Brain Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Short And Long Term Changes In Nmda Receptor Binding In Mouse Brain Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Effects Of Chronic Treatment Of Olanzapine And Haloperidol On Peptide Yy Binding Densities In The Rat Brain, Xu-Feng Huang, Qing Wang
Xu-Feng Huang
This study examined regional changes of peptide YY (PYY) binding densities in the rat brain after chronic administration of olanzapine (1.2 mg/kg/day and haloperidol (2.0 mg/kg/day)for 36 days. PYY binding densities and distributions were detected by [125I] binding autoradiography after ratswere sacrificed either 2 h or 48 h after the last drug administration to examine both immediate and delayed effects following the drugwithdrawal. Following 2 h of drug administration, it showed that olanzapine administration significantly decreased PYY binding densities, predominantly in the posterodorsal part of medial amygdaloid nucleus (52 percent, pb0.05), dorsal part of medial geniculate nucleus (56 percent, pb0.05), …
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Opposing Short- And Long-Term Effects On Muscarinic M1/4 Receptor Binding Following Chronic Phencyclidine Treatment, Kelly Newell, Xu-Feng Huang, Katerina Zavitsanou
Xu-Feng Huang
No abstract provided.
Perinatal Phencyclidine Treatment Alters Neuregulin 1/Erbb4 Expression And Activation In Later Life, Teresa Du Bois, Kelly Newell, Xu-Feng Huang
Perinatal Phencyclidine Treatment Alters Neuregulin 1/Erbb4 Expression And Activation In Later Life, Teresa Du Bois, Kelly Newell, Xu-Feng Huang
Xu-Feng Huang
Schizophrenia is a complex and devastating mental disorder of unknown etiology. Hypofunction of N-methyl-d-aspartate (NMDA) receptors are implicated in the disorder, since phencyclidine (PCP) and other NMDA receptor antagonists mimic schizophrenia-like symptoms in humans and animals so well. Moreover, genetic linkage and post mortem studies strongly suggest a role for altered neuregulin 1 (Nrg1)/erbB4 signaling in schizophrenia pathology. This study investigated the relationship between the NMDA receptor and Nrg1 signaling pathways using the perinatal PCP animal model. Rats (n = 5/group) were treated with PCP (10 mg/kg) or saline on postnatal days (PN) 7, 9 and 11 and were sacrificed …
Perinatal Pcp Treatment Alters The Developmental Expression Of Prefrontal And Hippocampal Muscarinic Receptors, Kelly Newell, Xu-Feng Huang, Chao Deng, Teresa Du Bois, Mei Han
Perinatal Pcp Treatment Alters The Developmental Expression Of Prefrontal And Hippocampal Muscarinic Receptors, Kelly Newell, Xu-Feng Huang, Chao Deng, Teresa Du Bois, Mei Han
Xu-Feng Huang
Perinatal phencyclidine (PCP) treatment has been used to model brain pathological processes that may be present in schizophrenia such as increased apoptosis during early brain development, and long-term alterations in expression of parvalbumin-containing interneurons and glutamatergic N-methyl-d-aspartate (NMDA) receptors. We report that this treatment also affects receptor expression of another excitatory neurotransmitter receptor, the muscarinic receptor. Female rat pups received injections of the NMDA receptor antagonist PCP (10 mg/kg, s.c.) or saline on postnatal days (PN)7, 9 and 11. [3H]Pirenzepine binding to M1/4 receptors was examined at four time-points (PN12, 18, 32 and 96) following treatment cessation. Significant effects of …
Drop Out From Residential Treatment: Is It All Bad News?, C Morgan, Peter Kelly, Frank Deane, Trevor Crowe
Drop Out From Residential Treatment: Is It All Bad News?, C Morgan, Peter Kelly, Frank Deane, Trevor Crowe
Peter Kelly
No abstract provided.
Benchmarking Client Improvement Within Substance Abuse Treatment, Peter Kelly, Frank Deane
Benchmarking Client Improvement Within Substance Abuse Treatment, Peter Kelly, Frank Deane
Peter Kelly
No abstract provided.
Faith-Based Substance Abuse Treatment: Is It Just About God? Exploring Treatment Providers' Attitudes Toward Spirituality, Forgiveness And Secular Components Of Treatment, Geoffrey Lyons, Frank Deane, Peter Kelly
Faith-Based Substance Abuse Treatment: Is It Just About God? Exploring Treatment Providers' Attitudes Toward Spirituality, Forgiveness And Secular Components Of Treatment, Geoffrey Lyons, Frank Deane, Peter Kelly
Peter Kelly
Although spirituality and forgiveness components of substance abuse treatment programs ar'e viewed as important by faithbased substance abuse treatment providers researchers have not compared their relative importance to other treatment components. This study evaluated the perceived importance of spiritually and forgiveness-based treatment components in comparison to other secular psycho-educational components in faith-based treatment programs. A brief survey was completed by 99 Salvation Army drug and alcohol treatment providers employed within Australian residential rehabilitation programs. The survey examined the relative importance treatment providers' placed on spiritual and secular components of treatment. Attitudes towards spiritual components of treatment, such as Christian education …