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Social and Behavioral Sciences Commons™
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Articles 1 - 7 of 7
Full-Text Articles in Social and Behavioral Sciences
Effects Of A Novel, Non-Toxic Histone Deacetylase Inhibitor On Hippocampal Memory Formation, Histone Acetylation, And Bdnf Gene Expression In Male Mice, Sarah Brianna Beamish
Effects Of A Novel, Non-Toxic Histone Deacetylase Inhibitor On Hippocampal Memory Formation, Histone Acetylation, And Bdnf Gene Expression In Male Mice, Sarah Brianna Beamish
Theses and Dissertations
Memory dysfunction is a common symptom of aging, neuropsychiatric disorders, and neurodegenerative disorders, yet truly effective treatments for memory loss do not exist. De novo gene transcription is a molecular requirement for long-term memory formation. The transcription of genes related to synaptic plasticity and learning are regulated in part by histone acetylation, an epigenetic mechanism that regulates chromatin accessibility. Pharmacological compounds that maintain histone acetylation, called histone deacetylase inhibitors (HDACi), enhance memory by preventing deacetylation of core histone proteins, which initiates binding of transcriptional machinery to open chromatin. Therefore, HDACi are potentially promising therapeutics that could be used to prevent …
The Association Of Aerobic Fitness With Resting State Functional Connectivity And Verbal Learning And Memory In Healthy Young Adults, Kyle Joseph Jennette
The Association Of Aerobic Fitness With Resting State Functional Connectivity And Verbal Learning And Memory In Healthy Young Adults, Kyle Joseph Jennette
Theses and Dissertations
The beneficial effects of exercise and cardiopulmonary fitness on general health, quality of life, and reduction of mortality are well known in older adults. There is evidence to support the positive effects of exercise and aerobic fitness on psychiatric and neurocognitive function in children, adults, and older adults. Indeed, many studies have explored the positive effects of aerobic fitness on slowing cognitive decline associated with normal and pathological aging. However, comparatively fewer empirical studies in the literature exist to support and understand the effects of aerobic fitness on the developing brain, particularly during adolescence and young adulthood, especially as it …
Shaped By The Environment: The Influence Of Childhood Trauma Exposure, Individual Socioeconomic Position, And Neighborhood Disadvantage On Brain Morphology, Elisabeth Kathleen Webb
Shaped By The Environment: The Influence Of Childhood Trauma Exposure, Individual Socioeconomic Position, And Neighborhood Disadvantage On Brain Morphology, Elisabeth Kathleen Webb
Theses and Dissertations
The relationship between an individual’s socioeconomic position (SEP) and their overall physical and mental health has been well demonstrated. Far less is known about how area-level factors, such as neighborhood disadvantage, “get under the skin”. Previous research indicates lower SEP and childhood trauma negatively effects brain structure and function. The hippocampus, amygdala, and ventromedial prefrontal cortex (vmPFC) are particularly vulnerable to adversity. The current study investigated how individual SEP, childhood trauma, and neighborhood disadvantage impact these structures. Two-hundred and fifteen individuals were recruited from an Emergency Department in southeastern Wisconsin. Two-weeks post-traumatic injury, participants completed a structural magnetic resonance imaging …
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Theses and Dissertations
Markers of cognitive impairment are needed to distinguish normal from pathological aging prior to the onset of clinical symptomology to improve Alzheimer’s disease (AD) treatment or prevention efforts. AD pathology is believed to develop years or even decades prior to diagnosis in medial temporal lobe subregions that provide input to the hippocampus (Braak & Braak, 1991), disrupting the ability of the hippocampus to bind individual elements of an experience to form cohesive memory representations. Eye movement behavior is a sensitive index of learning and effects of memory on eye movements have been shown to emerge rapidly (within 500-750ms of stimuli …
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Memory-Based Viewing: A Potential Marker Of Pathological Aging, Jenna Blujus
Theses and Dissertations
Markers of cognitive impairment are needed to distinguish normal from pathological aging prior to the onset of clinical symptomology to improve Alzheimer’s disease (AD) treatment or prevention efforts. AD pathology is believed to develop years or even decades prior to diagnosis in medial temporal lobe subregions that provide input to the hippocampus (Braak & Braak, 1991), disrupting the ability of the hippocampus to bind individual elements of an experience to form cohesive memory representations. Eye movement behavior is a sensitive index of learning and effects of memory on eye movements have been shown to emerge rapidly (within 500-750ms of stimuli …
The Role Of Brain-Synthesized E2 In Hippocampal Learning And Memory Consolidation In Female Mice, Jennifer Tuscher
The Role Of Brain-Synthesized E2 In Hippocampal Learning And Memory Consolidation In Female Mice, Jennifer Tuscher
Theses and Dissertations
The potent estrogen 17beta-Estradiol (E2) plays a critical role in neuroprotection, serving as an important trophic factor for neurons in the hippocampus, basal forebrain, and prefrontal cortex (Brinton, 2001). In the hippocampus, E2 promotes neurogenesis (Tanapat et al., 1999, Prange-Kiel et al., 2006), protects against cell death after ischemic injury (Garcia-Segura et al., 2001, Zhao and Brinton, 2007), and helps maintain spine morphology crucial for synaptic connectivity and memory (Woolley et al., 1990; Gould et al., 1990, Woolley and McEwen, 1992, Li et al., 2004). However, the mechanisms through which E2 promotes synaptic plasticity and enhances memory function are largely …
Neurophysiological And Morphological Plasticity In Rat Hippocampus And Medial Prefrontal Cortex Following Trace Fear Conditioning, Chenghui Song
Neurophysiological And Morphological Plasticity In Rat Hippocampus And Medial Prefrontal Cortex Following Trace Fear Conditioning, Chenghui Song
Theses and Dissertations
Pavlovian fear conditioning provides a useful model system for investigating the mechanisms underlying associative learning. In recent years, there has been an increasing interest in "trace" fear conditioning, which requires conscious awareness of the contingency of CS and US therefore considered as a rodent model of explicit fear. Acquisition of trace fear conditioning requires an intact hippocampus and medial prefrontal cortex (mPFC), but the underlying mechanisms are still unclear. The current set of studies investigated how trace fear conditioning affects neuronal plasticity in both hippocampus and mPFC in adult rats. Trace fear conditioning significantly enhanced both intrinsic excitability and synaptic …