Social and Behavioral Sciences Commons^™

Trustworthiness Appraisal Deficits In Borderline Personality Disorder Are Associated With Prefrontal Cortex, Not Amygdala, Impairment, Eric A. Fertuck, Jack Grinband, J. John Mann, Joy Hirsch, Kevin Ochsner, Paul Pilkonis, Jeff Erbe, Barbara Stanley

Publications and Research

Background

Borderline Personality Disorder (BPD) is associated with sensitivity to signals of interpersonal threats and misplaced trust in others. The amygdala, an integral part of the threat evaluation and response network, responds to both fear- and trust-related stimuli in non-clinical samples, and is more sensitive to emotional stimuli in BPD compared to controls. However, it is unknown whether the amygdalar response can account for deficits of trust and elevated sensitivity to interpersonal threat in BPD.

Methods

Facial stimuli were presented to 16 medication-free women with BPD and 17 demographically-matched healthy controls (total n = 33). Participants appraised fearfulness or trustworthiness …

Smaller Hippocampal Volume In Posttraumatic Stress Disorder: A Multisite Enigma-Pgc Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia, Mark W. Logue, Sanne Jh Van Rooij, Emily L. Dennis, Sarah L. Davis, Lauren O’Connor

Publications and Research

BACKGROUND—Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD), but findings have not always been consistent. Here, we present the results of a large-scale neuroimaging consortium study on PTSD conducted by the Psychiatric Genomics Consortium (PGC)–Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) PTSD Working Group.

METHODS—We analyzed neuroimaging and clinical data from 1868 subjects (794 PTSD patients) contributed by 16 cohorts, representing the largest neuroimaging study of PTSD to date. We assessed the volumes of eight subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, and lateral ventricle). We used a standardized image-analysis and …