Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Heritable Variation In Reward Sensitivity And Impulsive Cction And Choice In A Genetically Diverse Inbred Mouse Panel, Lauren S. Bailey
Heritable Variation In Reward Sensitivity And Impulsive Cction And Choice In A Genetically Diverse Inbred Mouse Panel, Lauren S. Bailey
Graduate Dissertations and Theses
Research in animal models and human subjects points towards reward sensitivity and impulsivity as being characteristics that predict greater positive subjective responses to stimulant drugs. The Collaborative Cross (CC) recombinant inbred mouse strains and their inbred founders are a powerful genetic reference panel that has potential as a tool for revealing genetic correlations. The CC/DO founder strains were used to examine the heritability of reward sensitivity and impulsivity traits. Founder strains were tested for activity in an open field, reward sensitivity, and reversal learning (impulsive action) or delay discounting (impulsive choice). Significant heritability for anticipatory responding within the reversal task, …
Thiamine Deficiency And Alcohol Exposure Both Lead To An Impulsive Phenotype, Robin J. Zimmer
Thiamine Deficiency And Alcohol Exposure Both Lead To An Impulsive Phenotype, Robin J. Zimmer
Graduate Dissertations and Theses
The detrimental effects of alcohol consumption, including impulsivity, cognitive inflexibility, and neuropathology, are due to a confluence of factors that often occur in addition to alcoholism. We examined the effects of chronic alcohol exposure and thiamine deficiency (or supplementation) in isolation, as well as in concert, to further our understanding of the independent effects of each treatment and how they interact. Our results demonstrated that both chronic alcohol exposure and moderate thiamine deficiency induce an impulsive phenotype. Importantly, the increased impulsivity induced by thiamine deficiency was protracted as compared to that exhibited after chronic alcohol alone. Additionally, differential pathology was …