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Faculty of Science, Medicine and Health - Papers: part A

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Healing At Home: Developing A Model For Ambulatory Alcohol "Detox" In An Aboriginal Community Controlled Health Service, Jonathan Brett, Angela Dawson, Rowena G. Ivers, Leanne Lawrence, Sarah Barclay, Kate M. Conigrave Jan 2017

Healing At Home: Developing A Model For Ambulatory Alcohol "Detox" In An Aboriginal Community Controlled Health Service, Jonathan Brett, Angela Dawson, Rowena G. Ivers, Leanne Lawrence, Sarah Barclay, Kate M. Conigrave

Faculty of Science, Medicine and Health - Papers: part A

Indigenous Peoples who have been colonized typically face a greater burden of injury, disease, and social disruption associated with alcohol use (Kirmayer, Brass, & Tait, 2000). However, they often also encounter many barriers to accessing treatment for alcohol use disorders (Gray, Stearne, Wilson, & Doyle, 2010). Aboriginal and Torres Strait Islander Australians (here described as Aboriginal Australians) experience 3-8 times the prevalence of alcohol-related illness, injury, and death than the general population (Calabria, Doran, Vos, Shakeshaft, & Hall, 2010). But their barriers to treatment access for alcohol dependence include transport difficulties, fear of discrimination, and lack of culturally secure services …


Changes In Diet Quality During A 12 Month Weight Loss Randomised Controlled Trial, Cinthya Wibisono, Yasmine Probst, Elizabeth Neale, Linda C. Tapsell Jan 2017

Changes In Diet Quality During A 12 Month Weight Loss Randomised Controlled Trial, Cinthya Wibisono, Yasmine Probst, Elizabeth Neale, Linda C. Tapsell

Faculty of Science, Medicine and Health - Papers: part A

Background: Reductions in energy intake are seen in weight loss trials, but whether this occurs with improvements to diet quality (DQ) is less established. The aim of this study was to evaluate changes in diet quality in a sample of volunteers in a weight loss trial. Methods: This was a secondary analysis of dietary data from a lifestyle intervention trial (the HealthTrack study) which advised on dietary guidelines. The trial ran for 12 months with three treatment groups: control (general advice C), intervention (individualised advice, I), and intervention plus a supplement of walnuts (IW). Both the published a priori diet …


The Translational Controlled Tumour Protein Tctp: Biological Functions And Regulation, Ulrich A. Bommer Jan 2017

The Translational Controlled Tumour Protein Tctp: Biological Functions And Regulation, Ulrich A. Bommer

Faculty of Science, Medicine and Health - Papers: part A

The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease …


A 6-Month Randomised Controlled Trial Investigating Effects Of Mediterranean-Style Diet And Fish Oil Supplementation On Dietary Behaviour Change, Mental And Cardiometabolic Health And Health-Related Quality Of Life In Adults With Depression (Helfimed): Study Protocol, Dorota M. Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Kerin O'Dea, Sarah Blunden, Barbara J. Meyer, Leonie Segal, Natalie Parletta Jan 2016

A 6-Month Randomised Controlled Trial Investigating Effects Of Mediterranean-Style Diet And Fish Oil Supplementation On Dietary Behaviour Change, Mental And Cardiometabolic Health And Health-Related Quality Of Life In Adults With Depression (Helfimed): Study Protocol, Dorota M. Zarnowiecki, Jihyun Cho, Amy Wilson, Svetlana Bogomolova, Anthony Villani, Catherine Itsiopoulos, Theo Niyonsenga, Kerin O'Dea, Sarah Blunden, Barbara J. Meyer, Leonie Segal, Natalie Parletta

Faculty of Science, Medicine and Health - Papers: part A

Background: Modern diets, characterised by excess consumption of processed foods, are accompanied by an epidemic of chronic diseases. Cardiovascular disease and depression carry a large burden of disease and often occur together. Poor dietary patterns have been identified as an independent risk factor for depression while healthy diets with minimally processed food are protective. Traditional Mediterranean diets have been shown to reduce risk of cardiovascular disease; however there is a need for clinical trials in people with depression. This paper reports the study protocol of a Mediterranean-style diet intervention conducted in adults with self-reported depression. Methods/design: HELFIMED is a parallel …


A Randomised Controlled Trial Of A Consumer-Focused E-Health Strategy For Cardiovascular Risk Management In Primary Care: The Consumer Navigation Of Electronic Cardiovascular Tools (Connect) Study Protocol, Julie Redfern, Tim Usherwood, Mark Fort Harris, A Rodgers, Noel Hayman, Kathryn S. Panaretto, C Chow, A Lau, Lis Neubeck, G Coorey, F Hersch, E Heeley, Anushka Dr Anushka Patel, S Jan, Nicholas Arnold Zwar, David Peiris Jan 2014

A Randomised Controlled Trial Of A Consumer-Focused E-Health Strategy For Cardiovascular Risk Management In Primary Care: The Consumer Navigation Of Electronic Cardiovascular Tools (Connect) Study Protocol, Julie Redfern, Tim Usherwood, Mark Fort Harris, A Rodgers, Noel Hayman, Kathryn S. Panaretto, C Chow, A Lau, Lis Neubeck, G Coorey, F Hersch, E Heeley, Anushka Dr Anushka Patel, S Jan, Nicholas Arnold Zwar, David Peiris

Faculty of Science, Medicine and Health - Papers: part A

Introduction: Fewer than half of all people at highest risk of a cardiovascular event are receiving and adhering to best practice recommendations to lower their risk. In this project, we examine the role of an e-health-assisted consumer-focused strategy as a means of overcoming these gaps between evidence and practice. Consumer Navigation of Electronic Cardiovascular Tools (CONNECT) aims to test whether a consumer-focused e-health strategy provided to Aboriginal and Torres Strait Islander and non-indigenous adults, recruited through primary care, at moderate-to-high risk of a cardiovascular disease event will improve risk factor control when compared with usual care. Methods and analysis: Randomised …


Preventive Evidence Into Practice (Pep) Study: Implementation Of Guidelines To Prevent Primary Vascular Disease In General Practice Protocol For A Cluster Randomised Controlled Trial, Mark Fort Harris, Jane Lloyd, John Litt, Mieke Van Driel, Danielle Mazza, Grant Russell, Jane Smith, Chris Del Mar, Elizabeth Denney-Wilson, Sharon M. Parker, Yordanka Krastev, Upali W. Jayasinghe, Richard J. Taylor, Nicholas Zwar, Jinty Wilson, Helen Bolger-Harris, Justine Waters Jan 2013

Preventive Evidence Into Practice (Pep) Study: Implementation Of Guidelines To Prevent Primary Vascular Disease In General Practice Protocol For A Cluster Randomised Controlled Trial, Mark Fort Harris, Jane Lloyd, John Litt, Mieke Van Driel, Danielle Mazza, Grant Russell, Jane Smith, Chris Del Mar, Elizabeth Denney-Wilson, Sharon M. Parker, Yordanka Krastev, Upali W. Jayasinghe, Richard J. Taylor, Nicholas Zwar, Jinty Wilson, Helen Bolger-Harris, Justine Waters

Faculty of Science, Medicine and Health - Papers: part A

Background: There are significant gaps in the implementation and uptake of evidence-based guideline recommendations for cardiovascular disease (CVD) and diabetes in Australian general practice. This study protocol describes the methodology for a cluster randomised trial to evaluate the effectiveness of a model that aims to improve the implementation of these guidelines in Australian general practice developed by a collaboration between researchers, non-government organisations, and the profession.Methods: We hypothesise that the intervention will alter the behaviour of clinicians and patients resulting in improvements of recording of lifestyle and physiological risk factors (by 20%) and increased adherence to guideline recommendations for: the …


Care Of Patients With A Diagnosis Of Chronic Obstructive Pulmonary Disease: A Cluster Randomised Controlled Trial, Nicholas Zwar, Oshana Hermiz, Elizabeth J. Comino, Sandy Middleton, Sanjyot Vagholkar, Wei Xuan, Stephen F. Wilson, Guy B. Marks Jan 2012

Care Of Patients With A Diagnosis Of Chronic Obstructive Pulmonary Disease: A Cluster Randomised Controlled Trial, Nicholas Zwar, Oshana Hermiz, Elizabeth J. Comino, Sandy Middleton, Sanjyot Vagholkar, Wei Xuan, Stephen F. Wilson, Guy B. Marks

Faculty of Science, Medicine and Health - Papers: part A

Objective: To evaluate a partnership model of care for patients with a diagnosis of chronic obstructive pulmonary disease (COPD). Design, setting and participants: Cluster randomised controlled trial with blinded outcome assessment of 44 general practices in south-western Sydney comprising 451 people with a diagnosis of COPD, conducted between 2006 and 2009. Intervention: Participants from intervention group practices were visited at their home by a registered nurse with specific training in COPD care who worked with the general practitioner, the patient and other health professionals to develop and implement an individualised care plan based on best-practice guidelines. Participants from control group …