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Full-Text Articles in Social and Behavioral Sciences
Differentiation Of Bone Marrow Stem Cells On Inkjet Printed Silk Lines, Skander Limem, Paul Calvert, Hyeon Joo Kim, David L. Kaplan
Differentiation Of Bone Marrow Stem Cells On Inkjet Printed Silk Lines, Skander Limem, Paul Calvert, Hyeon Joo Kim, David L. Kaplan
Faculty of Science, Medicine and Health - Papers: part A
Water based silk solutions were successfully inkjet printed for the first time into patterns of parallel lines onto vinyl plastic substrates. Human bone marrow stromal cells (hMSCs) were seeded on the silk printed patterns and cultured in the presence of 100 ng/ml of bone morphogenic protein (BMP-2). After one week of culture cell growth and attachment showed site specificity on the silk printed lines. Both alkaline phosphatase activity and cell morphology indicated hBMSCs differentiation into osteogenic cells along the silk printed lines. After 4 week of culture, the cellular bridging of adjacent silk printed lines took place for all interline …
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Systemic Levels Of Interleukin-6 And Matrix Metalloproteinase-9 In Patients With Multiple Myeloma May Be Useful As Prognostic Indexes Of Bone Disease, Aikaterini Sfiridaki, Spyridon Miyakis, George Tsirakis, Athanasios Alegakis, Andreas M. Passam, Ermioni Kandidaki, Andrerw N. Margioris, Michael Alexandrakis
Faculty of Science, Medicine and Health - Papers: part A
Multiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma- produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examined the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption. Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78"91.27 vs. 59.25"33.09 ng/mL, p-0.004). Additionally, free …