Open Access. Powered by Scholars. Published by Universities.®
Social and Behavioral Sciences Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Social and Behavioral Sciences
Effects Of Dexamethasone On Posterior Capsule Opacification-Like Changes In A Rat Lens Explant Model, Kylie Mansfield, Anna Cerra, Coral Chamberlain
Effects Of Dexamethasone On Posterior Capsule Opacification-Like Changes In A Rat Lens Explant Model, Kylie Mansfield, Anna Cerra, Coral Chamberlain
Faculty of Science, Medicine and Health - Papers: part A
Purpose: Many patients whose sight is initially restored by cataract surgery eventually suffer secondary loss of vision because of posterior capsule opacification (PCO; after-cataract), a condition in which lens epithelial cells left behind at surgery become aberrant and migrate into the light path. The aim of this study was to determine whether dexamethasone (DEX), an anti-inflammatory agent widely used before and after cataract surgery, influences the behavior of lens cells under conditions relevant to PCO development.
Methods: An established rat PCO model was used in which explanted epithelial cells attached to the lens capsule are exposed sequentially to TGFβ2 and …