Social and Behavioral Sciences Commons^™

Indirect Radio-Chemo-Beta Therapy: A Targeted Approach To Increase Biological Efficiency Of X-Rays Based On Energy, Sianne Oktaria, Stephanie Corde, Michael L. F Lerch, Konstantin K. Konstantinov, Anatoly B. Rosenfeld, Moeava Tehei

Faculty of Engineering and Information Sciences - Papers: Part A

Despite the use of multimodal treatments incorporating surgery, chemotherapy and radiotherapy, local control of gliomas remains a major challenge. The potential of a new treatment approach called indirect radio-chemo-beta therapy using the synergy created by combining methotrexate (MTX) with bromodeoxyuridine (BrUdR) under optimum energy x-ray irradiation is assessed. 9L rat gliosarcoma cells pre-treated with 0.01 μM MTX and/or 10 μM BrUdR were irradiated in vitro with 50 kVp, 125 kVp, 250 kVp, 6 MV and 10 MV x-rays. The cytotoxicity was assessed using clonogenic survival as the radiobiological endpoint. The photon energy with maximum effect was determined using radiation sensitization …