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Social and Behavioral Sciences Commons™
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Full-Text Articles in Social and Behavioral Sciences
Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Faculty Publications
The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects in vivo to the human variant. The current study investigated whether OPRM1 C77G influences HPA axis response to stress in rhesus macaques. We analyzed plasma adrenocorticotropic hormone (ACTH) and cortisol levels measured in response to three different stressors: 1) …
The Cortisol Awakening Response (Car) In 2-To 4-Year-Old Children: Effects Of Acute Nighttime Sleep Restriction, Wake Time, And Daytime Napping, Colleen E. Gribbin, Sarah Enos Watamura, Alyssa Cairns, John R. Harsh, Monique K. Lebourgeois
The Cortisol Awakening Response (Car) In 2-To 4-Year-Old Children: Effects Of Acute Nighttime Sleep Restriction, Wake Time, And Daytime Napping, Colleen E. Gribbin, Sarah Enos Watamura, Alyssa Cairns, John R. Harsh, Monique K. Lebourgeois
Faculty Publications
The cortisol awakening response (CAR) is presumed critically important for healthy adaptation. The current literature, however, is hampered by systematic measurement difficulties relative to awakening, especially with young children. While reports suggest the CAR is smaller in children than adults, well-controlled research in early childhood is scarce. We examined whether robust CARs exist in 2- to 4-year-old children and if sleep restriction, wake timing, and napping influence the CAR (n?=?7). During a 25-day in-home protocol, researchers collected four salivary cortisol samples (0, 15, 30, 45?min post-wake) following five polysomnographic sleep recordings on nonconsecutive days after 4?hr (morning nap), 7?hr (afternoon …