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Social and Behavioral Sciences Commons™
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Articles 1 - 2 of 2
Full-Text Articles in Social and Behavioral Sciences
Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry
Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry
Faculty Publications
A powerful convergence of genetics, neuroimaging and epidemiological research has identified biological pathways mediating individual differences in complex behavioral processes and related risk for disease. Orthologous genetic variation in non-human primates represents a unique opportunity to characterize the detailed molecular and cellular mechanisms which bias behaviorally- and clinically-relevant brain function. We report that a rhesus macaque orthologue of a common polymorphism of the serotonin transporter gene (rh5-HTTLPR) has strikingly similar effects on behavior and brain morphology to those in humans. Specifically, the rh5- HTTLPR Short allele broadly impacts cognitive choice behavior and brain morphology without observably affecting 5-HT transporter or …
Alcohol Response And Consumption In Adolescent Rhesus Macaques: Life History And Genetic Influences, Melanie L. Schwandt, Stephen G. Lindell, Scott Chen, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Alcohol Response And Consumption In Adolescent Rhesus Macaques: Life History And Genetic Influences, Melanie L. Schwandt, Stephen G. Lindell, Scott Chen, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Faculty Publications
The use of alcohol by adolescents is a growing problem and has become an important research topic in the etiology of the alcohol use disorders. A key component of this research has been the development of animal models of adolescent alcohol consumption and alcohol response. Due to their extended period of adolescence, rhesus macaques are especially well-suited for modeling alcoholrelated phenotypes that contribute to the adolescent propensity for alcohol consumption. In this review, we discuss studies from our laboratory that have investigated both the initial response to acute alcohol administration and the consumption of alcohol in voluntary self-administration paradigms in …