Social and Behavioral Sciences Commons^™

Association Between Exposure To Air Pollution And Hippocampal Volume In Adults In The Uk Biobank, Dawson W. Hedges, Lance D. Erickson, Jackie Kunzelman, Bruce L. Brown, Shawn D. Gale

Faculty Publications

Background: The hippocampus is important for memory processing. Several neuropsychiatric diseases including Alzheimer’s disease are associated with reduced hippocampal volume, and further the hippocampus appears vulnerable to environmental insult. Air pollution has been associated with cardiovascular disease, abnormal brain structure, and cognitive deficits.

Objective: Because of hippocampal vulnerability to environmental insults and based on the association between exposure to air pollution and cognitive function and brain structure, we evaluated the association between exposure to toxins in air pollution and left and right hippocampal volume using brain-imaging and air-pollution data from the UK Biobank, a large community-based dataset.

Methods …

Cardiovascular Factors Moderate The Association Of Infection Burden With Cognitive Function In Young To Middle-Aged U.S. Adults, Bruce L. Brown, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges, Andrew N. Berrett, Evan L. Thacker

Faculty Publications

Background: Infectious diseases might affect cognitive aging and dementia risk, possibly via neuroinflammation. Similarly, risk factors for cardiovascular and cerebrovascular diseases are associated with cognitive function and dementia. We hypothesized that cardiovascular risk factors moderate the association of exposure to infectious diseases with cognitive function.

Methods: We studied 5662 participants aged 20 to 59 years from the third National Health and Nutrition Examination Survey (1988–1994) in the United States. We used linear regression to investigate whether the Framingham general cardiovascular risk index moderated the association of infection burden based on exposure to eight different infectious diseases with cognitive functioning as …