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Full-Text Articles in Social and Behavioral Sciences
Experimental Immunology And The Potential For Osteopathological Reconstructions : Pursuing An Experimental Foundation For The Skeletal Inflammatory Index., Megan Elizabeth Duncanson
Experimental Immunology And The Potential For Osteopathological Reconstructions : Pursuing An Experimental Foundation For The Skeletal Inflammatory Index., Megan Elizabeth Duncanson
Electronic Theses and Dissertations
Individuals who mount a strong inflammatory response may produce a shift in the systemic levels of inflammatory mediators, which may lead to a potential hyper-inflammatory phenotype (HIP). Systemic inflammation can increase severity in local inflammatory processes detected in bone lesions. This thesis investigated in vitro if human immune cells pre-treated with inflammatory inducers would affect the inflammatory response against Porphyromonas gingivalis or Staphylococcus aureus (both associated with osteological lesions). We exposed human peripheral blood mononuclear cells to bacterial lysates, or pro-inflammatory cytokines. Sequentially, we exposed the same culture to either P. gingivalis or S. aureus. The final expression of …
Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham
Detecting Evidence Of Systemic Inflammation From Osteological Markers In The Indian Knoll Population Of Ohio County, Kentucky., Krysta Wilham
Electronic Theses and Dissertations
Indian Knoll is an Archaic shell midden site located in the Green River region of west-central Kentucky, and was excavated twice in the first half of the 20th century. While Indian Knoll has been the subject of frequent bioarchaeological studies, the present study presents an osteological analysis of the relationships between skeletal markers commonly associated with local inflammatory processes, and that have the potential to be used as proxies for systemic inflammation. The analysis revealed a significant positive association in the presence of periodontal disease (PD) and periosteal lesions (PL), suggesting a potential underlying hyper-inflammatory status or phenotype. These …