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Effects Of Nicotine And Anatoxin-A Exposures On The Operant Performance Of Rats, Kimberly Ann Jarema

Dissertations

Tolerance has previously been shown to develop to nicotine's effects on operant behavior. This experiment explored whether tolerance would still develop when nicotine administrations were separated by three weeks. Anatoxin-a, a nicotinic-receptor agonist, was also tested and the results were compared to nicotine. Male Long Evans rats performed under a multiple VR30 VI30-sec food-reinforcement schedule. Phase I rats were divided into 6 groups of 8 that received four weekly subcutaneous injections of nicotine (0.0-1.8 mg/kg) and anatoxin-a (0-250 mcg/kg) prior to testing sessions. An ED50 was derived, for each compound, from the VR dose-response curve. Phase II rats were divided …