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Functional Correlates Of Verbal Working Memory In Healthy Aging And Early Alzheimer's Disease, Michael Adam Sugarman

Wayne State University Theses

Deficits in the working memory system are common in patients diagnosed with Alzheimer's disease (AD). However, little is known regarding the neurobiological basis of this impairment. The current study examined the neurobiological functional correlates of the working memory system in early AD patients and cognitively intact control participants using a word list repetition task performed during positron emission tomography (PET). Compared to a reading control task, both the AD and control groups utilized a network of parietal, frontal, and cerebellar regions while completing the word rehearsal task. However, control participants displayed greater activation in all regions, especially in the parietal …