Social and Behavioral Sciences Commons^™

Catecholaminergic Neuromodulation Shapes Intrinsic Mri Functional Connectivity In The Human Brain, Ruud L. Van Den Brink, Thomas Pfeffer, Christopher M. Warren, Peter R. Murphy, Klodiana-Daphne Tona, Nic J. Van Der Wee, Eric Giltay, Martijn S. Van Noorden, Serge A. Rombouts, Tobias H. Donner, Sander Nieuwenhuis

Psychology Faculty Publications

The brain commonly exhibits spontaneous (i.e., in the absence of a task) fluctuations in neural activity that are correlated across brain regions. It has been established that the spatial structure, or topography, of these intrinsic correlations is in part determined by the fixed anatomical connectivity between regions. However, it remains unclear which factors dynamically sculpt this topography as a function of brain state. Potential candidate factors are subcortical catecholaminergic neuromodulatory systems, such as the locus ceruleus-norepinephrine system, which send diffuse projections to most parts of the forebrain. Here, we systematically characterized the effects of endogenous central neuromodulation on correlated fluctuations …