Social and Behavioral Sciences Commons^™

Behavioral Mechanisms Of Pramipexole-Induced Impulsivity: Discrimination Processes Underlying Decision-Making, Patrick S. Johnson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Impulsivity represents a substantial and devastating cost to our economic, cultural, and physical prosperity. Using quantitative models of choice behavior, researchers are able to identify environmental conditions likely to promote impulsive decision-making. Such an approach is especially valuable in experimental efforts to better understand how drugs negatively affect choice in humans and nonhumans alike. For instance, pramipexole, a dopamine agonist medication prescribed for Parkinson’s disease, has been associated with reports of increased rates of impulsive behavior. By which behavioral mechanisms pramipexole achieves these effects is unknown and requires further investigation.

The research reported herein sought to clarify pramipexole’s effects on …