Social and Behavioral Sciences Commons^™

Systematic Evaluation Of Machine-Learning Methods For Identifying Human-Pathogen Protein-Protein Interactions, Huaming Chen, Fuyi Li, Lei Wang, Yaochu Jin, Chi-Hung Chi, Lukasz Kurgan, Jiangning Song, Jun Shen

Faculty of Engineering and Information Sciences - Papers: Part B

In recent years, high-throughput experimental techniques have significantly enhanced the accuracy and coverage of protein–protein interaction identification, including human–pathogen protein–protein interactions (HP-PPIs). Despite this progress, experimental methods are, in general, expensive in terms of both time and labour costs, especially considering that there are enormous amounts of potential protein-interacting partners. Developing computational methods to predict interactions between human and bacteria pathogen has thus become critical and meaningful, in both facilitating the detection of interactions and mining incomplete interaction maps. In this paper, we present a systematic evaluation of machine learning-based computational methods for human–bacterium protein–protein interactions (HB-PPIs). We first reviewed …