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Articles 1 - 9 of 9
Full-Text Articles in Social and Behavioral Sciences
Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman
Maternal Obesity Is Associated With The Formation Of Small Dense Ldl And Hypoadiponectinemia In The Third Trimester, Barbara J. Meyer, Frances M. Stewart, Elizabeth A. Brown, Josephine Cooney, Solveig Nilsson, Gunilla Olivecrona, Jane E. Ramsay, Bruce A. Griffin, Muriel J. Caslake, Dilys J. Freeman
Faculty of Science, Medicine and Health - Papers: part A
CONTEXT: Maternal obesity is associated with high plasma triglyceride, poor vascular function, and an increased risk for pregnancy complications. In normal-weight pregnant women, higher triglyceride is associated with increased small, dense low-density lipoprotein (LDL). HYPOTHESIS: In obese pregnancy, increased plasma triglyceride concentrations result in triglyceride enrichment of very low-density lipoprotein-1 particles and formation of small dense LDL via lipoprotein lipase. DESIGN: Women (n = 55) of body mass index of 18-46 kg/m(2) were sampled longitudinally at 12, 26, and 35 weeks' gestation and 4 months postnatally. SETTING: Women were recruited at hospital antenatal appointments, and study visits were in a …
Soil Formation Rates Determined From Uranium-Series Isotope Disequilibria In Soil Profiles From The Southeastern Australian Highlands, P O. Suresh, A Dosseto, P P. Hesse, H K. Handley
Soil Formation Rates Determined From Uranium-Series Isotope Disequilibria In Soil Profiles From The Southeastern Australian Highlands, P O. Suresh, A Dosseto, P P. Hesse, H K. Handley
Faculty of Science, Medicine and Health - Papers: part A
The sustainability of soil resources is determined by the balance between the rates of production and removal of soils. Samples from four weathering profiles at Frogs Hollow in the upper catchment area of the Murrumbidgee River (southeastern Australia) were analyzed for their uranium-series (U-series) isotopic composition to estimate soil production rates. Sequential leaching was conducted on sample aliquots to assess how U-series nuclides are distributed between primary and secondary minerals. Soil is increasingly weathered from bottom to top which is evident from the decrease in (234U/238U) ratios and increase in relative quartz content with decreasing soil depth. One soil profile …
Hydroxyl Radical Formation In The Gas Phase Oxidation Of Distonic 2-Methylphenyl Radical Cations, Matthew Prendergast, Phillip A. Cooper, Benjamin B. Kirk, Gabriel Da Silva, Stephen J. Blanksby, Adam J. Trevitt
Hydroxyl Radical Formation In The Gas Phase Oxidation Of Distonic 2-Methylphenyl Radical Cations, Matthew Prendergast, Phillip A. Cooper, Benjamin B. Kirk, Gabriel Da Silva, Stephen J. Blanksby, Adam J. Trevitt
Faculty of Science, Medicine and Health - Papers: part A
The reactions of distonic 4-(N,N,N-trimethylammonium)-2-methylphenyl and 5-(N,N,N-trimethylammonium)-2-methylphenyl radical cations (m/z 149) with O 2 are studied in the gas phase using ion-trap mass spectrometry. Photodissociation (PD) of halogenated precursors gives rise to the target distonic charge-tagged methylphenyl radical whereas collision-induced dissociation (CID) is found to produce unreactive radical ions. The PD generated distonic radicals, however, react rapidly with O2 to form [M + O2]•+ and [M + O2 - OH]•+ ions, detected at m/z 181 and m/z 164, respectively. Quantum chemical calculations using G3SX(MP3) and M06-2X theories are deployed to examine key decomposition pathways of the 5-(N,N,N-trimethylammonium)-2-methylphenylperoxyl radical and rationalise …
The Itsaq Gneiss Complex Of Greenland: Episodic 3900 To 3660 Ma Juvenile Crust Formation And Recycling In The 3660 To 3600 Ma Isukasian Orogeny, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Hiroshi Hidaka, Keewook Yi, Seung Ryeol Lee, Tomoyuki Kamiichi
The Itsaq Gneiss Complex Of Greenland: Episodic 3900 To 3660 Ma Juvenile Crust Formation And Recycling In The 3660 To 3600 Ma Isukasian Orogeny, Allen P. Nutman, Vickie C. Bennett, Clark R. L Friend, Hiroshi Hidaka, Keewook Yi, Seung Ryeol Lee, Tomoyuki Kamiichi
Faculty of Science, Medicine and Health - Papers: part A
From the 3000 km2 Eoarchean Itsaq Gneiss Complex (IGC) of Greenland, zircon U-Pb dating of numerous meta-granitoid and orthogneiss samples is integrated with geologic observations, whole rock geochemistry and a strategic subset of zircon Hf and whole rock Nd isotopic measurements. This shows that there are multiple episodes of TTG suite formation from ∼3890 to 3660 Ma, characterized by zircon initial εHf≈0 and whole rock initial εNd of > +2. These rocks mostly have geochemical signatures of partial melting of eclogitized mafic sources, with a subset of high magnesian, low silica rocks indicating fusion by fluid fluxing of upper mantle sources. …
Formation Of Dimethylketene And Methacrolein By Reaction Of The Ch Radical With Acetone, Fabien Goulay, Adeeb Derakhshan, Eamonn Maher, Adam J. Trevitt, John D. Savee, Adam M. Scheer, David L. Osborn, Craig A. Taatjes
Formation Of Dimethylketene And Methacrolein By Reaction Of The Ch Radical With Acetone, Fabien Goulay, Adeeb Derakhshan, Eamonn Maher, Adam J. Trevitt, John D. Savee, Adam M. Scheer, David L. Osborn, Craig A. Taatjes
Faculty of Science, Medicine and Health - Papers: part A
The reaction of the methylidyne radical (CH) with acetone ((CH3)2CO) is studied at room temperature and at a pressure of 4 Torr (533.3 Pa) using a multiplexed photoionization mass spectrometer coupled to the tunable vacuum ultraviolet synchrotron radiation of the Advanced Light Source at Lawrence Berkeley National Laboratory. The CH radicals are generated by 248 nm multiphoton photolysis of bromoform and react with acetone in an excess of helium and nitrogen gas flow. The main observed reaction exit channel is elimination of a hydrogen atom to form C4H6O isomers. Analysis of photoionization spectra identifies dimethylketene and methacrolein as the only …
Protease-Activated Alpha-2-Macroglobulin Can Inhibit Amyloid Formation Via Two Distinct Mechanisms, Amy R. Wyatt, Patrick Constantinescu, Heath Ecroyd, Christopher M. Dobson, Mark R. Wilson, Janet R. Kumita, Justin J. Yerbury
Protease-Activated Alpha-2-Macroglobulin Can Inhibit Amyloid Formation Via Two Distinct Mechanisms, Amy R. Wyatt, Patrick Constantinescu, Heath Ecroyd, Christopher M. Dobson, Mark R. Wilson, Janet R. Kumita, Justin J. Yerbury
Faculty of Science, Medicine and Health - Papers: part A
α2-Macroglobulin (α2M) is an extracellular chaperone that inhibits amorphous and fibrillar protein aggregation. The reaction of α2M with proteases results in an ‘activated’ conformation, where the proteases become covalently-linked within the interior of a cage-like structure formed by α2M. This study investigates, the effect of activation on the ability of α2M to inhibit amyloid formation by Aβ1–42 and I59T human lysozyme and shows that protease-activated α2M can act via two distinct mechanisms: (i) by trapping proteases that remain able to degrade polypeptide chains and (ii) by a chaperone action that prevents misfolded clients from continuing along the amyloid forming pathway.
P2x7 Receptor Activation Induces Reactive Oxygen Species Formation In Erythroid Cells, Bin Wang, Ronald Sluyter
P2x7 Receptor Activation Induces Reactive Oxygen Species Formation In Erythroid Cells, Bin Wang, Ronald Sluyter
Faculty of Science, Medicine and Health - Papers: part A
The presence of P2X7 on erythroid cells is well established, but its physiological role remains unclear. The current study aimed to determine if P2X7 activation induces reactive oxygen species (ROS) formation in murine erythroleukaemia (MEL) cells, a commonly used erythroid cell line. ATP induced ROS formation in a time- and concentration-dependent fashion. The most potent P2X7 agonist, 2′(3′)-O-(4-benzoylbenzoyl)ATP, but not UTP or ADP, also induced ROS formation. The P2X7 antagonist, A-438079, impaired ATP-induced ROS formation. The ROS scavenger, N-acetyl-l-cysteine, and the ROS inhibitor, diphenyleneiodonium, also impaired P2X7-induced ROS formation, but use of enzyme-specific ROS inhibitors failed to identify the intracellular …
P2x7 Receptor Activation Induces Reactive Oxygen Species Formation And Cell Death In Murine Eoc13 Microglia, Rachael Bartlett, Justin J. Yerbury, Ronald Sluyter
P2x7 Receptor Activation Induces Reactive Oxygen Species Formation And Cell Death In Murine Eoc13 Microglia, Rachael Bartlett, Justin J. Yerbury, Ronald Sluyter
Faculty of Science, Medicine and Health - Papers: part A
The P2X7 purinergic receptor is a ligand-gated cation channel expressed on leukocytes including microglia. This study aimed to determine if P2X7 activation induces the uptake of organic cations, reactive oxygen species (ROS) formation, and death in the murine microglial EOC13 cell line. Using the murine macrophage J774 cell line as a positive control, RT-PCR, immunoblotting, and immunolabelling established the presence of P2X7 in EOC13 cells. A cytofluorometric assay demonstrated that the P2X7 agonists adenosine-5'-triphosphate (ATP) and 2' (3')-O-(4-benzoylbenzoyl) ATP induced ethidium(+) or YO-PRO-1(2+) uptake into both cell lines. ATP induced ethidium+ uptake into EOC13 cells in a concentration-dependent manner, with …
Measurements Of Reactive Trace Gases And Variable O3 Formation Rates In Some South Carolina Biomass Burning Plumes, S K. Akagi, Robert J. Yokelson, I R. Burling, S Meinardi, I Simpson, D R. Blake, G R. Mcmeeking, A Sullivan, T Lee, S Kreidenweis, S Urbanski, J Reardon, D W.T Griffith, T J. Johnson, D R. Weise
Measurements Of Reactive Trace Gases And Variable O3 Formation Rates In Some South Carolina Biomass Burning Plumes, S K. Akagi, Robert J. Yokelson, I R. Burling, S Meinardi, I Simpson, D R. Blake, G R. Mcmeeking, A Sullivan, T Lee, S Kreidenweis, S Urbanski, J Reardon, D W.T Griffith, T J. Johnson, D R. Weise
Faculty of Science, Medicine and Health - Papers: part A
In October–November 2011 we measured trace gas emission factors from seven prescribed fires in South Carolina (SC), US, using two Fourier transform infrared spectrometer (FTIR) systems and whole air sampling (WAS) into canisters followed by gas-chromatographic analysis. A total of 97 trace gas species were quantified from both airborne and ground-based sampling platforms, making this one of the most detailed field studies of fire emissions to date. The measurements include the first emission factors for a suite of monoterpenes produced by heating vegetative fuels during field fires. The first quantitative FTIR observations of limonene in smoke are reported along with …